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Protein

Eotaxin

Gene

Ccl11

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

In response to the presence of allergens, this protein directly promotes the accumulation of eosinophils (a prominent feature of allergic inflammatory reactions), but not lymphocytes, macrophages or neutrophils.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionCytokine
Biological processChemotaxis, Inflammatory response

Names & Taxonomyi

Protein namesi
Recommended name:
Eotaxin
Alternative name(s):
C-C motif chemokine 11
Eosinophil chemotactic protein
Small-inducible cytokine A11
Gene namesi
Name:Ccl11
Synonyms:Scya11
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 11

Organism-specific databases

MGIiMGI:103576 Ccl11

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 23Sequence analysisAdd BLAST23
ChainiPRO_000000519724 – 97EotaxinAdd BLAST74

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi32 ↔ 57By similarity
Disulfide bondi33 ↔ 73By similarity
Glycosylationi94O-linked (GalNAc...) threonineBy similarity1

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiP48298
PRIDEiP48298

PTM databases

iPTMnetiP48298
PhosphoSitePlusiP48298

Expressioni

Tissue specificityi

Expressed constitutively in the thymus. Expression inducible in the lung (type I alveolar epithelial cells), intestine, heart, spleen, kidney.

Inductioni

By interferon gamma and lipopolysaccharides (LPS).

Gene expression databases

BgeeiENSMUSG00000020676 Expressed in 118 organ(s), highest expression level in uterine cervix
CleanExiMM_CCL11
GenevisibleiP48298 MM

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000000342

Structurei

3D structure databases

ProteinModelPortaliP48298
SMRiP48298
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410J1ST Eukaryota
ENOG410YXJU LUCA
GeneTreeiENSGT00900000140949
HOGENOMiHOG000036686
HOVERGENiHBG017871
InParanoidiP48298
KOiK16597
OMAiEKEICAD
OrthoDBiEOG091G14KV
PhylomeDBiP48298
TreeFamiTF334888

Family and domain databases

InterProiView protein in InterPro
IPR039809 Chemokine_b/g/d
IPR000827 Chemokine_CC_CS
IPR001811 Chemokine_IL8-like_dom
IPR036048 Interleukin_8-like_sf
PANTHERiPTHR12015 PTHR12015, 1 hit
PfamiView protein in Pfam
PF00048 IL8, 1 hit
SMARTiView protein in SMART
SM00199 SCY, 1 hit
SUPFAMiSSF54117 SSF54117, 1 hit
PROSITEiView protein in PROSITE
PS00472 SMALL_CYTOKINES_CC, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P48298-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MQSSTALLFL LLTVTSFTSQ VLAHPGSIPT SCCFIMTSKK IPNTLLKSYK
60 70 80 90
RITNNRCTLK AIVFKTRLGK EICADPKKKW VQDATKHLDQ KLQTPKP
Length:97
Mass (Da):10,893
Last modified:February 1, 1996 - v1
Checksum:i36C9812107FC6CA7
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U26426 mRNA Translation: AAC52256.1
U40672 mRNA Translation: AAA99776.1
AF128205 mRNA Translation: AAF22546.1
AF128206 mRNA Translation: AAF22547.1
AF128207 mRNA Translation: AAF22548.1
AF128208 mRNA Translation: AAF22549.1
AF128209 mRNA Translation: AAF22550.1
AK010146 mRNA Translation: BAB26731.1
BC027521 mRNA Translation: AAH27521.1
U77462 Genomic DNA Translation: AAC53321.1
CCDSiCCDS36246.1
RefSeqiNP_035460.1, NM_011330.3
UniGeneiMm.4686

Genome annotation databases

EnsembliENSMUST00000000342; ENSMUSP00000000342; ENSMUSG00000020676
GeneIDi20292
KEGGimmu:20292
UCSCiuc007kmr.2 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U26426 mRNA Translation: AAC52256.1
U40672 mRNA Translation: AAA99776.1
AF128205 mRNA Translation: AAF22546.1
AF128206 mRNA Translation: AAF22547.1
AF128207 mRNA Translation: AAF22548.1
AF128208 mRNA Translation: AAF22549.1
AF128209 mRNA Translation: AAF22550.1
AK010146 mRNA Translation: BAB26731.1
BC027521 mRNA Translation: AAH27521.1
U77462 Genomic DNA Translation: AAC53321.1
CCDSiCCDS36246.1
RefSeqiNP_035460.1, NM_011330.3
UniGeneiMm.4686

3D structure databases

ProteinModelPortaliP48298
SMRiP48298
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000000342

PTM databases

iPTMnetiP48298
PhosphoSitePlusiP48298

Proteomic databases

PaxDbiP48298
PRIDEiP48298

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000000342; ENSMUSP00000000342; ENSMUSG00000020676
GeneIDi20292
KEGGimmu:20292
UCSCiuc007kmr.2 mouse

Organism-specific databases

CTDi6356
MGIiMGI:103576 Ccl11

Phylogenomic databases

eggNOGiENOG410J1ST Eukaryota
ENOG410YXJU LUCA
GeneTreeiENSGT00900000140949
HOGENOMiHOG000036686
HOVERGENiHBG017871
InParanoidiP48298
KOiK16597
OMAiEKEICAD
OrthoDBiEOG091G14KV
PhylomeDBiP48298
TreeFamiTF334888

Miscellaneous databases

PROiPR:P48298
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000020676 Expressed in 118 organ(s), highest expression level in uterine cervix
CleanExiMM_CCL11
GenevisibleiP48298 MM

Family and domain databases

InterProiView protein in InterPro
IPR039809 Chemokine_b/g/d
IPR000827 Chemokine_CC_CS
IPR001811 Chemokine_IL8-like_dom
IPR036048 Interleukin_8-like_sf
PANTHERiPTHR12015 PTHR12015, 1 hit
PfamiView protein in Pfam
PF00048 IL8, 1 hit
SMARTiView protein in SMART
SM00199 SCY, 1 hit
SUPFAMiSSF54117 SSF54117, 1 hit
PROSITEiView protein in PROSITE
PS00472 SMALL_CYTOKINES_CC, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiCCL11_MOUSE
AccessioniPrimary (citable) accession number: P48298
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1996
Last sequence update: February 1, 1996
Last modified: November 7, 2018
This is version 148 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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