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Protein

Homeobox protein GBX-2

Gene

Gbx2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

May act as a transcription factor for cell pluripotency and differentiation in the embryo.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi247 – 306HomeoboxPROSITE-ProRule annotationAdd BLAST60

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDNA-binding
Biological processTranscription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
Homeobox protein GBX-2
Alternative name(s):
Gastrulation and brain-specific homeobox protein 2
Stimulated by retinoic acid gene 7 protein
Gene namesi
Name:Gbx2
Synonyms:Mmoxa, Stra7
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 1

Organism-specific databases

MGIiMGI:95668 Gbx2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000488811 – 348Homeobox protein GBX-2Add BLAST348

Proteomic databases

PaxDbiP48031
PRIDEiP48031

PTM databases

iPTMnetiP48031
PhosphoSitePlusiP48031

Expressioni

Tissue specificityi

Expressed in adult brain, spleen and female genital tract. No expression in heart, liver, lung, kidney, or testis.

Developmental stagei

Expressed during gastrulation in the three primitive germ layers and in the pharyngeal arches. In later stages, expressed in the developing nervous system, midbrain/ hindbrain boundary, cerebellum anlage, certain rhombomeres, regions of the spinal cord, and in the developing dorsal thalamus and corpus striatum.

Gene expression databases

BgeeiENSMUSG00000034486 Expressed in 130 organ(s), highest expression level in embryo
CleanExiMM_GBX2
GenevisibleiP48031 MM

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000048508

Structurei

3D structure databases

ProteinModelPortaliP48031
SMRiP48031
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi56 – 63Poly-Pro8
Compositional biasi121 – 124Poly-Ala4
Compositional biasi248 – 251Poly-Arg4

Keywords - Domaini

Homeobox

Phylogenomic databases

eggNOGiKOG0489 Eukaryota
ENOG410ZTBY LUCA
GeneTreeiENSGT00910000144024
HOGENOMiHOG000060099
HOVERGENiHBG003967
InParanoidiP48031
KOiK09321
OMAiFMPYRSV
OrthoDBiEOG091G0SCQ
PhylomeDBiP48031
TreeFamiTF351530

Family and domain databases

CDDicd00086 homeodomain, 1 hit
InterProiView protein in InterPro
IPR031250 GBX-2
IPR009057 Homeobox-like_sf
IPR017970 Homeobox_CS
IPR001356 Homeobox_dom
IPR020479 Homeobox_metazoa
PANTHERiPTHR24334:SF3 PTHR24334:SF3, 1 hit
PfamiView protein in Pfam
PF00046 Homeobox, 1 hit
PRINTSiPR00024 HOMEOBOX
SMARTiView protein in SMART
SM00389 HOX, 1 hit
SUPFAMiSSF46689 SSF46689, 1 hit
PROSITEiView protein in PROSITE
PS00027 HOMEOBOX_1, 1 hit
PS50071 HOMEOBOX_2, 1 hit

Sequencei

Sequence statusi: Complete.

P48031-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSAAFPPSLM MMQRPLGSST AFSIDSLIGS PPQPSPGHFV YTGYPMFMPY
60 70 80 90 100
RPVVLPPPPP PPPALPQAAL QPALPPAHPH HQIPSLPTGF CSSLAQGMAL
110 120 130 140 150
TSTLMATLPG GFSASPQHQE AAAARKFAPQ PLPGGGNFDK AEALQADAED
160 170 180 190 200
GKAFLAKEGS LLAFSAAEAV QASLVGAVRG QGKDESKVED DPKGKEESFS
210 220 230 240 250
LESDVDYSSD DNLPGQTAHK EEDPGHALEE TPQSGGAAGS TTSTGKNRRR
260 270 280 290 300
RTAFTSEQLL ELEKEFHCKK YLSLTERSQI AHALKLSEVQ VKIWFQNRRA
310 320 330 340
KWKRVKAGNA NSKTGEPSRN PKIVVPIPVH VSRFAIRSQH QQLEQARP
Length:348
Mass (Da):37,359
Last modified:February 1, 1996 - v1
Checksum:iCF8594653EA8295B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z48800 mRNA Translation: CAA88737.1
U74300 Genomic DNA Translation: AAC61877.1
BC116965 mRNA Translation: AAI16966.1
BC120492 mRNA Translation: AAI20493.1
L39770 mRNA Translation: AAA65185.1
M81661 Genomic DNA Translation: AAA63314.1
CCDSiCCDS15150.1
PIRiS52720
RefSeqiNP_034392.1, NM_010262.3
UniGeneiMm.204730

Genome annotation databases

EnsembliENSMUST00000036954; ENSMUSP00000048508; ENSMUSG00000034486
GeneIDi14472
KEGGimmu:14472
UCSCiuc007bzb.1 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z48800 mRNA Translation: CAA88737.1
U74300 Genomic DNA Translation: AAC61877.1
BC116965 mRNA Translation: AAI16966.1
BC120492 mRNA Translation: AAI20493.1
L39770 mRNA Translation: AAA65185.1
M81661 Genomic DNA Translation: AAA63314.1
CCDSiCCDS15150.1
PIRiS52720
RefSeqiNP_034392.1, NM_010262.3
UniGeneiMm.204730

3D structure databases

ProteinModelPortaliP48031
SMRiP48031
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000048508

PTM databases

iPTMnetiP48031
PhosphoSitePlusiP48031

Proteomic databases

PaxDbiP48031
PRIDEiP48031

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000036954; ENSMUSP00000048508; ENSMUSG00000034486
GeneIDi14472
KEGGimmu:14472
UCSCiuc007bzb.1 mouse

Organism-specific databases

CTDi2637
MGIiMGI:95668 Gbx2

Phylogenomic databases

eggNOGiKOG0489 Eukaryota
ENOG410ZTBY LUCA
GeneTreeiENSGT00910000144024
HOGENOMiHOG000060099
HOVERGENiHBG003967
InParanoidiP48031
KOiK09321
OMAiFMPYRSV
OrthoDBiEOG091G0SCQ
PhylomeDBiP48031
TreeFamiTF351530

Miscellaneous databases

PROiPR:P48031
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000034486 Expressed in 130 organ(s), highest expression level in embryo
CleanExiMM_GBX2
GenevisibleiP48031 MM

Family and domain databases

CDDicd00086 homeodomain, 1 hit
InterProiView protein in InterPro
IPR031250 GBX-2
IPR009057 Homeobox-like_sf
IPR017970 Homeobox_CS
IPR001356 Homeobox_dom
IPR020479 Homeobox_metazoa
PANTHERiPTHR24334:SF3 PTHR24334:SF3, 1 hit
PfamiView protein in Pfam
PF00046 Homeobox, 1 hit
PRINTSiPR00024 HOMEOBOX
SMARTiView protein in SMART
SM00389 HOX, 1 hit
SUPFAMiSSF46689 SSF46689, 1 hit
PROSITEiView protein in PROSITE
PS00027 HOMEOBOX_1, 1 hit
PS50071 HOMEOBOX_2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiGBX2_MOUSE
AccessioniPrimary (citable) accession number: P48031
Secondary accession number(s): Q14A66
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1996
Last sequence update: February 1, 1996
Last modified: November 7, 2018
This is version 145 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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