UniProtKB - P48302 (EDNRB_MOUSE)
Protein
Endothelin receptor type B
Gene
Ednrb
Organism
Mus musculus (Mouse)
Status
Functioni
Non-specific receptor for endothelin 1, 2, and 3. Mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system. Essential component in the normal development of two neuronal crest-derived cell lineages.
GO - Molecular functioni
- endothelin receptor activity Source: MGI
- peptide hormone binding Source: MGI
- type 1 angiotensin receptor binding Source: MGI
GO - Biological processi
- aging Source: Ensembl
- calcium-mediated signaling Source: UniProtKB
- cellular response to lipopolysaccharide Source: Ensembl
- cGMP-mediated signaling Source: MGI
- developmental pigmentation Source: MGI
- endothelin receptor signaling pathway Source: MGI
- enteric nervous system development Source: BHF-UCL
- enteric smooth muscle cell differentiation Source: BHF-UCL
- epithelial fluid transport Source: MGI
- G protein-coupled receptor signaling pathway Source: MGI
- macrophage chemotaxis Source: MGI
- melanocyte differentiation Source: MGI
- negative regulation of apoptotic process Source: MGI
- negative regulation of cellular protein metabolic process Source: MGI
- negative regulation of neuron maturation Source: BHF-UCL
- negative regulation of transcription by RNA polymerase II Source: BHF-UCL
- neural crest cell migration Source: MGI
- peripheral nervous system development Source: MGI
- phospholipase C-activating G protein-coupled receptor signaling pathway Source: MGI
- pigmentation Source: MGI
- positive regulation of cell population proliferation Source: MGI
- positive regulation of cytosolic calcium ion concentration Source: MGI
- positive regulation of penile erection Source: MGI
- positive regulation of protein phosphorylation Source: MGI
- positive regulation of renal sodium excretion Source: MGI
- positive regulation of urine volume Source: MGI
- posterior midgut development Source: MGI
- regulation of blood pressure Source: MGI
- regulation of epithelial cell proliferation Source: MGI
- regulation of fever generation Source: MGI
- regulation of pH Source: MGI
- regulation of sensory perception of pain Source: MGI
- response to endothelin Source: MGI
- response to lipopolysaccharide Source: MGI
- response to organic cyclic compound Source: Ensembl
- response to pain Source: MGI
- sensory perception of pain Source: MGI
- vasoconstriction Source: MGI
- vasodilation Source: MGI
- vein smooth muscle contraction Source: MGI
Keywordsi
Molecular function | G-protein coupled receptor, Receptor, Transducer |
Enzyme and pathway databases
Reactomei | R-MMU-375276, Peptide ligand-binding receptors R-MMU-416476, G alpha (q) signalling events |
Names & Taxonomyi
Protein namesi | Recommended name: Endothelin receptor type BCuratedShort name: ET-B Short name: ET-BR Alternative name(s): Endothelin receptor non-selective type |
Gene namesi | Name:EdnrbImported |
Organismi | Mus musculus (Mouse) |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Proteomesi |
|
Organism-specific databases
MGIi | MGI:102720, Ednrb |
Subcellular locationi
Plasma membrane
- Cell membrane By similarity; Multi-pass membrane protein
Note: internalized after activation by endothelins.By similarity
Nucleus
- nuclear membrane Source: MGI
Plasma Membrane
- plasma membrane Source: UniProtKB
Other locations
- integral component of membrane Source: UniProtKB-KW
- membrane Source: MGI
- membrane raft Source: MGI
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 27 – 101 | ExtracellularSequence analysisAdd BLAST | 75 | |
Transmembranei | 102 – 126 | Helical; Name=1Sequence analysisAdd BLAST | 25 | |
Topological domaini | 127 – 137 | CytoplasmicSequence analysisAdd BLAST | 11 | |
Transmembranei | 138 – 163 | Helical; Name=2Sequence analysisAdd BLAST | 26 | |
Topological domaini | 164 – 175 | ExtracellularSequence analysisAdd BLAST | 12 | |
Transmembranei | 176 – 197 | Helical; Name=3Sequence analysisAdd BLAST | 22 | |
Topological domaini | 198 – 218 | CytoplasmicSequence analysisAdd BLAST | 21 | |
Transmembranei | 219 – 243 | Helical; Name=4Sequence analysisAdd BLAST | 25 | |
Topological domaini | 244 – 271 | ExtracellularSequence analysisAdd BLAST | 28 | |
Transmembranei | 272 – 296 | Helical; Name=5Sequence analysisAdd BLAST | 25 | |
Topological domaini | 297 – 324 | CytoplasmicSequence analysisAdd BLAST | 28 | |
Transmembranei | 325 – 350 | Helical; Name=6Sequence analysisAdd BLAST | 26 | |
Topological domaini | 351 – 362 | ExtracellularSequence analysisAdd BLAST | 12 | |
Transmembranei | 363 – 389 | Helical; Name=7Sequence analysisAdd BLAST | 27 | |
Topological domaini | 390 – 442 | CytoplasmicSequence analysisAdd BLAST | 53 |
Keywords - Cellular componenti
Cell membrane, MembranePTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 26 | Sequence analysisAdd BLAST | 26 | |
ChainiPRO_0000012730 | 27 – 442 | Endothelin receptor type BAdd BLAST | 416 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Glycosylationi | 60 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Disulfide bondi | 174 ↔ 255 | PROSITE-ProRule annotation | ||
Modified residuei | 305 | PhosphoserineBy similarity | 1 | |
Lipidationi | 402 | S-palmitoyl cysteineSequence analysis | 1 | |
Lipidationi | 403 | S-palmitoyl cysteineSequence analysis | 1 | |
Lipidationi | 405 | S-palmitoyl cysteineSequence analysis | 1 | |
Modified residuei | 419 | PhosphoserineBy similarity | 1 | |
Modified residuei | 439 | PhosphotyrosineBy similarity | 1 | |
Modified residuei | 440 | PhosphoserineBy similarity | 1 | |
Modified residuei | 441 | PhosphoserineBy similarity | 1 | |
Modified residuei | 442 | PhosphoserineBy similarity | 1 |
Keywords - PTMi
Disulfide bond, Glycoprotein, Lipoprotein, Palmitate, PhosphoproteinProteomic databases
MaxQBi | P48302 |
PaxDbi | P48302 |
PRIDEi | P48302 |
ProteomicsDBi | 277798 |
PTM databases
GlyGeni | P48302, 1 site |
iPTMneti | P48302 |
PhosphoSitePlusi | P48302 |
SwissPalmi | P48302 |
Expressioni
Gene expression databases
Bgeei | ENSMUSG00000022122, Expressed in pineal body and 310 other tissues |
Genevisiblei | P48302, MM |
Interactioni
GO - Molecular functioni
- type 1 angiotensin receptor binding Source: MGI
Protein-protein interaction databases
STRINGi | 10090.ENSMUSP00000126057 |
Chemistry databases
BindingDBi | P48302 |
Miscellaneous databases
RNActi | P48302, protein |
Family & Domainsi
Sequence similaritiesi
Belongs to the G-protein coupled receptor 1 family. Endothelin receptor subfamily. EDNRB sub-subfamily.PROSITE-ProRule annotation
Keywords - Domaini
Signal, Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | KOG3656, Eukaryota |
GeneTreei | ENSGT01020000230470 |
HOGENOMi | CLU_009579_28_0_1 |
InParanoidi | P48302 |
OMAi | GFDMITT |
OrthoDBi | 876925at2759 |
PhylomeDBi | P48302 |
TreeFami | TF331292 |
Family and domain databases
InterProi | View protein in InterPro IPR000499, Endthln_rcpt IPR001112, ETB_rcpt IPR000276, GPCR_Rhodpsn IPR017452, GPCR_Rhodpsn_7TM |
Pfami | View protein in Pfam PF00001, 7tm_1, 1 hit |
PRINTSi | PR00571, ENDOTHELINBR PR00366, ENDOTHELINR PR00237, GPCRRHODOPSN |
SMARTi | View protein in SMART SM01381, 7TM_GPCR_Srsx, 1 hit |
PROSITEi | View protein in PROSITE PS00237, G_PROTEIN_RECEP_F1_1, 1 hit PS50262, G_PROTEIN_RECEP_F1_2, 1 hit |
i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
P48302-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MQSPASRCGR ALVALLLACG FLGVWGEKRG FPPAQATLSL LGTKEVMTPP
60 70 80 90 100
TKTSWTRGSN SSLMRSSAPA EVTKGGRGAG VPPRSFPPPC QRNIEISKTF
110 120 130 140 150
KYINTIVSCL VFVLGIIGNS TLLRIIYKNK CMRNGPNILI ASLALGDLLH
160 170 180 190 200
IIIDIPINTY KLLAEDWPFG AEMCKLVPFI QKASVGITVL SLCALSIDRY
210 220 230 240 250
RAVASWSRIK GIGVPKWTAV EIVLIWVVSV VLAVPEAIGF DMITSDYKGK
260 270 280 290 300
PLRVCMLNPF QKTAFMQFYK TAKDWWLFSF YFCLPLAITA VFYTLMTCEM
310 320 330 340 350
LRKKSGMQIA LNDHLKQRRE VAKTVFCLVL VFALCWLPLH LSRILKLTLY
360 370 380 390 400
DQSNPHRCEL LSFLLVLDYI GINMASLNSC INPIALYLVS KRFKNCFKSC
410 420 430 440
LCCWCQTFEE KQSLEEKQSC LKFKANDHGY DNFRSSNKYS SS
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U32329 mRNA Translation: AAB60508.1 AK076426 mRNA Translation: BAC36337.1 AK082103 mRNA Translation: BAC38409.1 AK083415 mRNA Translation: BAC38908.1 AK085532 mRNA Translation: BAC39465.1 BC026553 mRNA Translation: AAH26553.1 |
CCDSi | CCDS27317.1 |
RefSeqi | NP_001129533.1, NM_001136061.2 NP_001263225.1, NM_001276296.1 NP_031930.1, NM_007904.4 XP_006518578.1, XM_006518515.2 |
Genome annotation databases
Ensembli | ENSMUST00000022718; ENSMUSP00000022718; ENSMUSG00000022122 ENSMUST00000172237; ENSMUSP00000126057; ENSMUSG00000022122 ENSMUST00000227824; ENSMUSP00000154806; ENSMUSG00000022122 |
GeneIDi | 13618 |
KEGGi | mmu:13618 |
UCSCi | uc007uww.3, mouse |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U32329 mRNA Translation: AAB60508.1 AK076426 mRNA Translation: BAC36337.1 AK082103 mRNA Translation: BAC38409.1 AK083415 mRNA Translation: BAC38908.1 AK085532 mRNA Translation: BAC39465.1 BC026553 mRNA Translation: AAH26553.1 |
CCDSi | CCDS27317.1 |
RefSeqi | NP_001129533.1, NM_001136061.2 NP_001263225.1, NM_001276296.1 NP_031930.1, NM_007904.4 XP_006518578.1, XM_006518515.2 |
3D structure databases
SMRi | P48302 |
ModBasei | Search... |
Protein-protein interaction databases
STRINGi | 10090.ENSMUSP00000126057 |
Chemistry databases
BindingDBi | P48302 |
ChEMBLi | CHEMBL1681617 |
Protein family/group databases
GPCRDBi | Search... |
PTM databases
GlyGeni | P48302, 1 site |
iPTMneti | P48302 |
PhosphoSitePlusi | P48302 |
SwissPalmi | P48302 |
Proteomic databases
MaxQBi | P48302 |
PaxDbi | P48302 |
PRIDEi | P48302 |
ProteomicsDBi | 277798 |
Protocols and materials databases
Antibodypediai | 4509, 464 antibodies |
Genome annotation databases
Ensembli | ENSMUST00000022718; ENSMUSP00000022718; ENSMUSG00000022122 ENSMUST00000172237; ENSMUSP00000126057; ENSMUSG00000022122 ENSMUST00000227824; ENSMUSP00000154806; ENSMUSG00000022122 |
GeneIDi | 13618 |
KEGGi | mmu:13618 |
UCSCi | uc007uww.3, mouse |
Organism-specific databases
CTDi | 1910 |
MGIi | MGI:102720, Ednrb |
Phylogenomic databases
eggNOGi | KOG3656, Eukaryota |
GeneTreei | ENSGT01020000230470 |
HOGENOMi | CLU_009579_28_0_1 |
InParanoidi | P48302 |
OMAi | GFDMITT |
OrthoDBi | 876925at2759 |
PhylomeDBi | P48302 |
TreeFami | TF331292 |
Enzyme and pathway databases
Reactomei | R-MMU-375276, Peptide ligand-binding receptors R-MMU-416476, G alpha (q) signalling events |
Miscellaneous databases
BioGRID-ORCSi | 13618, 3 hits in 54 CRISPR screens |
ChiTaRSi | Ednrb, mouse |
PROi | PR:P48302 |
RNActi | P48302, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSMUSG00000022122, Expressed in pineal body and 310 other tissues |
Genevisiblei | P48302, MM |
Family and domain databases
InterProi | View protein in InterPro IPR000499, Endthln_rcpt IPR001112, ETB_rcpt IPR000276, GPCR_Rhodpsn IPR017452, GPCR_Rhodpsn_7TM |
Pfami | View protein in Pfam PF00001, 7tm_1, 1 hit |
PRINTSi | PR00571, ENDOTHELINBR PR00366, ENDOTHELINR PR00237, GPCRRHODOPSN |
SMARTi | View protein in SMART SM01381, 7TM_GPCR_Srsx, 1 hit |
PROSITEi | View protein in PROSITE PS00237, G_PROTEIN_RECEP_F1_1, 1 hit PS50262, G_PROTEIN_RECEP_F1_2, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | EDNRB_MOUSE | |
Accessioni | P48302Primary (citable) accession number: P48302 Secondary accession number(s): Q542M3 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | February 1, 1996 |
Last sequence update: | February 1, 1996 | |
Last modified: | April 7, 2021 | |
This is version 161 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- 7-transmembrane G-linked receptors
List of 7-transmembrane G-linked receptor entries - MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families