UniProtKB - P48201 (AT5G3_HUMAN)
ATP synthase F(0) complex subunit C3, mitochondrial
ATP5MC3
Functioni
Mitochondrial membrane ATP synthase (F1F0 ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F1 - containing the extramembraneous catalytic core and F0 - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F1 is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F0 domain. A homomeric c-ring of probably 10 subunits is part of the complex rotary element.
Miscellaneous
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sitei | 125 | Reversibly protonated during proton transportBy similarity | 1 |
GO - Molecular functioni
- lipid binding Source: UniProtKB-KW
- proton transmembrane transporter activity Source: InterPro
GO - Biological processi
- ATP synthesis coupled proton transport Source: GO_Central
Keywordsi
Biological process | Hydrogen ion transport, Ion transport, Transport |
Ligand | Lipid-binding |
Enzyme and pathway databases
PathwayCommonsi | P48201 |
Reactomei | R-HSA-163210, Formation of ATP by chemiosmotic coupling R-HSA-8949613, Cristae formation |
SignaLinki | P48201 |
Protein family/group databases
TCDBi | 3.A.2.1.15, the h(+)- or na(+)-translocating f-type, v-type and a-type atpase (f-atpase) superfamily |
Names & Taxonomyi
Protein namesi | Recommended name: ATP synthase F(0) complex subunit C3, mitochondrialCuratedAlternative name(s): ATP synthase lipid-binding protein ATP synthase membrane subunit c locus 3Imported ATP synthase proteolipid P3 ATP synthase proton-transporting mitochondrial F(0) complex subunit C3 ATPase protein 9 ATPase subunit c |
Gene namesi | |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:843, ATP5MC3 |
MIMi | 602736, gene |
neXtProti | NX_P48201 |
VEuPathDBi | HostDB:ENSG00000154518 |
Subcellular locationi
Mitochondrion
Mitochondrion
- mitochondrial outer membrane Source: Reactome
- mitochondrial proton-transporting ATP synthase complex, coupling factor F(o) Source: GO_Central
Other locations
- integral component of membrane Source: UniProtKB-KW
- proton-transporting ATP synthase complex, coupling factor F(o) Source: GO_Central
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Transmembranei | 83 – 103 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 118 – 138 | HelicalSequence analysisAdd BLAST | 21 |
Keywords - Cellular componenti
CF(0), Membrane, MitochondrionPathology & Biotechi
Organism-specific databases
OpenTargetsi | ENSG00000154518 |
PharmGKBi | PA25133 |
Miscellaneous databases
Pharosi | P48201, Tdark |
Genetic variation databases
BioMutai | ATP5G3 |
DMDMi | 1352048 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Transit peptidei | 1 – 67 | MitochondrionAdd BLAST | 67 | |
ChainiPRO_0000002567 | 68 – 142 | ATP synthase F(0) complex subunit C3, mitochondrialAdd BLAST | 75 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 110 | N6,N6,N6-trimethyllysine1 Publication | 1 |
Post-translational modificationi
Keywords - PTMi
MethylationProteomic databases
EPDi | P48201 |
jPOSTi | P48201 |
MassIVEi | P48201 |
MaxQBi | P48201 |
PaxDbi | P48201 |
PeptideAtlasi | P48201 |
PRIDEi | P48201 |
ProteomicsDBi | 55872 |
TopDownProteomicsi | P48201 |
PTM databases
iPTMneti | P48201 |
PhosphoSitePlusi | P48201 |
Expressioni
Gene expression databases
Bgeei | ENSG00000154518, Expressed in heart right ventricle and 254 other tissues |
Genevisiblei | P48201, HS |
Organism-specific databases
HPAi | ENSG00000154518, Tissue enhanced (heart muscle, tongue) |
Interactioni
Subunit structurei
F-type ATPases have 2 components, CF1 - the catalytic core - and CF0 - the membrane proton channel. CF1 has five subunits: alpha3, beta3, gamma1, delta1, epsilon1. CF0 has three main subunits: a, b and c.
Interacts with TMEM70 and TMEM242 (PubMed:33753518).
1 PublicationProtein-protein interaction databases
BioGRIDi | 107003, 17 interactors |
ComplexPortali | CPX-6151, Mitochondrial proton-transporting ATP synthase complex |
IntActi | P48201, 8 interactors |
STRINGi | 9606.ENSP00000284727 |
Miscellaneous databases
RNActi | P48201, protein |
Family & Domainsi
Sequence similaritiesi
Keywords - Domaini
Transit peptide, Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | KOG3025, Eukaryota |
GeneTreei | ENSGT00940000154298 |
HOGENOMi | CLU_116822_1_0_1 |
InParanoidi | P48201 |
OMAi | CKMFACA |
OrthoDBi | 1564365at2759 |
PhylomeDBi | P48201 |
TreeFami | TF300140 |
Family and domain databases
Gene3Di | 1.20.20.10, 1 hit |
HAMAPi | MF_01396, ATP_synth_c_bact, 1 hit |
InterProi | View protein in InterPro IPR000454, ATP_synth_F0_csu IPR020537, ATP_synth_F0_csu_DDCD_BS IPR038662, ATP_synth_F0_csu_sf IPR002379, ATPase_proteolipid_c-like_dom IPR035921, F/V-ATP_Csub_sf |
PANTHERi | PTHR10031, PTHR10031, 1 hit |
Pfami | View protein in Pfam PF00137, ATP-synt_C, 1 hit |
PRINTSi | PR00124, ATPASEC |
SUPFAMi | SSF81333, SSF81333, 1 hit |
PROSITEi | View protein in PROSITE PS00605, ATPASE_C, 1 hit |
i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
10 20 30 40 50
MFACAKLACT PSLIRAGSRV AYRPISASVL SRPEASRTGE GSTVFNGAQN
60 70 80 90 100
GVSQLIQREF QTSAISRDID TAAKFIGAGA ATVGVAGSGA GIGTVFGSLI
110 120 130 140
IGYARNPSLK QQLFSYAILG FALSEAMGLF CLMVAFLILF AM
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_011922 | 93 | G → E. Corresponds to variant dbSNP:rs1802622Ensembl. | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U09813 mRNA Translation: AAA78807.1 AK311999 mRNA Translation: BAG34937.1 AC096649 Genomic DNA Translation: AAX88970.1 CH471058 Genomic DNA Translation: EAX11106.1 CH471058 Genomic DNA Translation: EAX11107.1 BC106881 mRNA Translation: AAI06882.1 |
CCDSi | CCDS2263.1 |
PIRi | I38612 |
RefSeqi | NP_001002258.1, NM_001002258.4 NP_001680.1, NM_001689.4 |
Genome annotation databases
Ensembli | ENST00000284727; ENSP00000284727; ENSG00000154518 ENST00000392541; ENSP00000376324; ENSG00000154518 ENST00000409194; ENSP00000387317; ENSG00000154518 |
GeneIDi | 518 |
KEGGi | hsa:518 |
MANE-Selecti | ENST00000284727.9; ENSP00000284727.4; NM_001689.5; NP_001680.1 |
UCSCi | uc002ujz.5, human |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U09813 mRNA Translation: AAA78807.1 AK311999 mRNA Translation: BAG34937.1 AC096649 Genomic DNA Translation: AAX88970.1 CH471058 Genomic DNA Translation: EAX11106.1 CH471058 Genomic DNA Translation: EAX11107.1 BC106881 mRNA Translation: AAI06882.1 |
CCDSi | CCDS2263.1 |
PIRi | I38612 |
RefSeqi | NP_001002258.1, NM_001002258.4 NP_001680.1, NM_001689.4 |
3D structure databases
SMRi | P48201 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 107003, 17 interactors |
ComplexPortali | CPX-6151, Mitochondrial proton-transporting ATP synthase complex |
IntActi | P48201, 8 interactors |
STRINGi | 9606.ENSP00000284727 |
Protein family/group databases
TCDBi | 3.A.2.1.15, the h(+)- or na(+)-translocating f-type, v-type and a-type atpase (f-atpase) superfamily |
PTM databases
iPTMneti | P48201 |
PhosphoSitePlusi | P48201 |
Genetic variation databases
BioMutai | ATP5G3 |
DMDMi | 1352048 |
Proteomic databases
EPDi | P48201 |
jPOSTi | P48201 |
MassIVEi | P48201 |
MaxQBi | P48201 |
PaxDbi | P48201 |
PeptideAtlasi | P48201 |
PRIDEi | P48201 |
ProteomicsDBi | 55872 |
TopDownProteomicsi | P48201 |
Protocols and materials databases
Antibodypediai | 53295, 44 antibodies from 16 providers |
DNASUi | 518 |
Genome annotation databases
Ensembli | ENST00000284727; ENSP00000284727; ENSG00000154518 ENST00000392541; ENSP00000376324; ENSG00000154518 ENST00000409194; ENSP00000387317; ENSG00000154518 |
GeneIDi | 518 |
KEGGi | hsa:518 |
MANE-Selecti | ENST00000284727.9; ENSP00000284727.4; NM_001689.5; NP_001680.1 |
UCSCi | uc002ujz.5, human |
Organism-specific databases
CTDi | 518 |
GeneCardsi | ATP5MC3 |
HGNCi | HGNC:843, ATP5MC3 |
HPAi | ENSG00000154518, Tissue enhanced (heart muscle, tongue) |
MIMi | 602736, gene |
neXtProti | NX_P48201 |
OpenTargetsi | ENSG00000154518 |
PharmGKBi | PA25133 |
VEuPathDBi | HostDB:ENSG00000154518 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG3025, Eukaryota |
GeneTreei | ENSGT00940000154298 |
HOGENOMi | CLU_116822_1_0_1 |
InParanoidi | P48201 |
OMAi | CKMFACA |
OrthoDBi | 1564365at2759 |
PhylomeDBi | P48201 |
TreeFami | TF300140 |
Enzyme and pathway databases
PathwayCommonsi | P48201 |
Reactomei | R-HSA-163210, Formation of ATP by chemiosmotic coupling R-HSA-8949613, Cristae formation |
SignaLinki | P48201 |
Miscellaneous databases
BioGRID-ORCSi | 518, 6 hits in 1047 CRISPR screens |
ChiTaRSi | ATP5G3, human |
GeneWikii | ATP5G3 |
GenomeRNAii | 518 |
Pharosi | P48201, Tdark |
PROi | PR:P48201 |
RNActi | P48201, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000154518, Expressed in heart right ventricle and 254 other tissues |
Genevisiblei | P48201, HS |
Family and domain databases
Gene3Di | 1.20.20.10, 1 hit |
HAMAPi | MF_01396, ATP_synth_c_bact, 1 hit |
InterProi | View protein in InterPro IPR000454, ATP_synth_F0_csu IPR020537, ATP_synth_F0_csu_DDCD_BS IPR038662, ATP_synth_F0_csu_sf IPR002379, ATPase_proteolipid_c-like_dom IPR035921, F/V-ATP_Csub_sf |
PANTHERi | PTHR10031, PTHR10031, 1 hit |
Pfami | View protein in Pfam PF00137, ATP-synt_C, 1 hit |
PRINTSi | PR00124, ATPASEC |
SUPFAMi | SSF81333, SSF81333, 1 hit |
PROSITEi | View protein in PROSITE PS00605, ATPASE_C, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | AT5G3_HUMAN | |
Accessioni | P48201Primary (citable) accession number: P48201 Secondary accession number(s): B2R4Z0, D3DPF0, Q4ZFX7 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | February 1, 1996 |
Last sequence update: | February 1, 1996 | |
Last modified: | February 23, 2022 | |
This is version 180 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human chromosome 2
Human chromosome 2: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families