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UniProtKB - P48148 (RHO1_DROME)

Entry version 193 (02 Dec 2020)
Sequence version 1 (01 Feb 1996)
Previous versions | rss
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Protein

Ras-like GTP-binding protein Rho1

Gene

Rho1

Organism
Drosophila melanogaster (Fruit fly)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Has a role in regulating actin cytoskeletal organization: required during early development for proper execution of morphogenetic movements of individual cells and groups of cells important for the formation of the embryonic body plan (PubMed:10556060, PubMed:24535826, PubMed:25739458). Plays a role in regulating dorsal closure during embryogenesis (PubMed:10556060, PubMed:10323867). During axis elongation, required for Rho-kinase Rok planar polarity and adherens junction localization as well as for generating a planar polarized distribution of the actin-binding protein Shrm (PubMed:24535826). During embryogenesis, acts upstream of wash to regulate the developmental migration of tail hemocytes anteriorly along the ventral midline (PubMed:25739458). May have a role in eye development (PubMed:7835340).5 Publications

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes a region in the protein which binds nucleotide phosphates. It always involves more than one amino acid and includes all residues involved in nucleotide-binding.<p><a href='/help/np_bind' target='_top'>More...</a></p>Nucleotide bindingi12 – 19GTPBy similarity8
Nucleotide bindingi59 – 63GTPBy similarity5
Nucleotide bindingi117 – 120GTPBy similarity4

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionActin-binding, Developmental protein
Biological processSensory transduction, Vision
LigandGTP-binding, Nucleotide-binding

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-DME-114604, GPVI-mediated activation cascade
R-DME-193634, Axonal growth inhibition (RHOA activation)
R-DME-194840, Rho GTPase cycle
R-DME-198203, PI3K/AKT activation
R-DME-2173791, TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)
R-DME-350368, Activation of RHO1 by FZ:DSH complex
R-DME-350407, RHO1 GTPase cycle
R-DME-350480, Activation of non-muscle Myosin II
R-DME-392451, G beta:gamma signalling through PI3Kgamma
R-DME-3928662, EPHB-mediated forward signaling
R-DME-3928663, EPHA-mediated growth cone collapse
R-DME-416482, G alpha (12/13) signalling events
R-DME-416572, Sema4D induced cell migration and growth-cone collapse
R-DME-4420097, VEGFA-VEGFR2 Pathway
R-DME-450728, Inhibition of actin polymerisation
R-DME-5625740, RHO GTPases activate PKNs
R-DME-5625900, RHO GTPases activate CIT
R-DME-5627117, RHO GTPases Activate ROCKs
R-DME-5663220, RHO GTPases Activate Formins
R-DME-5666185, RHO GTPases Activate Rhotekin and Rhophilins
R-DME-5689896, Ovarian tumor domain proteases
R-DME-6785631, ERBB2 Regulates Cell Motility
R-DME-6798695, Neutrophil degranulation
R-DME-8849471, PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Ras-like GTP-binding protein Rho1
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Rho1Imported
ORF Names:CG8416Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiDrosophila melanogaster (Fruit fly)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri7227 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Ecdysozoa › Arthropoda › Hexapoda › Insecta › Pterygota › Neoptera › Holometabola › Diptera › Brachycera › Muscomorpha › Ephydroidea › Drosophilidae › Drosophila › Sophophora ›
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000803 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 2R

Organism-specific databases

Drosophila genome database

More...FlyBasei		FBgn0014020, Rho1

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell membrane, Cytoplasm, Cytoskeleton, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the 'Pathology and Biotech' section describes the in vivo effects caused by ablation of the gene (or one or more transcripts) coding for the protein described in the entry. This includes gene knockout and knockdown, provided experiments have been performed in the context of a whole organism or a specific tissue, and not at the single-cell level.<p><a href='/help/disruption_phenotype' target='_top'>More...</a></p>Disruption phenotypei

Embryonic lethal. Embryos exhibit severe defects in head involution and imperfect dorsal closure. During head involution, the head structures fail to internalize resulting in holes in the dorsal anterior region of the cuticle. The disruption in the dorsal surface stretches the ventral surface, causing the cuticle to bow.1 Publication

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology%5Fand%5Fbiotech%5Fsection">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi27 – 29KDQ → AAA: Reduces binding to wash. Reduces the number of hemocytes migrating anteriorly from the tail during embryogenesis. 1 Publication3
Mutagenesisi39F → V: No effect on binding to wash and no effect on tail hemocyte developmental migration from the tail. 1 Publication1
Mutagenesisi51 – 54KQVE → AAAA: No effect on binding to wash. 1 Publication4

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001988851 – 189Ras-like GTP-binding protein Rho1Add BLAST189
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section describes a propeptide, which is a part of a protein that is cleaved during maturation or activation. Once cleaved, a propeptide generally has no independent biological function.<p><a href='/help/propep' target='_top'>More...</a></p>PropeptideiPRO_0000281238190 – 192Removed in mature formBy similarity3

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei189Cysteine methyl esterBy similarity1
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section specifies the position(s) and the type of covalently attached lipid group(s).<p><a href='/help/lipid' target='_top'>More...</a></p>Lipidationi189S-geranylgeranyl cysteineBy similarity1

Keywords - PTMi

Lipoprotein, Methylation, Prenylation

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		P48148

PRoteomics IDEntifications database

More...PRIDEi		P48148

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed in hemocytes (at protein level).1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		FBgn0014020, Expressed in saliva-secreting gland and 52 other tissues

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		P48148, DM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with capu (PubMed:10556060).

Interacts (via REM repeats) with Pkn (via N-terminus) (PubMed:10323867, PubMed:17507675).

Interacts (via N-terminus) with wash (via N-terminus) (PubMed:25739458).

3 Publications

GO - Molecular functioni

Complete GO annotation on QuickGO ...

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		62500, 91 interactors

Database of interacting proteins

More...DIPi		DIP-22676N

Protein interaction database and analysis system

More...IntActi		P48148, 1 interactor

STRING: functional protein association networks

More...STRINGi		7227.FBpp0086354

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		P48148

Database of comparative protein structure models

More...ModBasei		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a short (usually not more than 20 amino acids) conserved sequence motif of biological significance.<p><a href='/help/motif' target='_top'>More...</a></p>Motifi34 – 42Effector regionSequence analysis9

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the small GTPase superfamily. Rho family.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG0393, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00950000182945

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_041217_21_2_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		P48148

Identification of Orthologs from Complete Genome Data

More...OMAi		RWIPEIK

Database of Orthologous Groups

More...OrthoDBi		1166960at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		P48148

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR027417, P-loop_NTPase
IPR005225, Small_GTP-bd_dom
IPR001806, Small_GTPase
IPR003578, Small_GTPase_Rho

Pfam protein domain database

More...Pfami		View protein in Pfam
PF00071, Ras, 1 hit

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF52540, SSF52540, 1 hit

TIGRFAMs; a protein family database

More...TIGRFAMsi		TIGR00231, small_GTP, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS51420, RHO, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

P48148-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MTTIRKKLVI VGDGACGKTC LLIVFSKDQF PEVYVPTVFE NYVADIEVDG 
        60         70         80         90        100
KQVELALWDT AGQEDYDRLR PLSYPDTDVI LMCFSVDSPD SLENIPEKWT 
       110        120        130        140        150
PEVKHFCPNV PIILVGNKKD LRNDPNTIRD LAKMKQEPVK PQEGRAMAEK 
       160        170        180        190 
INAFAYLECS AKSKEGVRDV FETATRAALQ VKKRKKTRCL LL
Length:192
Mass (Da):21,723
Last modified:February 1, 1996 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iB89C7D884E1743CF
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
L38311 mRNA Translation: AAA67042.1
AF177871 Genomic DNA Translation: AAF01183.1
AF177872 mRNA Translation: AAF01184.1
AF177873 mRNA Translation: AAF01185.1
AF177874 mRNA Translation: AAF01186.1
AE013599 Genomic DNA Translation: AAM70944.1
AE013599 Genomic DNA Translation: AAM70945.1
AE013599 Genomic DNA Translation: AAM70946.1
AE013599 Genomic DNA Translation: AAS64843.1
AE013599 Genomic DNA Translation: AAS64844.1
AY119536 mRNA Translation: AAM50190.1
BT010085 mRNA Translation: AAQ22554.1

Protein sequence database of the Protein Information Resource

More...PIRi		S54294

NCBI Reference Sequences

More...RefSeqi		NP_477098.1, NM_057750.4
NP_599135.1, NM_134308.3
NP_599136.1, NM_134309.2
NP_725524.1, NM_166139.3
NP_995849.1, NM_206127.2
NP_995850.1, NM_206128.2

Genome annotation databases

Ensembl metazoan genome annotation project

More...EnsemblMetazoai		FBtr0087211; FBpp0086353; FBgn0014020
FBtr0087212; FBpp0086354; FBgn0014020
FBtr0087213; FBpp0086355; FBgn0014020
FBtr0087214; FBpp0086356; FBgn0014020
FBtr0087216; FBpp0089129; FBgn0014020
FBtr0087217; FBpp0089130; FBgn0014020

Database of genes from NCBI RefSeq genomes

More...GeneIDi		36775

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		dme:Dmel_CG8416

UCSC genome browser

More...UCSCi		CG8416-RC, d. melanogaster

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L38311 mRNA Translation: AAA67042.1
AF177871 Genomic DNA Translation: AAF01183.1
AF177872 mRNA Translation: AAF01184.1
AF177873 mRNA Translation: AAF01185.1
AF177874 mRNA Translation: AAF01186.1
AE013599 Genomic DNA Translation: AAM70944.1
AE013599 Genomic DNA Translation: AAM70945.1
AE013599 Genomic DNA Translation: AAM70946.1
AE013599 Genomic DNA Translation: AAS64843.1
AE013599 Genomic DNA Translation: AAS64844.1
AY119536 mRNA Translation: AAM50190.1
BT010085 mRNA Translation: AAQ22554.1
PIRiS54294
RefSeqiNP_477098.1, NM_057750.4
NP_599135.1, NM_134308.3
NP_599136.1, NM_134309.2
NP_725524.1, NM_166139.3
NP_995849.1, NM_206127.2
NP_995850.1, NM_206128.2

3D structure databases

SMRiP48148
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi62500, 91 interactors
DIPiDIP-22676N
IntActiP48148, 1 interactor
STRINGi7227.FBpp0086354

Proteomic databases

PaxDbiP48148
PRIDEiP48148

Genome annotation databases

EnsemblMetazoaiFBtr0087211; FBpp0086353; FBgn0014020
FBtr0087212; FBpp0086354; FBgn0014020
FBtr0087213; FBpp0086355; FBgn0014020
FBtr0087214; FBpp0086356; FBgn0014020
FBtr0087216; FBpp0089129; FBgn0014020
FBtr0087217; FBpp0089130; FBgn0014020
GeneIDi36775
KEGGidme:Dmel_CG8416
UCSCiCG8416-RC, d. melanogaster

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		36775
FlyBaseiFBgn0014020, Rho1

Phylogenomic databases

eggNOGiKOG0393, Eukaryota
GeneTreeiENSGT00950000182945
HOGENOMiCLU_041217_21_2_1
InParanoidiP48148
OMAiRWIPEIK
OrthoDBi1166960at2759
PhylomeDBiP48148

Enzyme and pathway databases

ReactomeiR-DME-114604, GPVI-mediated activation cascade
R-DME-193634, Axonal growth inhibition (RHOA activation)
R-DME-194840, Rho GTPase cycle
R-DME-198203, PI3K/AKT activation
R-DME-2173791, TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)
R-DME-350368, Activation of RHO1 by FZ:DSH complex
R-DME-350407, RHO1 GTPase cycle
R-DME-350480, Activation of non-muscle Myosin II
R-DME-392451, G beta:gamma signalling through PI3Kgamma
R-DME-3928662, EPHB-mediated forward signaling
R-DME-3928663, EPHA-mediated growth cone collapse
R-DME-416482, G alpha (12/13) signalling events
R-DME-416572, Sema4D induced cell migration and growth-cone collapse
R-DME-4420097, VEGFA-VEGFR2 Pathway
R-DME-450728, Inhibition of actin polymerisation
R-DME-5625740, RHO GTPases activate PKNs
R-DME-5625900, RHO GTPases activate CIT
R-DME-5627117, RHO GTPases Activate ROCKs
R-DME-5663220, RHO GTPases Activate Formins
R-DME-5666185, RHO GTPases Activate Rhotekin and Rhophilins
R-DME-5689896, Ovarian tumor domain proteases
R-DME-6785631, ERBB2 Regulates Cell Motility
R-DME-6798695, Neutrophil degranulation
R-DME-8849471, PTK6 Regulates RHO GTPases, RAS GTPase and MAP kinases

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		36775, 3 hits in 3 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		Rho1, fly

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		36775

Protein Ontology

More...PROi		PR:P48148

Gene expression databases

BgeeiFBgn0014020, Expressed in saliva-secreting gland and 52 other tissues
GenevisibleiP48148, DM

Family and domain databases

InterProiView protein in InterPro
IPR027417, P-loop_NTPase
IPR005225, Small_GTP-bd_dom
IPR001806, Small_GTPase
IPR003578, Small_GTPase_Rho
PfamiView protein in Pfam
PF00071, Ras, 1 hit
SUPFAMiSSF52540, SSF52540, 1 hit
TIGRFAMsiTIGR00231, small_GTP, 1 hit
PROSITEiView protein in PROSITE
PS51420, RHO, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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MobiDB: a database of protein disorder and mobility annotations

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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiRHO1_DROME
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P48148
Secondary accession number(s): A4UZI6, Q0E958, Q9V3J0
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1996
Last sequence update: February 1, 1996
Last modified: December 2, 2020
This is version 193 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase
  2. SIMILARITY comments
    Index of protein domains and families
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