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Protein

Lithostathine-1-beta

Gene

REG1B

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Might act as an inhibitor of spontaneous calcium carbonate precipitation. May be associated with neuronal sprouting in brain, and with brain and pancreas regeneration.

GO - Molecular functioni

  • oligosaccharide binding Source: GO_Central
  • peptidoglycan binding Source: GO_Central
  • transmembrane signaling receptor activity Source: GO_Central

GO - Biological processi

Keywordsi

LigandLectin

Names & Taxonomyi

Protein namesi
Recommended name:
Lithostathine-1-beta
Alternative name(s):
Pancreatic stone protein 2
Short name:
PSP-2
Regenerating islet-derived protein 1-beta
Short name:
REG-1-beta
Regenerating protein I beta
Gene namesi
Name:REG1B
Synonyms:PSPS2, REGL
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 2

Organism-specific databases

EuPathDBiHostDB:ENSG00000172023.7
HGNCiHGNC:9952 REG1B
MIMi167771 gene
neXtProtiNX_P48304

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Organism-specific databases

DisGeNETi5968
OpenTargetsiENSG00000172023
PharmGKBiPA34319

Polymorphism and mutation databases

BioMutaiREG1B
DMDMi1346460

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 22By similarityAdd BLAST22
ChainiPRO_000001742523 – 166Lithostathine-1-betaAdd BLAST144

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi27O-linked (GalNAc...) threonine1 Publication1
Disulfide bondi36 ↔ 47PROSITE-ProRule annotation
Disulfide bondi64 ↔ 162PROSITE-ProRule annotation
Disulfide bondi137 ↔ 154PROSITE-ProRule annotation

Post-translational modificationi

All O-linked glycans consist of Gal-GlcNAc-Gal-GalNAc tetrasaccharide core and get elongated (microheterogeneity).1 Publication

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiP48304
PeptideAtlasiP48304
PRIDEiP48304
ProteomicsDBi55874

PTM databases

iPTMnetiP48304
PhosphoSitePlusiP48304

Expressioni

Gene expression databases

BgeeiENSG00000172023 Expressed in 80 organ(s), highest expression level in body of pancreas
CleanExiHS_REG1B
ExpressionAtlasiP48304 baseline and differential
GenevisibleiP48304 HS

Organism-specific databases

HPAiHPA045549
HPA045579

Interactioni

Protein-protein interaction databases

BioGridi111900, 3 interactors
IntActiP48304, 2 interactors
MINTiP48304
STRINGi9606.ENSP00000303206

Structurei

3D structure databases

ProteinModelPortaliP48304
SMRiP48304
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini34 – 164C-type lectinPROSITE-ProRule annotationAdd BLAST131

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiKOG4297 Eukaryota
ENOG410XPJ1 LUCA
GeneTreeiENSGT00700000104249
HOGENOMiHOG000010281
HOVERGENiHBG004151
InParanoidiP48304
OMAiKDESCEK
OrthoDBiEOG091G0OLC
PhylomeDBiP48304

Family and domain databases

Gene3Di3.10.100.10, 1 hit
InterProiView protein in InterPro
IPR001304 C-type_lectin-like
IPR016186 C-type_lectin-like/link_sf
IPR018378 C-type_lectin_CS
IPR016187 CTDL_fold
PfamiView protein in Pfam
PF00059 Lectin_C, 1 hit
SMARTiView protein in SMART
SM00034 CLECT, 1 hit
SUPFAMiSSF56436 SSF56436, 1 hit
PROSITEiView protein in PROSITE
PS00615 C_TYPE_LECTIN_1, 1 hit
PS50041 C_TYPE_LECTIN_2, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

P48304-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAQTNSFFML ISSLMFLSLS QGQESQTELP NPRISCPEGT NAYRSYCYYF
60 70 80 90 100
NEDPETWVDA DLYCQNMNSG NLVSVLTQAE GAFVASLIKE SSTDDSNVWI
110 120 130 140 150
GLHDPKKNRR WHWSSGSLVS YKSWDTGSPS SANAGYCASL TSCSGFKKWK
160
DESCEKKFSF VCKFKN
Length:166
Mass (Da):18,665
Last modified:February 1, 1996 - v1
Checksum:iD1DC20E11AE5DDE8
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
H7BZ24H7BZ24_HUMAN
Lithostathine-1-beta
REG1B
149Annotation score:

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_050121109R → H. Corresponds to variant dbSNP:rs7586984Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L08010 Genomic DNA Translation: AAA18204.1
D17291 Genomic DNA Translation: BAA04124.1
D16816 mRNA Translation: BAA04091.1
BC027895 mRNA Translation: AAH27895.1
CCDSiCCDS1963.1
PIRiS34591 RGHU1B
RefSeqiNP_006498.1, NM_006507.3
UniGeneiHs.4158
Hs.708865

Genome annotation databases

EnsembliENST00000305089; ENSP00000303206; ENSG00000172023
GeneIDi5968
KEGGihsa:5968

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Cross-referencesi

Web resourcesi

Functional Glycomics Gateway - Glycan Binding

Lithostathine A

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L08010 Genomic DNA Translation: AAA18204.1
D17291 Genomic DNA Translation: BAA04124.1
D16816 mRNA Translation: BAA04091.1
BC027895 mRNA Translation: AAH27895.1
CCDSiCCDS1963.1
PIRiS34591 RGHU1B
RefSeqiNP_006498.1, NM_006507.3
UniGeneiHs.4158
Hs.708865

3D structure databases

ProteinModelPortaliP48304
SMRiP48304
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi111900, 3 interactors
IntActiP48304, 2 interactors
MINTiP48304
STRINGi9606.ENSP00000303206

PTM databases

iPTMnetiP48304
PhosphoSitePlusiP48304

Polymorphism and mutation databases

BioMutaiREG1B
DMDMi1346460

Proteomic databases

PaxDbiP48304
PeptideAtlasiP48304
PRIDEiP48304
ProteomicsDBi55874

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000305089; ENSP00000303206; ENSG00000172023
GeneIDi5968
KEGGihsa:5968

Organism-specific databases

CTDi5968
DisGeNETi5968
EuPathDBiHostDB:ENSG00000172023.7
GeneCardsiREG1B
HGNCiHGNC:9952 REG1B
HPAiHPA045549
HPA045579
MIMi167771 gene
neXtProtiNX_P48304
OpenTargetsiENSG00000172023
PharmGKBiPA34319
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG4297 Eukaryota
ENOG410XPJ1 LUCA
GeneTreeiENSGT00700000104249
HOGENOMiHOG000010281
HOVERGENiHBG004151
InParanoidiP48304
OMAiKDESCEK
OrthoDBiEOG091G0OLC
PhylomeDBiP48304

Miscellaneous databases

GeneWikiiREG1B
GenomeRNAii5968
PROiPR:P48304
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000172023 Expressed in 80 organ(s), highest expression level in body of pancreas
CleanExiHS_REG1B
ExpressionAtlasiP48304 baseline and differential
GenevisibleiP48304 HS

Family and domain databases

Gene3Di3.10.100.10, 1 hit
InterProiView protein in InterPro
IPR001304 C-type_lectin-like
IPR016186 C-type_lectin-like/link_sf
IPR018378 C-type_lectin_CS
IPR016187 CTDL_fold
PfamiView protein in Pfam
PF00059 Lectin_C, 1 hit
SMARTiView protein in SMART
SM00034 CLECT, 1 hit
SUPFAMiSSF56436 SSF56436, 1 hit
PROSITEiView protein in PROSITE
PS00615 C_TYPE_LECTIN_1, 1 hit
PS50041 C_TYPE_LECTIN_2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiREG1B_HUMAN
AccessioniPrimary (citable) accession number: P48304
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1996
Last sequence update: February 1, 1996
Last modified: November 7, 2018
This is version 147 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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