UniProtKB - P48061 (SDF1_HUMAN)
Protein
Stromal cell-derived factor 1
Gene
CXCL12
Organism
Homo sapiens (Human)
Status
Functioni
Chemoattractant active on T-lymphocytes and monocytes but not neutrophils. Activates the C-X-C chemokine receptor CXCR4 to induce a rapid and transient rise in the level of intracellular calcium ions and chemotaxis. SDF-1-beta(3-72) and SDF-1-alpha(3-67) show a reduced chemotactic activity. Binding to cell surface proteoglycans seems to inhibit formation of SDF-1-alpha(3-67) and thus to preserve activity on local sites. Also binds to atypical chemokine receptor ACKR3, which activates the beta-arrestin pathway and acts as a scavenger receptor for SDF-1. Binds to the allosteric site (site 2) of integrins and activates integrins ITGAV:ITGB3, ITGA4:ITGB1 and ITGA5:ITGB1 in a CXCR4-independent manner (PubMed:29301984). Acts as a positive regulator of monocyte migration and a negative regulator of monocyte adhesion via the LYN kinase. Stimulates migration of monocytes and T-lymphocytes through its receptors, CXCR4 and ACKR3, and decreases monocyte adherence to surfaces coated with ICAM-1, a ligand for beta-2 integrins. SDF1A/CXCR4 signaling axis inhibits beta-2 integrin LFA-1 mediated adhesion of monocytes to ICAM-1 through LYN kinase. Inhibits CXCR4-mediated infection by T-cell line-adapted HIV-1. Plays a protective role after myocardial infarction. Induces down-regulation and internalization of ACKR3 expressed in various cells. Has several critical functions during embryonic development; required for B-cell lymphopoiesis, myelopoiesis in bone marrow and heart ventricular septum formation. Stimulates the proliferation of bone marrow-derived B-cell progenitors in the presence of IL7 as well as growth of stromal cell-dependent pre-B-cells (By similarity).By similarity7 Publications
Sites
| Feature key | Position(s) | DescriptionActions | Graphical view | Length |
|---|---|---|---|---|
| Sitei | 45 | Important for integrin interaction and activation1 Publication | 1 | |
| Sitei | 46 | Important for dimer formation | 1 | |
| Sitei | 48 | Important for integrin interaction and activation1 Publication | 1 | |
| Binding sitei | 62 | Heparin | 1 | |
| Sitei | 64 | Important for integrin interaction and activation1 Publication | 1 | |
| Binding sitei | 69 | Heparin | 1 | |
| Binding sitei | 85 | Heparin | 1 |
GO - Molecular functioni
- chemokine activity Source: UniProtKB
- chemokine receptor binding Source: UniProtKB
- CXCR chemokine receptor binding Source: BHF-UCL
- growth factor activity Source: UniProtKB-KW
- integrin binding Source: UniProtKB
- signaling receptor binding Source: ProtInc
GO - Biological processi
- adult locomotory behavior Source: Ensembl
- animal organ regeneration Source: Ensembl
- antimicrobial humoral immune response mediated by antimicrobial peptide Source: UniProtKB
- axon guidance Source: GO_Central
- blood circulation Source: ProtInc
- cell adhesion Source: ProtInc
- cell chemotaxis Source: UniProtKB
- cellular calcium ion homeostasis Source: ProtInc
- cellular response to chemokine Source: BHF-UCL
- chemokine (C-X-C motif) ligand 12 signaling pathway Source: BHF-UCL
- chemokine-mediated signaling pathway Source: BHF-UCL
- chemotaxis Source: UniProtKB
- defense response Source: InterPro
- detection of mechanical stimulus involved in sensory perception of pain Source: Ensembl
- detection of temperature stimulus involved in sensory perception of pain Source: Ensembl
- G protein-coupled receptor signaling pathway Source: Reactome
- immune response Source: ProtInc
- induction of positive chemotaxis Source: GO_Central
- integrin activation Source: UniProtKB
- killing of cells of other organism Source: UniProtKB
- negative regulation of dendritic cell apoptotic process Source: BHF-UCL
- negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage Source: BHF-UCL
- negative regulation of leukocyte tethering or rolling Source: UniProtKB
- neuron migration Source: Ensembl
- positive regulation of axon extension involved in axon guidance Source: Ensembl
- positive regulation of calcium ion import Source: BHF-UCL
- positive regulation of cell adhesion Source: MGI
- positive regulation of cell migration Source: GO_Central
- positive regulation of dopamine secretion Source: Ensembl
- positive regulation of endothelial cell proliferation Source: Ensembl
- positive regulation of monocyte chemotaxis Source: UniProtKB
- positive regulation of T cell migration Source: MGI
- regulation of actin polymerization or depolymerization Source: ProtInc
- response to heat Source: Ensembl
- response to hypoxia Source: Ensembl
- response to peptide hormone Source: Ensembl
- response to radiation Source: Ensembl
- response to ultrasound Source: Ensembl
- response to virus Source: ProtInc
- signal transduction Source: ProtInc
- T cell chemotaxis Source: UniProtKB
- telencephalon cell migration Source: Ensembl
- viral process Source: UniProtKB-KW
Keywordsi
| Molecular function | Cytokine, Growth factor |
| Biological process | Chemotaxis, Host-virus interaction |
Enzyme and pathway databases
| PathwayCommonsi | P48061 |
| Reactomei | R-HSA-1251985, Nuclear signaling by ERBB4 R-HSA-376176, Signaling by ROBO receptors R-HSA-380108, Chemokine receptors bind chemokines R-HSA-418594, G alpha (i) signalling events R-HSA-9018519, Estrogen-dependent gene expression |
| SIGNORi | P48061 |
Names & Taxonomyi
| Protein namesi | Recommended name: Stromal cell-derived factor 1Short name: SDF-1 Short name: hSDF-1 Alternative name(s): C-X-C motif chemokine 12 Intercrine reduced in hepatomas Short name: IRH Short name: hIRH Pre-B cell growth-stimulating factor Short name: PBSF Cleaved into the following 2 chains: |
| Gene namesi | Name:CXCL12 Synonyms:SDF1, SDF1A, SDF1B |
| Organismi | Homo sapiens (Human) |
| Taxonomic identifieri | 9606 [NCBI] |
| Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
| Proteomesi |
|
Organism-specific databases
| EuPathDBi | HostDB:ENSG00000107562.16 |
| HGNCi | HGNC:10672, CXCL12 |
| MIMi | 600835, gene |
| neXtProti | NX_P48061 |
Subcellular locationi
Extracellular region or secreted
Extracellular region or secreted
- collagen-containing extracellular matrix Source: BHF-UCL
- extracellular exosome Source: UniProtKB
- extracellular region Source: Reactome
Nucleus
- nucleus Source: Ensembl
Plasma Membrane
- external side of plasma membrane Source: GO_Central
Other locations
- cytoplasm Source: Ensembl
Keywords - Cellular componenti
SecretedPathology & Biotechi
Mutagenesis
| Feature key | Position(s) | DescriptionActions | Graphical view | Length |
|---|---|---|---|---|
| Mutagenesisi | 22 – 23 | Missing : Abolished CXCR4 activation ability, but only slightly impaired binding to the receptor. 1 Publication | 2 | |
| Mutagenesisi | 22 | K → A: Loss of chemotactic activity. 2 Publications | 1 | |
| Mutagenesisi | 22 | K → R: Abolished CXCR4 activation ability, but only slightly impaired binding to the receptor. 2 Publications | 1 | |
| Mutagenesisi | 22 | Missing : Abolished CXCR4 activation ability, but only slightly impaired binding to the receptor. 2 Publications | 1 | |
| Mutagenesisi | 23 | P → G: Abolished CXCR4 activation ability, but only slightly impaired binding to the receptor. 1 Publication | 1 | |
| Mutagenesisi | 25 – 27 | SLS → AQA: Significantly impaired CXCR4 activation ability, but only slightly impaired binding to the receptor. 1 Publication | 3 | |
| Mutagenesisi | 28 | Y → A: Impaired CXCR4 activation ability, but only slightly impaired binding to the receptor. 1 Publication | 1 | |
| Mutagenesisi | 28 | Y → H: No significant effect on CXCR4 binding or activation. 1 Publication | 1 | |
| Mutagenesisi | 29 | R → K: Slightly impaired binding and activation of CXCR4. 2 Publications | 1 | |
| Mutagenesisi | 29 | R → Q: Greatly impaired chemotactic activity and enhanced inhibition by heparin. 2 Publications | 1 | |
| Mutagenesisi | 33 – 38 | RFFESH → AAAAAA: Significantly decreased chemotactic activity. 1 Publication | 6 | |
| Mutagenesisi | 33 | R → A: Significantly decreased anti-HIV-1 and chemotactic activities. 2 Publications | 1 | |
| Mutagenesisi | 33 | R → Q: Slightly impaired chemotactic activity and enhanced inhibition by heparin. Greatly impaired chemotactic activity; when associated with Q-29. 2 Publications | 1 | |
| Mutagenesisi | 34 | F → A: No effect on anti-HIV-1 and chemotactic activities. Slightly impaired chemotactic activity and no effect on inhibition by heparin; when associated with A-35. 1 Publication | 1 | |
| Mutagenesisi | 35 | F → A: No effect on anti-HIV-1 and chemotactic activities. Slightly impaired chemotactic activity and no effect on inhibition by heparin; when associated with A-34. 1 Publication | 1 | |
| Mutagenesisi | 36 – 38 | ESH → QSN: Slightly impaired chemotactic activity, no effect on inhibition by heparin. 1 Publication | 3 | |
| Mutagenesisi | 36 | E → A: No effect on anti-HIV-1 and chemotactic activities. 1 Publication | 1 | |
| Mutagenesisi | 37 | S → A: No effect on anti-HIV-1 and chemotactic activities. 1 Publication | 1 | |
| Mutagenesisi | 38 | H → A: No effect on anti-HIV-1 and chemotactic activities. 1 Publication | 1 | |
| Mutagenesisi | 41 | R → A: No effect on CXCR4 activation. 1 Publication | 1 | |
| Mutagenesisi | 45 – 48 | KHLK → SSLS: Loss of heparin-binding capacity. 1 Publication | 4 | |
| Mutagenesisi | 45 | K → E: Loss of integrin activation; when associated with E-48 or E-64. 1 Publication | 1 | |
| Mutagenesisi | 46 | H → A: Reduced dimerization in neutral pH. Eliminates the pH dependence of dimerization. 3 Publications | 1 | |
| Mutagenesisi | 46 | H → L: No significant effect on dimerization in neutral pH. Eliminates the pH dependence of dimerization. 3 Publications | 1 | |
| Mutagenesisi | 46 | H → N: Slightly impaired CXCR4 activation and clear resistance to inhibition by heparin; when associated with Q-48; Q-62; Q-68 and N-69. 3 Publications | 1 | |
| Mutagenesisi | 46 | H → R: No effect on CXCR4 activation. Impaired dimer formation, leading to increased chemotactic activity. Eliminates the pH dependence of dimerization. 3 Publications | 1 | |
| Mutagenesisi | 48 | K → A: Impaired CXCR4 activation. 2 Publications | 1 | |
| Mutagenesisi | 48 | K → E: Impaired CXCR4 activation. Loss of integrin activation; when associated with E-45 or E-64. 3 Publications | 1 | |
| Mutagenesisi | 48 | K → Q: Slightly impaired CXCR4 activation and clear resistance to inhibition by heparin; when associated with N-46; Q-62; Q-68 and N-69. 2 Publications | 1 | |
| Mutagenesisi | 52 – 56 | TPNCA → GPGCG: Slightly impaired chemotactic activity, no effect on inhibition by heparin. 1 Publication | 5 | |
| Mutagenesisi | 57 | L → C: Formation of an intermolecular disulfide bond, leading to a locked dimer; when associated with C-86. No effect on CXCR4 activation, but loss of chemotactic activity; when associated with C-86. | 1 | |
| Mutagenesisi | 60 | V → A: Impaired CXCR4 activation. 1 Publication | 1 | |
| Mutagenesisi | 62 | R → A: No effect on CXCR4 activation. 2 Publications | 1 | |
| Mutagenesisi | 62 | R → Q: Slightly impaired CXCR4 activation and clear resistance to inhibition by heparin; when associated with N-46; Q-48; Q-68 and N-69. 2 Publications | 1 | |
| Mutagenesisi | 64 | K → E: Loss of integrin activation; when associated with E-45 or E-48. 1 Publication | 1 | |
| Mutagenesisi | 68 | R → A: Impaired CXCR4 activation. 2 Publications | 1 | |
| Mutagenesisi | 68 | R → E: Greatly impaired CXCR4 activation. 2 Publications | 1 | |
| Mutagenesisi | 68 | R → Q: Slightly impaired CXCR4 activation and clear resistance to inhibition by heparin; when associated with N-46; Q-48; Q-62 and N-69. 2 Publications | 1 | |
| Mutagenesisi | 69 | Q → N: Slightly impaired CXCR4 activation and clear resistance to inhibition by heparin; when associated with N-46; Q-48; Q-62 and Q-68. 1 Publication | 1 | |
| Mutagenesisi | 70 | V → A: Impaired CXCR4 activation. 1 Publication | 1 | |
| Mutagenesisi | 81 | E → A: No effect on CXCR4 activation. 1 Publication | 1 | |
| Mutagenesisi | 84 | E → A: No effect on CXCR4 activation. 1 Publication | 1 | |
| Mutagenesisi | 85 | K → A: No effect on CXCR4 activation. 1 Publication | 1 | |
| Mutagenesisi | 86 | A → C: Formation of an intermolecular disulfide bond, leading to a locked dimer; when associated with C-57. No effect on CXCR4 activation, but loss of chemotactic activity; when associated with C-57. | 1 |
Organism-specific databases
| DisGeNETi | 6387 |
| MalaCardsi | CXCL12 |
| OpenTargetsi | ENSG00000107562 |
| PharmGKBi | PA35602 |
Miscellaneous databases
| Pharosi | P48061, Tbio |
Chemistry databases
| ChEMBLi | CHEMBL3286074 |
| DrugBanki | DB05934, CTCE-0214 DB06822, Tinzaparin |
| DrugCentrali | P48061 |
Polymorphism and mutation databases
| BioMutai | CXCL12 |
| DMDMi | 1352728 |
PTM / Processingi
Molecule processing
| Feature key | Position(s) | DescriptionActions | Graphical view | Length |
|---|---|---|---|---|
| Signal peptidei | 1 – 21 | Sequence analysisAdd BLAST | 21 | |
| ChainiPRO_0000005109 | 22 – 93 | Stromal cell-derived factor 1Add BLAST | 72 | |
| ChainiPRO_0000005110 | 24 – 93 | SDF-1-beta(3-72)Add BLAST | 70 | |
| ChainiPRO_0000005111 | 24 – 88 | SDF-1-alpha(3-67)Add BLAST | 65 |
Amino acid modifications
| Feature key | Position(s) | DescriptionActions | Graphical view | Length |
|---|---|---|---|---|
| Disulfide bondi | 30 ↔ 55 | |||
| Disulfide bondi | 32 ↔ 71 |
Post-translational modificationi
Processed forms SDF-1-beta(3-72) and SDF-1-alpha(3-67) are produced after secretion by proteolytic cleavage of isoforms Beta and Alpha, respectively. The N-terminal processing is probably achieved by DPP4. Isoform Alpha is first cleaved at the C-terminus to yield a SDF-1-alpha(1-67) intermediate before being processed at the N-terminus. The C-terminal processing of isoform Alpha is reduced by binding to heparin and, probably, cell surface proteoglycans.1 Publication
Keywords - PTMi
Disulfide bondProteomic databases
| jPOSTi | P48061 |
| MassIVEi | P48061 |
| PaxDbi | P48061 |
| PeptideAtlasi | P48061 |
| PRIDEi | P48061 |
| ProteomicsDBi | 43681 55853 [P48061-1] 55854 [P48061-2] 55855 [P48061-3] 55856 [P48061-4] 55857 [P48061-5] 55858 [P48061-6] |
PTM databases
| iPTMneti | P48061 |
| PhosphoSitePlusi | P48061 |
Expressioni
Tissue specificityi
Isoform Alpha and isoform Beta are ubiquitously expressed, with highest levels detected in liver, pancreas and spleen. Isoform Gamma is mainly expressed in heart, with weak expression detected in several other tissues. Isoform Delta, isoform Epsilon and isoform Theta have highest expression levels in pancreas, with lower levels detected in heart, kidney, liver and spleen.1 Publication
Developmental stagei
Isoform Alpha is ubiquitously expressed in fetal tissues. Isoform Beta and isoform Delta have more limited expression patterns, with highest levels detected in fetal spleen and fetal liver, respectively. Isoform Gamma and isoform Theta are weakly detected in fetal kidney.1 Publication
Gene expression databases
| Bgeei | ENSG00000107562, Expressed in myometrium and 232 other tissues |
| Genevisiblei | P48061, HS |
Organism-specific databases
| HPAi | ENSG00000107562, Low tissue specificity |
Interactioni
Subunit structurei
Monomer or homodimer; in equilibrium. Dimer formation is induced by non acidic pH and the presence of multivalent anions, and by binding to CXCR4 or heparin. Monomeric form is required for full chemotactic activity and resistance to ischemia/reperfusion injury, whereas the dimeric form acts as a partial agonist of CXCR4, stimulating Ca2+ mobilization but with no chemotactic activity and instead acts as a selective antagonist that blocks chemotaxis induced by the monomeric form.
Interacts with the N-terminus of ACKR3.
Interacts with integrin subunit ITGB3 (via the allosteric site (site 2)) (PubMed:29301984).
8 Publications(Microbial infection) Interacts with molluscum contagiosum virus protein MC148.
1 PublicationBinary interactionsi
Hide detailsP48061
GO - Molecular functioni
- chemokine activity Source: UniProtKB
- chemokine receptor binding Source: UniProtKB
- CXCR chemokine receptor binding Source: BHF-UCL
- growth factor activity Source: UniProtKB-KW
- integrin binding Source: UniProtKB
- signaling receptor binding Source: ProtInc
Protein-protein interaction databases
| BioGRIDi | 112288, 9 interactors |
| DIPi | DIP-391N |
| IntActi | P48061, 27 interactors |
| MINTi | P48061 |
| STRINGi | 9606.ENSP00000379140 |
Chemistry databases
| BindingDBi | P48061 |
Miscellaneous databases
| RNActi | P48061, protein |
Structurei
Secondary structure
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details3D structure databases
| SMRi | P48061 |
| ModBasei | Search... |
| PDBe-KBi | Search... |
Miscellaneous databases
| EvolutionaryTracei | P48061 |
Family & Domainsi
Region
| Feature key | Position(s) | DescriptionActions | Graphical view | Length |
|---|---|---|---|---|
| Regioni | 29 – 33 | Receptor and heparin bindingCurated | 5 | |
| Regioni | 39 – 41 | Receptor binding | 3 | |
| Regioni | 41 – 51 | Heparin bindingAdd BLAST | 11 | |
| Regioni | 48 – 50 | Receptor binding | 3 | |
| Regioni | 60 – 70 | Receptor bindingAdd BLAST | 11 |
Motif
| Feature key | Position(s) | DescriptionActions | Graphical view | Length |
|---|---|---|---|---|
| Motifi | 22 – 23 | Receptor activation motif | 2 |
Sequence similaritiesi
Belongs to the intercrine alpha (chemokine CxC) family.Curated
Keywords - Domaini
SignalPhylogenomic databases
| eggNOGi | ENOG502S54U, Eukaryota |
| GeneTreei | ENSGT00390000014056 |
| HOGENOMi | CLU_2262823_0_0_1 |
| InParanoidi | P48061 |
| KOi | K10031 |
| OMAi | STPNCAL |
| OrthoDBi | 1462231at2759 |
| PhylomeDBi | P48061 |
| TreeFami | TF353159 |
Family and domain databases
| CDDi | cd00273, Chemokine_CXC, 1 hit |
| InterProi | View protein in InterPro IPR001811, Chemokine_IL8-like_dom IPR033899, CXC_Chemokine_domain IPR039813, CXCL12 IPR036048, Interleukin_8-like_sf |
| PANTHERi | PTHR18837, PTHR18837, 1 hit |
| Pfami | View protein in Pfam PF00048, IL8, 1 hit |
| SMARTi | View protein in SMART SM00199, SCY, 1 hit |
| SUPFAMi | SSF54117, SSF54117, 1 hit |
Sequences (7)i
Sequence statusi: Complete.
Sequence processingi: The displayed sequence is further processed into a mature form.
This entry describes 7 isoformsi produced by alternative splicing. AlignAdd to basketIsoform Beta (identifier: P48061-1) [UniParc]FASTAAdd to basket
Also known as: SDF-1-beta(1-72), hSDF-1beta
This isoform has been chosen as the canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
10 20 30 40 50
MNAKVVVVLV LVLTALCLSD GKPVSLSYRC PCRFFESHVA RANVKHLKIL
60 70 80 90
NTPNCALQIV ARLKNNNRQV CIDPKLKWIQ EYLEKALNKR FKM
Isoform Alpha (identifier: P48061-2) [UniParc]FASTAAdd to basket
Also known as: SDF-1-alpha(1-68), hSDF-1alpha
The sequence of this isoform differs from the canonical sequence as follows:
90-93: Missing.
Isoform Gamma (identifier: P48061-3) [UniParc]FASTAAdd to basket
Also known as: hSDF-1gamma, SDF-1g
The sequence of this isoform differs from the canonical sequence as follows:
90-93: RFKM → GRREEKVGKKEKIGKKKRQKKRKAAQKRKN
Isoform Delta (identifier: P48061-4) [UniParc]FASTAAdd to basket
Also known as: hSDF-1delta
The sequence of this isoform differs from the canonical sequence as follows:
89-93: KRFKM → NLISAAPAGKRVIAGARALHPSPPRACPTARALCEIRLWPPPEWSWPSPGDV
Isoform Epsilon (identifier: P48061-5) [UniParc]FASTAAdd to basket
Also known as: hSDFepsilon
The sequence of this isoform differs from the canonical sequence as follows:
89-93: KRFKM → NC
Isoform Theta (identifier: P48061-6) [UniParc]FASTAAdd to basket
Also known as: hSDFphi, hSDFtheta, Phi
The sequence of this isoform differs from the canonical sequence as follows:
90-93: RFKM → IWLYGNAETSR
Mass spectrometryi
Molecular mass is 7959 Da. Determined by ESI. The measured range is 22-89.1 Publication
Molecular mass is 7606 Da. Determined by ESI. The measured range is 24-88.1 Publication
Molecular mass is 8522 Da. Determined by ESI. The measured range is 22-93.1 Publication
Molecular mass is 8297 Da. Determined by ESI. The measured range is 24-93.1 Publication
Alternative sequence
| Feature key | Position(s) | DescriptionActions | Graphical view | Length |
|---|---|---|---|---|
| Alternative sequenceiVSP_054781 | 39 – 93 | VARAN…KRFKM → YCTCLIRVSFHGATPLTQGS WVLYSLSCAGGETGLREPGP MVSPRVESHQEGRLGVPGPV NLGKA in isoform 7. 1 PublicationAdd BLAST | 55 | |
| Alternative sequenceiVSP_042118 | 89 – 93 | KRFKM → NLISAAPAGKRVIAGARALH PSPPRACPTARALCEIRLWP PPEWSWPSPGDV in isoform Delta. 1 Publication | 5 | |
| Alternative sequenceiVSP_042119 | 89 – 93 | KRFKM → NC in isoform Epsilon. 1 Publication | 5 | |
| Alternative sequenceiVSP_001056 | 90 – 93 | Missing in isoform Alpha. 6 Publications | 4 | |
| Alternative sequenceiVSP_041209 | 90 – 93 | RFKM → GRREEKVGKKEKIGKKKRQK KRKAAQKRKN in isoform Gamma. 2 Publications | 4 | |
| Alternative sequenceiVSP_042120 | 90 – 93 | RFKM → IWLYGNAETSR in isoform Theta. 1 Publication | 4 |
Sequence databases
Genome annotation databases
| Ensembli | ENST00000343575; ENSP00000339913; ENSG00000107562 [P48061-2] ENST00000374426; ENSP00000363548; ENSG00000107562 [P48061-3] ENST00000374429; ENSP00000363551; ENSG00000107562 [P48061-1] ENST00000395793; ENSP00000379139; ENSG00000107562 [P48061-7] ENST00000395794; ENSP00000379140; ENSG00000107562 [P48061-4] ENST00000395795; ENSP00000379141; ENSG00000107562 [P48061-7] |
| GeneIDi | 6387 |
| KEGGi | hsa:6387 |
| UCSCi | uc001jbf.5, human [P48061-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Web resourcesi
| Wikipedia SDF-1 entry |
| SeattleSNPs |
Sequence databases
3D structure databases
| Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
| 1A15 | X-ray | 2.20 | A/B | 22-88 | [»] | |
| 1QG7 | X-ray | 2.00 | A/B | 22-88 | [»] | |
| 1SDF | NMR | - | A | 22-88 | [»] | |
| 1VMC | NMR | - | A | 22-89 | [»] | |
| 2J7Z | X-ray | 1.95 | A/B | 22-89 | [»] | |
| 2K01 | NMR | - | A/C | 22-89 | [»] | |
| 2K03 | NMR | - | A/C | 22-89 | [»] | |
| 2K04 | NMR | - | A/C | 22-89 | [»] | |
| 2K05 | NMR | - | A/C | 22-89 | [»] | |
| 2KEC | NMR | - | A | 22-89 | [»] | |
| 2KED | NMR | - | A | 22-89 | [»] | |
| 2KEE | NMR | - | A | 22-89 | [»] | |
| 2KOL | NMR | - | A | 22-89 | [»] | |
| 2N55 | NMR | - | A | 22-89 | [»] | |
| 2NWG | X-ray | 2.07 | A/B | 22-88 | [»] | |
| 2SDF | NMR | - | A | 22-88 | [»] | |
| 3GV3 | X-ray | 1.60 | A | 26-88 | [»] | |
| 3HP3 | X-ray | 2.20 | A/B/C/D/E/F/G/H/I/J | 22-88 | [»] | |
| 4LMQ | X-ray | 2.77 | D/F | 29-89 | [»] | |
| 4UAI | X-ray | 1.90 | A/B | 22-89 | [»] | |
| SMRi | P48061 | |||||
| ModBasei | Search... | |||||
| PDBe-KBi | Search... | |||||
Protein-protein interaction databases
| BioGRIDi | 112288, 9 interactors |
| DIPi | DIP-391N |
| IntActi | P48061, 27 interactors |
| MINTi | P48061 |
| STRINGi | 9606.ENSP00000379140 |
Chemistry databases
| BindingDBi | P48061 |
| ChEMBLi | CHEMBL3286074 |
| DrugBanki | DB05934, CTCE-0214 DB06822, Tinzaparin |
| DrugCentrali | P48061 |
PTM databases
| iPTMneti | P48061 |
| PhosphoSitePlusi | P48061 |
Polymorphism and mutation databases
| BioMutai | CXCL12 |
| DMDMi | 1352728 |
Proteomic databases
| jPOSTi | P48061 |
| MassIVEi | P48061 |
| PaxDbi | P48061 |
| PeptideAtlasi | P48061 |
| PRIDEi | P48061 |
| ProteomicsDBi | 43681 55853 [P48061-1] 55854 [P48061-2] 55855 [P48061-3] 55856 [P48061-4] 55857 [P48061-5] 55858 [P48061-6] |
Protocols and materials databases
| ABCDi | P48061, 3 sequenced antibodies |
| Antibodypediai | 4314, 856 antibodies |
Genome annotation databases
| Ensembli | ENST00000343575; ENSP00000339913; ENSG00000107562 [P48061-2] ENST00000374426; ENSP00000363548; ENSG00000107562 [P48061-3] ENST00000374429; ENSP00000363551; ENSG00000107562 [P48061-1] ENST00000395793; ENSP00000379139; ENSG00000107562 [P48061-7] ENST00000395794; ENSP00000379140; ENSG00000107562 [P48061-4] ENST00000395795; ENSP00000379141; ENSG00000107562 [P48061-7] |
| GeneIDi | 6387 |
| KEGGi | hsa:6387 |
| UCSCi | uc001jbf.5, human [P48061-1] |
Organism-specific databases
| CTDi | 6387 |
| DisGeNETi | 6387 |
| EuPathDBi | HostDB:ENSG00000107562.16 |
| GeneCardsi | CXCL12 |
| HGNCi | HGNC:10672, CXCL12 |
| HPAi | ENSG00000107562, Low tissue specificity |
| MalaCardsi | CXCL12 |
| MIMi | 600835, gene |
| neXtProti | NX_P48061 |
| OpenTargetsi | ENSG00000107562 |
| PharmGKBi | PA35602 |
| GenAtlasi | Search... |
Phylogenomic databases
| eggNOGi | ENOG502S54U, Eukaryota |
| GeneTreei | ENSGT00390000014056 |
| HOGENOMi | CLU_2262823_0_0_1 |
| InParanoidi | P48061 |
| KOi | K10031 |
| OMAi | STPNCAL |
| OrthoDBi | 1462231at2759 |
| PhylomeDBi | P48061 |
| TreeFami | TF353159 |
Enzyme and pathway databases
| PathwayCommonsi | P48061 |
| Reactomei | R-HSA-1251985, Nuclear signaling by ERBB4 R-HSA-376176, Signaling by ROBO receptors R-HSA-380108, Chemokine receptors bind chemokines R-HSA-418594, G alpha (i) signalling events R-HSA-9018519, Estrogen-dependent gene expression |
| SIGNORi | P48061 |
Miscellaneous databases
| BioGRID-ORCSi | 6387, 6 hits in 874 CRISPR screens |
| ChiTaRSi | CXCL12, human |
| EvolutionaryTracei | P48061 |
| GeneWikii | Stromal_cell-derived_factor-1 |
| GenomeRNAii | 6387 |
| Pharosi | P48061, Tbio |
| PROi | PR:P48061 |
| RNActi | P48061, protein |
| SOURCEi | Search... |
Gene expression databases
| Bgeei | ENSG00000107562, Expressed in myometrium and 232 other tissues |
| Genevisiblei | P48061, HS |
Family and domain databases
| CDDi | cd00273, Chemokine_CXC, 1 hit |
| InterProi | View protein in InterPro IPR001811, Chemokine_IL8-like_dom IPR033899, CXC_Chemokine_domain IPR039813, CXCL12 IPR036048, Interleukin_8-like_sf |
| PANTHERi | PTHR18837, PTHR18837, 1 hit |
| Pfami | View protein in Pfam PF00048, IL8, 1 hit |
| SMARTi | View protein in SMART SM00199, SCY, 1 hit |
| SUPFAMi | SSF54117, SSF54117, 1 hit |
| ProtoNeti | Search... |
| MobiDBi | Search... |
Entry informationi
| Entry namei | SDF1_HUMAN | |
| Accessioni | P48061Primary (citable) accession number: P48061 Secondary accession number(s): B2R4G0 Q9H554 | |
| Entry historyi | Integrated into UniProtKB/Swiss-Prot: | February 1, 1996 |
| Last sequence update: | February 1, 1996 | |
| Last modified: | August 12, 2020 | |
| This is version 208 of the entry and version 1 of the sequence. See complete history. | ||
| Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
| Annotation program | Chordata Protein Annotation Program | |
| Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. | |
Miscellaneousi
Keywords - Technical termi
3D-structure, Reference proteomeDocuments
- Human chromosome 10
Human chromosome 10: entries, gene names and cross-references to MIM - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families
Main funding by:
National Institutes of Health
The European Molecular Biology Laboratory
State Secretariat for Education, Research and InnovationSERI
The European Molecular Biology LaboratoryState Secretariat for Education, Research and InnovationSERIWe'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.
Do not show this banner again