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Protein

Growth arrest and DNA damage-inducible protein GADD45 alpha

Gene

Gadd45a

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Might affect PCNA interaction with some CDK (cell division protein kinase) complexes; stimulates DNA excision repair in vitro and inhibits entry of cells into S phase. In T-cells, functions as a regulator of p38 MAPKs by inhibiting p88 phosphorylation and activity.1 Publication

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processCell cycle, DNA damage, Growth arrest

Enzyme and pathway databases

ReactomeiR-MMU-6804114 TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest

Names & Taxonomyi

Protein namesi
Recommended name:
Growth arrest and DNA damage-inducible protein GADD45 alpha
Alternative name(s):
DNA damage-inducible transcript 1 protein
Short name:
DDIT-1
Gene namesi
Name:Gadd45a
Synonyms:Ddit1, Gadd45
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 6

Organism-specific databases

MGIiMGI:107799 Gadd45a

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001483321 – 165Growth arrest and DNA damage-inducible protein GADD45 alphaAdd BLAST165

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2PhosphothreonineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiP48316
PRIDEiP48316

PTM databases

PhosphoSitePlusiP48316

Expressioni

Inductioni

By various types of DNA damage and growth arrest.

Gene expression databases

BgeeiENSMUSG00000036390 Expressed in 291 organ(s), highest expression level in lens of camera-type eye
CleanExiMM_GADD45A
ExpressionAtlasiP48316 baseline and differential
GenevisibleiP48316 MM

Interactioni

Subunit structurei

Interacts with AURKA, GADD45GIP1 and PCNA (By similarity). Interacts with MAPK14.By similarity1 Publication

GO - Molecular functioni

Protein-protein interaction databases

BioGridi199077, 6 interactors
IntActiP48316, 1 interactor
STRINGi10090.ENSMUSP00000044034

Structurei

3D structure databases

ProteinModelPortaliP48316
SMRiP48316
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni1 – 16Intrinsically disorderedBy similarityAdd BLAST16
Regioni105 – 118Intrinsically disorderedBy similarityAdd BLAST14

Sequence similaritiesi

Belongs to the GADD45 family.Curated

Phylogenomic databases

eggNOGiENOG410IFHI Eukaryota
ENOG4111M8M LUCA
GeneTreeiENSGT00390000016506
HOGENOMiHOG000013221
HOVERGENiHBG051684
InParanoidiP48316
KOiK04402
OMAiQWVPIIN
OrthoDBiEOG091G0RHU
PhylomeDBiP48316
TreeFamiTF300196

Family and domain databases

Gene3Di3.30.1330.30, 1 hit
InterProiView protein in InterPro
IPR024824 GADD45
IPR029064 L30e-like
IPR004038 Ribosomal_L7Ae/L30e/S12e/Gad45
PANTHERiPTHR10411 PTHR10411, 1 hit
PfamiView protein in Pfam
PF01248 Ribosomal_L7Ae, 1 hit
SUPFAMiSSF55315 SSF55315, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All

P48316-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MTLEEFSAAE QKTERMDTVG DALEEVLSKA RSQRTITVGV YEAAKLLNVD
60 70 80 90 100
PDNVVLCLLA ADEDDDRDVA LQIHFTLIRA FCCENDINIL RVSNPGRLAE
110 120 130 140 150
LLLLENDAGP AESGGAAQTP DLHCVLVTNP HSSQWKDPAL SQLICFCRES
160
RYMDQWVPVI NLPER
Length:165
Mass (Da):18,339
Last modified:February 1, 1996 - v1
Checksum:iC96BAB354A84770F
GO

Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A0N4SW99A0A0N4SW99_MOUSE
Growth arrest and DNA damage-induci...
Gadd45a
131Annotation score:
A0A0N4SVJ9A0A0N4SVJ9_MOUSE
Growth arrest and DNA damage-induci...
Gadd45a
60Annotation score:

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L28177 mRNA Translation: AAA37656.1
U00937 Unassigned DNA Translation: AAC27351.1
BC011141 mRNA Translation: AAH11141.1
CCDSiCCDS20217.1
PIRiB56535
RefSeqiNP_031862.1, NM_007836.1
UniGeneiMm.72235

Genome annotation databases

EnsembliENSMUST00000043098; ENSMUSP00000044034; ENSMUSG00000036390
GeneIDi13197
KEGGimmu:13197
UCSCiuc009cfc.1 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L28177 mRNA Translation: AAA37656.1
U00937 Unassigned DNA Translation: AAC27351.1
BC011141 mRNA Translation: AAH11141.1
CCDSiCCDS20217.1
PIRiB56535
RefSeqiNP_031862.1, NM_007836.1
UniGeneiMm.72235

3D structure databases

ProteinModelPortaliP48316
SMRiP48316
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi199077, 6 interactors
IntActiP48316, 1 interactor
STRINGi10090.ENSMUSP00000044034

PTM databases

PhosphoSitePlusiP48316

Proteomic databases

PaxDbiP48316
PRIDEiP48316

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000043098; ENSMUSP00000044034; ENSMUSG00000036390
GeneIDi13197
KEGGimmu:13197
UCSCiuc009cfc.1 mouse

Organism-specific databases

CTDi1647
MGIiMGI:107799 Gadd45a

Phylogenomic databases

eggNOGiENOG410IFHI Eukaryota
ENOG4111M8M LUCA
GeneTreeiENSGT00390000016506
HOGENOMiHOG000013221
HOVERGENiHBG051684
InParanoidiP48316
KOiK04402
OMAiQWVPIIN
OrthoDBiEOG091G0RHU
PhylomeDBiP48316
TreeFamiTF300196

Enzyme and pathway databases

ReactomeiR-MMU-6804114 TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest

Miscellaneous databases

PROiPR:P48316
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000036390 Expressed in 291 organ(s), highest expression level in lens of camera-type eye
CleanExiMM_GADD45A
ExpressionAtlasiP48316 baseline and differential
GenevisibleiP48316 MM

Family and domain databases

Gene3Di3.30.1330.30, 1 hit
InterProiView protein in InterPro
IPR024824 GADD45
IPR029064 L30e-like
IPR004038 Ribosomal_L7Ae/L30e/S12e/Gad45
PANTHERiPTHR10411 PTHR10411, 1 hit
PfamiView protein in Pfam
PF01248 Ribosomal_L7Ae, 1 hit
SUPFAMiSSF55315 SSF55315, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiGA45A_MOUSE
AccessioniPrimary (citable) accession number: P48316
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1996
Last sequence update: February 1, 1996
Last modified: September 12, 2018
This is version 126 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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Main funding by: National Institutes of Health

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