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Protein

Iron-responsive element-binding protein 2

Gene

IREB2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

RNA-binding protein that binds to iron-responsive elements (IRES), which are stem-loop structures found in the 5'-UTR of ferritin, and delta aminolevulinic acid synthase mRNAs, and in the 3'-UTR of transferrin receptor mRNA. Binding to the IRE element in ferritin results in the repression of its mRNA translation. Binding of the protein to the transferrin receptor mRNA inhibits the degradation of this otherwise rapidly degraded mRNA.1 Publication

<p>This subsection of the ‘Function’ section provides information relevant to cofactors. A cofactor is any non-protein substance required for a protein to be catalytically active. Some cofactors are inorganic, such as the metal atoms zinc, iron, and copper in various oxidation states. Others, such as most vitamins, are organic.<p><a href='/help/cofactor' target='_top'>More...</a></p>Cofactori

[4Fe-4S] clusterBy similarityNote: Binds 1 [4Fe-4S] cluster per subunit. [4Fe-4S]-binding affects RNA-binding activity, thereby inhibiting activity of the protein.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Function’ section indicates at which position the protein binds a given metal ion. The nature of the metal is indicated in the ‘Description’ field.<p><a href='/help/metal' target='_top'>More...</a></p>Metal bindingi512Iron-sulfur (4Fe-4S)By similarity1
Metal bindingi578Iron-sulfur (4Fe-4S)By similarity1
Metal bindingi581Iron-sulfur (4Fe-4S)By similarity1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • 4 iron, 4 sulfur cluster binding Source: GO_Central
  • aconitate hydratase activity Source: GO_Central
  • iron-responsive element binding Source: UniProtKB
  • metal ion binding Source: UniProtKB-KW
  • regulatory region RNA binding Source: GO_Central
  • RNA binding Source: UniProtKB
  • translation repressor activity Source: InterPro

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionRNA-binding
Ligand4Fe-4S, Iron, Iron-sulfur, Metal-binding

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-917937 Iron uptake and transport

SIGNOR Signaling Network Open Resource

More...
SIGNORi
P48200

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Iron-responsive element-binding protein 2
Short name:
IRE-BP 2
Alternative name(s):
Iron regulatory protein 2
Short name:
IRP2
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:IREB2
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 15

Organism-specific databases

Eukaryotic Pathogen Database Resources

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EuPathDBi
HostDB:ENSG00000136381.12

Human Gene Nomenclature Database

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HGNCi
HGNC:6115 IREB2

Online Mendelian Inheritance in Man (OMIM)

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MIMi
147582 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_P48200

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
3658

Open Targets

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OpenTargetsi
ENSG00000136381

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA29914

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
IREB2

Domain mapping of disease mutations (DMDM)

More...
DMDMi
308153591

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000766841 – 963Iron-responsive element-binding protein 2Add BLAST963

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Ubiquitinated and degraded by the proteasome in presence of high level of iron and oxygen. Ubiquitinated by a SCF complex containing FBXL5. Upon iron and oxygen depletion FBXL5 is degraded, preventing ubiquitination and allowing its RNA-binding activity.3 Publications

Keywords - PTMi

Ubl conjugation

Proteomic databases

Encyclopedia of Proteome Dynamics

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EPDi
P48200

MaxQB - The MaxQuant DataBase

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MaxQBi
P48200

PaxDb, a database of protein abundance averages across all three domains of life

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PaxDbi
P48200

PeptideAtlas

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PeptideAtlasi
P48200

PRoteomics IDEntifications database

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PRIDEi
P48200

ProteomicsDB human proteome resource

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ProteomicsDBi
55871

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

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iPTMneti
P48200

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

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PhosphoSitePlusi
P48200

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

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Bgeei
ENSG00000136381 Expressed in 214 organ(s), highest expression level in neocortex

CleanEx database of gene expression profiles

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CleanExi
HS_IREB2

ExpressionAtlas, Differential and Baseline Expression

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ExpressionAtlasi
P48200 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
P48200 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
CAB032885
HPA040371
HPA068982

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with RBCK1 isoform 1 and isoform 2 only in iron-rich conditions (PubMed:12629548). Interacts (when associated with the 4Fe-4S) with FBXL5 (PubMed:19762596, PubMed:19762597). Interacts with CIAO1 and CIAO2A (PubMed:23891004).4 Publications

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

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BioGridi
109866, 27 interactors

Protein interaction database and analysis system

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IntActi
P48200, 4 interactors

STRING: functional protein association networks

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STRINGi
9606.ENSP00000258886

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

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ProteinModelPortali
P48200

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
P48200

Database of comparative protein structure models

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ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the aconitase/IPM isomerase family.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

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eggNOGi
KOG0452 Eukaryota
COG1048 LUCA

Ensembl GeneTree

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GeneTreei
ENSGT00940000157796

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

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HOGENOMi
HOG000025704

The HOVERGEN Database of Homologous Vertebrate Genes

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HOVERGENi
HBG073693

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
P48200

KEGG Orthology (KO)

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KOi
K22416

Identification of Orthologs from Complete Genome Data

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OMAi
EHTGFSK

Database of Orthologous Groups

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OrthoDBi
EOG091G01IX

Database for complete collections of gene phylogenies

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PhylomeDBi
P48200

TreeFam database of animal gene trees

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TreeFami
TF313476

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

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Gene3Di
3.20.19.10, 1 hit
3.30.499.10, 1 hit

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR015931 Acnase/IPM_dHydase_lsu_aba_1/3
IPR001030 Acoase/IPM_deHydtase_lsu_aba
IPR015928 Aconitase/3IPM_dehydase_swvl
IPR006249 Aconitase/IRP2
IPR018136 Aconitase_4Fe-4S_BS
IPR036008 Aconitase_4Fe-4S_dom
IPR000573 AconitaseA/IPMdHydase_ssu_swvl
IPR029755 IRE-BP2

The PANTHER Classification System

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PANTHERi
PTHR11670 PTHR11670, 1 hit
PTHR11670:SF31 PTHR11670:SF31, 1 hit

Pfam protein domain database

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Pfami
View protein in Pfam
PF00330 Aconitase, 2 hits
PF00694 Aconitase_C, 1 hit

Protein Motif fingerprint database; a protein domain database

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PRINTSi
PR00415 ACONITASE

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF53732 SSF53732, 1 hit

TIGRFAMs; a protein family database

More...
TIGRFAMsi
TIGR01341 aconitase_1, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00450 ACONITASE_1, 1 hit
PS01244 ACONITASE_2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 5 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: P48200-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MDAPKAGYAF EYLIETLNDS SHKKFFDVSK LGTKYDVLPY SIRVLLEAAV
60 70 80 90 100
RNCDGFLMKK EDVMNILDWK TKQSNVEVPF FPARVLLQDF TGIPAMVDFA
110 120 130 140 150
AMREAVKTLG GDPEKVHPAC PTDLTVDHSL QIDFSKCAIQ NAPNPGGGDL
160 170 180 190 200
QKAGKLSPLK VQPKKLPCRG QTTCRGSCDS GELGRNSGTF SSQIENTPIL
210 220 230 240 250
CPFHLQPVPE PETVLKNQEV EFGRNRERLQ FFKWSSRVFK NVAVIPPGTG
260 270 280 290 300
MAHQINLEYL SRVVFEEKDL LFPDSVVGTD SHITMVNGLG ILGWGVGGIE
310 320 330 340 350
TEAVMLGLPV SLTLPEVVGC ELTGSSNPFV TSIDVVLGIT KHLRQVGVAG
360 370 380 390 400
KFVEFFGSGV SQLSIVDRTT IANMCPEYGA ILSFFPVDNV TLKHLEHTGF
410 420 430 440 450
SKAKLESMET YLKAVKLFRN DQNSSGEPEY SQVIQINLNS IVPSVSGPKR
460 470 480 490 500
PQDRVAVTDM KSDFQACLNE KVGFKGFQIA AEKQKDIVSI HYEGSEYKLS
510 520 530 540 550
HGSVVIAAVI SCTNNCNPSV MLAAGLLAKK AVEAGLRVKP YIRTSLSPGS
560 570 580 590 600
GMVTHYLSSS GVLPYLSKLG FEIVGYGCSI CVGNTAPLSD AVLNAVKQGD
610 620 630 640 650
LVTCGILSGN KNFEGRLCDC VRANYLASPP LVVAYAIAGT VNIDFQTEPL
660 670 680 690 700
GTDPTGKNIY LHDIWPSREE VHRVEEEHVI LSMFKALKDK IEMGNKRWNS
710 720 730 740 750
LEAPDSVLFP WDLKSTYIRC PSFFDKLTKE PIALQAIENA HVLLYLGDSV
760 770 780 790 800
TTDHISPAGS IARNSAAAKY LTNRGLTPRE FNSYGARRGN DAVMTRGTFA
810 820 830 840 850
NIKLFNKFIG KPAPKTIHFP SGQTLDVFEA AELYQKEGIP LIILAGKKYG
860 870 880 890 900
SGNSRDWAAK GPYLLGVKAV LAESYEKIHK DHLIGIGIAP LQFLPGENAD
910 920 930 940 950
SLGLSGRETF SLTFPEELSP GITLNIQTST GKVFSVIASF EDDVEITLYK
960
HGGLLNFVAR KFS
Length:963
Mass (Da):105,059
Last modified:September 12, 2018 - v4
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i051228C6CE5362FD
GO
Isoform 2 (identifier: P48200-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     342-342: H → V
     343-962: Missing.

Show »
Length:343
Mass (Da):37,501
Checksum:i9DD71F8776C918FF
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 5 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
H0YNL8H0YNL8_HUMAN
Iron-responsive element-binding pro...
IREB2
220Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0YN46H0YN46_HUMAN
Iron-responsive element-binding pro...
IREB2
89Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0YLE0H0YLE0_HUMAN
Iron-responsive element-binding pro...
IREB2
38Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0YMA8H0YMA8_HUMAN
Iron-responsive element-binding pro...
IREB2
46Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H0YL48H0YL48_HUMAN
Iron-responsive element-binding pro...
IREB2
51Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAA79926 differs from that shown. Reason: Frameshift at positions 605 and 611.Curated
The sequence BAD92640 differs from that shown. Reason: Frameshift at position 727.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti195E → G in BAF85681 (PubMed:14702039).Curated1
Sequence conflicti239F → L in AAA69901 (PubMed:7983023).Curated1
Sequence conflicti239F → L in BAF85681 (PubMed:14702039).Curated1
Sequence conflicti239F → L in AAA79926 (PubMed:7622457).Curated1
Sequence conflicti452Q → R in AAA79926 (PubMed:7622457).Curated1
Sequence conflicti458T → P in BAF85681 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_058410580I → T7 PublicationsCorresponds to variant dbSNP:rs2230940Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting. The information stored in this subsection is used to automatically construct alternative protein sequence(s) for display.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_056823342H → V in isoform 2. 2 Publications1
Alternative sequenceiVSP_056824343 – 962Missing in isoform 2. 2 PublicationsAdd BLAST620

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
M58511 mRNA Translation: AAA69901.1
AB586699 mRNA Translation: BAJ19024.1
AK292992 mRNA Translation: BAF85681.1
AB209403 mRNA Translation: BAD92640.1 Frameshift.
DQ496102 Genomic DNA Translation: ABF47091.1
AC011270 Genomic DNA No translation available.
AC027228 Genomic DNA No translation available.
KF459563 Genomic DNA No translation available.
CH471136 Genomic DNA Translation: EAW99169.1
BC017880 mRNA Translation: AAH17880.1
BC117481 mRNA Translation: AAI17482.1
BC117483 mRNA Translation: AAI17484.1
U20180 mRNA Translation: AAA79926.1 Frameshift.
AL133439 mRNA Translation: CAB62825.1

The Consensus CDS (CCDS) project

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CCDSi
CCDS10302.1 [P48200-1]
CCDS81912.1 [P48200-2]

Protein sequence database of the Protein Information Resource

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PIRi
B57238

NCBI Reference Sequences

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RefSeqi
NP_001307870.1, NM_001320941.1
NP_001307872.1, NM_001320943.1 [P48200-2]
NP_004127.1, NM_004136.3

UniGene gene-oriented nucleotide sequence clusters

More...
UniGenei
Hs.436031

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000258886; ENSP00000258886; ENSG00000136381 [P48200-1]
ENST00000560440; ENSP00000452938; ENSG00000136381 [P48200-2]

Database of genes from NCBI RefSeq genomes

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GeneIDi
3658

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:3658

UCSC genome browser

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UCSCi
uc002bdq.4 human [P48200-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M58511 mRNA Translation: AAA69901.1
AB586699 mRNA Translation: BAJ19024.1
AK292992 mRNA Translation: BAF85681.1
AB209403 mRNA Translation: BAD92640.1 Frameshift.
DQ496102 Genomic DNA Translation: ABF47091.1
AC011270 Genomic DNA No translation available.
AC027228 Genomic DNA No translation available.
KF459563 Genomic DNA No translation available.
CH471136 Genomic DNA Translation: EAW99169.1
BC017880 mRNA Translation: AAH17880.1
BC117481 mRNA Translation: AAI17482.1
BC117483 mRNA Translation: AAI17484.1
U20180 mRNA Translation: AAA79926.1 Frameshift.
AL133439 mRNA Translation: CAB62825.1
CCDSiCCDS10302.1 [P48200-1]
CCDS81912.1 [P48200-2]
PIRiB57238
RefSeqiNP_001307870.1, NM_001320941.1
NP_001307872.1, NM_001320943.1 [P48200-2]
NP_004127.1, NM_004136.3
UniGeneiHs.436031

3D structure databases

ProteinModelPortaliP48200
SMRiP48200
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi109866, 27 interactors
IntActiP48200, 4 interactors
STRINGi9606.ENSP00000258886

PTM databases

iPTMnetiP48200
PhosphoSitePlusiP48200

Polymorphism and mutation databases

BioMutaiIREB2
DMDMi308153591

Proteomic databases

EPDiP48200
MaxQBiP48200
PaxDbiP48200
PeptideAtlasiP48200
PRIDEiP48200
ProteomicsDBi55871

Protocols and materials databases

The DNASU plasmid repository

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DNASUi
3658
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000258886; ENSP00000258886; ENSG00000136381 [P48200-1]
ENST00000560440; ENSP00000452938; ENSG00000136381 [P48200-2]
GeneIDi3658
KEGGihsa:3658
UCSCiuc002bdq.4 human [P48200-1]

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
3658
DisGeNETi3658
EuPathDBiHostDB:ENSG00000136381.12

GeneCards: human genes, protein and diseases

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GeneCardsi
IREB2

H-Invitational Database, human transcriptome db

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H-InvDBi
HIX0012477
HGNCiHGNC:6115 IREB2
HPAiCAB032885
HPA040371
HPA068982
MIMi147582 gene
neXtProtiNX_P48200
OpenTargetsiENSG00000136381
PharmGKBiPA29914

GenAtlas: human gene database

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GenAtlasi
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Phylogenomic databases

eggNOGiKOG0452 Eukaryota
COG1048 LUCA
GeneTreeiENSGT00940000157796
HOGENOMiHOG000025704
HOVERGENiHBG073693
InParanoidiP48200
KOiK22416
OMAiEHTGFSK
OrthoDBiEOG091G01IX
PhylomeDBiP48200
TreeFamiTF313476

Enzyme and pathway databases

ReactomeiR-HSA-917937 Iron uptake and transport
SIGNORiP48200

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
IREB2 human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
3658

Protein Ontology

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PROi
PR:P48200

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
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Gene expression databases

BgeeiENSG00000136381 Expressed in 214 organ(s), highest expression level in neocortex
CleanExiHS_IREB2
ExpressionAtlasiP48200 baseline and differential
GenevisibleiP48200 HS

Family and domain databases

Gene3Di3.20.19.10, 1 hit
3.30.499.10, 1 hit
InterProiView protein in InterPro
IPR015931 Acnase/IPM_dHydase_lsu_aba_1/3
IPR001030 Acoase/IPM_deHydtase_lsu_aba
IPR015928 Aconitase/3IPM_dehydase_swvl
IPR006249 Aconitase/IRP2
IPR018136 Aconitase_4Fe-4S_BS
IPR036008 Aconitase_4Fe-4S_dom
IPR000573 AconitaseA/IPMdHydase_ssu_swvl
IPR029755 IRE-BP2
PANTHERiPTHR11670 PTHR11670, 1 hit
PTHR11670:SF31 PTHR11670:SF31, 1 hit
PfamiView protein in Pfam
PF00330 Aconitase, 2 hits
PF00694 Aconitase_C, 1 hit
PRINTSiPR00415 ACONITASE
SUPFAMiSSF53732 SSF53732, 1 hit
TIGRFAMsiTIGR01341 aconitase_1, 1 hit
PROSITEiView protein in PROSITE
PS00450 ACONITASE_1, 1 hit
PS01244 ACONITASE_2, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiIREB2_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P48200
Secondary accession number(s): A0A0A6YY96
, A8KAC7, E1CJT9, H0YKU0, Q13095, Q1HE21, Q59FQ7, Q8WVK6, Q9UF17
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1996
Last sequence update: September 12, 2018
Last modified: December 5, 2018
This is version 166 of the entry and version 4 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 15
    Human chromosome 15: entries, gene names and cross-references to MIM
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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