UniProtKB - P48286 (RL22_THETH)
Protein
50S ribosomal protein L22
Gene
rplV
Organism
Thermus thermophilus
Status
Functioni
This protein binds specifically to 23S rRNA; its binding is stimulated by other ribosomal proteins, e.g. L4, L17, and L20. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome (By similarity).By similarity
The globular domain of the protein is one of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that penetrates into the center of the 70S ribosome. This extension seems to form part of the wall of the exit tunnel (By similarity). Deleting residues 82 to 84 (the equivalent deletion in E.coli renders cells resistant to erythromycin) would probably cause the tip of the hairpin to penetrate into the tunnel.By similarity
GO - Molecular functioni
- rRNA binding Source: UniProtKB-UniRule
- structural constituent of ribosome Source: InterPro
GO - Biological processi
- translation Source: UniProtKB-UniRule
Keywordsi
Molecular function | Ribonucleoprotein, Ribosomal protein, RNA-binding, rRNA-binding |
Names & Taxonomyi
Protein namesi | Recommended name: 50S ribosomal protein L22 |
Gene namesi | Name:rplV Synonyms:rpl22 |
Organismi | Thermus thermophilus |
Taxonomic identifieri | 274 [NCBI] |
Taxonomic lineagei | Bacteria › Deinococcus-Thermus › Deinococci › Thermales › Thermaceae › Thermus |
Pathology & Biotechi
Mutagenesis
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Mutagenesisi | 82 – 84 | Missing : Alters the orientation of the tip of the beta-hairpin, bending it into the polypeptide exit tunnel. | 3 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000125250 | 1 – 113 | 50S ribosomal protein L22Add BLAST | 113 |
Interactioni
Subunit structurei
Part of the 50S ribosomal subunit.
Structurei
Secondary structure
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details3D structure databases
SMRi | P48286 |
ModBasei | Search... |
PDBe-KBi | Search... |
Miscellaneous databases
EvolutionaryTracei | P48286 |
Family & Domainsi
Sequence similaritiesi
Belongs to the universal ribosomal protein uL22 family.Curated
Family and domain databases
CDDi | cd00336, Ribosomal_L22, 1 hit |
Gene3Di | 3.90.470.10, 1 hit |
HAMAPi | MF_01331_B, Ribosomal_L22_B, 1 hit |
InterProi | View protein in InterPro IPR001063, Ribosomal_L22 IPR018260, Ribosomal_L22/L17_CS IPR036394, Ribosomal_L22/L17_sf IPR005727, Ribosomal_L22_bac/chlpt-type |
PANTHERi | PTHR13501, PTHR13501, 1 hit |
Pfami | View protein in Pfam PF00237, Ribosomal_L22, 1 hit |
SUPFAMi | SSF54843, SSF54843, 1 hit |
TIGRFAMsi | TIGR01044, rplV_bact, 1 hit |
PROSITEi | View protein in PROSITE PS00464, RIBOSOMAL_L22, 1 hit |
i Sequence
Sequence statusi: Complete.
P48286-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MEAKAIARYV RISPRKVRLV VDLIRGKSLE EARNILRYTN KRGAYFVAKV
60 70 80 90 100
LESAAANAVN NHDMLEDRLY VKAAYVDEGP ALKRVLPRAR GRADIIKKRT
110
SHITVILGEK HGK
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | X84708 Genomic DNA Translation: CAA59196.1 |
RefSeqi | WP_011173710.1, NZ_LR027517.1 |
Genome annotation databases
GeneIDi | 3169835 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | X84708 Genomic DNA Translation: CAA59196.1 |
RefSeqi | WP_011173710.1, NZ_LR027517.1 |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
1BXE | X-ray | 1.90 | A | 1-113 | [»] | |
1I4J | X-ray | 1.80 | A/B | 1-113 | [»] | |
1TWV | model | - | L | 1-113 | [»] | |
SMRi | P48286 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Genome annotation databases
GeneIDi | 3169835 |
Miscellaneous databases
EvolutionaryTracei | P48286 |
Family and domain databases
CDDi | cd00336, Ribosomal_L22, 1 hit |
Gene3Di | 3.90.470.10, 1 hit |
HAMAPi | MF_01331_B, Ribosomal_L22_B, 1 hit |
InterProi | View protein in InterPro IPR001063, Ribosomal_L22 IPR018260, Ribosomal_L22/L17_CS IPR036394, Ribosomal_L22/L17_sf IPR005727, Ribosomal_L22_bac/chlpt-type |
PANTHERi | PTHR13501, PTHR13501, 1 hit |
Pfami | View protein in Pfam PF00237, Ribosomal_L22, 1 hit |
SUPFAMi | SSF54843, SSF54843, 1 hit |
TIGRFAMsi | TIGR01044, rplV_bact, 1 hit |
PROSITEi | View protein in PROSITE PS00464, RIBOSOMAL_L22, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | RL22_THETH | |
Accessioni | P48286Primary (citable) accession number: P48286 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | February 1, 1996 |
Last sequence update: | February 1, 1996 | |
Last modified: | April 7, 2021 | |
This is version 100 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Prokaryotic Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
3D-structureDocuments
- Ribosomal proteins
Ribosomal proteins families and list of entries - PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families