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Protein

Sodium- and chloride-dependent GABA transporter 3

Gene

SLC6A11

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Terminates the action of GABA by its high affinity sodium-dependent reuptake into presynaptic terminals.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processNeurotransmitter transport, Symport, Transport

Enzyme and pathway databases

ReactomeiR-HSA-442660 Na+/Cl- dependent neurotransmitter transporters
R-HSA-71288 Creatine metabolism
R-HSA-888593 Reuptake of GABA
SIGNORiP48066

Protein family/group databases

TCDBi2.A.22.3.9 the neurotransmitter:sodium symporter (nss) family

Names & Taxonomyi

Protein namesi
Recommended name:
Sodium- and chloride-dependent GABA transporter 3
Short name:
GAT-3
Alternative name(s):
Solute carrier family 6 member 11
Gene namesi
Name:SLC6A11
Synonyms:GABT3, GAT3
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 3

Organism-specific databases

EuPathDBiHostDB:ENSG00000132164.9
HGNCiHGNC:11044 SLC6A11
MIMi607952 gene
neXtProtiNX_P48066

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 58CytoplasmicSequence analysisAdd BLAST58
Transmembranei59 – 79Helical; Name=1Sequence analysisAdd BLAST21
Transmembranei87 – 106Helical; Name=2Sequence analysisAdd BLAST20
Transmembranei131 – 151Helical; Name=3Sequence analysisAdd BLAST21
Topological domaini152 – 225ExtracellularSequence analysisAdd BLAST74
Transmembranei226 – 244Helical; Name=4Sequence analysisAdd BLAST19
Transmembranei253 – 270Helical; Name=5Sequence analysisAdd BLAST18
Transmembranei306 – 323Helical; Name=6Sequence analysisAdd BLAST18
Transmembranei335 – 356Helical; Name=7Sequence analysisAdd BLAST22
Transmembranei389 – 408Helical; Name=8Sequence analysisAdd BLAST20
Transmembranei438 – 456Helical; Name=9Sequence analysisAdd BLAST19
Transmembranei473 – 493Helical; Name=10Sequence analysisAdd BLAST21
Transmembranei514 – 533Helical; Name=11Sequence analysisAdd BLAST20
Transmembranei553 – 571Helical; Name=12Sequence analysisAdd BLAST19
Topological domaini572 – 632CytoplasmicSequence analysisAdd BLAST61

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi6538
OpenTargetsiENSG00000132164
PharmGKBiPA35907

Chemistry databases

ChEMBLiCHEMBL5208
DrugBankiDB00349 Clobazam
DB08848 Guvacine

Polymorphism and mutation databases

BioMutaiSLC6A11
DMDMi1352531

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002147841 – 632Sodium- and chloride-dependent GABA transporter 3Add BLAST632

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei21PhosphoserineBy similarity1
Glycosylationi187N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi190N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi198N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Glycoprotein, Phosphoprotein

Proteomic databases

EPDiP48066
MaxQBiP48066
PaxDbiP48066
PeptideAtlasiP48066
PRIDEiP48066
ProteomicsDBi55860

PTM databases

iPTMnetiP48066
PhosphoSitePlusiP48066

Expressioni

Tissue specificityi

Widespread distribution in the brain.

Gene expression databases

BgeeiENSG00000132164 Expressed in 134 organ(s), highest expression level in medial globus pallidus
CleanExiHS_SLC6A11
GenevisibleiP48066 HS

Organism-specific databases

HPAiHPA037981

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000254488

Chemistry databases

BindingDBiP48066

Structurei

3D structure databases

ProteinModelPortaliP48066
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3659 Eukaryota
COG0733 LUCA
GeneTreeiENSGT00760000118857
HOGENOMiHOG000116406
HOVERGENiHBG071421
InParanoidiP48066
KOiK05039
OMAiIKWCWKI
OrthoDBiEOG091G08PX
PhylomeDBiP48066
TreeFamiTF343812

Family and domain databases

CDDicd11508 SLC6sbd_GAT3, 1 hit
InterProiView protein in InterPro
IPR000175 Na/ntran_symport
IPR002982 Na/ntran_symport_GABA_GAT3
IPR037272 SNS_sf
PANTHERiPTHR11616 PTHR11616, 1 hit
PfamiView protein in Pfam
PF00209 SNF, 1 hit
PRINTSiPR01197 GAT3TRNSPORT
PR00176 NANEUSMPORT
SUPFAMiSSF161070 SSF161070, 1 hit
PROSITEiView protein in PROSITE
PS00610 NA_NEUROTRAN_SYMP_1, 1 hit
PS00754 NA_NEUROTRAN_SYMP_2, 1 hit
PS50267 NA_NEUROTRAN_SYMP_3, 1 hit

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket
Isoform 1 (identifier: P48066-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MTAEKALPLG NGKAAEEARE SEAPGGGCSS GGAAPARHPR VKRDKAVHER
60 70 80 90 100
GHWNNKVEFV LSVAGEIIGL GNVWRFPYLC YKNGGGAFLI PYVVFFICCG
110 120 130 140 150
IPVFFLETAL GQFTSEGGIT CWRKVCPLFE GIGYATQVIE AHLNVYYIII
160 170 180 190 200
LAWAIFYLSN CFTTELPWAT CGHEWNTENC VEFQKLNVSN YSHVSLQNAT
210 220 230 240 250
SPVMEFWEHR VLAISDGIEH IGNLRWELAL CLLAAWTICY FCIWKGTKST
260 270 280 290 300
GKVVYVTATF PYIMLLILLI RGVTLPGASE GIKFYLYPDL SRLSDPQVWV
310 320 330 340 350
DAGTQIFFSY AICLGCLTAL GSYNNYNNNC YRDCIMLCCL NSGTSFVAGF
360 370 380 390 400
AIFSVLGFMA YEQGVPIAEV AESGPGLAFI AYPKAVTMMP LSPLWATLFF
410 420 430 440 450
MMLIFLGLDS QFVCVESLVT AVVDMYPKVF RRGYRRELLI LALSVISYFL
460 470 480 490 500
GLVMLTEGGM YIFQLFDSYA ASGMCLLFVA IFECICIGWV YGSNRFYDNI
510 520 530 540 550
EDMIGYRPPS LIKWCWMIMT PGICAGIFIF FLIKYKPLKY NNIYTYPAWG
560 570 580 590 600
YGIGWLMALS SMLCIPLWIC ITVWKTEGTL PEKLQKLTTP STDLKMRGKL
610 620 630
GVSPRMVTVN DCDAKLKSDG TIAAITEKET HF
Length:632
Mass (Da):70,606
Last modified:February 1, 1996 - v1
Checksum:iD75C5B988E983278
GO
Isoform 2 (identifier: P48066-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     209-632: Missing.

Note: No experimental confirmation available.
Show »
Length:208
Mass (Da):23,036
Checksum:i993E85CD5C8E2ACB
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti284F → L in BAG35593 (PubMed:14702039).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_056539209 – 632Missing in isoform 2. 1 PublicationAdd BLAST424

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
S75989 mRNA Translation: AAB33570.1
AK312719 mRNA Translation: BAG35593.1
AC018495 Genomic DNA No translation available.
AC027128 Genomic DNA No translation available.
CH471055 Genomic DNA Translation: EAW64086.1
BC036083 mRNA Translation: AAH36083.1
CCDSiCCDS2602.1 [P48066-1]
CCDS82734.1 [P48066-2]
RefSeqiNP_001304335.1, NM_001317406.1 [P48066-2]
NP_055044.1, NM_014229.2 [P48066-1]
UniGeneiHs.655078
Hs.657405

Genome annotation databases

EnsembliENST00000254488; ENSP00000254488; ENSG00000132164 [P48066-1]
ENST00000454147; ENSP00000404120; ENSG00000132164 [P48066-2]
GeneIDi6538
KEGGihsa:6538
UCSCiuc003bvy.2 human [P48066-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiS6A11_HUMAN
AccessioniPrimary (citable) accession number: P48066
Secondary accession number(s): B2R6U6, Q8IYC9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1996
Last sequence update: February 1, 1996
Last modified: September 12, 2018
This is version 147 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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