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Protein

Vitamin D3 receptor

Gene

Vdr

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Nuclear receptor for calcitriol, the active form of vitamin D3 which mediates the action of this vitamin on cells. Enters the nucleus upon vitamin D3 binding where it forms heterodimers with the retinoid X receptor/RXR. The VDR-RXR heterodimers bind to specific response elements on DNA and activate the transcription of vitamin D3-responsive target genes. Recruited to promoters via its interaction with BAZ1B/WSTF which mediates the interaction with acetylated histones, an essential step for VDR-promoter association. Plays a central role in calcium homeostasis.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei143Vitamin D3By similarity1
Binding sitei300Vitamin D3By similarity1
Binding sitei392Vitamin D3By similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi21 – 96Nuclear receptorPROSITE-ProRule annotationAdd BLAST76
Zinc fingeri24 – 44NR C4-typePROSITE-ProRule annotationAdd BLAST21
Zinc fingeri60 – 84NR C4-typePROSITE-ProRule annotationAdd BLAST25

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDNA-binding, Receptor
Biological processTranscription, Transcription regulation
LigandMetal-binding, Zinc

Enzyme and pathway databases

ReactomeiR-MMU-196791 Vitamin D (calciferol) metabolism
R-MMU-383280 Nuclear Receptor transcription pathway

Names & Taxonomyi

Protein namesi
Recommended name:
Vitamin D3 receptor
Short name:
VDR
Alternative name(s):
1,25-dihydroxyvitamin D3 receptor
Nuclear receptor subfamily 1 group I member 1
Gene namesi
Name:Vdr
Synonyms:Nr1i1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 15

Organism-specific databases

MGIiMGI:103076 Vdr

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

Pathology & Biotechi

Chemistry databases

ChEMBLiCHEMBL5601

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000535431 – 422Vitamin D3 receptorAdd BLAST422

Proteomic databases

MaxQBiP48281
PaxDbiP48281
PeptideAtlasiP48281
PRIDEiP48281

PTM databases

iPTMnetiP48281
PhosphoSitePlusiP48281

Expressioni

Inductioni

By 1,25-dihydroxyvitamin D3 in kidney.1 Publication

Gene expression databases

BgeeiENSMUSG00000022479 Expressed in 157 organ(s), highest expression level in small intestine
CleanExiMM_VDR
ExpressionAtlasiP48281 baseline and differential
GenevisibleiP48281 MM

Interactioni

Subunit structurei

Homodimer in the absence of bound vitamin D3. Heterodimer with RXRA after vitamin D3 binding. Interacts with SMAD3. Interacts with MED1, NCOA1, NCOA2, NCOA3 and NCOA6 coactivators, leading to a strong increase of transcription of target genes. Interacts with the corepressor NCOR1. Interacts (in a ligand-dependent manner) with BAZ1B/WSTF. Interacts with SNW1. Interacts with IRX4, the interaction doesn't affect its transactivation activity.By similarity

Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

BioGridi204511, 4 interactors
ComplexPortaliCPX-673 RXRalpha-VDR nuclear hormone receptor complex
CPX-872 RXRbeta-VDR nuclear hormone receptor complex
CORUMiP48281
DIPiDIP-31478N
IntActiP48281, 11 interactors
MINTiP48281
STRINGi10090.ENSMUSP00000023119

Chemistry databases

BindingDBiP48281

Structurei

3D structure databases

ProteinModelPortaliP48281
SMRiP48281
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini127 – 418NR LBDPROSITE-ProRule annotationAdd BLAST292

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni97 – 126HingeAdd BLAST30
Regioni222 – 232Vitamin D3 bindingBy similarityAdd BLAST11
Regioni241 – 259Interaction with coactivator LXXLL motifBy similarityAdd BLAST19
Regioni266 – 273Vitamin D3 bindingBy similarity8

Domaini

Composed of three domains: a modulating N-terminal domain, a DNA-binding domain and a C-terminal ligand-binding domain.By similarity

Sequence similaritiesi

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri24 – 44NR C4-typePROSITE-ProRule annotationAdd BLAST21
Zinc fingeri60 – 84NR C4-typePROSITE-ProRule annotationAdd BLAST25

Keywords - Domaini

Zinc-finger

Phylogenomic databases

eggNOGiKOG3575 Eukaryota
ENOG410XRZC LUCA
GeneTreeiENSGT00870000136372
HOGENOMiHOG000220844
HOVERGENiHBG108655
InParanoidiP48281
KOiK08539
OMAiPECSMKL
OrthoDBiEOG091G05X3
TreeFamiTF316304

Family and domain databases

Gene3Di3.30.50.10, 1 hit
InterProiView protein in InterPro
IPR035500 NHR_like_dom_sf
IPR000536 Nucl_hrmn_rcpt_lig-bd
IPR001723 Nuclear_hrmn_rcpt
IPR000324 VitD_rcpt
IPR001628 Znf_hrmn_rcpt
IPR013088 Znf_NHR/GATA
PfamiView protein in Pfam
PF00104 Hormone_recep, 1 hit
PF00105 zf-C4, 1 hit
PRINTSiPR00398 STRDHORMONER
PR00047 STROIDFINGER
PR00350 VITAMINDR
SMARTiView protein in SMART
SM00430 HOLI, 1 hit
SM00399 ZnF_C4, 1 hit
SUPFAMiSSF48508 SSF48508, 1 hit
PROSITEiView protein in PROSITE
PS51843 NR_LBD, 1 hit
PS00031 NUCLEAR_REC_DBD_1, 1 hit
PS51030 NUCLEAR_REC_DBD_2, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 4 potential isoforms that are computationally mapped.Show allAlign All

P48281-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MEAMAASTSL PDPGDFDRNV PRICGVCGDR ATGFHFNAMT CEGCKGFFRR
60 70 80 90 100
SMKRKALFTC PFNGDCRITK DNRRHCQACR LKRCVDIGMM KEFILTDEEV
110 120 130 140 150
QRKREMIMKR KEEEALKDSL RPKLSEEQQH IIAILLDAHH KTYDPTYADF
160 170 180 190 200
RDFRPPIRAD VSTGSYSPRP TLSFSGDSSS NSDLYTPSLD MMEPASFSTM
210 220 230 240 250
DLNEEGSDDP SVTLDLSPLS MLPHLADLVS YSIQKVIGFA KMIPGFRDLT
260 270 280 290 300
SDDQIVLLKS SAIEVIMLRS NQSFTLDDMS WDCGSQDYKY DITDVSRAGH
310 320 330 340 350
TLELIEPLIK FQVGLKKLNL HEEEHVLLMA ICIVSPDRPG VQDAKLVEAI
360 370 380 390 400
QDRLSNTLQT YIRCRHPPPG SHQLYAKMIQ KLADLRSLNE EHSKQYRSLS
410 420
FQPENSMKLT PLVLEVFGNE IS
Length:422
Mass (Da):47,834
Last modified:July 27, 2011 - v2
Checksum:i4614DD4A129F2732
GO

Computationally mapped potential isoform sequencesi

There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
D3Z3H9D3Z3H9_MOUSE
Vitamin D3 receptor
Vdr
75Annotation score:
G3UZP9G3UZP9_MOUSE
Vitamin D3 receptor
Vdr
51Annotation score:
G3UXG5G3UXG5_MOUSE
Vitamin D3 receptor
Vdr
21Annotation score:
G3UWM9G3UWM9_MOUSE
Vitamin D3 receptor
Vdr
17Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti276L → M in BAA06737 (PubMed:7835717).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D31969 mRNA Translation: BAA06737.1
AK030339 mRNA Translation: BAC26911.1
AK154647 mRNA Translation: BAE32738.1
CH466550 Genomic DNA Translation: EDL04218.1
BC006716 mRNA Translation: AAH06716.1
CCDSiCCDS27784.1
PIRiPC4019
RefSeqiNP_033530.2, NM_009504.4
UniGeneiMm.245084

Genome annotation databases

EnsembliENSMUST00000023119; ENSMUSP00000023119; ENSMUSG00000022479
GeneIDi22337
KEGGimmu:22337
UCSCiuc007xlk.1 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D31969 mRNA Translation: BAA06737.1
AK030339 mRNA Translation: BAC26911.1
AK154647 mRNA Translation: BAE32738.1
CH466550 Genomic DNA Translation: EDL04218.1
BC006716 mRNA Translation: AAH06716.1
CCDSiCCDS27784.1
PIRiPC4019
RefSeqiNP_033530.2, NM_009504.4
UniGeneiMm.245084

3D structure databases

ProteinModelPortaliP48281
SMRiP48281
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi204511, 4 interactors
ComplexPortaliCPX-673 RXRalpha-VDR nuclear hormone receptor complex
CPX-872 RXRbeta-VDR nuclear hormone receptor complex
CORUMiP48281
DIPiDIP-31478N
IntActiP48281, 11 interactors
MINTiP48281
STRINGi10090.ENSMUSP00000023119

Chemistry databases

BindingDBiP48281
ChEMBLiCHEMBL5601

PTM databases

iPTMnetiP48281
PhosphoSitePlusiP48281

Proteomic databases

MaxQBiP48281
PaxDbiP48281
PeptideAtlasiP48281
PRIDEiP48281

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000023119; ENSMUSP00000023119; ENSMUSG00000022479
GeneIDi22337
KEGGimmu:22337
UCSCiuc007xlk.1 mouse

Organism-specific databases

CTDi7421
MGIiMGI:103076 Vdr

Phylogenomic databases

eggNOGiKOG3575 Eukaryota
ENOG410XRZC LUCA
GeneTreeiENSGT00870000136372
HOGENOMiHOG000220844
HOVERGENiHBG108655
InParanoidiP48281
KOiK08539
OMAiPECSMKL
OrthoDBiEOG091G05X3
TreeFamiTF316304

Enzyme and pathway databases

ReactomeiR-MMU-196791 Vitamin D (calciferol) metabolism
R-MMU-383280 Nuclear Receptor transcription pathway

Miscellaneous databases

ChiTaRSiVdr mouse
PROiPR:P48281
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000022479 Expressed in 157 organ(s), highest expression level in small intestine
CleanExiMM_VDR
ExpressionAtlasiP48281 baseline and differential
GenevisibleiP48281 MM

Family and domain databases

Gene3Di3.30.50.10, 1 hit
InterProiView protein in InterPro
IPR035500 NHR_like_dom_sf
IPR000536 Nucl_hrmn_rcpt_lig-bd
IPR001723 Nuclear_hrmn_rcpt
IPR000324 VitD_rcpt
IPR001628 Znf_hrmn_rcpt
IPR013088 Znf_NHR/GATA
PfamiView protein in Pfam
PF00104 Hormone_recep, 1 hit
PF00105 zf-C4, 1 hit
PRINTSiPR00398 STRDHORMONER
PR00047 STROIDFINGER
PR00350 VITAMINDR
SMARTiView protein in SMART
SM00430 HOLI, 1 hit
SM00399 ZnF_C4, 1 hit
SUPFAMiSSF48508 SSF48508, 1 hit
PROSITEiView protein in PROSITE
PS51843 NR_LBD, 1 hit
PS00031 NUCLEAR_REC_DBD_1, 1 hit
PS51030 NUCLEAR_REC_DBD_2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiVDR_MOUSE
AccessioniPrimary (citable) accession number: P48281
Secondary accession number(s): Q922X0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1996
Last sequence update: July 27, 2011
Last modified: September 12, 2018
This is version 160 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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Main funding by: National Institutes of Health

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