LIMS1

Functionⁱ

Adapter protein in a cytoplasmic complex linking beta-integrins to the actin cytoskeleton, bridges the complex to cell surface receptor tyrosine kinases and growth factor receptors. Involved in the regulation of cell survival, cell proliferation and cell differentiation.

GO - Molecular functionⁱ

protein kinase binding
Source: UniProtKB
Inferred from physical interactionⁱ
- 20926685
zinc ion binding
Source: UniProtKB
Inferred from direct assayⁱ
- 19074270

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

cell aging
Source: ProtInc
Traceable author statementⁱ
- 7517666
cell junction assembly Source: Reactome
cellular response to transforming growth factor beta stimulus
Source: UniProtKB
Inferred from expression patternⁱ
- 21390327
establishment of protein localization
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- 20926685
negative regulation of transcription, DNA-templated
Source: UniProtKB
Inferred from direct assayⁱ
- 21390327
positive regulation of cell-substrate adhesion
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- 20926685
positive regulation of focal adhesion assembly
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- 20926685
positive regulation of gene expression
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- 20926685
positive regulation of GTPase activity
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- 20926685
positive regulation of NIK/NF-kappaB signaling
Source: CAFA
Inferred from mutant phenotypeⁱ
- 21343177
positive regulation of substrate adhesion-dependent cell spreading
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- 20926685
protein heterooligomerization Source: Ensembl
tumor necrosis factor-mediated signaling pathway
Source: CAFA
Inferred from mutant phenotypeⁱ
- 21343177

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Ligand	Metal-binding, Zinc

Ligand

Metal-binding, Zinc

Enzyme and pathway databases

Reactomeⁱ	R-HSA-446353 Cell-extracellular matrix interactions R-HSA-446388 Regulation of cytoskeletal remodeling and cell spreading by IPP complex components

Reactomeⁱ

R-HSA-446353 Cell-extracellular matrix interactions
R-HSA-446388 Regulation of cytoskeletal remodeling and cell spreading by IPP complex components

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: LIM and senescent cell antigen-like-containing domain protein 1 Alternative name(s): Particularly interesting new Cys-His protein 1 Short name: PINCH-1 Renal carcinoma antigen NY-REN-48
Gene namesⁱ	Name:LIMS1 Synonyms:PINCH, PINCH1
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 2

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000169756.16
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:6616 LIMS1
MIMⁱ	602567 gene
neXtProtⁱ	NX_P48059

Keywords - Cellular componentⁱ

Cell junction, Cell membrane, Membrane

Pathology & Biotechⁱ

Mutagenesis

Feature key	Position(s)	DescriptionActions	Length
Mutagenesisⁱ	42	F → A: Loss of interaction with ILK and loss of localization to focal adhesion. 2 Publications	1
Mutagenesisⁱ	56	R → A: Alters interaction with ILK. 1 Publication	1
Mutagenesisⁱ	61	H → D: Alters interaction with ILK. 1 Publication	1
Mutagenesisⁱ	62	D → A: Alters interaction with ILK. 1 Publication	1
Mutagenesisⁱ	66	L → D: Alters interaction with ILK. 1 Publication	1

Organism-specific databases

DisGeNET More...DisGeNETⁱ	3987
Open Targets More...OpenTargetsⁱ	ENSG00000169756
PharmGKBⁱ	PA30389

Polymorphism and mutation databases

BioMutaⁱ	LIMS1
DMDMⁱ	18266876

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Initiator methionineⁱ		Removed1 Publication
ChainⁱPRO_0000075888	2 – 325	LIM and senescent cell antigen-like-containing domain protein 1Add BLAST		324

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Modified residueⁱ	2	N-acetylalanine1 Publication		1

Keywords - PTMⁱ

Acetylation

Proteomic databases

EPDⁱ	P48059
MaxQB - The MaxQuant DataBase More...MaxQBⁱ	P48059
PaxDbⁱ	P48059
PeptideAtlas More...PeptideAtlasⁱ	P48059
PRIDEⁱ	P48059
ProteomicsDBⁱ	55846 55847 [P48059-2] 55848 [P48059-3] 55849 [P48059-4] 55850 [P48059-5]

2D gel databases

USC-OGP 2-DE database More...OGPⁱ	P48059

OGPⁱ

P48059

PTM databases

iPTMnetⁱ	P48059
PhosphoSitePlusⁱ	P48059

Expressionⁱ

Tissue specificityⁱ

Expressed in most tissues except in the brain.

Gene expression databases

Bgeeⁱ	ENSG00000169756 Expressed in 207 organ(s), highest expression level in endometrium
CleanExⁱ	HS_LIMS1
ExpressionAtlasⁱ	P48059 baseline and differential
Genevisibleⁱ	P48059 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	HPA058455 HPA061230

HPAⁱ

HPA058455
HPA061230

Interactionⁱ

Subunit structureⁱ

Interacts (via LIM zinc-binding 5) with TGFB1I1 (By similarity). Interacts with integrin-linked protein kinase 1 (ILK) via the first LIM domain, and in competition with LIMS2. Part of the heterotrimeric IPP complex composed of integrin-linked kinase (ILK), LIMS1 or LIMS2, and PARVA. Interacts with SH3/SH2 adapter NCK2, thereby linking the complex to cell surface receptors.By similarity4 Publications

Binary interactionsⁱ

With	Entry	#Exp.	IntAct	Notes
Hoxa1	P09022	3	EBI-306928,EBI-3957603	From Mus musculus.
ILK	Q13418	10	EBI-306928,EBI-747644
Ilk	O55222	3	EBI-306928,EBI-6690138	From Mus musculus.
NCK2	O43639	2	EBI-306928,EBI-713635
RSU1	Q15404	4	EBI-306928,EBI-1057132

GO - Molecular functionⁱ

protein kinase binding
Source: UniProtKB
Inferred from physical interactionⁱ
- 20926685

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

BioGridⁱ	110175, 37 interactors
Database of interacting proteins More...DIPⁱ	DIP-40671N
IntActⁱ	P48059, 53 interactors
Molecular INTeraction database More...MINTⁱ	P48059
STRINGⁱ	9606.ENSP00000446121

Structureⁱ

Secondary structure

Legend: HelixTurnBeta strandPDB Structure known for this area

Feature key	Position(s)	DescriptionActions	Length
Turnⁱ	11 – 13	Combined sources	3
Beta strandⁱ	22 – 26	Combined sources	5
Beta strandⁱ	29 – 32	Combined sources	4
Turnⁱ	33 – 35	Combined sources	3
Turnⁱ	39 – 41	Combined sources	3
Helixⁱ	46 – 48	Combined sources	3
Beta strandⁱ	51 – 53	Combined sources	3
Beta strandⁱ	56 – 58	Combined sources	3
Helixⁱ	60 – 66	Combined sources	7
Beta strandⁱ	72 – 74	Combined sources	3
Beta strandⁱ	83 – 85	Combined sources	3
Beta strandⁱ	88 – 90	Combined sources	3
Turnⁱ	92 – 94	Combined sources	3
Beta strandⁱ	98 – 100	Combined sources	3
Beta strandⁱ	105 – 107	Combined sources	3
Beta strandⁱ	110 – 112	Combined sources	3
Beta strandⁱ	115 – 117	Combined sources	3
Helixⁱ	119 – 126	Combined sources	8
Turnⁱ	136 – 138	Combined sources	3
Beta strandⁱ	150 – 152	Combined sources	3
Turnⁱ	156 – 158	Combined sources	3
Beta strandⁱ	162 – 164	Combined sources	3
Beta strandⁱ	173 – 175	Combined sources	3
Beta strandⁱ	178 – 180	Combined sources	3
Helixⁱ	182 – 186	Combined sources	5
Turnⁱ	194 – 197	Combined sources	4
Beta strandⁱ	210 – 213	Combined sources	4
Turnⁱ	214 – 216	Combined sources	3
Turnⁱ	220 – 222	Combined sources	3
Beta strandⁱ	227 – 229	Combined sources	3
Beta strandⁱ	232 – 234	Combined sources	3
Beta strandⁱ	237 – 239	Combined sources	3
Helixⁱ	241 – 247	Combined sources	7

Show more details

3D structure databases

ProteinModelPortalⁱ	P48059
SMRⁱ	P48059
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Miscellaneous databases

EvolutionaryTraceⁱ	P48059

EvolutionaryTraceⁱ

P48059

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Length
Domainⁱ	10 – 62	LIM zinc-binding 1PROSITE-ProRule annotationAdd BLAST	53
Domainⁱ	71 – 121	LIM zinc-binding 2PROSITE-ProRule annotationAdd BLAST	51
Domainⁱ	135 – 184	LIM zinc-binding 3PROSITE-ProRule annotationAdd BLAST	50
Domainⁱ	193 – 243	LIM zinc-binding 4PROSITE-ProRule annotationAdd BLAST	51
Domainⁱ	252 – 303	LIM zinc-binding 5PROSITE-ProRule annotationAdd BLAST	52

Keywords - Domainⁱ

LIM domain, Repeat

Phylogenomic databases

eggNOGⁱ	KOG2272 Eukaryota ENOG410XP46 LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00760000118910
HOGENOMⁱ	HOG000253950
HOVERGENⁱ	HBG000053
InParanoidⁱ	P48059
OMAⁱ	CRECNER
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G08K3
PhylomeDBⁱ	P48059
TreeFamⁱ	TF314113

Family and domain databases

InterProⁱ	View protein in InterPro IPR017351 PINCH IPR001781 Znf_LIM
PANTHERⁱ	PTHR24210 PTHR24210, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00412 LIM, 5 hits
PIRSFⁱ	PIRSF038003 PINCH, 1 hit
SMARTⁱ	View protein in SMART SM00132 LIM, 5 hits
PROSITEⁱ	View protein in PROSITE PS00478 LIM_DOMAIN_1, 4 hits PS50023 LIM_DOMAIN_2, 5 hits

Sequences (5+)ⁱ

Sequence statusⁱ: Complete.

Sequence processingⁱ: The displayed sequence is further processed into a mature form.

This entry describes 5 isoformsⁱ produced by alternative splicing. Align Add to basket

This entry has 5 described isoforms and 5 potential isoforms that are computationally mapped.Show all Align All

Isoform 1 (identifier: P48059-1) [UniParc]FASTA Add to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MANALASATC ERCKGGFAPA EKIVNSNGEL YHEQCFVCAQ CFQQFPEGLF 
        60         70         80         90        100
YEFEGRKYCE HDFQMLFAPC CHQCGEFIIG RVIKAMNNSW HPECFRCDLC 
       110        120        130        140        150
QEVLADIGFV KNAGRHLCRP CHNREKARGL GKYICQKCHA IIDEQPLIFK 
       160        170        180        190        200
NDPYHPDHFN CANCGKELTA DARELKGELY CLPCHDKMGV PICGACRRPI 
       210        220        230        240        250
EGRVVNAMGK QWHVEHFVCA KCEKPFLGHR HYERKGLAYC ETHYNQLFGD 
       260        270        280        290        300
VCFHCNRVIE GDVVSALNKA WCVNCFACST CNTKLTLKNK FVEFDMKPVC 
       310        320 
KKCYEKFPLE LKKRLKKLAE TLGRK

Length:325

Mass (Da):37,251

Last modified:January 23, 2007 - v4

Checksum:ⁱE665FEB11D849CAE

GO

Isoform 2 (identifier: P48059-2) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
1-1: M → MLGVAAGMTHSNM

« Hide

        10         20         30         40         50
MLGVAAGMTH SNMANALASA TCERCKGGFA PAEKIVNSNG ELYHEQCFVC 
        60         70         80         90        100
AQCFQQFPEG LFYEFEGRKY CEHDFQMLFA PCCHQCGEFI IGRVIKAMNN 
       110        120        130        140        150
SWHPECFRCD LCQEVLADIG FVKNAGRHLC RPCHNREKAR GLGKYICQKC 
       160        170        180        190        200
HAIIDEQPLI FKNDPYHPDH FNCANCGKEL TADARELKGE LYCLPCHDKM 
       210        220        230        240        250
GVPICGACRR PIEGRVVNAM GKQWHVEHFV CAKCEKPFLG HRHYERKGLA 
       260        270        280        290        300
YCETHYNQLF GDVCFHCNRV IEGDVVSALN KAWCVNCFAC STCNTKLTLK 
       310        320        330 
NKFVEFDMKP VCKKCYEKFP LELKKRLKKL AETLGRK

Note: No experimental confirmation available.

Show »

Length:337

Mass (Da):38,422

Checksum:ⁱ8577792E1A56418B

GO

Isoform 3 (identifier: P48059-3) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
1-1: M → MAFSGRARPCIIPENEEIPRAALNTVHEANGTEDERAVSKLQRRHSDVKVYKEFCDFYAKFNM

« Hide

        10         20         30         40         50
MAFSGRARPC IIPENEEIPR AALNTVHEAN GTEDERAVSK LQRRHSDVKV 
        60         70         80         90        100
YKEFCDFYAK FNMANALASA TCERCKGGFA PAEKIVNSNG ELYHEQCFVC 
       110        120        130        140        150
AQCFQQFPEG LFYEFEGRKY CEHDFQMLFA PCCHQCGEFI IGRVIKAMNN 
       160        170        180        190        200
SWHPECFRCD LCQEVLADIG FVKNAGRHLC RPCHNREKAR GLGKYICQKC 
       210        220        230        240        250
HAIIDEQPLI FKNDPYHPDH FNCANCGKEL TADARELKGE LYCLPCHDKM 
       260        270        280        290        300
GVPICGACRR PIEGRVVNAM GKQWHVEHFV CAKCEKPFLG HRHYERKGLA 
       310        320        330        340        350
YCETHYNQLF GDVCFHCNRV IEGDVVSALN KAWCVNCFAC STCNTKLTLK 
       360        370        380 
NKFVEFDMKP VCKKCYEKFP LELKKRLKKL AETLGRK

Show »

Length:387

Mass (Da):44,390

Checksum:ⁱ3AB2EDB2203CEBFF

GO

Isoform 4 (identifier: P48059-4) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
1-1: M → MTCNM

« Hide

        10         20         30         40         50
MTCNMANALA SATCERCKGG FAPAEKIVNS NGELYHEQCF VCAQCFQQFP 
        60         70         80         90        100
EGLFYEFEGR KYCEHDFQML FAPCCHQCGE FIIGRVIKAM NNSWHPECFR 
       110        120        130        140        150
CDLCQEVLAD IGFVKNAGRH LCRPCHNREK ARGLGKYICQ KCHAIIDEQP 
       160        170        180        190        200
LIFKNDPYHP DHFNCANCGK ELTADARELK GELYCLPCHD KMGVPICGAC 
       210        220        230        240        250
RRPIEGRVVN AMGKQWHVEH FVCAKCEKPF LGHRHYERKG LAYCETHYNQ 
       260        270        280        290        300
LFGDVCFHCN RVIEGDVVSA LNKAWCVNCF ACSTCNTKLT LKNKFVEFDM 
       310        320 
KPVCKKCYEK FPLELKKRLK KLAETLGRK

Show »

Length:329

Mass (Da):37,701

Checksum:ⁱA69518B2E12F39A5

GO

Isoform 5 (identifier: P48059-5) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
1-1: M → MTALQLKELSHSGLYRRRRDRPDSLRVNGLPEEELSNM

« Hide

        10         20         30         40         50
MTALQLKELS HSGLYRRRRD RPDSLRVNGL PEEELSNMAN ALASATCERC 
        60         70         80         90        100
KGGFAPAEKI VNSNGELYHE QCFVCAQCFQ QFPEGLFYEF EGRKYCEHDF 
       110        120        130        140        150
QMLFAPCCHQ CGEFIIGRVI KAMNNSWHPE CFRCDLCQEV LADIGFVKNA 
       160        170        180        190        200
GRHLCRPCHN REKARGLGKY ICQKCHAIID EQPLIFKNDP YHPDHFNCAN 
       210        220        230        240        250
CGKELTADAR ELKGELYCLP CHDKMGVPIC GACRRPIEGR VVNAMGKQWH 
       260        270        280        290        300
VEHFVCAKCE KPFLGHRHYE RKGLAYCETH YNQLFGDVCF HCNRVIEGDV 
       310        320        330        340        350
VSALNKAWCV NCFACSTCNT KLTLKNKFVE FDMKPVCKKC YEKFPLELKK 
       360 
RLKKLAETLG RK

Show »

Length:362

Mass (Da):41,571

Checksum:ⁱB2123BE2DDC4736C

GO

Computationally mapped potential isoform sequencesⁱ

There are 5 potential isoforms mapped to this entry.BLAST Align Show all Add to basket

Entry	Entry name	Protein names	Gene names	Length	Annotation

F8WC86	F8WC86_HUMAN	LIM and senescent cell antigen-like... LIM and senescent cell antigen-like-containing domain protein 1	LIMS1	117	Annotation score:
F8WE10	F8WE10_HUMAN	LIM and senescent cell antigen-like... LIM and senescent cell antigen-like-containing domain protein 1	LIMS1	100	Annotation score:
C9JF46	C9JF46_HUMAN	LIM and senescent cell antigen-like... LIM and senescent cell antigen-like-containing domain protein 1	LIMS1	176	Annotation score:
F8WB59	F8WB59_HUMAN	LIM and senescent cell antigen-like... LIM and senescent cell antigen-like-containing domain protein 1	LIMS1	55	Annotation score:
A0A0M3HER1	A0A0M3HER1_HUMAN	LIM and senescent cell antigen-like... LIM and senescent cell antigen-like-containing domain protein 1	LIMS1	209	Annotation score:

Experimental Info

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Sequence conflictⁱ	78	I → T in AAH05341 (PubMed:15489334).Curated		1
Sequence conflictⁱ	262	D → G in AAH05341 (PubMed:15489334).Curated		1

Alternative sequence

Feature key	Position(s)	DescriptionActions	Length
Alternative sequenceⁱVSP_042672	1	M → MLGVAAGMTHSNM in isoform 2. 1 Publication	1
Alternative sequenceⁱVSP_043210	1	M → MAFSGRARPCIIPENEEIPR AALNTVHEANGTEDERAVSK LQRRHSDVKVYKEFCDFYAK FNM in isoform 3. 1 Publication	1
Alternative sequenceⁱVSP_043211	1	M → MTCNM in isoform 4. Curated	1
Alternative sequenceⁱVSP_043212	1	M → MTALQLKELSHSGLYRRRRD RPDSLRVNGLPEEELSNM in isoform 5. 1 Publication	1

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	U09284 mRNA Translation: AAA20086.2 AK296992 mRNA Translation: BAH12469.1 AK302411 mRNA Translation: BAH13699.1 AK304260 mRNA Translation: BAH14143.1 AK314217 mRNA Translation: BAG36891.1 AC010095 Genomic DNA Translation: AAY14983.1 AC012487 Genomic DNA No translation available. BC005341 mRNA Translation: AAH05341.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS2078.1 [P48059-1] CCDS54382.1 [P48059-2] CCDS54383.1 [P48059-4] CCDS54384.1 [P48059-5] CCDS54385.1 [P48059-3]
PIRⁱ	JC2324
NCBI Reference Sequences More...RefSeqⁱ	NP_001180411.1, NM_001193482.1 [P48059-4] NP_001180412.1, NM_001193483.2 [P48059-2] NP_001180413.1, NM_001193484.1 [P48059-5] NP_001180414.1, NM_001193485.2 [P48059-3] NP_001180417.1, NM_001193488.1 [P48059-1] NP_004978.2, NM_004987.5 [P48059-1]
UniGeneⁱ	Hs.597715 Hs.613268

Genome annotation databases

Ensemblⁱ	ENST00000332345; ENSP00000331775; ENSG00000169756 [P48059-1] ENST00000338045; ENSP00000337598; ENSG00000169756 [P48059-3] ENST00000393310; ENSP00000376987; ENSG00000169756 [P48059-1] ENST00000409441; ENSP00000387264; ENSG00000169756 [P48059-5] ENST00000410093; ENSP00000386926; ENSG00000169756 [P48059-4] ENST00000544547; ENSP00000437912; ENSG00000169756 [P48059-2]
GeneIDⁱ	3987
KEGGⁱ	hsa:3987
UCSC genome browser More...UCSCⁱ	uc002teg.4 human [P48059-1]

Keywords - Coding sequence diversityⁱ

Alternative splicing

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
P48059	LIM and senescent cell antigen-like-containing domain protein		CALJA		388	UniRef100_P48059
LIM and senescent cell antigen-like-containing domain protein		MACMU		325
UPI00005A2140		PONAB		240
UPI00059B04C2		AILME		261
LIM and senescent cell antigen-like-containing domain protein		CALJA		387
P48059-2	LIM and senescent cell antigen-like-containing domain protein		MACMU		337	UniRef100_F7GXN4
LIM and senescent cell antigen-like-containing domain protein		PANTR		337
LIM and senescent cell antigen-like-containing domain protein		CALJA		337
LIM and senescent cell antigen-like-containing domain protein		PAPAN		337
LIM and senescent cell antigen-like-containing domain protein		CHLSB		337
+1
P48059-4	LIM and senescent cell antigen-like-containing domain protein		CALJA		329	UniRef100_F7I2K6
LIM and senescent cell antigen-like-containing domain protein		SAIBB		329
LIM and senescent cell antigen-like-containing domain protein		COLAP		329
LIM and senescent cell antigen-like-containing domain protein		CERAT		329
LIM and senescent cell antigen-like-containing domain protein		RHIRO		329
+3
P48059-5	LIM and senescent cell antigen-like-containing domain protein		MACMU		362	UniRef100_F7GXP0
LIM and senescent cell antigen-like-containing domain protein		COLAP		362
LIM and senescent cell antigen-like-containing domain protein		CERAT		362
LIM and senescent cell antigen-like-containing domain protein		RHIRO		362
LIM and senescent cell antigen-like-containing domain protein		PAPAN		362
+3

Protein	Similar proteins		Species	Score	Length	Source
P48059	LIM and senescent cell antigen-like-containing domain protein 1		MOUSE		325	UniRef90_P48059
LIM and senescent cell antigen-like-containing domain protein		CALJA		388
LIM and senescent cell antigen-like-containing domain protein		MACMU		325
LIM and senescent cell antigen-like-containing domain protein		RHIBE		412
LIM and senescent cell antigen-like-containing domain protein		RHIRO		399
+247
P48059-2	LIM and senescent cell antigen-like-containing domain protein		MUSPF		337	UniRef90_M3YH73
LIM domain-containing protein		Austrofundulus limnaeus		343
LIM domain-containing protein		TAKRU		343
LIM and senescent cell antigen-like-containing domain protein		BOVIN		337
LIM and senescent cell antigen-like-containing domain protein		Cebus capucinus imitator		337
+62
P48059-4	LIM and senescent cell antigen-like-containing domain protein		MUSPF		337	UniRef90_M3YH73
LIM domain-containing protein		Austrofundulus limnaeus		343
LIM domain-containing protein		TAKRU		343
LIM and senescent cell antigen-like-containing domain protein		BOVIN		337
LIM and senescent cell antigen-like-containing domain protein		Cebus capucinus imitator		337
+62
P48059-5	LIM and senescent cell antigen-like-containing domain protein		MACMU		362	UniRef90_F7GXP0
LIM and senescent cell antigen-like-containing domain protein		COLAP		362
LIM and senescent cell antigen-like-containing domain protein		CERAT		362
LIM and senescent cell antigen-like-containing domain protein		RHIRO		362
LIM and senescent cell antigen-like-containing domain protein		PAPAN		362
+64

Protein	Similar proteins		Species	Score	Length	Source
P48059	LIM and senescent cell antigen-like-containing domain protein 1		MOUSE		325	UniRef50_P48059
LIM and senescent cell antigen-like-containing domain protein 2	)	HUMAN		341
LIM and senescent cell antigen-like-containing domain protein 2		BOVIN		341
LIM and senescent cell antigen-like-containing domain protein		CALJA		388
LIM and senescent cell antigen-like-containing domain protein		MACMU		325
+1200
P48059-5	LIM and senescent cell antigen-like-containing domain protein		MACMU		362	UniRef50_F7GXP0
LIM and senescent cell antigen-like-containing domain protein		COLAP		362
LIM and senescent cell antigen-like-containing domain protein		CERAT		362
LIM and senescent cell antigen-like-containing domain protein		RHIRO		362
LIM and senescent cell antigen-like-containing domain protein		PAPAN		362
+114

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	U09284 mRNA Translation: AAA20086.2 AK296992 mRNA Translation: BAH12469.1 AK302411 mRNA Translation: BAH13699.1 AK304260 mRNA Translation: BAH14143.1 AK314217 mRNA Translation: BAG36891.1 AC010095 Genomic DNA Translation: AAY14983.1 AC012487 Genomic DNA No translation available. BC005341 mRNA Translation: AAH05341.1
CCDSⁱ	CCDS2078.1 [P48059-1] CCDS54382.1 [P48059-2] CCDS54383.1 [P48059-4] CCDS54384.1 [P48059-5] CCDS54385.1 [P48059-3]
PIRⁱ	JC2324
RefSeqⁱ	NP_001180411.1, NM_001193482.1 [P48059-4] NP_001180412.1, NM_001193483.2 [P48059-2] NP_001180413.1, NM_001193484.1 [P48059-5] NP_001180414.1, NM_001193485.2 [P48059-3] NP_001180417.1, NM_001193488.1 [P48059-1] NP_004978.2, NM_004987.5 [P48059-1]
UniGeneⁱ	Hs.597715 Hs.613268

3D structure databases

Select the link destinations: Protein Data Bank Europe More...PDBeⁱ Protein Data Bank RCSB More...RCSB PDBⁱ Protein Data Bank Japan More...PDBjⁱ Links Updated	PDB entry	Method	Resolution (Å)	Chain	Positions	PDBsum
	1G47	NMR	-	A	1-70	[»]
	1NYP	NMR	-	A	188-251	[»]
	1U5S	NMR	-	B	188-251	[»]
	2COR	NMR	-	A	125-190	[»]
	2D8X	NMR	-	A	71-127	[»]
	2KBX	NMR	-	B	1-70	[»]
	3F6Q	X-ray	1.60	B	6-68	[»]
	4HI8	X-ray	1.20	B	6-68	[»]
	4HI9	X-ray	1.20	B	6-68	[»]
ProteinModelPortalⁱ	P48059
SMRⁱ	P48059
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	110175, 37 interactors
DIPⁱ	DIP-40671N
IntActⁱ	P48059, 53 interactors
MINTⁱ	P48059
STRINGⁱ	9606.ENSP00000446121

PTM databases

iPTMnetⁱ	P48059
PhosphoSitePlusⁱ	P48059

Polymorphism and mutation databases

BioMutaⁱ	LIMS1
DMDMⁱ	18266876

2D gel databases

OGPⁱ	P48059

OGPⁱ

P48059

Proteomic databases

EPDⁱ	P48059
MaxQBⁱ	P48059
PaxDbⁱ	P48059
PeptideAtlasⁱ	P48059
PRIDEⁱ	P48059
ProteomicsDBⁱ	55846 55847 [P48059-2] 55848 [P48059-3] 55849 [P48059-4] 55850 [P48059-5]

Protocols and materials databases

The DNASU plasmid repository More...DNASUⁱ	3987
Structural Biology Knowledgebase	Search...

Genome annotation databases

Ensemblⁱ	ENST00000332345; ENSP00000331775; ENSG00000169756 [P48059-1] ENST00000338045; ENSP00000337598; ENSG00000169756 [P48059-3] ENST00000393310; ENSP00000376987; ENSG00000169756 [P48059-1] ENST00000409441; ENSP00000387264; ENSG00000169756 [P48059-5] ENST00000410093; ENSP00000386926; ENSG00000169756 [P48059-4] ENST00000544547; ENSP00000437912; ENSG00000169756 [P48059-2]
GeneIDⁱ	3987
KEGGⁱ	hsa:3987
UCSCⁱ	uc002teg.4 human [P48059-1]

Organism-specific databases

CTDⁱ	3987
DisGeNETⁱ	3987
EuPathDBⁱ	HostDB:ENSG00000169756.16
GeneCardsⁱ	LIMS1
HGNCⁱ	HGNC:6616 LIMS1
HPAⁱ	HPA058455 HPA061230
MIMⁱ	602567 gene
neXtProtⁱ	NX_P48059
OpenTargetsⁱ	ENSG00000169756
PharmGKBⁱ	PA30389
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	KOG2272 Eukaryota ENOG410XP46 LUCA
GeneTreeⁱ	ENSGT00760000118910
HOGENOMⁱ	HOG000253950
HOVERGENⁱ	HBG000053
InParanoidⁱ	P48059
OMAⁱ	CRECNER
OrthoDBⁱ	EOG091G08K3
PhylomeDBⁱ	P48059
TreeFamⁱ	TF314113

Enzyme and pathway databases

Reactomeⁱ	R-HSA-446353 Cell-extracellular matrix interactions R-HSA-446388 Regulation of cytoskeletal remodeling and cell spreading by IPP complex components

Reactomeⁱ

R-HSA-446353 Cell-extracellular matrix interactions
R-HSA-446388 Regulation of cytoskeletal remodeling and cell spreading by IPP complex components

Miscellaneous databases

ChiTaRSⁱ	LIMS1 human
EvolutionaryTraceⁱ	P48059
GeneWikiⁱ	LIMS1
GenomeRNAiⁱ	3987
Protein Ontology More...PROⁱ	PR:P48059
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000169756 Expressed in 207 organ(s), highest expression level in endometrium
CleanExⁱ	HS_LIMS1
ExpressionAtlasⁱ	P48059 baseline and differential
Genevisibleⁱ	P48059 HS

Family and domain databases

InterProⁱ	View protein in InterPro IPR017351 PINCH IPR001781 Znf_LIM
PANTHERⁱ	PTHR24210 PTHR24210, 1 hit
Pfamⁱ	View protein in Pfam PF00412 LIM, 5 hits
PIRSFⁱ	PIRSF038003 PINCH, 1 hit
SMARTⁱ	View protein in SMART SM00132 LIM, 5 hits
PROSITEⁱ	View protein in PROSITE PS00478 LIM_DOMAIN_1, 4 hits PS50023 LIM_DOMAIN_2, 5 hits
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	LIMS1_HUMAN
Accessionⁱ	P48059Primary (citable) accession number: P48059 Secondary accession number(s): B2RAJ4 , B7Z483, B7Z7R3, B7Z907, Q53TE0, Q9BS44
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	February 1, 1996
	Last sequence update:	January 23, 2007
	Last modified:	September 12, 2018
	This is version 188 of the entry and version 4 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

Human chromosome 2
Human chromosome 2: entries, gene names and cross-references to MIM
PDB cross-references
Index of Protein Data Bank (PDB) cross-references
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

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UniProtKB - P48059 (LIMS1_HUMAN)

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LIM and senescent cell antigen-like-containing domain protein 1

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<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

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GO - Biological processi

Enzyme and pathway databases

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<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

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Amino acid modifications

Keywords - PTMi

Proteomic databases

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<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

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Secondary structure

3D structure databases

Miscellaneous databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

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Keywords - Domaini

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Keywords - Coding sequence diversityi

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

GO - Molecular functionⁱ

Structureⁱ

Family & Domainsⁱ

Keywords - Domainⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ