Ccl11

Functionⁱ

In response to the presence of allergens, this protein directly promotes the accumulation of eosinophils (a prominent feature of allergic inflammatory reactions), but not lymphocytes, macrophages or neutrophils.

GO - Molecular functionⁱ

CCR3 chemokine receptor binding Source: MGI
CCR chemokine receptor binding
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
chemokine activity Source: MGI
protein dimerization activity Source: MGI
receptor ligand activity Source: MGI

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

actin filament organization Source: MGI
branching involved in mammary gland duct morphogenesis
Source: MGI
Inferred from mutant phenotypeⁱ
- 10804170
cellular response to interferon-gamma
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
cellular response to interleukin-1
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
cellular response to tumor necrosis factor
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
chemokine-mediated signaling pathway
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
chronic inflammatory response Source: Ensembl
cytoskeleton organization Source: MGI
eosinophil chemotaxis Source: MGI
ERK1 and ERK2 cascade Source: MGI
G protein-coupled receptor signaling pathway
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
inflammatory response
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
lymphocyte chemotaxis
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
mammary duct terminal end bud growth
Source: MGI
Inferred from mutant phenotypeⁱ
- 10804170
mast cell chemotaxis Source: MGI
monocyte chemotaxis
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
neutrophil chemotaxis
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
positive regulation of actin filament polymerization Source: MGI
positive regulation of angiogenesis
Source: BHF-UCL
Inferred from mutant phenotypeⁱ
- 19525930
positive regulation of cell migration Source: MGI
positive regulation of endothelial cell proliferation Source: MGI
positive regulation of ERK1 and ERK2 cascade
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
positive regulation of GTPase activity Source: MGI
regulation of cell shape Source: MGI
response to interleukin-13 Source: Ensembl
response to interleukin-4 Source: Ensembl

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Cytokine
Biological process	Chemotaxis, Inflammatory response

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Eotaxin Alternative name(s): C-C motif chemokine 11 Eosinophil chemotactic protein Small-inducible cytokine A11
Gene namesⁱ	Name:Ccl11 Synonyms:Scya11
Organismⁱ	Mus musculus (Mouse)
Taxonomic identifierⁱ	10090 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus
Proteomesⁱ	UP000000589 Componentⁱ: Chromosome 11

Organism-specific databases

MGIⁱ	MGI:103576 Ccl11

Keywords - Cellular componentⁱ

Secreted

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Signal peptideⁱ	1 – 23	Sequence analysisAdd BLAST		23
ChainⁱPRO_0000005197	24 – 97	EotaxinAdd BLAST		74

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Disulfide bondⁱ	32 ↔ 57	By similarity
Disulfide bondⁱ	33 ↔ 73	By similarity
Glycosylationⁱ	94	O-linked (GalNAc...) threonineBy similarity	1

Keywords - PTMⁱ

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbⁱ	P48298
PRIDEⁱ	P48298

PTM databases

iPTMnetⁱ	P48298
PhosphoSitePlusⁱ	P48298

Expressionⁱ

Tissue specificityⁱ

Expressed constitutively in the thymus. Expression inducible in the lung (type I alveolar epithelial cells), intestine, heart, spleen, kidney.

Inductionⁱ

By interferon gamma and lipopolysaccharides (LPS).

Gene expression databases

Bgeeⁱ	ENSMUSG00000020676 Expressed in 118 organ(s), highest expression level in uterine cervix
CleanExⁱ	MM_CCL11
Genevisibleⁱ	P48298 MM

Interactionⁱ

GO - Molecular functionⁱ

CCR3 chemokine receptor binding Source: MGI
CCR chemokine receptor binding
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
chemokine activity Source: MGI
protein dimerization activity Source: MGI
receptor ligand activity Source: MGI

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

STRINGⁱ	10090.ENSMUSP00000000342

STRINGⁱ

10090.ENSMUSP00000000342

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	P48298
SMRⁱ	P48298
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Sequence similaritiesⁱ

Belongs to the intercrine beta (chemokine CC) family.Curated

Keywords - Domainⁱ

Signal

Phylogenomic databases

eggNOGⁱ	ENOG410J1ST Eukaryota ENOG410YXJU LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00900000140949
HOGENOMⁱ	HOG000036686
HOVERGENⁱ	HBG017871
InParanoidⁱ	P48298
KEGG Orthology (KO) More...KOⁱ	K16597
OMAⁱ	EKEICAD
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G14KV
PhylomeDBⁱ	P48298
TreeFamⁱ	TF334888

Family and domain databases

InterProⁱ	View protein in InterPro IPR039809 Chemokine_b/g/d IPR000827 Chemokine_CC_CS IPR001811 Chemokine_IL8-like_dom IPR036048 Interleukin_8-like_sf
PANTHERⁱ	PTHR12015 PTHR12015, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00048 IL8, 1 hit
SMARTⁱ	View protein in SMART SM00199 SCY, 1 hit
SUPFAMⁱ	SSF54117 SSF54117, 1 hit
PROSITEⁱ	View protein in PROSITE PS00472 SMALL_CYTOKINES_CC, 1 hit

Sequenceⁱ

Sequence statusⁱ: Complete.

Sequence processingⁱ: The displayed sequence is further processed into a mature form.

P48298-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MQSSTALLFL LLTVTSFTSQ VLAHPGSIPT SCCFIMTSKK IPNTLLKSYK 
        60         70         80         90 
RITNNRCTLK AIVFKTRLGK EICADPKKKW VQDATKHLDQ KLQTPKP

Length:97

Mass (Da):10,893

Last modified:February 1, 1996 - v1

Checksum:ⁱ36C9812107FC6CA7

GO

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	U26426 mRNA Translation: AAC52256.1 U40672 mRNA Translation: AAA99776.1 AF128205 mRNA Translation: AAF22546.1 AF128206 mRNA Translation: AAF22547.1 AF128207 mRNA Translation: AAF22548.1 AF128208 mRNA Translation: AAF22549.1 AF128209 mRNA Translation: AAF22550.1 AK010146 mRNA Translation: BAB26731.1 BC027521 mRNA Translation: AAH27521.1 U77462 Genomic DNA Translation: AAC53321.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS36246.1
NCBI Reference Sequences More...RefSeqⁱ	NP_035460.1, NM_011330.3
UniGeneⁱ	Mm.4686

Genome annotation databases

Ensemblⁱ	ENSMUST00000000342; ENSMUSP00000000342; ENSMUSG00000020676
GeneIDⁱ	20292
KEGGⁱ	mmu:20292
UCSC genome browser More...UCSCⁱ	uc007kmr.2 mouse

Similar proteinsⁱ

90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
P48298	Eotaxin		RAT		97	UniRef90_P48298
UPI000A304D89		MUSPA		97
UPI000A318B4F		MUSCR		97

Protein	Similar proteins		Species	Score	Length	Source
P48298	Eotaxin		RAT		97	UniRef50_P48298
Eotaxin		CAVPO		96
C-C motif chemokine		MESAU		97
C-C motif chemokine 8		NEOSC		99
C-C motif chemokine		LOXAF		97
+28

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	U26426 mRNA Translation: AAC52256.1 U40672 mRNA Translation: AAA99776.1 AF128205 mRNA Translation: AAF22546.1 AF128206 mRNA Translation: AAF22547.1 AF128207 mRNA Translation: AAF22548.1 AF128208 mRNA Translation: AAF22549.1 AF128209 mRNA Translation: AAF22550.1 AK010146 mRNA Translation: BAB26731.1 BC027521 mRNA Translation: AAH27521.1 U77462 Genomic DNA Translation: AAC53321.1
CCDSⁱ	CCDS36246.1
RefSeqⁱ	NP_035460.1, NM_011330.3
UniGeneⁱ	Mm.4686

3D structure databases

ProteinModelPortalⁱ	P48298
SMRⁱ	P48298
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

STRINGⁱ	10090.ENSMUSP00000000342

STRINGⁱ

10090.ENSMUSP00000000342

PTM databases

iPTMnetⁱ	P48298
PhosphoSitePlusⁱ	P48298

Proteomic databases

PaxDbⁱ	P48298
PRIDEⁱ	P48298

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

Ensemblⁱ	ENSMUST00000000342; ENSMUSP00000000342; ENSMUSG00000020676
GeneIDⁱ	20292
KEGGⁱ	mmu:20292
UCSCⁱ	uc007kmr.2 mouse

Organism-specific databases

CTDⁱ	6356
MGIⁱ	MGI:103576 Ccl11

Phylogenomic databases

eggNOGⁱ	ENOG410J1ST Eukaryota ENOG410YXJU LUCA
GeneTreeⁱ	ENSGT00900000140949
HOGENOMⁱ	HOG000036686
HOVERGENⁱ	HBG017871
InParanoidⁱ	P48298
KOⁱ	K16597
OMAⁱ	EKEICAD
OrthoDBⁱ	EOG091G14KV
PhylomeDBⁱ	P48298
TreeFamⁱ	TF334888

Miscellaneous databases

Protein Ontology More...PROⁱ	PR:P48298
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSMUSG00000020676 Expressed in 118 organ(s), highest expression level in uterine cervix
CleanExⁱ	MM_CCL11
Genevisibleⁱ	P48298 MM

Family and domain databases

InterProⁱ	View protein in InterPro IPR039809 Chemokine_b/g/d IPR000827 Chemokine_CC_CS IPR001811 Chemokine_IL8-like_dom IPR036048 Interleukin_8-like_sf
PANTHERⁱ	PTHR12015 PTHR12015, 1 hit
Pfamⁱ	View protein in Pfam PF00048 IL8, 1 hit
SMARTⁱ	View protein in SMART SM00199 SCY, 1 hit
SUPFAMⁱ	SSF54117 SSF54117, 1 hit
PROSITEⁱ	View protein in PROSITE PS00472 SMALL_CYTOKINES_CC, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	CCL11_MOUSE
Accessionⁱ	P48298Primary (citable) accession number: P48298
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	February 1, 1996
	Last sequence update:	February 1, 1996
	Last modified:	November 7, 2018
	This is version 148 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

Documents

SIMILARITY comments
Index of protein domains and families
MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - P48298 (CCL11_MOUSE)

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Eotaxin

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted

Extracellular region or secreted

Other locations

Keywords - Cellular componenti

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Phylogenomic databases

Family and domain databases

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

GO - Molecular functionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Domainⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ