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UniProtKB - P48298 (CCL11_MOUSE)
Protein
Eotaxin
Gene
Ccl11
Organism
Mus musculus (Mouse)
Status
Functioni
In response to the presence of allergens, this protein directly promotes the accumulation of eosinophils (a prominent feature of allergic inflammatory reactions), but not lymphocytes, macrophages or neutrophils (PubMed:7568052, PubMed:8574847).
Binds to CCR3 (By similarity).
By similarity2 PublicationsGO - Molecular functioni
- CCR3 chemokine receptor binding Source: MGI
- CCR chemokine receptor binding Source: GO_Central
- chemokine activity Source: MGI
- protein dimerization activity Source: MGI
- receptor ligand activity Source: MGI
GO - Biological processi
- actin filament organization Source: MGI
- branching involved in mammary gland duct morphogenesis Source: MGI
- cellular response to interferon-gamma Source: GO_Central
- cellular response to interleukin-1 Source: GO_Central
- cellular response to tumor necrosis factor Source: GO_Central
- chemokine-mediated signaling pathway Source: GO_Central
- chronic inflammatory response Source: Ensembl
- eosinophil chemotaxis Source: MGI
- ERK1 and ERK2 cascade Source: MGI
- G protein-coupled receptor signaling pathway Source: GO_Central
- inflammatory response Source: GO_Central
- learning or memory Source: ARUK-UCL
- lymphocyte chemotaxis Source: GO_Central
- mammary duct terminal end bud growth Source: MGI
- mast cell chemotaxis Source: MGI
- modulation of age-related behavioral decline Source: ARUK-UCL
- monocyte chemotaxis Source: GO_Central
- negative regulation of neurogenesis Source: ARUK-UCL
- neutrophil chemotaxis Source: GO_Central
- positive regulation of actin filament polymerization Source: Ensembl
- positive regulation of angiogenesis Source: BHF-UCL
- positive regulation of cell migration Source: Ensembl
- positive regulation of endothelial cell proliferation Source: Ensembl
- positive regulation of ERK1 and ERK2 cascade Source: GO_Central
- positive regulation of GTPase activity Source: GO_Central
- regulation of cell shape Source: Ensembl
- response to interleukin-13 Source: Ensembl
- response to interleukin-4 Source: Ensembl
Keywordsi
Molecular function | Cytokine |
Biological process | Chemotaxis, Inflammatory response |
Names & Taxonomyi
Protein namesi | Recommended name: EotaxinAlternative name(s): C-C motif chemokine 11 Eosinophil chemotactic protein Small-inducible cytokine A11 |
Gene namesi | Name:Ccl11 Synonyms:Scya11 |
Organismi | Mus musculus (Mouse) |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Proteomesi |
|
Organism-specific databases
MGIi | MGI:103576, Ccl11 |
VEuPathDBi | HostDB:ENSMUSG00000020676 |
Subcellular locationi
Extracellular region or secreted
- Secreted 1 Publication
Extracellular region or secreted
- extracellular region Source: MGI
- extracellular space Source: MGI
Keywords - Cellular componenti
SecretedPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 23 | Sequence analysisAdd BLAST | 23 | |
ChainiPRO_0000005197 | 24 – 97 | EotaxinAdd BLAST | 74 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Disulfide bondi | 32 ↔ 57 | By similarity | ||
Disulfide bondi | 33 ↔ 73 | By similarity | ||
Glycosylationi | 94 | O-linked (GalNAc...) threonineBy similarity | 1 |
Keywords - PTMi
Disulfide bond, GlycoproteinProteomic databases
PaxDbi | P48298 |
PRIDEi | P48298 |
PTM databases
GlyGeni | P48298, 1 site |
iPTMneti | P48298 |
PhosphoSitePlusi | P48298 |
Expressioni
Tissue specificityi
Expressed constitutively in the thymus. Expression inducible in the lung (type I alveolar epithelial cells), intestine, heart, spleen, kidney.1 Publication
Inductioni
By interferon gamma and lipopolysaccharides (LPS) (PubMed:7568052). By interleukin-13 (IL13) (PubMed:15647285).2 Publications
Gene expression databases
Bgeei | ENSMUSG00000020676, Expressed in uterine cervix and 146 other tissues |
Genevisiblei | P48298, MM |
Interactioni
GO - Molecular functioni
- CCR3 chemokine receptor binding Source: MGI
- CCR chemokine receptor binding Source: GO_Central
- chemokine activity Source: MGI
- protein dimerization activity Source: MGI
- receptor ligand activity Source: MGI
Protein-protein interaction databases
BioGRIDi | 203117, 1 interactor |
STRINGi | 10090.ENSMUSP00000000342 |
Miscellaneous databases
RNActi | P48298, protein |
Family & Domainsi
Sequence similaritiesi
Belongs to the intercrine beta (chemokine CC) family.Curated
Keywords - Domaini
SignalPhylogenomic databases
eggNOGi | ENOG502S8M4, Eukaryota |
GeneTreei | ENSGT01030000234602 |
HOGENOMi | CLU_141716_1_0_1 |
InParanoidi | P48298 |
OMAi | CFTLANR |
OrthoDBi | 1575018at2759 |
PhylomeDBi | P48298 |
TreeFami | TF334888 |
Family and domain databases
InterProi | View protein in InterPro IPR039809, Chemokine_b/g/d IPR000827, Chemokine_CC_CS IPR001811, Chemokine_IL8-like_dom IPR036048, Interleukin_8-like_sf |
PANTHERi | PTHR12015, PTHR12015, 1 hit |
Pfami | View protein in Pfam PF00048, IL8, 1 hit |
SMARTi | View protein in SMART SM00199, SCY, 1 hit |
SUPFAMi | SSF54117, SSF54117, 1 hit |
PROSITEi | View protein in PROSITE PS00472, SMALL_CYTOKINES_CC, 1 hit |
i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
P48298-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MQSSTALLFL LLTVTSFTSQ VLAHPGSIPT SCCFIMTSKK IPNTLLKSYK
60 70 80 90
RITNNRCTLK AIVFKTRLGK EICADPKKKW VQDATKHLDQ KLQTPKP
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U26426 mRNA Translation: AAC52256.1 U40672 mRNA Translation: AAA99776.1 AF128205 mRNA Translation: AAF22546.1 AF128206 mRNA Translation: AAF22547.1 AF128207 mRNA Translation: AAF22548.1 AF128208 mRNA Translation: AAF22549.1 AF128209 mRNA Translation: AAF22550.1 AK010146 mRNA Translation: BAB26731.1 BC027521 mRNA Translation: AAH27521.1 U77462 Genomic DNA Translation: AAC53321.1 |
CCDSi | CCDS36246.1 |
RefSeqi | NP_035460.1, NM_011330.3 |
Genome annotation databases
Ensembli | ENSMUST00000000342; ENSMUSP00000000342; ENSMUSG00000020676 |
GeneIDi | 20292 |
KEGGi | mmu:20292 |
UCSCi | uc007kmr.2, mouse |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U26426 mRNA Translation: AAC52256.1 U40672 mRNA Translation: AAA99776.1 AF128205 mRNA Translation: AAF22546.1 AF128206 mRNA Translation: AAF22547.1 AF128207 mRNA Translation: AAF22548.1 AF128208 mRNA Translation: AAF22549.1 AF128209 mRNA Translation: AAF22550.1 AK010146 mRNA Translation: BAB26731.1 BC027521 mRNA Translation: AAH27521.1 U77462 Genomic DNA Translation: AAC53321.1 |
CCDSi | CCDS36246.1 |
RefSeqi | NP_035460.1, NM_011330.3 |
3D structure databases
AlphaFoldDBi | P48298 |
SMRi | P48298 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 203117, 1 interactor |
STRINGi | 10090.ENSMUSP00000000342 |
PTM databases
GlyGeni | P48298, 1 site |
iPTMneti | P48298 |
PhosphoSitePlusi | P48298 |
Proteomic databases
PaxDbi | P48298 |
PRIDEi | P48298 |
Protocols and materials databases
ABCDi | P48298, 1 sequenced antibody |
Antibodypediai | 15485, 401 antibodies from 42 providers |
DNASUi | 20292 |
Genome annotation databases
Ensembli | ENSMUST00000000342; ENSMUSP00000000342; ENSMUSG00000020676 |
GeneIDi | 20292 |
KEGGi | mmu:20292 |
UCSCi | uc007kmr.2, mouse |
Organism-specific databases
CTDi | 6356 |
MGIi | MGI:103576, Ccl11 |
VEuPathDBi | HostDB:ENSMUSG00000020676 |
Phylogenomic databases
eggNOGi | ENOG502S8M4, Eukaryota |
GeneTreei | ENSGT01030000234602 |
HOGENOMi | CLU_141716_1_0_1 |
InParanoidi | P48298 |
OMAi | CFTLANR |
OrthoDBi | 1575018at2759 |
PhylomeDBi | P48298 |
TreeFami | TF334888 |
Miscellaneous databases
BioGRID-ORCSi | 20292, 2 hits in 73 CRISPR screens |
PROi | PR:P48298 |
RNActi | P48298, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSMUSG00000020676, Expressed in uterine cervix and 146 other tissues |
Genevisiblei | P48298, MM |
Family and domain databases
InterProi | View protein in InterPro IPR039809, Chemokine_b/g/d IPR000827, Chemokine_CC_CS IPR001811, Chemokine_IL8-like_dom IPR036048, Interleukin_8-like_sf |
PANTHERi | PTHR12015, PTHR12015, 1 hit |
Pfami | View protein in Pfam PF00048, IL8, 1 hit |
SMARTi | View protein in SMART SM00199, SCY, 1 hit |
SUPFAMi | SSF54117, SSF54117, 1 hit |
PROSITEi | View protein in PROSITE PS00472, SMALL_CYTOKINES_CC, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | CCL11_MOUSE | |
Accessioni | P48298Primary (citable) accession number: P48298 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | February 1, 1996 |
Last sequence update: | February 1, 1996 | |
Last modified: | May 25, 2022 | |
This is version 168 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families