Endothelin receptor type B

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functionⁱ

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functionⁱ

• endothelin receptor activity Source: MGI <p>Inferred from Direct Assay</p> <p>Used to indicate a direct assay for the function, process or component indicated by the GO term.</p> <p>More information in the <a href="http://geneontology.org/page/guide%2Dgo%2Devidence%2Dcodes#ida">GO evidence code guide</a></p> Inferred from direct assayⁱ
  • "The first inner loop of endothelin receptor type B is necessary for specific coupling to Galpha 13."
    Liu B., Wu D.
    J Biol Chem 278:2384-2387(2003) [PubMed] [Europe PMC] [Abstract]
• peptide hormone binding Source: MGI
• type 1 angiotensin receptor binding Source: MGI

GO - Biological processⁱ

• aging Source: Ensembl
• calcium-mediated signaling Source: UniProtKB
• cellular response to lipopolysaccharide Source: Ensembl
• cGMP-mediated signaling Source: MGI
• developmental pigmentation Source: MGI <p>Inferred from Mutant Phenotype</p> <p>Describes annotations that are concluded from looking at variations or changes in a gene product such as mutations or abnormal levels and includes techniques such as knockouts, overexpression, anti-sense experiments and use of specific protein inhibitors.</p> <p>More information in the <a href="http://geneontology.org/page/guide%2Dgo%2Devidence%2Dcodes#imp">GO evidence code guide</a></p> Inferred from mutant phenotypeⁱ
  • "Effects of G-protein mutations on skin color."
    Van Raamsdonk C.D., Fitch K.R., Fuchs H., de Angelis M.H., Barsh G.S.
    Nat Genet 36:961-968(2004) [PubMed] [Europe PMC] [Abstract]
• endothelin receptor signaling pathway Source: MGI
• enteric nervous system development Source: BHF-UCLInferred from direct assayⁱ
  • "Inhibition of in vitro enteric neuronal development by endothelin-3: mediation by endothelin B receptors."
    Wu J.J., Chen J.X., Rothman T.P., Gershon M.D.
    Development 126:1161-1173(1999) [PubMed] [Europe PMC] [Abstract]
• enteric smooth muscle cell differentiation Source: BHF-UCLInferred from direct assayⁱ
  • "Inhibition of in vitro enteric neuronal development by endothelin-3: mediation by endothelin B receptors."
    Wu J.J., Chen J.X., Rothman T.P., Gershon M.D.
    Development 126:1161-1173(1999) [PubMed] [Europe PMC] [Abstract]
• epithelial fluid transport Source: MGI
• G protein-coupled receptor signaling pathway Source: MGIInferred from direct assayⁱ
  • "The first inner loop of endothelin receptor type B is necessary for specific coupling to Galpha 13."
    Liu B., Wu D.
    J Biol Chem 278:2384-2387(2003) [PubMed] [Europe PMC] [Abstract]
• macrophage chemotaxis Source: MGI
• melanocyte differentiation Source: MGIInferred from direct assayⁱ
  • "Multiple roles for endothelin in melanocyte development: regulation of progenitor number and stimulation of differentiation."
    Reid K., Turnley A.M., Maxwell G.D., Kurihara Y., Kurihara H., Bartlett P.F., Murphy M.
    Development 122:3911-3919(1996) [PubMed] [Europe PMC] [Abstract]
• negative regulation of apoptotic process Source: MGI
• negative regulation of cellular protein metabolic process Source: MGI
• negative regulation of neuron maturation Source: BHF-UCLInferred from direct assayⁱ
  • "Inhibition of in vitro enteric neuronal development by endothelin-3: mediation by endothelin B receptors."
    Wu J.J., Chen J.X., Rothman T.P., Gershon M.D.
    Development 126:1161-1173(1999) [PubMed] [Europe PMC] [Abstract]
• negative regulation of transcription by RNA polymerase II Source: BHF-UCLInferred from direct assayⁱ
  • "Inhibition of in vitro enteric neuronal development by endothelin-3: mediation by endothelin B receptors."
    Wu J.J., Chen J.X., Rothman T.P., Gershon M.D.
    Development 126:1161-1173(1999) [PubMed] [Europe PMC] [Abstract]
• neural crest cell migration Source: MGIInferred from mutant phenotypeⁱ
  • "The temporal requirement for endothelin receptor-B signalling during neural crest development."
    Shin M.K., Levorse J.M., Ingram R.S., Tilghman S.M.
    Nature 402:496-501(1999) [PubMed] [Europe PMC] [Abstract]
• peripheral nervous system development Source: MGIInferred from mutant phenotypeⁱ
  • "Intercellular signals downstream of endothelin receptor-B mediate colonization of the large intestine by enteric neuroblasts."
    Kapur R.P., Sweetser D.A., Doggett B., Siebert J.R., Palmiter R.D.
    Development 121:3787-3795(1995) [PubMed] [Europe PMC] [Abstract]
• phospholipase C-activating G protein-coupled receptor signaling pathway Source: MGI
• pigmentation Source: MGIInferred from mutant phenotypeⁱ
  • "Interaction of the murine dilute suppressor gene (dsu) with fourteen coat color mutations."
    Moore K.J., Swing D.A., Copeland N.G., Jenkins N.A.
    Genetics 125:421-430(1990) [PubMed] [Europe PMC] [Abstract]
• positive regulation of cell population proliferation Source: MGI
• positive regulation of cytosolic calcium ion concentration Source: MGI
• positive regulation of penile erection Source: MGI
• positive regulation of protein phosphorylation Source: MGI
• positive regulation of renal sodium excretion Source: MGI
• positive regulation of urine volume Source: MGI
• posterior midgut development Source: MGIInferred from mutant phenotypeⁱ
  • "Intercellular signals downstream of endothelin receptor-B mediate colonization of the large intestine by enteric neuroblasts."
    Kapur R.P., Sweetser D.A., Doggett B., Siebert J.R., Palmiter R.D.
    Development 121:3787-3795(1995) [PubMed] [Europe PMC] [Abstract]
• regulation of blood pressure Source: MGIInferred from mutant phenotypeⁱ
  • "Endothelin in the central control of cardiovascular and respiratory functions."
    Kuwaki T., Ling G.Y., Onodera M., Ishii T., Nakamura A., Ju K.H., Cao W.H., Kumada M., Kurihara H., Kurihara Y., Yazaki Y., Ohuchi T., Yanagisawa M., Fukuda Y.
    Clin Exp Pharmacol Physiol 26:989-994(1999) [PubMed] [Europe PMC] [Abstract]
• regulation of epithelial cell proliferation Source: MGI
• regulation of fever generation Source: MGI
• regulation of pH Source: MGIInferred from mutant phenotypeⁱ
  • "Endothelin-1/endothelin-B receptor-mediated increases in NHE3 activity in chronic metabolic acidosis."
    Laghmani K., Preisig P.A., Moe O.W., Yanagisawa M., Alpern R.J.
    J Clin Invest 107:1563-1569(2001) [PubMed] [Europe PMC] [Abstract]
• regulation of sensory perception of pain Source: MGI
• response to endothelin Source: MGI
• response to lipopolysaccharide Source: MGI
• response to organic cyclic compound Source: Ensembl
• response to pain Source: MGI
• sensory perception of pain Source: MGI
• vasoconstriction Source: MGI
• vasodilation Source: MGI
• vein smooth muscle contraction Source: MGI

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsⁱ

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyⁱ

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationⁱ

• UniProt annotation
• GO - Cellular component

Topology

Keywords - Cellular componentⁱ

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechⁱ

Chemistry databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingⁱ

Molecule processing

Amino acid modifications

Keywords - PTMⁱ

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressionⁱ

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactionⁱ

GO - Molecular functionⁱ

• type 1 angiotensin receptor binding Source: MGI

Protein-protein interaction databases

Chemistry databases

Miscellaneous databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structureⁱ

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsⁱ

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesⁱ

Keywords - Domainⁱ

Phylogenomic databases

Family and domain databases

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequenceⁱ

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusⁱ: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingⁱ: The displayed sequence is further processed into a mature form.

        10         20         30         40         50
MQSPASRCGR ALVALLLACG FLGVWGEKRG FPPAQATLSL LGTKEVMTPP 
        60         70         80         90        100
TKTSWTRGSN SSLMRSSAPA EVTKGGRGAG VPPRSFPPPC QRNIEISKTF 
       110        120        130        140        150
KYINTIVSCL VFVLGIIGNS TLLRIIYKNK CMRNGPNILI ASLALGDLLH 
       160        170        180        190        200
IIIDIPINTY KLLAEDWPFG AEMCKLVPFI QKASVGITVL SLCALSIDRY 
       210        220        230        240        250
RAVASWSRIK GIGVPKWTAV EIVLIWVVSV VLAVPEAIGF DMITSDYKGK 
       260        270        280        290        300
PLRVCMLNPF QKTAFMQFYK TAKDWWLFSF YFCLPLAITA VFYTLMTCEM 
       310        320        330        340        350
LRKKSGMQIA LNDHLKQRRE VAKTVFCLVL VFALCWLPLH LSRILKLTLY 
       360        370        380        390        400
DQSNPHRCEL LSFLLVLDYI GINMASLNSC INPIALYLVS KRFKNCFKSC 
       410        420        430        440 
LCCWCQTFEE KQSLEEKQSC LKFKANDHGY DNFRSSNKYS SS         

Sequence databases

Genome annotation databases

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsⁱ

• 90% Identity
• 50% Identity

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesⁱ

Sequence databases

3D structure databases

Protein-protein interaction databases

Chemistry databases

Protein family/group databases

PTM databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationⁱ

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousⁱ

Keywords - Technical termⁱ

Documents

1. 7-transmembrane G-linked receptors
   List of 7-transmembrane G-linked receptor entries
2. MGD cross-references
   Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
3. SIMILARITY comments
   Index of protein domains and families