UniProtKB - P48301 (TEAD2_MOUSE)
Transcriptional enhancer factor TEF-4
Tead2
Functioni
Transcription factor which plays a key role in the Hippo signaling pathway, a pathway involved in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein MST1/MST2, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Acts by mediating gene expression of YAP1 and WWTR1/TAZ, thereby regulating cell proliferation, migration and epithelial mesenchymal transition (EMT) induction (By similarity).
Binds to the SPH and GT-IIC 'enhansons' (5'-GTGGAATGT-3'). May be involved in the gene regulation of neural development. Binds to the M-CAT motif.
By similarityRegions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
DNA bindingi | 38 – 114 | TEAPROSITE-ProRule annotationAdd BLAST | 77 |
GO - Molecular functioni
- disordered domain specific binding Source: MGI
- DNA binding Source: MGI
- DNA-binding transcription factor activity Source: MGI
- DNA-binding transcription factor activity, RNA polymerase II-specific Source: MGI
- RNA polymerase II cis-regulatory region sequence-specific DNA binding Source: MGI
- sequence-specific double-stranded DNA binding Source: MGI
- transcription coactivator binding Source: MGI
GO - Biological processi
- cellular response to retinoic acid Source: MGI
- embryonic heart tube morphogenesis Source: MGI
- embryonic organ development Source: GO_Central
- hippo signaling Source: MGI
- lateral mesoderm development Source: MGI
- negative regulation of cell death Source: UniProtKB
- neural tube closure Source: MGI
- notochord development Source: MGI
- paraxial mesoderm development Source: MGI
- positive regulation of transcription, DNA-templated Source: MGI
- positive regulation of transcription by RNA polymerase II Source: MGI
- protein-containing complex assembly Source: MGI
- regulation of stem cell differentiation Source: MGI
- regulation of transcription by RNA polymerase II Source: GO_Central
- vasculogenesis Source: MGI
Keywordsi
Molecular function | Activator, DNA-binding |
Biological process | Transcription, Transcription regulation |
Enzyme and pathway databases
Reactomei | R-MMU-2032785, YAP1- and WWTR1 (TAZ)-stimulated gene expression R-MMU-8951671, RUNX3 regulates YAP1-mediated transcription |
Names & Taxonomyi
Protein namesi | Recommended name: Transcriptional enhancer factor TEF-4Alternative name(s): ETEF-1 Embryonic TEA domain-containing factor Short name: ETF TEA domain family member 2 Short name: TEAD-2 |
Gene namesi | Name:Tead2 Synonyms:Etdf, Etf, Tef4 |
Organismi | Mus musculus (Mouse) |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Proteomesi |
|
Organism-specific databases
MGIi | MGI:104904, Tead2 |
VEuPathDBi | HostDB:ENSMUSG00000030796 |
Subcellular locationi
Nucleus
Cytosol
- cytosol Source: MGI
Nucleus
- nucleoplasm Source: MGI
- TEAD-YAP complex Source: MGI
Other locations
- intracellular membrane-bounded organelle Source: MGI
- transcription regulator complex Source: MGI
Keywords - Cellular componenti
NucleusPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000205933 | 1 – 445 | Transcriptional enhancer factor TEF-4Add BLAST | 445 |
Proteomic databases
PaxDbi | P48301 |
PRIDEi | P48301 |
ProteomicsDBi | 259369 |
PTM databases
iPTMneti | P48301 |
PhosphoSitePlusi | P48301 |
Expressioni
Tissue specificityi
Developmental stagei
Gene expression databases
Bgeei | ENSMUSG00000030796, Expressed in hindlimb bud and 127 other tissues |
Genevisiblei | P48301, MM |
Interactioni
Subunit structurei
Interacts with YAP1 and WWTR1/TAZ.
By similarityGO - Molecular functioni
- disordered domain specific binding Source: MGI
- transcription coactivator binding Source: MGI
Protein-protein interaction databases
BioGRIDi | 204099, 3 interactors |
CORUMi | P48301 |
IntActi | P48301, 1 interactor |
STRINGi | 10090.ENSMUSP00000103431 |
Miscellaneous databases
RNActi | P48301, protein |
Family & Domainsi
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 1 – 47 | DisorderedSequence analysisAdd BLAST | 47 | |
Regioni | 172 – 445 | Transcriptional activationSequence analysisAdd BLAST | 274 | |
Regioni | 191 – 217 | DisorderedSequence analysisAdd BLAST | 27 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 195 – 217 | Pro residuesSequence analysisAdd BLAST | 23 |
Phylogenomic databases
eggNOGi | KOG3841, Eukaryota |
GeneTreei | ENSGT00950000182956 |
HOGENOMi | CLU_012515_2_0_1 |
InParanoidi | P48301 |
OMAi | WQTRALG |
OrthoDBi | 823827at2759 |
PhylomeDBi | P48301 |
TreeFami | TF313443 |
Family and domain databases
Gene3Di | 6.10.20.40, 1 hit |
InterProi | View protein in InterPro IPR000818, TEA/ATTS_dom IPR038096, TEA/ATTS_sf IPR016361, TEF_metazoa IPR041086, YBD |
Pfami | View protein in Pfam PF01285, TEA, 1 hit PF17725, YBD, 1 hit |
PIRSFi | PIRSF002603, TEF, 1 hit |
PRINTSi | PR00065, TEADOMAIN |
SMARTi | View protein in SMART SM00426, TEA, 1 hit |
PROSITEi | View protein in PROSITE PS00554, TEA_1, 1 hit PS51088, TEA_2, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 7 potential isoforms that are computationally mapped.Show allAlign All
10 20 30 40 50
MGDPRTGAPL DDGGGWTGSE EGSEEGTGGS EGVGGDGSPD AEGVWSPDIE
60 70 80 90 100
QSFQEALAIY PPCGRRKIIL SDEGKMYGRN ELIARYIKLR TGKTRTRKQV
110 120 130 140 150
SSHIQVLARR KSREIQSKLK DQVSKDKAFQ TMATMSSAQL ISAPSLQAKL
160 170 180 190 200
GPSGPQATEL FQFWSGSSGP PWNVPDVKPF SQAPFSVSLT PPASDLPGYE
210 220 230 240 250
PPPALSPLPP PAPSPPAWQA RALGTARLQL IEFSAFVEPP DAVDSFQRHL
260 270 280 290 300
FVHISQQCPS PGAPPLESVD VRQIYDKFPE KKGGLRELYD RGPPHAFFLV
310 320 330 340 350
KFWADLNWGP SAEEAGSSGG GGGFYGVSSQ YESRELMTLT CSSKVCSFGK
360 370 380 390 400
QVVEKVETER AQLEDGRFVY RLLRSPMCEY LVNFLHKLRQ LPERYMMNSV
410 420 430 440
LENFTILQVV TNRDTQELLL CTAYVFEVST SERGAQYHIY RLVRD
Computationally mapped potential isoform sequencesi
There are 7 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketQ80UL2 | Q80UL2_MOUSE | Tead2 protein | Tead2 | 410 | Annotation score: | ||
A0A1B0GT36 | A0A1B0GT36_MOUSE | Transcriptional enhancer factor TEF... | Tead2 | 245 | Annotation score: | ||
A0A1B0GRZ4 | A0A1B0GRZ4_MOUSE | Transcriptional enhancer factor TEF... | Tead2 | 175 | Annotation score: | ||
A0A1B0GSN2 | A0A1B0GSN2_MOUSE | Transcriptional enhancer factor TEF... | Tead2 | 107 | Annotation score: | ||
A0A1B0GS07 | A0A1B0GS07_MOUSE | Transcriptional enhancer factor TEF... | Tead2 | 184 | Annotation score: | ||
A0A1B0GR00 | A0A1B0GR00_MOUSE | Transcriptional enhancer factor TEF... | Tead2 | 129 | Annotation score: | ||
A0A1B0GQX1 | A0A1B0GQX1_MOUSE | Transcriptional enhancer factor TEF... | Tead2 | 129 | Annotation score: |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 289 | Y → F in CAA64216 (PubMed:8702974).Curated | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | D50563 mRNA Translation: BAA09126.1 D83596 Genomic DNA Translation: BAA12018.1 X94442 mRNA Translation: CAA64216.1 Y10026 mRNA Translation: CAA71135.1 |
CCDSi | CCDS21236.1 |
PIRi | A57400 |
RefSeqi | NP_001272427.1, NM_001285498.1 NP_035695.1, NM_011565.2 XP_006540840.1, XM_006540777.2 |
Genome annotation databases
Ensembli | ENSMUST00000033060; ENSMUSP00000033060; ENSMUSG00000030796 ENSMUST00000107801; ENSMUSP00000103431; ENSMUSG00000030796 |
GeneIDi | 21677 |
KEGGi | mmu:21677 |
UCSCi | uc009gud.1, mouse |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | D50563 mRNA Translation: BAA09126.1 D83596 Genomic DNA Translation: BAA12018.1 X94442 mRNA Translation: CAA64216.1 Y10026 mRNA Translation: CAA71135.1 |
CCDSi | CCDS21236.1 |
PIRi | A57400 |
RefSeqi | NP_001272427.1, NM_001285498.1 NP_035695.1, NM_011565.2 XP_006540840.1, XM_006540777.2 |
3D structure databases
SMRi | P48301 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 204099, 3 interactors |
CORUMi | P48301 |
IntActi | P48301, 1 interactor |
STRINGi | 10090.ENSMUSP00000103431 |
PTM databases
iPTMneti | P48301 |
PhosphoSitePlusi | P48301 |
Proteomic databases
PaxDbi | P48301 |
PRIDEi | P48301 |
ProteomicsDBi | 259369 |
Protocols and materials databases
Antibodypediai | 31984, 259 antibodies from 33 providers |
DNASUi | 21677 |
Genome annotation databases
Ensembli | ENSMUST00000033060; ENSMUSP00000033060; ENSMUSG00000030796 ENSMUST00000107801; ENSMUSP00000103431; ENSMUSG00000030796 |
GeneIDi | 21677 |
KEGGi | mmu:21677 |
UCSCi | uc009gud.1, mouse |
Organism-specific databases
CTDi | 8463 |
MGIi | MGI:104904, Tead2 |
VEuPathDBi | HostDB:ENSMUSG00000030796 |
Phylogenomic databases
eggNOGi | KOG3841, Eukaryota |
GeneTreei | ENSGT00950000182956 |
HOGENOMi | CLU_012515_2_0_1 |
InParanoidi | P48301 |
OMAi | WQTRALG |
OrthoDBi | 823827at2759 |
PhylomeDBi | P48301 |
TreeFami | TF313443 |
Enzyme and pathway databases
Reactomei | R-MMU-2032785, YAP1- and WWTR1 (TAZ)-stimulated gene expression R-MMU-8951671, RUNX3 regulates YAP1-mediated transcription |
Miscellaneous databases
BioGRID-ORCSi | 21677, 6 hits in 63 CRISPR screens |
ChiTaRSi | Tead2, mouse |
PROi | PR:P48301 |
RNActi | P48301, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSMUSG00000030796, Expressed in hindlimb bud and 127 other tissues |
Genevisiblei | P48301, MM |
Family and domain databases
Gene3Di | 6.10.20.40, 1 hit |
InterProi | View protein in InterPro IPR000818, TEA/ATTS_dom IPR038096, TEA/ATTS_sf IPR016361, TEF_metazoa IPR041086, YBD |
Pfami | View protein in Pfam PF01285, TEA, 1 hit PF17725, YBD, 1 hit |
PIRSFi | PIRSF002603, TEF, 1 hit |
PRINTSi | PR00065, TEADOMAIN |
SMARTi | View protein in SMART SM00426, TEA, 1 hit |
PROSITEi | View protein in PROSITE PS00554, TEA_1, 1 hit PS51088, TEA_2, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | TEAD2_MOUSE | |
Accessioni | P48301Primary (citable) accession number: P48301 Secondary accession number(s): Q62297 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | February 1, 1996 |
Last sequence update: | February 1, 1996 | |
Last modified: | February 23, 2022 | |
This is version 158 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot