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Protein

Endothelin-3

Gene

Edn3

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Endothelins are endothelium-derived vasoconstrictor peptides.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionVasoactive, Vasoconstrictor

Enzyme and pathway databases

ReactomeiR-MMU-375276 Peptide ligand-binding receptors
R-MMU-416476 G alpha (q) signalling events

Names & Taxonomyi

Protein namesi
Recommended name:
Endothelin-3
Short name:
ET-3
Alternative name(s):
Preproendothelin-3
Short name:
PPET3
Gene namesi
Name:Edn3
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 2

Organism-specific databases

MGIiMGI:95285 Edn3

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 16Sequence analysisAdd BLAST16
PropeptideiPRO_000000811417 – 94Add BLAST78
PeptideiPRO_000000811597 – 117Endothelin-3Add BLAST21
PropeptideiPRO_0000008116118 – 214Add BLAST97

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi97 ↔ 111By similarity
Disulfide bondi99 ↔ 107By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei117 – 118Cleavage; by KELBy similarity2

Keywords - PTMi

Cleavage on pair of basic residues, Disulfide bond

Proteomic databases

PaxDbiP48299
PRIDEiP48299

PTM databases

PhosphoSitePlusiP48299

Expressioni

Gene expression databases

BgeeiENSMUSG00000027524 Expressed in 149 organ(s), highest expression level in iris
CleanExiMM_EDN3
ExpressionAtlasiP48299 baseline and differential
GenevisibleiP48299 MM

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000029030

Structurei

3D structure databases

ProteinModelPortaliP48299
SMRiP48299
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni159 – 173Endothelin-likeAdd BLAST15

Sequence similaritiesi

Belongs to the endothelin/sarafotoxin family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410IXXK Eukaryota
ENOG410YW48 LUCA
GeneTreeiENSGT00530000063310
HOGENOMiHOG000231110
HOVERGENiHBG051442
InParanoidiP48299
KOiK05227
OMAiSRCACVG
OrthoDBiEOG091G0OPZ
PhylomeDBiP48299
TreeFamiTF333184

Family and domain databases

InterProiView protein in InterPro
IPR020475 Endothelin
IPR019764 Endothelin_toxin_CS
IPR001928 Endothln-like_toxin
PfamiView protein in Pfam
PF00322 Endothelin, 1 hit
PRINTSiPR00365 ENDOTHELIN
SMARTiView protein in SMART
SM00272 END, 2 hits
PROSITEiView protein in PROSITE
PS00270 ENDOTHELIN, 2 hits

Sequence (1+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

P48299-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MEPGLWLLLG LTVTSAAGLV PCPQSGDSGR ASVSQGPPEA GSERGCEETV
60 70 80 90 100
AGPGERIVSP TVALPAQPES AGQERAPGRS GKQEDKGLPA HHRPRRCTCF
110 120 130 140 150
TYKDKECVYY CHLDIIWINT PEQTVPYGLS NYRESLRGKR SLGPVPESSQ
160 170 180 190 200
PSPWTRLRCT CMGADDKACA HFCARTRDVT SYSGRAERPA AEEMRETGGP
210
RQRLMSRTDK AHRP
Length:214
Mass (Da):23,322
Last modified:February 1, 1996 - v1
Checksum:i8911260872D6A713
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
E0CZ86E0CZ86_MOUSE
Endothelin-3
Edn3
166Annotation score:

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U32330 mRNA Translation: AAB60509.1
AK048006 mRNA Translation: BAC33211.1
AK049775 mRNA Translation: BAC33915.1
AK079150 mRNA Translation: BAC37561.1
CCDSiCCDS17156.1
PIRiI49351
RefSeqiNP_031929.1, NM_007903.5
UniGeneiMm.9478

Genome annotation databases

EnsembliENSMUST00000029030; ENSMUSP00000029030; ENSMUSG00000027524
GeneIDi13616
KEGGimmu:13616
UCSCiuc008ofi.2 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U32330 mRNA Translation: AAB60509.1
AK048006 mRNA Translation: BAC33211.1
AK049775 mRNA Translation: BAC33915.1
AK079150 mRNA Translation: BAC37561.1
CCDSiCCDS17156.1
PIRiI49351
RefSeqiNP_031929.1, NM_007903.5
UniGeneiMm.9478

3D structure databases

ProteinModelPortaliP48299
SMRiP48299
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000029030

PTM databases

PhosphoSitePlusiP48299

Proteomic databases

PaxDbiP48299
PRIDEiP48299

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000029030; ENSMUSP00000029030; ENSMUSG00000027524
GeneIDi13616
KEGGimmu:13616
UCSCiuc008ofi.2 mouse

Organism-specific databases

CTDi1908
MGIiMGI:95285 Edn3

Phylogenomic databases

eggNOGiENOG410IXXK Eukaryota
ENOG410YW48 LUCA
GeneTreeiENSGT00530000063310
HOGENOMiHOG000231110
HOVERGENiHBG051442
InParanoidiP48299
KOiK05227
OMAiSRCACVG
OrthoDBiEOG091G0OPZ
PhylomeDBiP48299
TreeFamiTF333184

Enzyme and pathway databases

ReactomeiR-MMU-375276 Peptide ligand-binding receptors
R-MMU-416476 G alpha (q) signalling events

Miscellaneous databases

PROiPR:P48299
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000027524 Expressed in 149 organ(s), highest expression level in iris
CleanExiMM_EDN3
ExpressionAtlasiP48299 baseline and differential
GenevisibleiP48299 MM

Family and domain databases

InterProiView protein in InterPro
IPR020475 Endothelin
IPR019764 Endothelin_toxin_CS
IPR001928 Endothln-like_toxin
PfamiView protein in Pfam
PF00322 Endothelin, 1 hit
PRINTSiPR00365 ENDOTHELIN
SMARTiView protein in SMART
SM00272 END, 2 hits
PROSITEiView protein in PROSITE
PS00270 ENDOTHELIN, 2 hits
ProtoNetiSearch...

Entry informationi

Entry nameiEDN3_MOUSE
AccessioniPrimary (citable) accession number: P48299
Secondary accession number(s): Q543L0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1996
Last sequence update: February 1, 1996
Last modified: November 7, 2018
This is version 134 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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