LIM and senescent cell antigen-like-containing domain protein 1

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functionⁱ

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functionⁱ

• protein kinase binding Source: UniProtKB <p>Inferred from Physical Interaction</p> <p>Covers physical interactions between the gene product of interest and another molecule (or ion, or complex).</p> <p>More information in the <a href="http://geneontology.org/page/guide%2Dgo%2Devidence%2Dcodes#ipi">GO evidence code guide</a></p> Inferred from physical interactionⁱ
  • "The roles of two distinct regions of PINCH-1 in the regulation of cell attachment and spreading."
    Ito S., Takahara Y., Hyodo T., Hasegawa H., Asano E., Hamaguchi M., Senga T.
    Mol. Biol. Cell 21:4120-4129(2010) [PubMed] [Europe PMC] [Abstract]
• zinc ion binding Source: UniProtKB <p>Inferred from Direct Assay</p> <p>Used to indicate a direct assay for the function, process or component indicated by the GO term.</p> <p>More information in the <a href="http://geneontology.org/page/guide%2Dgo%2Devidence%2Dcodes#ida">GO evidence code guide</a></p> Inferred from direct assayⁱ
  • Ref.14

    "The structural basis of integrin-linked kinase-PINCH interactions."
    Chiswell B.P., Zhang R., Murphy J.W., Boggon T.J., Calderwood D.A.
    Proc. Natl. Acad. Sci. U.S.A. 105:20677-20682(2008) [PubMed] [Europe PMC] [Abstract]

    Cited for: X-RAY CRYSTALLOGRAPHY (1.6 ANGSTROMS) OF 6-68 IN COMPLEX WITH ILK, MUTAGENESIS OF PHE-42; HIS-61; ASP-62 AND LEU-66.

GO - Biological processⁱ

• cell aging Source: ProtInc <p>Traceable Author Statement</p> <p>Used for information from review articles where the original experiments are traceable through that article and also for information from text books or dictionaries.</p> <p>More information in the <a href="http://geneontology.org/page/guide%2Dgo%2Devidence%2Dcodes#tas">GO evidence code guide</a></p> Traceable author statementⁱ
  • Ref.1

    "A new LIM protein containing an autoepitope homologous to 'senescent cell antigen'."
    Rearden A.
    Biochem. Biophys. Res. Commun. 201:1124-1131(1994) [PubMed] [Europe PMC] [Abstract]

    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
• cell-cell adhesion Source: GO_Central <p>Inferred from Biological aspect of Ancestor</p> <p>A type of phylogenetic evidence whereby an aspect of a descendent is inferred through the characterization of an aspect of a ancestral gene.</p> <p>More information in the <a href="http://geneontology.org/page/guide%2Dgo%2Devidence%2Dcodes#iba">GO evidence code guide</a></p> Inferred from biological aspect of ancestorⁱ
  • "Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium."
    Gaudet P., Livstone M.S., Lewis S.E., Thomas P.D.
    Brief. Bioinformatics 12:449-462(2011) [PubMed] [Europe PMC] [Abstract]
• cell-cell junction organization Source: GO_CentralInferred from biological aspect of ancestorⁱ
  • "Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium."
    Gaudet P., Livstone M.S., Lewis S.E., Thomas P.D.
    Brief. Bioinformatics 12:449-462(2011) [PubMed] [Europe PMC] [Abstract]
• cell junction assembly Source: Reactome
• cellular response to transforming growth factor beta stimulus Source: UniProtKB <p>Inferred from Expression Pattern</p> <p>Covers cases where the annotation is inferred from the timing or location of expression of a gene.</p> <p>More information in the <a href="http://geneontology.org/page/guide%2Dgo%2Devidence%2Dcodes#iep">GO evidence code guide</a></p> Inferred from expression patternⁱ
  • "PINCH1 is transcriptional regulator in podocytes that interacts with WT1 and represses podocalyxin expression."
    Wang D., Li Y., Wu C., Liu Y.
    PLoS ONE 6:e17048-e17048(2011) [PubMed] [Europe PMC] [Abstract]
• establishment of protein localization Source: UniProtKB <p>Inferred from Mutant Phenotype</p> <p>Describes annotations that are concluded from looking at variations or changes in a gene product such as mutations or abnormal levels and includes techniques such as knockouts, overexpression, anti-sense experiments and use of specific protein inhibitors.</p> <p>More information in the <a href="http://geneontology.org/page/guide%2Dgo%2Devidence%2Dcodes#imp">GO evidence code guide</a></p> Inferred from mutant phenotypeⁱ
  • "The roles of two distinct regions of PINCH-1 in the regulation of cell attachment and spreading."
    Ito S., Takahara Y., Hyodo T., Hasegawa H., Asano E., Hamaguchi M., Senga T.
    Mol. Biol. Cell 21:4120-4129(2010) [PubMed] [Europe PMC] [Abstract]
• negative regulation of transcription, DNA-templated Source: UniProtKBInferred from direct assayⁱ
  • "PINCH1 is transcriptional regulator in podocytes that interacts with WT1 and represses podocalyxin expression."
    Wang D., Li Y., Wu C., Liu Y.
    PLoS ONE 6:e17048-e17048(2011) [PubMed] [Europe PMC] [Abstract]
• positive regulation of cell-substrate adhesion Source: UniProtKBInferred from mutant phenotypeⁱ
  • "The roles of two distinct regions of PINCH-1 in the regulation of cell attachment and spreading."
    Ito S., Takahara Y., Hyodo T., Hasegawa H., Asano E., Hamaguchi M., Senga T.
    Mol. Biol. Cell 21:4120-4129(2010) [PubMed] [Europe PMC] [Abstract]
• positive regulation of focal adhesion assembly Source: UniProtKBInferred from mutant phenotypeⁱ
  • "The roles of two distinct regions of PINCH-1 in the regulation of cell attachment and spreading."
    Ito S., Takahara Y., Hyodo T., Hasegawa H., Asano E., Hamaguchi M., Senga T.
    Mol. Biol. Cell 21:4120-4129(2010) [PubMed] [Europe PMC] [Abstract]
• positive regulation of gene expression Source: UniProtKBInferred from mutant phenotypeⁱ
  • "The roles of two distinct regions of PINCH-1 in the regulation of cell attachment and spreading."
    Ito S., Takahara Y., Hyodo T., Hasegawa H., Asano E., Hamaguchi M., Senga T.
    Mol. Biol. Cell 21:4120-4129(2010) [PubMed] [Europe PMC] [Abstract]
• positive regulation of GTPase activity Source: UniProtKBInferred from mutant phenotypeⁱ
  • "The roles of two distinct regions of PINCH-1 in the regulation of cell attachment and spreading."
    Ito S., Takahara Y., Hyodo T., Hasegawa H., Asano E., Hamaguchi M., Senga T.
    Mol. Biol. Cell 21:4120-4129(2010) [PubMed] [Europe PMC] [Abstract]
• positive regulation of integrin-mediated signaling pathway Source: GO_CentralInferred from biological aspect of ancestorⁱ
  • "Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium."
    Gaudet P., Livstone M.S., Lewis S.E., Thomas P.D.
    Brief. Bioinformatics 12:449-462(2011) [PubMed] [Europe PMC] [Abstract]
• positive regulation of NIK/NF-kappaB signaling Source: CAFAInferred from mutant phenotypeⁱ
  • "Thymosin beta4 inhibits TNF-alpha-induced NF-kappaB activation, IL-8 expression, and the sensitizing effects by its partners PINCH-1 and ILK."
    Qiu P., Wheater M.K., Qiu Y., Sosne G.
    FASEB J. 25:1815-1826(2011) [PubMed] [Europe PMC] [Abstract]
• positive regulation of substrate adhesion-dependent cell spreading Source: UniProtKBInferred from mutant phenotypeⁱ
  • "The roles of two distinct regions of PINCH-1 in the regulation of cell attachment and spreading."
    Ito S., Takahara Y., Hyodo T., Hasegawa H., Asano E., Hamaguchi M., Senga T.
    Mol. Biol. Cell 21:4120-4129(2010) [PubMed] [Europe PMC] [Abstract]
• tumor necrosis factor-mediated signaling pathway Source: CAFAInferred from mutant phenotypeⁱ
  • "Thymosin beta4 inhibits TNF-alpha-induced NF-kappaB activation, IL-8 expression, and the sensitizing effects by its partners PINCH-1 and ILK."
    Qiu P., Wheater M.K., Qiu Y., Sosne G.
    FASEB J. 25:1815-1826(2011) [PubMed] [Europe PMC] [Abstract]

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsⁱ

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyⁱ

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationⁱ

Keywords - Cellular componentⁱ

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechⁱ

Mutagenesis

Organism-specific databases

Miscellaneous databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingⁱ

Molecule processing

Amino acid modifications

Keywords - PTMⁱ

Proteomic databases

2D gel databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressionⁱ

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityⁱ

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactionⁱ

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structureⁱ

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsⁱ

GO - Molecular functionⁱ

• protein kinase binding Source: UniProtKBInferred from physical interactionⁱ
  • "The roles of two distinct regions of PINCH-1 in the regulation of cell attachment and spreading."
    Ito S., Takahara Y., Hyodo T., Hasegawa H., Asano E., Hamaguchi M., Senga T.
    Mol. Biol. Cell 21:4120-4129(2010) [PubMed] [Europe PMC] [Abstract]

Protein-protein interaction databases

Miscellaneous databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structureⁱ

Secondary structure

3D structure databases

Miscellaneous databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsⁱ

Domains and Repeats

Keywords - Domainⁱ

Phylogenomic databases

Family and domain databases

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (5+)ⁱ

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusⁱ: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingⁱ: The displayed sequence is further processed into a mature form.

This entry has 5 described isoforms and 5 potential isoforms that are computationally mapped.Show allAlign All

        10         20         30         40         50
MANALASATC ERCKGGFAPA EKIVNSNGEL YHEQCFVCAQ CFQQFPEGLF 
        60         70         80         90        100
YEFEGRKYCE HDFQMLFAPC CHQCGEFIIG RVIKAMNNSW HPECFRCDLC 
       110        120        130        140        150
QEVLADIGFV KNAGRHLCRP CHNREKARGL GKYICQKCHA IIDEQPLIFK 
       160        170        180        190        200
NDPYHPDHFN CANCGKELTA DARELKGELY CLPCHDKMGV PICGACRRPI 
       210        220        230        240        250
EGRVVNAMGK QWHVEHFVCA KCEKPFLGHR HYERKGLAYC ETHYNQLFGD 
       260        270        280        290        300
VCFHCNRVIE GDVVSALNKA WCVNCFACST CNTKLTLKNK FVEFDMKPVC 
       310        320 
KKCYEKFPLE LKKRLKKLAE TLGRK                            

        10         20         30         40         50
MLGVAAGMTH SNMANALASA TCERCKGGFA PAEKIVNSNG ELYHEQCFVC 
        60         70         80         90        100
AQCFQQFPEG LFYEFEGRKY CEHDFQMLFA PCCHQCGEFI IGRVIKAMNN 
       110        120        130        140        150
SWHPECFRCD LCQEVLADIG FVKNAGRHLC RPCHNREKAR GLGKYICQKC 
       160        170        180        190        200
HAIIDEQPLI FKNDPYHPDH FNCANCGKEL TADARELKGE LYCLPCHDKM 
       210        220        230        240        250
GVPICGACRR PIEGRVVNAM GKQWHVEHFV CAKCEKPFLG HRHYERKGLA 
       260        270        280        290        300
YCETHYNQLF GDVCFHCNRV IEGDVVSALN KAWCVNCFAC STCNTKLTLK 
       310        320        330 
NKFVEFDMKP VCKKCYEKFP LELKKRLKKL AETLGRK               

        10         20         30         40         50
MAFSGRARPC IIPENEEIPR AALNTVHEAN GTEDERAVSK LQRRHSDVKV 
        60         70         80         90        100
YKEFCDFYAK FNMANALASA TCERCKGGFA PAEKIVNSNG ELYHEQCFVC 
       110        120        130        140        150
AQCFQQFPEG LFYEFEGRKY CEHDFQMLFA PCCHQCGEFI IGRVIKAMNN 
       160        170        180        190        200
SWHPECFRCD LCQEVLADIG FVKNAGRHLC RPCHNREKAR GLGKYICQKC 
       210        220        230        240        250
HAIIDEQPLI FKNDPYHPDH FNCANCGKEL TADARELKGE LYCLPCHDKM 
       260        270        280        290        300
GVPICGACRR PIEGRVVNAM GKQWHVEHFV CAKCEKPFLG HRHYERKGLA 
       310        320        330        340        350
YCETHYNQLF GDVCFHCNRV IEGDVVSALN KAWCVNCFAC STCNTKLTLK 
       360        370        380 
NKFVEFDMKP VCKKCYEKFP LELKKRLKKL AETLGRK               

        10         20         30         40         50
MTCNMANALA SATCERCKGG FAPAEKIVNS NGELYHEQCF VCAQCFQQFP 
        60         70         80         90        100
EGLFYEFEGR KYCEHDFQML FAPCCHQCGE FIIGRVIKAM NNSWHPECFR 
       110        120        130        140        150
CDLCQEVLAD IGFVKNAGRH LCRPCHNREK ARGLGKYICQ KCHAIIDEQP 
       160        170        180        190        200
LIFKNDPYHP DHFNCANCGK ELTADARELK GELYCLPCHD KMGVPICGAC 
       210        220        230        240        250
RRPIEGRVVN AMGKQWHVEH FVCAKCEKPF LGHRHYERKG LAYCETHYNQ 
       260        270        280        290        300
LFGDVCFHCN RVIEGDVVSA LNKAWCVNCF ACSTCNTKLT LKNKFVEFDM 
       310        320 
KPVCKKCYEK FPLELKKRLK KLAETLGRK                        

        10         20         30         40         50
MTALQLKELS HSGLYRRRRD RPDSLRVNGL PEEELSNMAN ALASATCERC 
        60         70         80         90        100
KGGFAPAEKI VNSNGELYHE QCFVCAQCFQ QFPEGLFYEF EGRKYCEHDF 
       110        120        130        140        150
QMLFAPCCHQ CGEFIIGRVI KAMNNSWHPE CFRCDLCQEV LADIGFVKNA 
       160        170        180        190        200
GRHLCRPCHN REKARGLGKY ICQKCHAIID EQPLIFKNDP YHPDHFNCAN 
       210        220        230        240        250
CGKELTADAR ELKGELYCLP CHDKMGVPIC GACRRPIEGR VVNAMGKQWH 
       260        270        280        290        300
VEHFVCAKCE KPFLGHRHYE RKGLAYCETH YNQLFGDVCF HCNRVIEGDV 
       310        320        330        340        350
VSALNKAWCV NCFACSTCNT KLTLKNKFVE FDMKPVCKKC YEKFPLELKK 
       360 
RLKKLAETLG RK                                          

Experimental Info

Alternative sequence

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityⁱ

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsⁱ

• 100% Identity
• 90% Identity
• 50% Identity

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesⁱ

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Polymorphism and mutation databases

2D gel databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationⁱ

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousⁱ

Keywords - Technical termⁱ

Documents

1. Human chromosome 2
   Human chromosome 2: entries, gene names and cross-references to MIM
2. MIM cross-references
   Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
3. PDB cross-references
   Index of Protein Data Bank (PDB) cross-references