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Protein

Annexin A5

Gene

Anxa5

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

This protein is an anticoagulant protein that acts as an indirect inhibitor of the thromboplastin-specific complex, which is involved in the blood coagulation cascade.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processBlood coagulation, Hemostasis
LigandCalcium, Calcium/phospholipid-binding

Enzyme and pathway databases

ReactomeiR-MMU-114608 Platelet degranulation

Names & Taxonomyi

Protein namesi
Recommended name:
Annexin A5
Alternative name(s):
Anchorin CII
Annexin V
Annexin-5
Calphobindin I
Short name:
CBP-I
Endonexin II
Lipocortin V
Placental anticoagulant protein 4
Short name:
PP4
Placental anticoagulant protein I
Short name:
PAP-I
Thromboplastin inhibitor
Vascular anticoagulant-alpha
Short name:
VAC-alpha
Gene namesi
Name:Anxa5
Synonyms:Anx5
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 3

Organism-specific databases

MGIiMGI:106008 Anxa5

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00000674882 – 319Annexin A5Add BLAST318

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylalanineBy similarity1
Cross-linki27Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO1); alternateBy similarity
Cross-linki27Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2); alternateBy similarity
Modified residuei35PhosphoserineCombined sources1
Modified residuei68N6-acetyllysineCombined sources1
Modified residuei74N6-acetyllysineBy similarity1
Modified residuei77N6-acetyllysineBy similarity1
Modified residuei95N6-acetyllysineCombined sources1
Modified residuei99N6-acetyllysineBy similarity1
Modified residuei288N6-succinyllysineCombined sources1

Post-translational modificationi

S-nitrosylation is induced by interferon-gamma and oxidatively-modified low-densitity lipoprotein (LDL(ox)) possibly implicating the iNOS-S100A8/9 transnitrosylase complex.By similarity

Keywords - PTMi

Acetylation, Isopeptide bond, Phosphoprotein, S-nitrosylation, Ubl conjugation

Proteomic databases

EPDiP48036
MaxQBiP48036
PaxDbiP48036
PeptideAtlasiP48036
PRIDEiP48036
TopDownProteomicsiP48036

2D gel databases

COMPLUYEAST-2DPAGEiP48036
REPRODUCTION-2DPAGEiIPI00317309
SWISS-2DPAGEiP48036

PTM databases

iPTMnetiP48036
PhosphoSitePlusiP48036
SwissPalmiP48036

Expressioni

Gene expression databases

BgeeiENSMUSG00000027712 Expressed in 316 organ(s), highest expression level in lung
CleanExiMM_ANXA5
ExpressionAtlasiP48036 baseline and differential
GenevisibleiP48036 MM

Interactioni

Subunit structurei

Monomer. Binds ATRX and EIF5B (By similarity).By similarity

Binary interactionsi

WithEntry#Exp.IntActNotes
Kcnma1Q084604EBI-1184119,EBI-1633915

GO - Molecular functioni

Protein-protein interaction databases

BioGridi198111, 4 interactors
IntActiP48036, 7 interactors
MINTiP48036
STRINGi10090.ENSMUSP00000029266

Structurei

3D structure databases

ProteinModelPortaliP48036
SMRiP48036
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati22 – 82Annexin 1Add BLAST61
Repeati94 – 154Annexin 2Add BLAST61
Repeati178 – 238Annexin 3Add BLAST61
Repeati253 – 313Annexin 4Add BLAST61

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi312 – 318[IL]-x-C-x-x-[DE] motifBy similarity7

Domaini

A pair of annexin repeats may form one binding site for calcium and phospholipid.
The [IL]-x-C-x-x-[DE] motif is a proposed target motif for cysteine S-nitrosylation mediated by the iNOS-S100A8/A9 transnitrosylase complex.By similarity

Sequence similaritiesi

Belongs to the annexin family.Curated

Keywords - Domaini

Annexin, Repeat

Phylogenomic databases

eggNOGiKOG0819 Eukaryota
ENOG410XPUN LUCA
GeneTreeiENSGT00760000118972
HOGENOMiHOG000158803
HOVERGENiHBG061815
InParanoidiP48036
KOiK16646
OMAiFAETLYY
OrthoDBiEOG091G0H6H
PhylomeDBiP48036
TreeFamiTF105452

Family and domain databases

Gene3Di1.10.220.10, 4 hits
InterProiView protein in InterPro
IPR001464 Annexin
IPR018502 Annexin_repeat
IPR018252 Annexin_repeat_CS
IPR037104 Annexin_sf
IPR002392 ANX5
PANTHERiPTHR10502:SF26 PTHR10502:SF26, 1 hit
PfamiView protein in Pfam
PF00191 Annexin, 4 hits
PRINTSiPR00196 ANNEXIN
PR00201 ANNEXINV
SMARTiView protein in SMART
SM00335 ANX, 4 hits
PROSITEiView protein in PROSITE
PS00223 ANNEXIN, 4 hits

Sequence (1+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

P48036-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MATRGTVTDF PGFDGRADAE VLRKAMKGLG TDEDSILNLL TSRSNAQRQE
60 70 80 90 100
IAQEFKTLFG RDLVDDLKSE LTGKFEKLIV AMMKPSRLYD AYELKHALKG
110 120 130 140 150
AGTDEKVLTE IIASRTPEEL SAIKQVYEEE YGSNLEDDVV GDTSGYYQRM
160 170 180 190 200
LVVLLQANRD PDTAIDDAQV ELDAQALFQA GELKWGTDEE KFITIFGTRS
210 220 230 240 250
VSHLRRVFDK YMTISGFQIE ETIDRETSGN LEQLLLAVVK SIRSIPAYLA
260 270 280 290 300
ETLYYAMKGA GTDDHTLIRV VVSRSEIDLF NIRKEFRKNF ATSLYSMIKG
310
DTSGDYKKAL LLLCGGEDD
Length:319
Mass (Da):35,752
Last modified:February 1, 1996 - v1
Checksum:i55055BAF2E1C36B7
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A0G2JGQ0A0A0G2JGQ0_MOUSE
Annexin A5
Anxa5
137Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti142D → G in BAE28107 (PubMed:16141072).Curated1
Sequence conflicti157A → G in AAH03716 (PubMed:15489334).Curated1
Sequence conflicti284K → N in BAE31952 (PubMed:16141072).Curated1
Sequence conflicti300G → S in BAE32026 (PubMed:16141072).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U29396 mRNA Translation: AAC52530.1
D63423 mRNA Translation: BAA09728.1
AJ230108
, AJ230110, AJ230111, AJ230114, AJ230116, AJ230118, AJ230119, AJ230120, AJ230121, AJ230122, AJ230123, AJ230124 Genomic DNA Translation: CAA13092.1
AK147740 mRNA Translation: BAE28107.1
AK152185 mRNA Translation: BAE31016.1
AK153388 mRNA Translation: BAE31952.1
AK153476 mRNA Translation: BAE32026.1
BC003716 mRNA Translation: AAH03716.1
CCDSiCCDS38416.1
RefSeqiNP_033803.1, NM_009673.2
UniGeneiMm.1620

Genome annotation databases

EnsembliENSMUST00000029266; ENSMUSP00000029266; ENSMUSG00000027712
GeneIDi11747
KEGGimmu:11747
UCSCiuc008ozj.2 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U29396 mRNA Translation: AAC52530.1
D63423 mRNA Translation: BAA09728.1
AJ230108
, AJ230110, AJ230111, AJ230114, AJ230116, AJ230118, AJ230119, AJ230120, AJ230121, AJ230122, AJ230123, AJ230124 Genomic DNA Translation: CAA13092.1
AK147740 mRNA Translation: BAE28107.1
AK152185 mRNA Translation: BAE31016.1
AK153388 mRNA Translation: BAE31952.1
AK153476 mRNA Translation: BAE32026.1
BC003716 mRNA Translation: AAH03716.1
CCDSiCCDS38416.1
RefSeqiNP_033803.1, NM_009673.2
UniGeneiMm.1620

3D structure databases

ProteinModelPortaliP48036
SMRiP48036
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi198111, 4 interactors
IntActiP48036, 7 interactors
MINTiP48036
STRINGi10090.ENSMUSP00000029266

PTM databases

iPTMnetiP48036
PhosphoSitePlusiP48036
SwissPalmiP48036

2D gel databases

COMPLUYEAST-2DPAGEiP48036
REPRODUCTION-2DPAGEiIPI00317309
SWISS-2DPAGEiP48036

Proteomic databases

EPDiP48036
MaxQBiP48036
PaxDbiP48036
PeptideAtlasiP48036
PRIDEiP48036
TopDownProteomicsiP48036

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000029266; ENSMUSP00000029266; ENSMUSG00000027712
GeneIDi11747
KEGGimmu:11747
UCSCiuc008ozj.2 mouse

Organism-specific databases

CTDi308
MGIiMGI:106008 Anxa5

Phylogenomic databases

eggNOGiKOG0819 Eukaryota
ENOG410XPUN LUCA
GeneTreeiENSGT00760000118972
HOGENOMiHOG000158803
HOVERGENiHBG061815
InParanoidiP48036
KOiK16646
OMAiFAETLYY
OrthoDBiEOG091G0H6H
PhylomeDBiP48036
TreeFamiTF105452

Enzyme and pathway databases

ReactomeiR-MMU-114608 Platelet degranulation

Miscellaneous databases

ChiTaRSiAnxa5 mouse
PROiPR:P48036
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000027712 Expressed in 316 organ(s), highest expression level in lung
CleanExiMM_ANXA5
ExpressionAtlasiP48036 baseline and differential
GenevisibleiP48036 MM

Family and domain databases

Gene3Di1.10.220.10, 4 hits
InterProiView protein in InterPro
IPR001464 Annexin
IPR018502 Annexin_repeat
IPR018252 Annexin_repeat_CS
IPR037104 Annexin_sf
IPR002392 ANX5
PANTHERiPTHR10502:SF26 PTHR10502:SF26, 1 hit
PfamiView protein in Pfam
PF00191 Annexin, 4 hits
PRINTSiPR00196 ANNEXIN
PR00201 ANNEXINV
SMARTiView protein in SMART
SM00335 ANX, 4 hits
PROSITEiView protein in PROSITE
PS00223 ANNEXIN, 4 hits
ProtoNetiSearch...

Entry informationi

Entry nameiANXA5_MOUSE
AccessioniPrimary (citable) accession number: P48036
Secondary accession number(s): Q3U5Q1
, Q3U5X4, Q3U8K1, Q3UGV0, Q99LA1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1996
Last sequence update: February 1, 1996
Last modified: September 12, 2018
This is version 149 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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Main funding by: National Institutes of Health

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