Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Melatonin receptor type 1A

Gene

MTNR1A

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

High affinity receptor for melatonin. Likely to mediate the reproductive and circadian actions of melatonin. The activity of this receptor is mediated by pertussis toxin sensitive G proteins that inhibit adenylate cyclase activity.

GO - Molecular functioni

  • hormone binding Source: BHF-UCL
  • melatonin receptor activity Source: BHF-UCL
  • organic cyclic compound binding Source: BHF-UCL

GO - Biological processi

Keywordsi

Molecular functionG-protein coupled receptor, Receptor, Transducer

Enzyme and pathway databases

ReactomeiR-HSA-373076 Class A/1 (Rhodopsin-like receptors)
R-HSA-418594 G alpha (i) signalling events
SignaLinkiP48039

Protein family/group databases

TCDBi9.A.14.1.3 the g-protein-coupled receptor (gpcr) family

Names & Taxonomyi

Protein namesi
Recommended name:
Melatonin receptor type 1A
Short name:
Mel-1A-R
Short name:
Mel1a receptor
Gene namesi
Name:MTNR1A
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 4

Organism-specific databases

EuPathDBiHostDB:ENSG00000168412.6
HGNCiHGNC:7463 MTNR1A
MIMi600665 gene
neXtProtiNX_P48039

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 29ExtracellularSequence analysisAdd BLAST29
Transmembranei30 – 50Helical; Name=1Sequence analysisAdd BLAST21
Topological domaini51 – 63CytoplasmicSequence analysisAdd BLAST13
Transmembranei64 – 84Helical; Name=2Sequence analysisAdd BLAST21
Topological domaini85 – 102ExtracellularSequence analysisAdd BLAST18
Transmembranei103 – 123Helical; Name=3Sequence analysisAdd BLAST21
Topological domaini124 – 142CytoplasmicSequence analysisAdd BLAST19
Transmembranei143 – 163Helical; Name=4Sequence analysisAdd BLAST21
Topological domaini164 – 187ExtracellularSequence analysisAdd BLAST24
Transmembranei188 – 208Helical; Name=5Sequence analysisAdd BLAST21
Topological domaini209 – 240CytoplasmicSequence analysisAdd BLAST32
Transmembranei241 – 261Helical; Name=6Sequence analysisAdd BLAST21
Topological domaini262 – 274ExtracellularSequence analysisAdd BLAST13
Transmembranei275 – 295Helical; Name=7Sequence analysisAdd BLAST21
Topological domaini296 – 350CytoplasmicSequence analysisAdd BLAST55

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi4543
OpenTargetsiENSG00000168412
PharmGKBiPA31267

Chemistry databases

ChEMBLiCHEMBL1945
DrugBankiDB06594 Agomelatine
DB01065 Melatonin
DB00980 Ramelteon
DB09071 Tasimelteon
DB05359 VEC-162
GuidetoPHARMACOLOGYi287

Polymorphism and mutation databases

BioMutaiMTNR1A
DMDMi1346544

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000698621 – 350Melatonin receptor type 1AAdd BLAST350

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi4N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi10N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi100 ↔ 177PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiP48039
PRIDEiP48039
ProteomicsDBi55836

PTM databases

iPTMnetiP48039

Expressioni

Tissue specificityi

Expressed in hypophyseal pars tuberalis and hypothalamic suprachiasmatic nuclei (SCN). Hippocampus.

Gene expression databases

BgeeiENSG00000168412 Expressed in 18 organ(s), highest expression level in cerebellum
CleanExiHS_MTNR1A
GenevisibleiP48039 HS

Interactioni

Binary interactionsi

Protein-protein interaction databases

BioGridi110639, 219 interactors
CORUMiP48039
ELMiP48039
IntActiP48039, 222 interactors
MINTiP48039
STRINGi9606.ENSP00000302811

Chemistry databases

BindingDBiP48039

Structurei

3D structure databases

ProteinModelPortaliP48039
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IHFY Eukaryota
ENOG4111ZZV LUCA
GeneTreeiENSGT00440000033318
HOGENOMiHOG000037953
HOVERGENiHBG052528
InParanoidiP48039
KOiK04285
OMAiHDVRNFV
OrthoDBiEOG091G0GO0
PhylomeDBiP48039
TreeFamiTF331693

Family and domain databases

InterProiView protein in InterPro
IPR000276 GPCR_Rhodpsn
IPR017452 GPCR_Rhodpsn_7TM
IPR002278 Mel_1A/1B_rcpt
IPR027459 Mel_rcpt_1
IPR000025 Melatonin_rcpt
PANTHERiPTHR43962 PTHR43962, 1 hit
PfamiView protein in Pfam
PF00001 7tm_1, 1 hit
PRINTSiPR00237 GPCRRHODOPSN
PR01149 MELATONIN1AR
PR00857 MELATONINR
SMARTiView protein in SMART
SM01381 7TM_GPCR_Srsx, 1 hit
PROSITEiView protein in PROSITE
PS00237 G_PROTEIN_RECEP_F1_1, 1 hit
PS50262 G_PROTEIN_RECEP_F1_2, 1 hit

Sequencei

Sequence statusi: Complete.

P48039-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MQGNGSALPN ASQPVLRGDG ARPSWLASAL ACVLIFTIVV DILGNLLVIL
60 70 80 90 100
SVYRNKKLRN AGNIFVVSLA VADLVVAIYP YPLVLMSIFN NGWNLGYLHC
110 120 130 140 150
QVSGFLMGLS VIGSIFNITG IAINRYCYIC HSLKYDKLYS SKNSLCYVLL
160 170 180 190 200
IWLLTLAAVL PNLRAGTLQY DPRIYSCTFA QSVSSAYTIA VVVFHFLVPM
210 220 230 240 250
IIVIFCYLRI WILVLQVRQR VKPDRKPKLK PQDFRNFVTM FVVFVLFAIC
260 270 280 290 300
WAPLNFIGLA VASDPASMVP RIPEWLFVAS YYMAYFNSCL NAIIYGLLNQ
310 320 330 340 350
NFRKEYRRII VSLCTARVFF VDSSNDVADR VKWKPSPLMT NNNVVKVDSV
Length:350
Mass (Da):39,375
Last modified:February 1, 1996 - v1
Checksum:iDF7C67111D2386ED
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_00926054R → W Exhibits significantly reduced B(max) and slightly enhanced affinity. 1 PublicationCorresponds to variant dbSNP:rs1800885Ensembl.1
Natural variantiVAR_009261157A → V Similar binding characteristics compared to wild-type. 1 PublicationCorresponds to variant dbSNP:rs1800884Ensembl.1
Natural variantiVAR_049420212I → T. Corresponds to variant dbSNP:rs7654853Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U14108 mRNA Translation: AAB17720.1
AB029933 Genomic DNA Translation: BAA85303.1
EU432127 mRNA Translation: ABY87926.1
BC074946 mRNA Translation: AAH74946.1
BC074947 mRNA Translation: AAH74947.1
BC126297 mRNA Translation: AAI26298.1
BC126299 mRNA Translation: AAI26300.1
CCDSiCCDS3848.1
PIRiI38848
RefSeqiNP_005949.1, NM_005958.4
UniGeneiHs.243467

Genome annotation databases

EnsembliENST00000307161; ENSP00000302811; ENSG00000168412
GeneIDi4543
KEGGihsa:4543
UCSCiuc003izd.2 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Cross-referencesi

Web resourcesi

Wikipedia

Melatonin receptor entry

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U14108 mRNA Translation: AAB17720.1
AB029933 Genomic DNA Translation: BAA85303.1
EU432127 mRNA Translation: ABY87926.1
BC074946 mRNA Translation: AAH74946.1
BC074947 mRNA Translation: AAH74947.1
BC126297 mRNA Translation: AAI26298.1
BC126299 mRNA Translation: AAI26300.1
CCDSiCCDS3848.1
PIRiI38848
RefSeqiNP_005949.1, NM_005958.4
UniGeneiHs.243467

3D structure databases

ProteinModelPortaliP48039
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi110639, 219 interactors
CORUMiP48039
ELMiP48039
IntActiP48039, 222 interactors
MINTiP48039
STRINGi9606.ENSP00000302811

Chemistry databases

BindingDBiP48039
ChEMBLiCHEMBL1945
DrugBankiDB06594 Agomelatine
DB01065 Melatonin
DB00980 Ramelteon
DB09071 Tasimelteon
DB05359 VEC-162
GuidetoPHARMACOLOGYi287

Protein family/group databases

TCDBi9.A.14.1.3 the g-protein-coupled receptor (gpcr) family
GPCRDBiSearch...

PTM databases

iPTMnetiP48039

Polymorphism and mutation databases

BioMutaiMTNR1A
DMDMi1346544

Proteomic databases

PaxDbiP48039
PRIDEiP48039
ProteomicsDBi55836

Protocols and materials databases

DNASUi4543
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000307161; ENSP00000302811; ENSG00000168412
GeneIDi4543
KEGGihsa:4543
UCSCiuc003izd.2 human

Organism-specific databases

CTDi4543
DisGeNETi4543
EuPathDBiHostDB:ENSG00000168412.6
GeneCardsiMTNR1A
HGNCiHGNC:7463 MTNR1A
MIMi600665 gene
neXtProtiNX_P48039
OpenTargetsiENSG00000168412
PharmGKBiPA31267
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IHFY Eukaryota
ENOG4111ZZV LUCA
GeneTreeiENSGT00440000033318
HOGENOMiHOG000037953
HOVERGENiHBG052528
InParanoidiP48039
KOiK04285
OMAiHDVRNFV
OrthoDBiEOG091G0GO0
PhylomeDBiP48039
TreeFamiTF331693

Enzyme and pathway databases

ReactomeiR-HSA-373076 Class A/1 (Rhodopsin-like receptors)
R-HSA-418594 G alpha (i) signalling events
SignaLinkiP48039

Miscellaneous databases

GeneWikiiMelatonin_receptor_1A
GenomeRNAii4543
PROiPR:P48039
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000168412 Expressed in 18 organ(s), highest expression level in cerebellum
CleanExiHS_MTNR1A
GenevisibleiP48039 HS

Family and domain databases

InterProiView protein in InterPro
IPR000276 GPCR_Rhodpsn
IPR017452 GPCR_Rhodpsn_7TM
IPR002278 Mel_1A/1B_rcpt
IPR027459 Mel_rcpt_1
IPR000025 Melatonin_rcpt
PANTHERiPTHR43962 PTHR43962, 1 hit
PfamiView protein in Pfam
PF00001 7tm_1, 1 hit
PRINTSiPR00237 GPCRRHODOPSN
PR01149 MELATONIN1AR
PR00857 MELATONINR
SMARTiView protein in SMART
SM01381 7TM_GPCR_Srsx, 1 hit
PROSITEiView protein in PROSITE
PS00237 G_PROTEIN_RECEP_F1_1, 1 hit
PS50262 G_PROTEIN_RECEP_F1_2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiMTR1A_HUMAN
AccessioniPrimary (citable) accession number: P48039
Secondary accession number(s): A0AVC5, B0M0L2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1996
Last sequence update: February 1, 1996
Last modified: September 12, 2018
This is version 160 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 4
    Human chromosome 4: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  4. SIMILARITY comments
    Index of protein domains and families
  5. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  6. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again