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Entry version 163 (16 Oct 2019)
Sequence version 3 (10 Aug 2010)
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Protein

Sodium- and chloride-dependent glycine transporter 1

Gene

SLC6A9

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Terminates the action of glycine by its high affinity sodium-dependent reuptake into presynaptic terminals. May play a role in regulation of glycine levels in NMDA receptor-mediated neurotransmission.

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • glycine:sodium symporter activity Source: ProtInc

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processAmino-acid transport, Neurotransmitter transport, Symport, Transport

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-442660 Na+/Cl- dependent neurotransmitter transporters

Protein family/group databases

Transport Classification Database

More...
TCDBi
2.A.22.2.12 the neurotransmitter:sodium symporter (nss) family

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Sodium- and chloride-dependent glycine transporter 1
Short name:
GlyT-1
Short name:
GlyT1
Alternative name(s):
Solute carrier family 6 member 9
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:SLC6A9
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 1

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:11056 SLC6A9

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
601019 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_P48067

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini1 – 108CytoplasmicSequence analysisAdd BLAST108
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei109 – 129Helical; Name=1Sequence analysisAdd BLAST21
Transmembranei136 – 156Helical; Name=2Sequence analysisAdd BLAST21
Transmembranei188 – 208Helical; Name=3Sequence analysisAdd BLAST21
Topological domaini209 – 285ExtracellularSequence analysisAdd BLAST77
Transmembranei286 – 306Helical; Name=4Sequence analysisAdd BLAST21
Transmembranei315 – 335Helical; Name=5Sequence analysisAdd BLAST21
Transmembranei360 – 380Helical; Name=6Sequence analysisAdd BLAST21
Transmembranei407 – 427Helical; Name=7Sequence analysisAdd BLAST21
Transmembranei450 – 470Helical; Name=8Sequence analysisAdd BLAST21
Transmembranei506 – 526Helical; Name=9Sequence analysisAdd BLAST21
Transmembranei530 – 550Helical; Name=10Sequence analysisAdd BLAST21
Transmembranei570 – 590Helical; Name=11Sequence analysisAdd BLAST21
Transmembranei610 – 630Helical; Name=12Sequence analysisAdd BLAST21
Topological domaini631 – 706CytoplasmicSequence analysisAdd BLAST76

Keywords - Cellular componenti

Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the ‘Pathology and Biotech’ section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

Glycine encephalopathy with normal serum glycine (GCENSG)2 Publications
The disease is caused by mutations affecting the gene represented in this entry.
Disease descriptionAn autosomal recessive, severe metabolic disorder characterized by arthrogryposis multiplex congenita, joint hyperlaxity, lack of neonatal respiratory effort, axial hypotonia, hypertonia with pronounced clonus, and delayed psychomotor development. Some patients may have dysmorphic facial features and/or brain imaging abnormalities. Laboratory studies show increased CSF glycine and normal or only mildly increased serum glycine. Most patients die in infancy.
Related information in OMIM
Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_078074407S → G in GCENSG. 1 PublicationCorresponds to variant dbSNP:rs1057519313Ensembl.1

Keywords - Diseasei

Disease mutation

Organism-specific databases

DisGeNET

More...
DisGeNETi
6536

GeneReviews a resource of expert-authored, peer-reviewed disease descriptions.

More...
GeneReviewsi
SLC6A9

MalaCards human disease database

More...
MalaCardsi
SLC6A9
MIMi617301 phenotype

Open Targets

More...
OpenTargetsi
ENSG00000196517

Orphanet; a database dedicated to information on rare diseases and orphan drugs

More...
Orphaneti
289863 Atypical glycine encephalopathy
289860 Infantile glycine encephalopathy

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA35916

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
P48067

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...
ChEMBLi
CHEMBL2337

Drug and drug target database

More...
DrugBanki
DB00145 Glycine

DrugCentral

More...
DrugCentrali
P48067

IUPHAR/BPS Guide to PHARMACOLOGY

More...
GuidetoPHARMACOLOGYi
935

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
SLC6A9

Domain mapping of disease mutations (DMDM)

More...
DMDMi
302393807

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002147801 – 706Sodium- and chloride-dependent glycine transporter 1Add BLAST706

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei673PhosphoserineBy similarity1
Modified residuei698PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
P48067

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
P48067

MaxQB - The MaxQuant DataBase

More...
MaxQBi
P48067

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
P48067

PeptideAtlas

More...
PeptideAtlasi
P48067

PRoteomics IDEntifications database

More...
PRIDEi
P48067

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
55861 [P48067-1]
55862 [P48067-2]
55863 [P48067-3]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
P48067

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
P48067

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Isoform GlyT-1A and isoform GlyT-1B can be found in brain, kidney, pancreas, lung, placenta and liver but isoform GlyT-1C is only found in brain.

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000196517 Expressed in 113 organ(s), highest expression level in C1 segment of cervical spinal cord

ExpressionAtlas, Differential and Baseline Expression

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ExpressionAtlasi
P48067 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
P48067 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA013977

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

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BioGridi
112427, 6 interactors

Protein interaction database and analysis system

More...
IntActi
P48067, 6 interactors

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000353791

Chemistry databases

BindingDB database of measured binding affinities

More...
BindingDBi
P48067

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG3659 Eukaryota
COG0733 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000157263

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
P48067

KEGG Orthology (KO)

More...
KOi
K05038

Database of Orthologous Groups

More...
OrthoDBi
250396at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
P48067

TreeFam database of animal gene trees

More...
TreeFami
TF343812

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR000175 Na/ntran_symport
IPR003028 Na/ntran_symport_glycine_GLY1
IPR037272 SNS_sf

The PANTHER Classification System

More...
PANTHERi
PTHR11616 PTHR11616, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00209 SNF, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR01204 GLY1TRNSPORT
PR00176 NANEUSMPORT

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF161070 SSF161070, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00610 NA_NEUROTRAN_SYMP_1, 1 hit
PS00754 NA_NEUROTRAN_SYMP_2, 1 hit
PS50267 NA_NEUROTRAN_SYMP_3, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 3 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 5 potential isoforms that are computationally mapped.Show allAlign All

Isoform GlyT-1C (identifier: P48067-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MSGGDTRAAI ARPRMAAAHG PVAPSSPEQV TLLPVQRSFF LPPFSGATPS
60 70 80 90 100
TSLAESVLKV WHGAYNSGLL PQLMAQHSLA MAQNGAVPSE ATKRDQNLKR
110 120 130 140 150
GNWGNQIEFV LTSVGYAVGL GNVWRFPYLC YRNGGGAFMF PYFIMLIFCG
160 170 180 190 200
IPLFFMELSF GQFASQGCLG VWRISPMFKG VGYGMMVVST YIGIYYNVVI
210 220 230 240 250
CIAFYYFFSS MTHVLPWAYC NNPWNTHDCA GVLDASNLTN GSRPAALPSN
260 270 280 290 300
LSHLLNHSLQ RTSPSEEYWR LYVLKLSDDI GNFGEVRLPL LGCLGVSWLV
310 320 330 340 350
VFLCLIRGVK SSGKVVYFTA TFPYVVLTIL FVRGVTLEGA FDGIMYYLTP
360 370 380 390 400
QWDKILEAKV WGDAASQIFY SLGCAWGGLI TMASYNKFHN NCYRDSVIIS
410 420 430 440 450
ITNCATSVYA GFVIFSILGF MANHLGVDVS RVADHGPGLA FVAYPEALTL
460 470 480 490 500
LPISPLWSLL FFFMLILLGL GTQFCLLETL VTAIVDEVGN EWILQKKTYV
510 520 530 540 550
TLGVAVAGFL LGIPLTSQAG IYWLLLMDNY AASFSLVVIS CIMCVAIMYI
560 570 580 590 600
YGHRNYFQDI QMMLGFPPPL FFQICWRFVS PAIIFFILVF TVIQYQPITY
610 620 630 640 650
NHYQYPGWAV AIGFLMALSS VLCIPLYAMF RLCRTDGDTL LQRLKNATKP
660 670 680 690 700
SRDWGPALLE HRTGRYAPTI APSPEDGFEV QPLHPDKAQI PIVGSNGSSR

LQDSRI
Length:706
Mass (Da):78,260
Last modified:August 10, 2010 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i654B208568F843F4
GO
Isoform GlyT-1A (identifier: P48067-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-83: MSGGDTRAAI...MAQHSLAMAQ → MVGKGAKGML

Show »
Length:633
Mass (Da):70,583
Checksum:i7D72C44BC76E80EA
GO
Isoform GlyT-1B (identifier: P48067-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     29-82: Missing.

Show »
Length:652
Mass (Da):72,482
Checksum:iAA1FDD1DF09E7BCA
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 5 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
J3KPA5J3KPA5_HUMAN
Transporter
SLC6A9
579Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E9PJ65E9PJ65_HUMAN
Transporter
SLC6A9
134Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
B7Z3A9B7Z3A9_HUMAN
Sodium- and chloride-dependent glyc...
SLC6A9
574Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
B7Z589B7Z589_HUMAN
Sodium- and chloride-dependent glyc...
SLC6A9
522Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E9PLM5E9PLM5_HUMAN
Sodium- and chloride-dependent glyc...
SLC6A9
116Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAB30784 differs from that shown. Reason: Frameshift.Curated
The sequence AAB30785 differs from that shown. Reason: Frameshift.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti373G → A in AAB30784 (PubMed:8183239).Curated1
Sequence conflicti373G → A in AAB30785 (PubMed:8183239).Curated1
Sequence conflicti682P → S in AAB30784 (PubMed:8183239).Curated1
Sequence conflicti682P → S in AAB30785 (PubMed:8183239).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_078074407S → G in GCENSG. 1 PublicationCorresponds to variant dbSNP:rs1057519313Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0062701 – 83MSGGD…LAMAQ → MVGKGAKGML in isoform GlyT-1A. 1 PublicationAdd BLAST83
Alternative sequenceiVSP_00627129 – 82Missing in isoform GlyT-1B. 1 PublicationAdd BLAST54

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
S70609 mRNA Translation: AAB30784.1 Frameshift.
S70612 mRNA Translation: AAB30785.1 Frameshift.
AL139220 Genomic DNA No translation available.
CH471059 Genomic DNA Translation: EAX07056.1
CH471059 Genomic DNA Translation: EAX07057.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS30695.1 [P48067-2]
CCDS41316.1 [P48067-3]
CCDS41317.1 [P48067-1]

Protein sequence database of the Protein Information Resource

More...
PIRi
I57956
I77912

NCBI Reference Sequences

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RefSeqi
NP_001020016.1, NM_001024845.2 [P48067-2]
NP_001315558.1, NM_001328629.1 [P48067-2]
NP_008865.2, NM_006934.3 [P48067-3]
NP_964012.2, NM_201649.3 [P48067-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

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Ensembli
ENST00000357730; ENSP00000350362; ENSG00000196517 [P48067-3]
ENST00000360584; ENSP00000353791; ENSG00000196517 [P48067-1]
ENST00000372310; ENSP00000361384; ENSG00000196517 [P48067-2]

Database of genes from NCBI RefSeq genomes

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GeneIDi
6536

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:6536

UCSC genome browser

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UCSCi
uc001cll.5 human [P48067-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
S70609 mRNA Translation: AAB30784.1 Frameshift.
S70612 mRNA Translation: AAB30785.1 Frameshift.
AL139220 Genomic DNA No translation available.
CH471059 Genomic DNA Translation: EAX07056.1
CH471059 Genomic DNA Translation: EAX07057.1
CCDSiCCDS30695.1 [P48067-2]
CCDS41316.1 [P48067-3]
CCDS41317.1 [P48067-1]
PIRiI57956
I77912
RefSeqiNP_001020016.1, NM_001024845.2 [P48067-2]
NP_001315558.1, NM_001328629.1 [P48067-2]
NP_008865.2, NM_006934.3 [P48067-3]
NP_964012.2, NM_201649.3 [P48067-1]

3D structure databases

Database of comparative protein structure models

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ModBasei
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SWISS-MODEL Interactive Workspace

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SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

BioGridi112427, 6 interactors
IntActiP48067, 6 interactors
STRINGi9606.ENSP00000353791

Chemistry databases

BindingDBiP48067
ChEMBLiCHEMBL2337
DrugBankiDB00145 Glycine
DrugCentraliP48067
GuidetoPHARMACOLOGYi935

Protein family/group databases

TCDBi2.A.22.2.12 the neurotransmitter:sodium symporter (nss) family

PTM databases

iPTMnetiP48067
PhosphoSitePlusiP48067

Polymorphism and mutation databases

BioMutaiSLC6A9
DMDMi302393807

Proteomic databases

jPOSTiP48067
MassIVEiP48067
MaxQBiP48067
PaxDbiP48067
PeptideAtlasiP48067
PRIDEiP48067
ProteomicsDBi55861 [P48067-1]
55862 [P48067-2]
55863 [P48067-3]

Protocols and materials databases

The DNASU plasmid repository

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DNASUi
6536

Genome annotation databases

EnsembliENST00000357730; ENSP00000350362; ENSG00000196517 [P48067-3]
ENST00000360584; ENSP00000353791; ENSG00000196517 [P48067-1]
ENST00000372310; ENSP00000361384; ENSG00000196517 [P48067-2]
GeneIDi6536
KEGGihsa:6536
UCSCiuc001cll.5 human [P48067-1]

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
6536
DisGeNETi6536

GeneCards: human genes, protein and diseases

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GeneCardsi
SLC6A9
GeneReviewsiSLC6A9
HGNCiHGNC:11056 SLC6A9
HPAiHPA013977
MalaCardsiSLC6A9
MIMi601019 gene
617301 phenotype
neXtProtiNX_P48067
OpenTargetsiENSG00000196517
Orphaneti289863 Atypical glycine encephalopathy
289860 Infantile glycine encephalopathy
PharmGKBiPA35916

GenAtlas: human gene database

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GenAtlasi
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Phylogenomic databases

eggNOGiKOG3659 Eukaryota
COG0733 LUCA
GeneTreeiENSGT00940000157263
InParanoidiP48067
KOiK05038
OrthoDBi250396at2759
PhylomeDBiP48067
TreeFamiTF343812

Enzyme and pathway databases

ReactomeiR-HSA-442660 Na+/Cl- dependent neurotransmitter transporters

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
SLC6A9 human

The Gene Wiki collection of pages on human genes and proteins

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GeneWikii
Glycine_transporter_1

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
6536
PharosiP48067

Protein Ontology

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PROi
PR:P48067

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
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Gene expression databases

BgeeiENSG00000196517 Expressed in 113 organ(s), highest expression level in C1 segment of cervical spinal cord
ExpressionAtlasiP48067 baseline and differential
GenevisibleiP48067 HS

Family and domain databases

InterProiView protein in InterPro
IPR000175 Na/ntran_symport
IPR003028 Na/ntran_symport_glycine_GLY1
IPR037272 SNS_sf
PANTHERiPTHR11616 PTHR11616, 1 hit
PfamiView protein in Pfam
PF00209 SNF, 1 hit
PRINTSiPR01204 GLY1TRNSPORT
PR00176 NANEUSMPORT
SUPFAMiSSF161070 SSF161070, 1 hit
PROSITEiView protein in PROSITE
PS00610 NA_NEUROTRAN_SYMP_1, 1 hit
PS00754 NA_NEUROTRAN_SYMP_2, 1 hit
PS50267 NA_NEUROTRAN_SYMP_3, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiSC6A9_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P48067
Secondary accession number(s): A6NDH1
, A6NII2, A6NNZ8, Q5TAB8, Q5TAB9, Q5TAC0
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1996
Last sequence update: August 10, 2010
Last modified: October 16, 2019
This is version 163 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  4. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  5. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
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