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Protein

Neuropeptides B/W receptor type 1

Gene

NPBWR1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Interacts specifically with a number of opioid ligands. Receptor for neuropeptides B and W, which may be involved in neuroendocrine system regulation, food intake and the organization of other signals. Has a higher affinity for neuropeptide B.

GO - Molecular functioni

  • G protein-coupled receptor activity Source: GO_Central
  • neuropeptide binding Source: GO_Central
  • neuropeptide receptor activity Source: InterPro
  • opioid receptor activity Source: ProtInc

GO - Biological processi

Keywordsi

Molecular functionG-protein coupled receptor, Receptor, Transducer

Enzyme and pathway databases

ReactomeiR-HSA-375276 Peptide ligand-binding receptors
R-HSA-418594 G alpha (i) signalling events

Names & Taxonomyi

Protein namesi
Recommended name:
Neuropeptides B/W receptor type 1
Alternative name(s):
G-protein coupled receptor 7
Gene namesi
Name:NPBWR1
Synonyms:GPR7
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 8

Organism-specific databases

EuPathDBiHostDB:ENSG00000183729.3
HGNCiHGNC:4522 NPBWR1
MIMi600730 gene
neXtProtiNX_P48145

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 37ExtracellularSequence analysisAdd BLAST37
Transmembranei38 – 61Helical; Name=1Sequence analysisAdd BLAST24
Topological domaini62 – 72CytoplasmicSequence analysisAdd BLAST11
Transmembranei73 – 97Helical; Name=2Sequence analysisAdd BLAST25
Topological domaini98 – 112ExtracellularSequence analysisAdd BLAST15
Transmembranei113 – 132Helical; Name=3Sequence analysisAdd BLAST20
Topological domaini133 – 157CytoplasmicSequence analysisAdd BLAST25
Transmembranei158 – 177Helical; Name=4Sequence analysisAdd BLAST20
Topological domaini178 – 202ExtracellularSequence analysisAdd BLAST25
Transmembranei203 – 224Helical; Name=5Sequence analysisAdd BLAST22
Topological domaini225 – 248CytoplasmicSequence analysisAdd BLAST24
Transmembranei249 – 273Helical; Name=6Sequence analysisAdd BLAST25
Topological domaini274 – 283ExtracellularSequence analysis10
Transmembranei284 – 298Helical; Name=7Sequence analysisAdd BLAST15
Topological domaini299 – 328CytoplasmicSequence analysisAdd BLAST30

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi2831
OpenTargetsiENSG00000183729
PharmGKBiPA28912

Chemistry databases

ChEMBLiCHEMBL1293293
GuidetoPHARMACOLOGYi303

Polymorphism and mutation databases

BioMutaiNPBWR1
DMDMi215274092

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000695181 – 328Neuropeptides B/W receptor type 1Add BLAST328

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi3N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi13N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi25N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi109 ↔ 188PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiP48145
PeptideAtlasiP48145
PRIDEiP48145
ProteomicsDBi55864

PTM databases

PhosphoSitePlusiP48145

Expressioni

Tissue specificityi

Found in cerebellum and frontal cortex. Detected at high levels in hippocampus, amygdala and trachea; at moderate levels in fetal brain, pituitary gland and prostate. Not in caudate, accumbens, kidney or liver. Also detected at high levels in lung carcinoma.1 Publication

Gene expression databases

BgeeiENSG00000183729 Expressed in 19 organ(s), highest expression level in temporal lobe
CleanExiHS_NPBWR1
ExpressionAtlasiP48145 baseline and differential
GenevisibleiP48145 HS

Interactioni

Protein-protein interaction databases

BioGridi109092, 2 interactors
IntActiP48145, 1 interactor
STRINGi9606.ENSP00000330284

Chemistry databases

BindingDBiP48145

Structurei

3D structure databases

ProteinModelPortaliP48145
SMRiP48145
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3656 Eukaryota
ENOG410XRW9 LUCA
GeneTreeiENSGT00760000118797
HOGENOMiHOG000230485
HOVERGENiHBG106919
InParanoidiP48145
KOiK05268
OMAiQLDSHAK
OrthoDBiEOG091G0HEN
PhylomeDBiP48145
TreeFamiTF315737

Family and domain databases

CDDicd15087 7tmA_NPBWR, 1 hit
InterProiView protein in InterPro
IPR000276 GPCR_Rhodpsn
IPR017452 GPCR_Rhodpsn_7TM
IPR009150 Neuropept_B/W_rcpt
IPR027348 NPBW1
PANTHERiPTHR24229:SF47 PTHR24229:SF47, 1 hit
PfamiView protein in Pfam
PF00001 7tm_1, 1 hit
PRINTSiPR00237 GPCRRHODOPSN
PR01855 NRPEPTIDEWR
PROSITEiView protein in PROSITE
PS00237 G_PROTEIN_RECEP_F1_1, 1 hit
PS50262 G_PROTEIN_RECEP_F1_2, 1 hit

Sequencei

Sequence statusi: Complete.

P48145-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MDNASFSEPW PANASGPDPA LSCSNASTLA PLPAPLAVAV PVVYAVICAV
60 70 80 90 100
GLAGNSAVLY VLLRAPRMKT VTNLFILNLA IADELFTLVL PINIADFLLR
110 120 130 140 150
QWPFGELMCK LIVAIDQYNT FSSLYFLTVM SADRYLVVLA TAESRRVAGR
160 170 180 190 200
TYSAARAVSL AVWGIVTLVV LPFAVFARLD DEQGRRQCVL VFPQPEAFWW
210 220 230 240 250
RASRLYTLVL GFAIPVSTIC VLYTTLLCRL HAMRLDSHAK ALERAKKRVT
260 270 280 290 300
FLVVAILAVC LLCWTPYHLS TVVALTTDLP QTPLVIAISY FITSLSYANS
310 320
CLNPFLYAFL DASFRRNLRQ LITCRAAA
Length:328
Mass (Da):36,103
Last modified:November 25, 2008 - v2
Checksum:i7A90F85AD64A3980
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti296S → T in AAC50197 (PubMed:7590751).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_03576519P → Q in a breast cancer sample; somatic mutation. 1 PublicationCorresponds to variant dbSNP:rs772418985Ensembl.1
Natural variantiVAR_047788135Y → F. Corresponds to variant dbSNP:rs33977775Ensembl.1
Natural variantiVAR_047789319R → C. Corresponds to variant dbSNP:rs36068168Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U22491 Genomic DNA Translation: AAC50197.1
CH471068 Genomic DNA Translation: EAW86722.1
BC069117 mRNA Translation: AAH69117.1
BC107101 mRNA Translation: AAI07102.1
CCDSiCCDS6151.1
PIRiI38973
RefSeqiNP_005276.2, NM_005285.3
UniGeneiHs.248117

Genome annotation databases

EnsembliENST00000331251; ENSP00000330284; ENSG00000183729
GeneIDi2831
KEGGihsa:2831
UCSCiuc011ldu.3 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U22491 Genomic DNA Translation: AAC50197.1
CH471068 Genomic DNA Translation: EAW86722.1
BC069117 mRNA Translation: AAH69117.1
BC107101 mRNA Translation: AAI07102.1
CCDSiCCDS6151.1
PIRiI38973
RefSeqiNP_005276.2, NM_005285.3
UniGeneiHs.248117

3D structure databases

ProteinModelPortaliP48145
SMRiP48145
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi109092, 2 interactors
IntActiP48145, 1 interactor
STRINGi9606.ENSP00000330284

Chemistry databases

BindingDBiP48145
ChEMBLiCHEMBL1293293
GuidetoPHARMACOLOGYi303

Protein family/group databases

GPCRDBiSearch...

PTM databases

PhosphoSitePlusiP48145

Polymorphism and mutation databases

BioMutaiNPBWR1
DMDMi215274092

Proteomic databases

PaxDbiP48145
PeptideAtlasiP48145
PRIDEiP48145
ProteomicsDBi55864

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000331251; ENSP00000330284; ENSG00000183729
GeneIDi2831
KEGGihsa:2831
UCSCiuc011ldu.3 human

Organism-specific databases

CTDi2831
DisGeNETi2831
EuPathDBiHostDB:ENSG00000183729.3
GeneCardsiNPBWR1
H-InvDBiHIX0034348
HGNCiHGNC:4522 NPBWR1
MIMi600730 gene
neXtProtiNX_P48145
OpenTargetsiENSG00000183729
PharmGKBiPA28912
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3656 Eukaryota
ENOG410XRW9 LUCA
GeneTreeiENSGT00760000118797
HOGENOMiHOG000230485
HOVERGENiHBG106919
InParanoidiP48145
KOiK05268
OMAiQLDSHAK
OrthoDBiEOG091G0HEN
PhylomeDBiP48145
TreeFamiTF315737

Enzyme and pathway databases

ReactomeiR-HSA-375276 Peptide ligand-binding receptors
R-HSA-418594 G alpha (i) signalling events

Miscellaneous databases

GeneWikiiNeuropeptides_B/W_receptor_1
GenomeRNAii2831
PROiPR:P48145
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000183729 Expressed in 19 organ(s), highest expression level in temporal lobe
CleanExiHS_NPBWR1
ExpressionAtlasiP48145 baseline and differential
GenevisibleiP48145 HS

Family and domain databases

CDDicd15087 7tmA_NPBWR, 1 hit
InterProiView protein in InterPro
IPR000276 GPCR_Rhodpsn
IPR017452 GPCR_Rhodpsn_7TM
IPR009150 Neuropept_B/W_rcpt
IPR027348 NPBW1
PANTHERiPTHR24229:SF47 PTHR24229:SF47, 1 hit
PfamiView protein in Pfam
PF00001 7tm_1, 1 hit
PRINTSiPR00237 GPCRRHODOPSN
PR01855 NRPEPTIDEWR
PROSITEiView protein in PROSITE
PS00237 G_PROTEIN_RECEP_F1_1, 1 hit
PS50262 G_PROTEIN_RECEP_F1_2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiNPBW1_HUMAN
AccessioniPrimary (citable) accession number: P48145
Secondary accession number(s): Q6NTC7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1996
Last sequence update: November 25, 2008
Last modified: November 7, 2018
This is version 154 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. Human chromosome 8
    Human chromosome 8: entries, gene names and cross-references to MIM
  6. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
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Main funding by: National Institutes of Health

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