UniProtKB - P48230 (T4S4_HUMAN)
Protein
Transmembrane 4 L6 family member 4
Gene
TM4SF4
Organism
Homo sapiens (Human)
Status
Functioni
Regulates the adhesive and proliferative status of intestinal epithelial cells. Can mediate density-dependent cell proliferation.
GO - Biological processi
- tissue regeneration Source: Ensembl
Enzyme and pathway databases
PathwayCommonsi | P48230 |
Protein family/group databases
TCDBi | 8.A.75.1.1, the transmembrane 4 superfamily 4 (tm4sf4) family |
Names & Taxonomyi
Protein namesi | Recommended name: Transmembrane 4 L6 family member 4Alternative name(s): Intestine and liver tetraspan membrane protein Short name: IL-TMP |
Gene namesi | Name:TM4SF4 Synonyms:ILTMP |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:11856, TM4SF4 |
MIMi | 606567, gene |
neXtProti | NX_P48230 |
VEuPathDBi | HostDB:ENSG00000169903.6 |
Subcellular locationi
Other locations
Other locations
- integral component of membrane Source: GO_Central
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 1 – 9 | CytoplasmicSequence analysis | 9 | |
Transmembranei | 10 – 30 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 31 – 45 | ExtracellularSequence analysisAdd BLAST | 15 | |
Transmembranei | 46 – 66 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 67 – 93 | CytoplasmicSequence analysisAdd BLAST | 27 | |
Transmembranei | 94 – 114 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 115 – 158 | ExtracellularSequence analysisAdd BLAST | 44 | |
Transmembranei | 159 – 179 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 180 – 202 | CytoplasmicSequence analysisAdd BLAST | 23 |
Keywords - Cellular componenti
MembranePathology & Biotechi
Organism-specific databases
DisGeNETi | 7104 |
OpenTargetsi | ENSG00000169903 |
PharmGKBi | PA36557 |
Miscellaneous databases
Pharosi | P48230, Tbio |
Genetic variation databases
BioMutai | TM4SF4 |
DMDMi | 1352457 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000219299 | 1 – 202 | Transmembrane 4 L6 family member 4Add BLAST | 202 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Glycosylationi | 124 | N-linked (GlcNAc...) asparagine1 Publication | 1 | |
Glycosylationi | 156 | N-linked (GlcNAc...) asparagineSequence analysis | 1 |
Post-translational modificationi
N-glycosylated. Glycosylation is required for the growth inhibitory effect.1 Publication
Keywords - PTMi
GlycoproteinProteomic databases
MassIVEi | P48230 |
PaxDbi | P48230 |
PeptideAtlasi | P48230 |
PRIDEi | P48230 |
ProteomicsDBi | 55873 |
PTM databases
GlyGeni | P48230, 2 sites |
iPTMneti | P48230 |
Expressioni
Tissue specificityi
Jejunum and liver.
Gene expression databases
Bgeei | ENSG00000169903, Expressed in gall bladder and 98 other tissues |
ExpressionAtlasi | P48230, baseline and differential |
Genevisiblei | P48230, HS |
Organism-specific databases
HPAi | ENSG00000169903, Group enriched (gallbladder, intestine, liver) |
Interactioni
Binary interactionsi
Hide detailsP48230
Protein-protein interaction databases
BioGRIDi | 112959, 23 interactors |
IntActi | P48230, 22 interactors |
MINTi | P48230 |
STRINGi | 9606.ENSP00000305852 |
Miscellaneous databases
RNActi | P48230, protein |
Family & Domainsi
Sequence similaritiesi
Belongs to the L6 tetraspanin family.Curated
Keywords - Domaini
Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | ENOG502QVGK, Eukaryota |
GeneTreei | ENSGT01010000222416 |
HOGENOMi | CLU_087168_1_0_1 |
InParanoidi | P48230 |
OMAi | VIDNNDH |
OrthoDBi | 922490at2759 |
PhylomeDBi | P48230 |
TreeFami | TF331371 |
Family and domain databases
InterProi | View protein in InterPro IPR008661, L6_membrane |
PANTHERi | PTHR14198, PTHR14198, 1 hit |
Pfami | View protein in Pfam PF05805, L6_membrane, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All
P48230-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MCTGGCARCL GGTLIPLAFF GFLANILLFF PGGKVIDDND HLSQEIWFFG
60 70 80 90 100
GILGSGVLMI FPALVFLGLK NNDCCGCCGN EGCGKRFAMF TSTIFAVVGF
110 120 130 140 150
LGAGYSFIIS AISINKGPKC LMANSTWGYP FHDGDYLNDE ALWNKCREPL
160 170 180 190 200
NVVPWNLTLF SILLVVGGIQ MVLCAIQVVN GLLGTLCGDC QCCGCCGGDG
PV
Computationally mapped potential isoform sequencesi
There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basketC9JVD2 | C9JVD2_HUMAN | Transmembrane 4 L6 family member 4 | TM4SF4 | 81 | Annotation score: |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U31449 mRNA Translation: AAA74745.1 BT007430 mRNA Translation: AAP36098.1 AK315464 mRNA Translation: BAG37851.1 CH471052 Genomic DNA Translation: EAW78871.1 BC001386 mRNA Translation: AAH01386.1 |
CCDSi | CCDS46932.1 |
RefSeqi | NP_004608.1, NM_004617.3 |
Genome annotation databases
Ensembli | ENST00000305354; ENSP00000305852; ENSG00000169903 |
GeneIDi | 7104 |
KEGGi | hsa:7104 |
UCSCi | uc003exd.3, human |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U31449 mRNA Translation: AAA74745.1 BT007430 mRNA Translation: AAP36098.1 AK315464 mRNA Translation: BAG37851.1 CH471052 Genomic DNA Translation: EAW78871.1 BC001386 mRNA Translation: AAH01386.1 |
CCDSi | CCDS46932.1 |
RefSeqi | NP_004608.1, NM_004617.3 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
BioGRIDi | 112959, 23 interactors |
IntActi | P48230, 22 interactors |
MINTi | P48230 |
STRINGi | 9606.ENSP00000305852 |
Protein family/group databases
TCDBi | 8.A.75.1.1, the transmembrane 4 superfamily 4 (tm4sf4) family |
PTM databases
GlyGeni | P48230, 2 sites |
iPTMneti | P48230 |
Genetic variation databases
BioMutai | TM4SF4 |
DMDMi | 1352457 |
Proteomic databases
MassIVEi | P48230 |
PaxDbi | P48230 |
PeptideAtlasi | P48230 |
PRIDEi | P48230 |
ProteomicsDBi | 55873 |
Protocols and materials databases
Antibodypediai | 33572, 135 antibodies |
DNASUi | 7104 |
Genome annotation databases
Ensembli | ENST00000305354; ENSP00000305852; ENSG00000169903 |
GeneIDi | 7104 |
KEGGi | hsa:7104 |
UCSCi | uc003exd.3, human |
Organism-specific databases
CTDi | 7104 |
DisGeNETi | 7104 |
GeneCardsi | TM4SF4 |
HGNCi | HGNC:11856, TM4SF4 |
HPAi | ENSG00000169903, Group enriched (gallbladder, intestine, liver) |
MIMi | 606567, gene |
neXtProti | NX_P48230 |
OpenTargetsi | ENSG00000169903 |
PharmGKBi | PA36557 |
VEuPathDBi | HostDB:ENSG00000169903.6 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | ENOG502QVGK, Eukaryota |
GeneTreei | ENSGT01010000222416 |
HOGENOMi | CLU_087168_1_0_1 |
InParanoidi | P48230 |
OMAi | VIDNNDH |
OrthoDBi | 922490at2759 |
PhylomeDBi | P48230 |
TreeFami | TF331371 |
Enzyme and pathway databases
PathwayCommonsi | P48230 |
Miscellaneous databases
BioGRID-ORCSi | 7104, 6 hits in 978 CRISPR screens |
ChiTaRSi | TM4SF4, human |
GenomeRNAii | 7104 |
Pharosi | P48230, Tbio |
PROi | PR:P48230 |
RNActi | P48230, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000169903, Expressed in gall bladder and 98 other tissues |
ExpressionAtlasi | P48230, baseline and differential |
Genevisiblei | P48230, HS |
Family and domain databases
InterProi | View protein in InterPro IPR008661, L6_membrane |
PANTHERi | PTHR14198, PTHR14198, 1 hit |
Pfami | View protein in Pfam PF05805, L6_membrane, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | T4S4_HUMAN | |
Accessioni | P48230Primary (citable) accession number: P48230 Secondary accession number(s): B2RDA4 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | February 1, 1996 |
Last sequence update: | February 1, 1996 | |
Last modified: | April 7, 2021 | |
This is version 153 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human chromosome 3
Human chromosome 3: entries, gene names and cross-references to MIM - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families