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Protein

Neuropeptides B/W receptor type 2

Gene

NPBWR2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Interacts specifically with a number of opioid ligands. Receptor for neuropeptides B and W, which may be involved in neuroendocrine system regulation, food intake and the organization of other signals.

GO - Molecular functioni

  • G protein-coupled receptor activity Source: GO_Central
  • neuropeptide binding Source: GO_Central
  • neuropeptide receptor activity Source: InterPro
  • opioid receptor activity Source: ProtInc

GO - Biological processi

  • G protein-coupled receptor signaling pathway Source: HGNC
  • neuropeptide signaling pathway Source: GO_Central

Keywordsi

Molecular functionG-protein coupled receptor, Receptor, Transducer

Enzyme and pathway databases

ReactomeiR-HSA-375276 Peptide ligand-binding receptors
R-HSA-418594 G alpha (i) signalling events

Protein family/group databases

TCDBi9.A.14.13.13 the g-protein-coupled receptor (gpcr) family

Names & Taxonomyi

Protein namesi
Recommended name:
Neuropeptides B/W receptor type 2
Alternative name(s):
G-protein coupled receptor 8
Gene namesi
Name:NPBWR2
Synonyms:GPR8
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 20

Organism-specific databases

EuPathDBiHostDB:ENSG00000125522.3
HGNCiHGNC:4530 NPBWR2
MIMi600731 gene
neXtProtiNX_P48146

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 45ExtracellularSequence analysisAdd BLAST45
Transmembranei46 – 69Helical; Name=1Sequence analysisAdd BLAST24
Topological domaini70 – 80CytoplasmicSequence analysisAdd BLAST11
Transmembranei81 – 105Helical; Name=2Sequence analysisAdd BLAST25
Topological domaini106 – 120ExtracellularSequence analysisAdd BLAST15
Transmembranei121 – 140Helical; Name=3Sequence analysisAdd BLAST20
Topological domaini141 – 165CytoplasmicSequence analysisAdd BLAST25
Transmembranei166 – 185Helical; Name=4Sequence analysisAdd BLAST20
Topological domaini186 – 211ExtracellularSequence analysisAdd BLAST26
Transmembranei212 – 233Helical; Name=5Sequence analysisAdd BLAST22
Topological domaini234 – 257CytoplasmicSequence analysisAdd BLAST24
Transmembranei258 – 282Helical; Name=6Sequence analysisAdd BLAST25
Topological domaini283 – 292ExtracellularSequence analysis10
Transmembranei293 – 307Helical; Name=7Sequence analysisAdd BLAST15
Topological domaini308 – 333CytoplasmicSequence analysisAdd BLAST26

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000125522
PharmGKBiPA28923

Chemistry databases

GuidetoPHARMACOLOGYi304

Polymorphism and mutation databases

BioMutaiNPBWR2

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000695221 – 333Neuropeptides B/W receptor type 2Add BLAST333

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi24N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi29N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi34N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi117 ↔ 197PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein, Lipoprotein, Palmitate

Proteomic databases

PaxDbiP48146
PeptideAtlasiP48146
PRIDEiP48146
ProteomicsDBi55865

PTM databases

iPTMnetiP48146
PhosphoSitePlusiP48146

Expressioni

Tissue specificityi

Detected at high levels in caudate nucleus, hyppocampus and amygdala; at moderate levels in the adult brain, thalamus, parietal cortex, pituitary gland, adrenal gland and lymph nodes.1 Publication

Gene expression databases

BgeeiENSG00000125522 Expressed in 8 organ(s), highest expression level in amniotic fluid
CleanExiHS_NPBWR2
GenevisibleiP48146 HS

Interactioni

Binary interactionsi

Protein-protein interaction databases

BioGridi109093, 10 interactors
IntActiP48146, 14 interactors
STRINGi9606.ENSP00000358783

Structurei

3D structure databases

ProteinModelPortaliP48146
SMRiP48146
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3656 Eukaryota
ENOG410XRW9 LUCA
GeneTreeiENSGT00760000118797
HOGENOMiHOG000230485
HOVERGENiHBG106919
InParanoidiP48146
KOiK08377
OMAiMLYKLRN
OrthoDBiEOG091G0HEN
PhylomeDBiP48146
TreeFamiTF315737

Family and domain databases

CDDicd15087 7tmA_NPBWR, 1 hit
InterProiView protein in InterPro
IPR000276 GPCR_Rhodpsn
IPR017452 GPCR_Rhodpsn_7TM
IPR009150 Neuropept_B/W_rcpt
IPR027349 NPBW2
PANTHERiPTHR24229:SF18 PTHR24229:SF18, 1 hit
PfamiView protein in Pfam
PF00001 7tm_1, 1 hit
PRINTSiPR00237 GPCRRHODOPSN
PR01855 NRPEPTIDEWR
SMARTiView protein in SMART
SM01381 7TM_GPCR_Srsx, 1 hit
PROSITEiView protein in PROSITE
PS00237 G_PROTEIN_RECEP_F1_1, 1 hit
PS50262 G_PROTEIN_RECEP_F1_2, 1 hit

Sequencei

Sequence statusi: Complete.

P48146-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MQAAGHPEPL DSRGSFSLPT MGANVSQDNG TGHNATFSEP LPFLYVLLPA
60 70 80 90 100
VYSGICAVGL TGNTAVILVI LRAPKMKTVT NVFILNLAVA DGLFTLVLPV
110 120 130 140 150
NIAEHLLQYW PFGELLCKLV LAVDHYNIFS SIYFLAVMSV DRYLVVLATV
160 170 180 190 200
RSRHMPWRTY RGAKVASLCV WLGVTVLVLP FFSFAGVYSN ELQVPSCGLS
210 220 230 240 250
FPWPEQVWFK ASRVYTLVLG FVLPVCTICV LYTDLLRRLR AVRLRSGAKA
260 270 280 290 300
LGKARRKVTV LVLVVLAVCL LCWTPFHLAS VVALTTDLPQ TPLVISMSYV
310 320 330
ITSLSYANSC LNPFLYAFLD DNFRKNFRSI LRC
Length:333
Mass (Da):36,861
Last modified:November 13, 2007 - v2
Checksum:i8C416473FD80B0BA
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti305S → T in AAC50198 (PubMed:7590751).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_03576692G → R in a colorectal cancer sample; somatic mutation. 1 PublicationCorresponds to variant dbSNP:rs768724424Ensembl.1
Natural variantiVAR_003579206Q → R2 PublicationsCorresponds to variant dbSNP:rs4809401Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U22492 Genomic DNA Translation: AAC50198.1
AL121581 Genomic DNA No translation available.
CH471077 Genomic DNA Translation: EAW75161.1
BC067481 mRNA Translation: AAH67481.1
BC067482 mRNA Translation: AAH67482.1
CCDSiCCDS13557.1
PIRiI38974
RefSeqiNP_005277.2, NM_005286.2
UniGeneiHs.248118

Genome annotation databases

EnsembliENST00000369768; ENSP00000358783; ENSG00000125522
ENST00000612646; ENSP00000484253; ENSG00000277339
GeneIDi2832
KEGGihsa:2832
UCSCiuc011abt.3 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U22492 Genomic DNA Translation: AAC50198.1
AL121581 Genomic DNA No translation available.
CH471077 Genomic DNA Translation: EAW75161.1
BC067481 mRNA Translation: AAH67481.1
BC067482 mRNA Translation: AAH67482.1
CCDSiCCDS13557.1
PIRiI38974
RefSeqiNP_005277.2, NM_005286.2
UniGeneiHs.248118

3D structure databases

ProteinModelPortaliP48146
SMRiP48146
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi109093, 10 interactors
IntActiP48146, 14 interactors
STRINGi9606.ENSP00000358783

Chemistry databases

GuidetoPHARMACOLOGYi304

Protein family/group databases

TCDBi9.A.14.13.13 the g-protein-coupled receptor (gpcr) family
GPCRDBiSearch...

PTM databases

iPTMnetiP48146
PhosphoSitePlusiP48146

Polymorphism and mutation databases

BioMutaiNPBWR2

Proteomic databases

PaxDbiP48146
PeptideAtlasiP48146
PRIDEiP48146
ProteomicsDBi55865

Protocols and materials databases

DNASUi2832
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000369768; ENSP00000358783; ENSG00000125522
ENST00000612646; ENSP00000484253; ENSG00000277339
GeneIDi2832
KEGGihsa:2832
UCSCiuc011abt.3 human

Organism-specific databases

CTDi2832
EuPathDBiHostDB:ENSG00000125522.3
GeneCardsiNPBWR2
H-InvDBiHIX0040594
HGNCiHGNC:4530 NPBWR2
MIMi600731 gene
neXtProtiNX_P48146
OpenTargetsiENSG00000125522
PharmGKBiPA28923
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3656 Eukaryota
ENOG410XRW9 LUCA
GeneTreeiENSGT00760000118797
HOGENOMiHOG000230485
HOVERGENiHBG106919
InParanoidiP48146
KOiK08377
OMAiMLYKLRN
OrthoDBiEOG091G0HEN
PhylomeDBiP48146
TreeFamiTF315737

Enzyme and pathway databases

ReactomeiR-HSA-375276 Peptide ligand-binding receptors
R-HSA-418594 G alpha (i) signalling events

Miscellaneous databases

GeneWikiiNeuropeptides_B/W_receptor_2
GenomeRNAii2832
PROiPR:P48146
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000125522 Expressed in 8 organ(s), highest expression level in amniotic fluid
CleanExiHS_NPBWR2
GenevisibleiP48146 HS

Family and domain databases

CDDicd15087 7tmA_NPBWR, 1 hit
InterProiView protein in InterPro
IPR000276 GPCR_Rhodpsn
IPR017452 GPCR_Rhodpsn_7TM
IPR009150 Neuropept_B/W_rcpt
IPR027349 NPBW2
PANTHERiPTHR24229:SF18 PTHR24229:SF18, 1 hit
PfamiView protein in Pfam
PF00001 7tm_1, 1 hit
PRINTSiPR00237 GPCRRHODOPSN
PR01855 NRPEPTIDEWR
SMARTiView protein in SMART
SM01381 7TM_GPCR_Srsx, 1 hit
PROSITEiView protein in PROSITE
PS00237 G_PROTEIN_RECEP_F1_1, 1 hit
PS50262 G_PROTEIN_RECEP_F1_2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiNPBW2_HUMAN
AccessioniPrimary (citable) accession number: P48146
Secondary accession number(s): Q6NWQ6, Q9H4K3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1996
Last sequence update: November 13, 2007
Last modified: November 7, 2018
This is version 168 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. Human chromosome 20
    Human chromosome 20: entries, gene names and cross-references to MIM
  6. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
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Main funding by: National Institutes of Health

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