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Protein

Glioma pathogenesis-related protein 1

Gene

GLIPR1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

GO - Biological processi

Enzyme and pathway databases

ReactomeiR-HSA-1989781 PPARA activates gene expression
R-HSA-6798695 Neutrophil degranulation

Names & Taxonomyi

Protein namesi
Recommended name:
Glioma pathogenesis-related protein 1
Short name:
GliPR 1
Alternative name(s):
Protein RTVP-1
Gene namesi
Name:GLIPR1
Synonyms:GLIPR, RTVP1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 12

Organism-specific databases

EuPathDBiHostDB:ENSG00000139278.9
HGNCiHGNC:17001 GLIPR1
MIMi602692 gene
neXtProtiNX_P48060

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei233 – 255HelicalSequence analysisAdd BLAST23

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi11010
OpenTargetsiENSG00000139278
PharmGKBiPA134988403

Chemistry databases

DrugBankiDB05337 SOT-107

Polymorphism and mutation databases

BioMutaiGLIPR1
DMDMi27735198

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 21Sequence analysisAdd BLAST21
ChainiPRO_000000627022 – 266Glioma pathogenesis-related protein 1Add BLAST245

Proteomic databases

EPDiP48060
MaxQBiP48060
PaxDbiP48060
PeptideAtlasiP48060
PRIDEiP48060
ProteomicsDBi55851
55852 [P48060-2]

PTM databases

iPTMnetiP48060
PhosphoSitePlusiP48060

Expressioni

Tissue specificityi

According to PubMed:8973356, it is ubiquitously expressed with high levels in lung and kidney and low levels in heart and liver. Highly expressed in cell lines derived from nervous system tumors arising from glia, low or absent in non-glial-derived nervous system tumor cell lines. Also found in fetal kidney. According to PubMed:7607567 it is expressed only in brain tumor glioblastoma multiforme/astrocytoma and not in other nervous system tumors or normal fetal or adult tissues.

Gene expression databases

BgeeiENSG00000139278 Expressed in 219 organ(s), highest expression level in leukocyte
CleanExiHS_GLIPR1
ExpressionAtlasiP48060 baseline and differential
GenevisibleiP48060 HS

Organism-specific databases

HPAiHPA011014

Interactioni

Protein-protein interaction databases

BioGridi116200, 8 interactors
IntActiP48060, 7 interactors
MINTiP48060
STRINGi9606.ENSP00000266659

Structurei

Secondary structure

1266
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliP48060
SMRiP48060
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP48060

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini38 – 175SCPAdd BLAST138

Sequence similaritiesi

Belongs to the CRISP family.Curated

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3017 Eukaryota
COG2340 LUCA
GeneTreeiENSGT00760000119004
HOGENOMiHOG000036879
HOVERGENiHBG072125
InParanoidiP48060
OMAiYKLHPNF
OrthoDBiEOG091G048D
PhylomeDBiP48060
TreeFamiTF316148

Family and domain databases

CDDicd05385 SCP_GLIPR-1_like, 1 hit
Gene3Di3.40.33.10, 1 hit
InterProiView protein in InterPro
IPR001283 Allrgn_V5/Tpx1
IPR018244 Allrgn_V5/Tpx1_CS
IPR014044 CAP_domain
IPR035940 CAP_sf
IPR034121 SCP_GLIPR-1-like
IPR002413 V5_allergen
PANTHERiPTHR10334 PTHR10334, 1 hit
PfamiView protein in Pfam
PF00188 CAP, 1 hit
PRINTSiPR00838 V5ALLERGEN
PR00837 V5TPXLIKE
SMARTiView protein in SMART
SM00198 SCP, 1 hit
SUPFAMiSSF55797 SSF55797, 1 hit
PROSITEiView protein in PROSITE
PS01009 CRISP_1, 1 hit
PS01010 CRISP_2, 1 hit

Sequences (2+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 3 potential isoforms that are computationally mapped.iShow all

Isoform 1 (identifier: P48060-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MRVTLATIAW MVSFVSNYSH TANILPDIEN EDFIKDCVRI HNKFRSEVKP
60 70 80 90 100
TASDMLYMTW DPALAQIAKA WASNCQFSHN TRLKPPHKLH PNFTSLGENI
110 120 130 140 150
WTGSVPIFSV SSAITNWYDE IQDYDFKTRI CKKVCGHYTQ VVWADSYKVG
160 170 180 190 200
CAVQFCPKVS GFDALSNGAH FICNYGPGGN YPTWPYKRGA TCSACPNNDK
210 220 230 240 250
CLDNLCVNRQ RDQVKRYYSV VYPGWPIYPR NRYTSLFLIV NSVILILSVI
260
ITILVQHKYP NLVLLD
Length:266
Mass (Da):30,366
Last modified:January 10, 2003 - v3
Checksum:iC0466C085EFB2B7A
GO
Isoform 2 (identifier: P48060-2) [UniParc]FASTAAdd to basket
Also known as: RTVP-1b

The sequence of this isoform differs from the canonical sequence as follows:
     142-266: VWADSYKVGC...HKYPNLVLLD → SQERGRDPNP...ISVLTDSETK

Note: Highly expressed in glioblastomas.
Show »
Length:237
Mass (Da):26,919
Checksum:i047EC17EE37A45C5
GO

Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
F6VVE8F6VVE8_HUMAN
Glioma pathogenesis-related protein...
GLIPR1
238Annotation score:
B4E3S5B4E3S5_HUMAN
cDNA FLJ50386, highly similar to Gl...
GLIPR1
148Annotation score:
J3QTC9J3QTC9_HUMAN
Glioma pathogenesis-related protein...
GLIPR1
89Annotation score:

Sequence cautioni

The sequence AAA82731 differs from that shown. Reason: Frameshift at position 3.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti257H → L in CAA63005 (PubMed:8973356).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_061128163D → E. Corresponds to variant dbSNP:rs28932170Ensembl.1
Natural variantiVAR_048833211R → Q. Corresponds to variant dbSNP:rs3736392Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_043902142 – 266VWADS…LVLLD → SQERGRDPNPKRGFLNLARE NPGLFGQIVTKLAAQFNFAL KFLALTLFPMEHILYATTDQ EGITQLGHIREEPPAVPAPI MTSVWTISVLTDSETK in isoform 2. 1 PublicationAdd BLAST125

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U16307 mRNA Translation: AAA82731.3 Frameshift.
X91911 mRNA Translation: CAA63005.1
AF400440 mRNA Translation: AAK92489.1
EF667354 mRNA Translation: ABV21587.1
BC012510 mRNA Translation: AAH12510.1
CCDSiCCDS9011.1 [P48060-1]
PIRiJC4131
JC5308
RefSeqiNP_006842.2, NM_006851.2 [P48060-1]
UniGeneiHs.205558

Genome annotation databases

EnsembliENST00000266659; ENSP00000266659; ENSG00000139278 [P48060-1]
GeneIDi11010
KEGGihsa:11010
UCSCiuc001sxs.4 human [P48060-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U16307 mRNA Translation: AAA82731.3 Frameshift.
X91911 mRNA Translation: CAA63005.1
AF400440 mRNA Translation: AAK92489.1
EF667354 mRNA Translation: ABV21587.1
BC012510 mRNA Translation: AAH12510.1
CCDSiCCDS9011.1 [P48060-1]
PIRiJC4131
JC5308
RefSeqiNP_006842.2, NM_006851.2 [P48060-1]
UniGeneiHs.205558

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3Q2RX-ray2.20A22-220[»]
3Q2UX-ray1.85A22-220[»]
ProteinModelPortaliP48060
SMRiP48060
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi116200, 8 interactors
IntActiP48060, 7 interactors
MINTiP48060
STRINGi9606.ENSP00000266659

Chemistry databases

DrugBankiDB05337 SOT-107

PTM databases

iPTMnetiP48060
PhosphoSitePlusiP48060

Polymorphism and mutation databases

BioMutaiGLIPR1
DMDMi27735198

Proteomic databases

EPDiP48060
MaxQBiP48060
PaxDbiP48060
PeptideAtlasiP48060
PRIDEiP48060
ProteomicsDBi55851
55852 [P48060-2]

Protocols and materials databases

DNASUi11010
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000266659; ENSP00000266659; ENSG00000139278 [P48060-1]
GeneIDi11010
KEGGihsa:11010
UCSCiuc001sxs.4 human [P48060-1]

Organism-specific databases

CTDi11010
DisGeNETi11010
EuPathDBiHostDB:ENSG00000139278.9
GeneCardsiGLIPR1
HGNCiHGNC:17001 GLIPR1
HPAiHPA011014
MIMi602692 gene
neXtProtiNX_P48060
OpenTargetsiENSG00000139278
PharmGKBiPA134988403
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3017 Eukaryota
COG2340 LUCA
GeneTreeiENSGT00760000119004
HOGENOMiHOG000036879
HOVERGENiHBG072125
InParanoidiP48060
OMAiYKLHPNF
OrthoDBiEOG091G048D
PhylomeDBiP48060
TreeFamiTF316148

Enzyme and pathway databases

ReactomeiR-HSA-1989781 PPARA activates gene expression
R-HSA-6798695 Neutrophil degranulation

Miscellaneous databases

ChiTaRSiGLIPR1 human
EvolutionaryTraceiP48060
GeneWikiiGLIPR1
GenomeRNAii11010
PROiPR:P48060
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000139278 Expressed in 219 organ(s), highest expression level in leukocyte
CleanExiHS_GLIPR1
ExpressionAtlasiP48060 baseline and differential
GenevisibleiP48060 HS

Family and domain databases

CDDicd05385 SCP_GLIPR-1_like, 1 hit
Gene3Di3.40.33.10, 1 hit
InterProiView protein in InterPro
IPR001283 Allrgn_V5/Tpx1
IPR018244 Allrgn_V5/Tpx1_CS
IPR014044 CAP_domain
IPR035940 CAP_sf
IPR034121 SCP_GLIPR-1-like
IPR002413 V5_allergen
PANTHERiPTHR10334 PTHR10334, 1 hit
PfamiView protein in Pfam
PF00188 CAP, 1 hit
PRINTSiPR00838 V5ALLERGEN
PR00837 V5TPXLIKE
SMARTiView protein in SMART
SM00198 SCP, 1 hit
SUPFAMiSSF55797 SSF55797, 1 hit
PROSITEiView protein in PROSITE
PS01009 CRISP_1, 1 hit
PS01010 CRISP_2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiGLIP1_HUMAN
AccessioniPrimary (citable) accession number: P48060
Secondary accession number(s): A7YET6
, F8VUC2, Q15409, Q969K2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1996
Last sequence update: January 10, 2003
Last modified: September 12, 2018
This is version 152 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome
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Main funding by: National Institutes of Health

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