FASLG

Functionⁱ

Cytokine that binds to TNFRSF6/FAS, a receptor that transduces the apoptotic signal into cells (PubMed:26334989, PubMed:9228058). Involved in cytotoxic T-cell-mediated apoptosis, natural killer cell-mediated apoptosis and in T-cell development (PubMed:9228058, PubMed:7528780, PubMed:9427603). Initiates fratricidal/suicidal activation-induced cell death (AICD) in antigen-activated T-cells contributing to the termination of immune responses (By similarity). TNFRSF6/FAS-mediated apoptosis has also a role in the induction of peripheral tolerance (By similarity). Binds to TNFRSF6B/DcR3, a decoy receptor that blocks apoptosis (PubMed:27806260).By similarity5 Publications

Tumor necrosis factor ligand superfamily member 6, soluble form: Induces FAS-mediated activation of NF-kappa-B, initiating non-apoptotic signaling pathways (By similarity). Can induce apoptosis but does not appear to be essential for this process (PubMed:27806260).By similarity1 Publication

FasL intracellular domain: Cytoplasmic form induces gene transcription inhibition.1 Publication

GO - Molecular functionⁱ

cytokine activity Source: UniProtKB-KW
death receptor binding Source: Ensembl
signaling receptor binding
Source: ProtInc
Traceable author statementⁱ
- 7826947
tumor necrosis factor receptor binding Source: Ensembl

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

activation of cysteine-type endopeptidase activity involved in apoptotic process
Source: BHF-UCL
Inferred from mutant phenotypeⁱ
- 18293083
apoptotic process
Source: ProtInc
Traceable author statementⁱ
- 8787672
apoptotic signaling pathway
Source: BHF-UCL
Inferred from direct assayⁱ
- 11101870
cell-cell signaling
Source: ProtInc
Traceable author statementⁱ
- 7826947
cellular chloride ion homeostasis Source: Ensembl
cytokine-mediated signaling pathway Source: Reactome
endosomal lumen acidification Source: Ensembl
extrinsic apoptotic signaling pathway
Source: UniProtKB
Inferred from direct assayⁱ
- 22891283
extrinsic apoptotic signaling pathway via death domain receptors
Source: BHF-UCL
Inferred from direct assayⁱ
- 18835034
immune response Source: InterPro
inflammatory cell apoptotic process Source: Ensembl
necroptotic process
Source: BHF-UCL
Inferred from direct assayⁱ
- 11101870
necroptotic signaling pathway
Source: BHF-UCL
Inferred from direct assayⁱ
- 11101870
negative regulation of angiogenesis
Source: BHF-UCL
Inferred from direct assayⁱ
- 18835034
negative regulation of extrinsic apoptotic signaling pathway via death domain receptors Source: Reactome
negative regulation of transcription by RNA polymerase II
Source: UniProtKB
Inferred from direct assayⁱ
- 17557115
positive regulation of apoptotic process
Source: UniProtKB
Inferred from direct assayⁱ
- 21625644
positive regulation of cell proliferation Source: Ensembl
positive regulation of endothelial cell apoptotic process
Source: BHF-UCL
Inferred from direct assayⁱ
- 18835034
positive regulation of epidermal growth factor receptor signaling pathway Source: Ensembl
positive regulation of I-kappaB kinase/NF-kappaB signaling
Source: UniProtKB
Inferred from expression patternⁱ
- 12761501
positive regulation of neuron apoptotic process Source: Ensembl
regulation of extrinsic apoptotic signaling pathway via death domain receptors Source: Reactome
release of sequestered calcium ion into cytosol by endoplasmic reticulum
Source: MGI
Inferred from direct assayⁱ
- 26582200
response to growth factor Source: Ensembl
response to lipopolysaccharide Source: Ensembl
retinal cell programmed cell death Source: Ensembl
signal transduction
Source: ProtInc
Traceable author statementⁱ
- 7826947
T cell apoptotic process
Source: UniProtKB
Inferred from direct assayⁱ
- 17076679
transcription, DNA-templated Source: UniProtKB-KW

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Cytokine, Repressor
Biological process	Apoptosis, Transcription, Transcription regulation

Enzyme and pathway databases

Reactomeⁱ	R-HSA-140534 via Death Receptors in the presence of ligand R-HSA-3371378 Regulation by c-FLIP R-HSA-5213460 RIPK1-mediated regulated necrosis R-HSA-5218900 CASP8 activity is inhibited R-HSA-6785807 Interleukin-4 and Interleukin-13 signaling R-HSA-69416 Dimerization of procaspase-8 R-HSA-75157 FasL/ CD95L signaling R-HSA-8862803 Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models
SIGNORⁱ	P48023

Reactomeⁱ

R-HSA-140534 via Death Receptors in the presence of ligand
R-HSA-3371378 Regulation by c-FLIP
R-HSA-5213460 RIPK1-mediated regulated necrosis
R-HSA-5218900 CASP8 activity is inhibited
R-HSA-6785807 Interleukin-4 and Interleukin-13 signaling
R-HSA-69416 Dimerization of procaspase-8
R-HSA-75157 FasL/ CD95L signaling
R-HSA-8862803 Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models

SIGNORⁱ

P48023

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Tumor necrosis factor ligand superfamily member 6 Alternative name(s): Apoptosis antigen ligand Short name: APTL CD95 ligand Short name: CD95-L Fas antigen ligand Short name: Fas ligand Short name: FasL CD_antigen: CD178 Cleaved into the following 4 chains: Tumor necrosis factor ligand superfamily member 6, membrane form Tumor necrosis factor ligand superfamily member 6, soluble form Alternative name(s): Receptor-binding FasL ectodomain Soluble Fas ligand Short name: sFasL ADAM10-processed FasL form Short name: APL FasL intracellular domain Short name: FasL ICD Alternative name(s): SPPL2A-processed FasL form Short name: SPA
Gene namesⁱ	Name:FASLG Synonyms:APT1LG1, CD95L, FASL, TNFSF6
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 1

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000117560.7
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:11936 FASLG
MIMⁱ	134638 gene
neXtProtⁱ	NX_P48023

Topology

Feature key	Position(s)	DescriptionActions	Length
Topological domainⁱ	1 – 80	CytoplasmicSequence analysisAdd BLAST	80
Transmembraneⁱ	81 – 102	Helical; Signal-anchor for type II membrane proteinSequence analysisAdd BLAST	22
Topological domainⁱ	103 – 281	ExtracellularSequence analysisAdd BLAST	179

Keywords - Cellular componentⁱ

Cell membrane, Cytoplasmic vesicle, Lysosome, Membrane, Nucleus, Secreted

Pathology & Biotechⁱ

Involvement in diseaseⁱ

Autoimmune lymphoproliferative syndrome 1B (ALPS1B)2 Publications

The disease is caused by mutations affecting the gene represented in this entry.

Disease descriptionA disorder of apoptosis that manifests in early childhood and results in the accumulation of autoreactive lymphocytes. It is characterized by non-malignant lymphadenopathy with hepatosplenomegaly, and autoimmune hemolytic anemia, thrombocytopenia and neutropenia.

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Natural variantⁱVAR_075568	202	C → S in ALPS1B; significant reduction in cytotoxicity and apoptosis and inhibition of the shedding of the soluble form. 1 Publication		1

Mutagenesis

Feature key	Position(s)	DescriptionActions	Length
Mutagenesisⁱ	206	P → D, F or R: Lowers binding to TNFRSF6 and reduces cytotoxicity more than 100-fold. 1 Publication	1
Mutagenesisⁱ	218	Y → F or R: Lowers binding to TNFRSF6 and abolishes cytotoxicity. 1 Publication	1
Mutagenesisⁱ	275	F → L: Abolishes binding to TNRFSF6 and cytotoxicity. 1 Publication	1

Organism-specific databases

DisGeNET More...DisGeNETⁱ	356
GeneReviewsⁱ	FASLG
MalaCards human disease database More...MalaCardsⁱ	FASLG
MIMⁱ	601859 phenotype
Open Targets More...OpenTargetsⁱ	ENSG00000117560
Orphanetⁱ	3261 Autoimmune lymphoproliferative syndrome
PharmGKBⁱ	PA56

Chemistry databases

ChEMBLⁱ	CHEMBL5714

ChEMBLⁱ

CHEMBL5714

Polymorphism and mutation databases

BioMutaⁱ	FASLG
DMDMⁱ	1345957

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Length
ChainⁱPRO_0000034500	1 – 281	Tumor necrosis factor ligand superfamily member 6, membrane formAdd BLAST	281
ChainⁱPRO_0000417152	1 – 129	ADAM10-processed FasL formAdd BLAST	129
ChainⁱPRO_0000416842	1 – 81	FasL intracellular domainAdd BLAST	81
ChainⁱPRO_0000034501	130 – 281	Tumor necrosis factor ligand superfamily member 6, soluble formAdd BLAST	152

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Glycosylationⁱ	184	N-linked (GlcNAc...) asparagineSequence analysis	1
Disulfide bondⁱ	202 ↔ 233	Combined sources1 Publication
Glycosylationⁱ	250	N-linked (GlcNAc...) asparagineSequence analysis	1
Glycosylationⁱ	260	N-linked (GlcNAc...) asparagineSequence analysis	1

Post-translational modificationⁱ

The soluble form derives from the membrane form by proteolytic processing. The membrane-bound form undergoes two successive intramembrane proteolytic cleavages. The first one is processed by ADAM10 producing an N-terminal fragment, which lacks the receptor-binding extracellular domain. This ADAM10-processed FasL (FasL APL) remnant form is still membrane anchored and further processed by SPPL2A that liberates the FasL intracellular domain (FasL ICD). FasL shedding by ADAM10 is a prerequisite for subsequent intramembrane cleavage by SPPL2A in T-cells.2 Publications

Phosphorylated by FGR on tyrosine residues; this is required for ubiquitination and subsequent internalization.1 Publication

Monoubiquitinated.1 Publication

Sites

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Siteⁱ	81 – 82	Cleavage; by SPPL2ACurated		2
Siteⁱ	129 – 130	Cleavage; by ADAM10Curated		2

Keywords - PTMⁱ

Disulfide bond, Glycoprotein, Ubl conjugation

Proteomic databases

PaxDbⁱ	P48023
PeptideAtlas More...PeptideAtlasⁱ	P48023
PRIDEⁱ	P48023
ProteomicsDBⁱ	55831 55832 [P48023-2]

PTM databases

iPTMnetⁱ	P48023
PhosphoSitePlusⁱ	P48023
SwissPalmⁱ	P48023

Miscellaneous databases

PMAP-CutDBⁱ	P48023

PMAP-CutDBⁱ

P48023

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSG00000117560 Expressed in 60 organ(s), highest expression level in leukocyte
CleanExⁱ	HS_FASLG
ExpressionAtlasⁱ	P48023 baseline and differential
Genevisibleⁱ	P48023 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	HPA054959

HPAⁱ

HPA054959

Interactionⁱ

Subunit structureⁱ

Homotrimer (PubMed:27806260). Interacts with ARHGAP9, BAIAP2L1, BTK, CACNB3, CACNB4, CRK, DLG2, DNMBP, DOCK4, EPS8L3, FGR, FYB1, FYN, HCK, ITK, ITSN2, KALRN, LYN, MACC1, MIA, MPP4, MYO15A, NCF1, NCK1, NCK2, NCKIPSD, OSTF1, PIK3R1, PSTPIP1, RIMBP3C, SAMSN1, SH3GL3, SH3PXD2B, SH3PXD2A, SH3RF2, SKAP2, SNX33, SNX9, SORBS3, SPTA1, SRC, SRGAP1, SRGAP2, SRGAP3, TEC, TJP3 and YES1.Curated3 Publications

Binary interactionsⁱ

With	Entry	#Exp.	IntAct	Notes
Ap2b1	Q9DBG3	2	EBI-495538,EBI-775229	From Mus musculus.
CASP8	Q14790	5	EBI-495538,EBI-78060
FADD	Q13158	4	EBI-495538,EBI-494804
FAS	P25445	4	EBI-495538,EBI-494743
FNBP1	Q96RU3	4	EBI-495538,EBI-1111248
FYN	P06241	2	EBI-495538,EBI-515315
ITK	Q08881	3	EBI-495538,EBI-968552
KRT40	Q6A162	3	EBI-495538,EBI-10171697
NCK1	A0A0S2Z4D7	3	EBI-495538,EBI-16429340
NCK1	P16333-1	4	EBI-495538,EBI-15578122
NCK2	O43639	3	EBI-495538,EBI-713635
NOTCH2NL	Q7Z3S9	3	EBI-495538,EBI-945833
PACSIN1	Q9BY11	4	EBI-495538,EBI-721769
PACSIN2	Q9UNF0	4	EBI-495538,EBI-742503
PACSIN3	Q9UKS6	4	EBI-495538,EBI-77926
PIK3R1	P27986	2	EBI-495538,EBI-79464
PSTPIP1	O43586	5	EBI-495538,EBI-1050964
RGS20	O76081	3	EBI-495538,EBI-1052678
RGS20	O76081-6	5	EBI-495538,EBI-10178530
Snx18	Q91ZR2	4	EBI-495538,EBI-6879954	From Mus musculus.
SNX33	Q8WV41	2	EBI-495538,EBI-2481535
SNX9	Q9Y5X1	2	EBI-495538,EBI-77848
SRGAP2	O75044	2	EBI-495538,EBI-1051034
TRIP10	Q15642	4	EBI-495538,EBI-739936
TRIP6	Q15654	3	EBI-495538,EBI-742327

GO - Molecular functionⁱ

cytokine activity Source: UniProtKB-KW
death receptor binding Source: Ensembl
signaling receptor binding
Source: ProtInc
Traceable author statementⁱ
- 7826947
tumor necrosis factor receptor binding Source: Ensembl

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

BioGridⁱ	106852, 83 interactors
Database of interacting proteins More...DIPⁱ	DIP-2997N
ELMⁱ	P48023
IntActⁱ	P48023, 80 interactors
Molecular INTeraction database More...MINTⁱ	P48023
STRINGⁱ	9606.ENSP00000356694

Structureⁱ

Secondary structure

Legend: HelixTurnBeta strandPDB Structure known for this area

Feature key	Position(s)	DescriptionActions	Length
Helixⁱ	137 – 142	Combined sources	6
Beta strandⁱ	146 – 151	Combined sources	6
Beta strandⁱ	157 – 159	Combined sources	3
Beta strandⁱ	165 – 168	Combined sources	4
Beta strandⁱ	170 – 177	Combined sources	8
Beta strandⁱ	180 – 182	Combined sources	3
Beta strandⁱ	187 – 201	Combined sources	15
Beta strandⁱ	207 – 214	Combined sources	8
Beta strandⁱ	218 – 220	Combined sources	3
Beta strandⁱ	222 – 229	Combined sources	8
Beta strandⁱ	239 – 251	Combined sources	13
Beta strandⁱ	256 – 262	Combined sources	7
Helixⁱ	264 – 266	Combined sources	3
Turnⁱ	271 – 273	Combined sources	3
Beta strandⁱ	274 – 280	Combined sources	7

Show more details

3D structure databases

ProteinModelPortalⁱ	P48023
SMRⁱ	P48023
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Compositional bias

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Compositional biasⁱ	4 – 70	Pro-richAdd BLAST		67
Compositional biasⁱ	45 – 65	Poly-ProAdd BLAST		21

Sequence similaritiesⁱ

Belongs to the tumor necrosis factor family.Curated

Keywords - Domainⁱ

Signal-anchor, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGⁱ	ENOG410IHZF Eukaryota ENOG4112D9R LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00530000062992
HOGENOMⁱ	HOG000290680
HOVERGENⁱ	HBG055128
InParanoidⁱ	P48023
KEGG Orthology (KO) More...KOⁱ	K04389
OMAⁱ	WEDTYGI
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0MFC
PhylomeDBⁱ	P48023
TreeFamⁱ	TF332169

Family and domain databases

Conserved Domains Database More...CDDⁱ	cd00184 TNF, 1 hit
Gene3Dⁱ	2.60.120.40, 1 hit
InterProⁱ	View protein in InterPro IPR028326 FASL IPR006053 TNF IPR021184 TNF_CS IPR006052 TNF_dom IPR008983 Tumour_necrosis_fac-like_dom
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00229 TNF, 1 hit
PRINTSⁱ	PR01681 FASLIGAND PR01234 TNECROSISFCT
SMARTⁱ	View protein in SMART SM00207 TNF, 1 hit
SUPFAMⁱ	SSF49842 SSF49842, 1 hit
PROSITEⁱ	View protein in PROSITE PS00251 TNF_1, 1 hit PS50049 TNF_2, 1 hit

Sequences (2)ⁱ

Sequence statusⁱ: Complete.

Sequence processingⁱ: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsⁱ produced by alternative splicing. Align Add to basket

Isoform 1 (identifier: P48023-1) [UniParc]FASTA Add to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MQQPFNYPYP QIYWVDSSAS SPWAPPGTVL PCPTSVPRRP GQRRPPPPPP 
        60         70         80         90        100
PPPLPPPPPP PPLPPLPLPP LKKRGNHSTG LCLLVMFFMV LVALVGLGLG 
       110        120        130        140        150
MFQLFHLQKE LAELRESTSQ MHTASSLEKQ IGHPSPPPEK KELRKVAHLT 
       160        170        180        190        200
GKSNSRSMPL EWEDTYGIVL LSGVKYKKGG LVINETGLYF VYSKVYFRGQ 
       210        220        230        240        250
SCNNLPLSHK VYMRNSKYPQ DLVMMEGKMM SYCTTGQMWA RSSYLGAVFN 
       260        270        280 
LTSADHLYVN VSELSLVNFE ESQTFFGLYK L

Length:281

Mass (Da):31,485

Last modified:February 1, 1996 - v1

Checksum:ⁱA8A6EB358246E9BB

GO

Isoform 2 (identifier: P48023-2) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
117-127: STSQMHTASSL → ATPVHPLKKRS
128-281: Missing.

« Hide

        10         20         30         40         50
MQQPFNYPYP QIYWVDSSAS SPWAPPGTVL PCPTSVPRRP GQRRPPPPPP 
        60         70         80         90        100
PPPLPPPPPP PPLPPLPLPP LKKRGNHSTG LCLLVMFFMV LVALVGLGLG 
       110        120 
MFQLFHLQKE LAELREATPV HPLKKRS

Show »

Length:127

Mass (Da):14,006

Checksum:ⁱF617D96B26B8E3BA

GO

Natural variant

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Natural variantⁱVAR_052583	189	Y → S. Corresponds to variant dbSNP:rs12079514Ensembl.		1
Natural variantⁱVAR_075568	202	C → S in ALPS1B; significant reduction in cytotoxicity and apoptosis and inhibition of the shedding of the soluble form. 1 Publication		1

Alternative sequence

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Alternative sequenceⁱVSP_006443	117 – 127	STSQMHTASSL → ATPVHPLKKRS in isoform 2. 1 PublicationAdd BLAST		11
Alternative sequenceⁱVSP_006444	128 – 281	Missing in isoform 2. 1 PublicationAdd BLAST		154

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	U08137 mRNA Translation: AAC50071.1 U11821 mRNA Translation: AAC50124.1 X89102 mRNA Translation: CAA61474.1 D38122 mRNA Translation: BAA07320.1 AF288573 mRNA Translation: AAG60017.1 Z96050 Genomic DNA No translation available. BC017502 mRNA Translation: AAH17502.1 AB013303 Genomic DNA Translation: BAA32542.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS1304.1 [P48023-1] CCDS76243.1 [P48023-2]
PIRⁱ	I38707
NCBI Reference Sequences More...RefSeqⁱ	NP_000630.1, NM_000639.2 [P48023-1] NP_001289675.1, NM_001302746.1 [P48023-2]
UniGeneⁱ	Hs.2007

Genome annotation databases

Ensemblⁱ	ENST00000340030; ENSP00000344739; ENSG00000117560 [P48023-2] ENST00000367721; ENSP00000356694; ENSG00000117560 [P48023-1]
GeneIDⁱ	356
KEGGⁱ	hsa:356
UCSC genome browser More...UCSCⁱ	uc001git.4 human [P48023-1]

Keywords - Coding sequence diversityⁱ

Alternative splicing, Polymorphism

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
P48023	FAS ligand		HUMAN		281	UniRef100_P48023
UPI0000155A8E		HUMAN		152

Protein	Similar proteins		Species	Score	Length	Source
P48023	Tumor necrosis factor ligand superfamily member 6		CERAT		280	UniRef90_P48023
Tumor necrosis factor ligand superfamily member 6		MACFA		280
Tumor necrosis factor ligand superfamily member 6		MACMU		280
Tumor necrosis factor ligand superfamily member 6		MACNE		280
FAS ligand		HUMAN		281
+25
P48023-2	Uncharacterized protein		COLAP		132	UniRef90_P48023-2
Uncharacterized protein		PAPAN		129
Uncharacterized protein		Cebus capucinus imitator		128
Tumor necrosis factor ligand superfamily member 6		MACMU		127
Uncharacterized protein		MANLE		132
+11

Protein	Similar proteins		Species	Score	Length	Source
P48023	Tumor necrosis factor ligand superfamily member 6		MACFA		280	UniRef50_P48023
Tumor necrosis factor ligand superfamily member 6		MACMU		280
Tumor necrosis factor ligand superfamily member 6		MACNE		280
Tumor necrosis factor ligand superfamily member 6		CERAT		280
Tumor necrosis factor ligand superfamily member 6		FELCA		280
+129
P48023-2	Uncharacterized protein		COLAP		132	UniRef50_P48023-2
Uncharacterized protein		PAPAN		129
Uncharacterized protein		Cebus capucinus imitator		128
Uncharacterized protein		RHIBE		127
Uncharacterized protein		MACFA		127
+34

Cross-referencesⁱ

Web resourcesⁱ

FASLGbase

FASLG mutation db

Wikipedia

FAS-ligand entry

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	U08137 mRNA Translation: AAC50071.1 U11821 mRNA Translation: AAC50124.1 X89102 mRNA Translation: CAA61474.1 D38122 mRNA Translation: BAA07320.1 AF288573 mRNA Translation: AAG60017.1 Z96050 Genomic DNA No translation available. BC017502 mRNA Translation: AAH17502.1 AB013303 Genomic DNA Translation: BAA32542.1
CCDSⁱ	CCDS1304.1 [P48023-1] CCDS76243.1 [P48023-2]
PIRⁱ	I38707
RefSeqⁱ	NP_000630.1, NM_000639.2 [P48023-1] NP_001289675.1, NM_001302746.1 [P48023-2]
UniGeneⁱ	Hs.2007

3D structure databases

Select the link destinations: Protein Data Bank Europe More...PDBeⁱ Protein Data Bank RCSB More...RCSB PDBⁱ Protein Data Bank Japan More...PDBjⁱ Links Updated	PDB entry	Method	Resolution (Å)	Chain	Positions	PDBsum
	1BZI	model	-	B/C	1-281	[»]
	4MSV	X-ray	2.50	A	130-281	[»]
	5L19	X-ray	2.00	A	130-281	[»]
	5L36	X-ray	3.10	A	130-281	[»]
ProteinModelPortalⁱ	P48023
SMRⁱ	P48023
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	106852, 83 interactors
DIPⁱ	DIP-2997N
ELMⁱ	P48023
IntActⁱ	P48023, 80 interactors
MINTⁱ	P48023
STRINGⁱ	9606.ENSP00000356694

Chemistry databases

ChEMBLⁱ	CHEMBL5714

ChEMBLⁱ

CHEMBL5714

PTM databases

iPTMnetⁱ	P48023
PhosphoSitePlusⁱ	P48023
SwissPalmⁱ	P48023

Polymorphism and mutation databases

BioMutaⁱ	FASLG
DMDMⁱ	1345957

Proteomic databases

PaxDbⁱ	P48023
PeptideAtlasⁱ	P48023
PRIDEⁱ	P48023
ProteomicsDBⁱ	55831 55832 [P48023-2]

Protocols and materials databases

The DNASU plasmid repository More...DNASUⁱ	356
Structural Biology Knowledgebase	Search...

Genome annotation databases

Ensemblⁱ	ENST00000340030; ENSP00000344739; ENSG00000117560 [P48023-2] ENST00000367721; ENSP00000356694; ENSG00000117560 [P48023-1]
GeneIDⁱ	356
KEGGⁱ	hsa:356
UCSCⁱ	uc001git.4 human [P48023-1]

Organism-specific databases

CTDⁱ	356
DisGeNETⁱ	356
EuPathDBⁱ	HostDB:ENSG00000117560.7
GeneCardsⁱ	FASLG
GeneReviewsⁱ	FASLG
HGNCⁱ	HGNC:11936 FASLG
HPAⁱ	HPA054959
MalaCardsⁱ	FASLG
MIMⁱ	134638 gene 601859 phenotype
neXtProtⁱ	NX_P48023
OpenTargetsⁱ	ENSG00000117560
Orphanetⁱ	3261 Autoimmune lymphoproliferative syndrome
PharmGKBⁱ	PA56
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	ENOG410IHZF Eukaryota ENOG4112D9R LUCA
GeneTreeⁱ	ENSGT00530000062992
HOGENOMⁱ	HOG000290680
HOVERGENⁱ	HBG055128
InParanoidⁱ	P48023
KOⁱ	K04389
OMAⁱ	WEDTYGI
OrthoDBⁱ	EOG091G0MFC
PhylomeDBⁱ	P48023
TreeFamⁱ	TF332169

Enzyme and pathway databases

Reactomeⁱ	R-HSA-140534 via Death Receptors in the presence of ligand R-HSA-3371378 Regulation by c-FLIP R-HSA-5213460 RIPK1-mediated regulated necrosis R-HSA-5218900 CASP8 activity is inhibited R-HSA-6785807 Interleukin-4 and Interleukin-13 signaling R-HSA-69416 Dimerization of procaspase-8 R-HSA-75157 FasL/ CD95L signaling R-HSA-8862803 Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models
SIGNORⁱ	P48023

Reactomeⁱ

R-HSA-140534 via Death Receptors in the presence of ligand
R-HSA-3371378 Regulation by c-FLIP
R-HSA-5213460 RIPK1-mediated regulated necrosis
R-HSA-5218900 CASP8 activity is inhibited
R-HSA-6785807 Interleukin-4 and Interleukin-13 signaling
R-HSA-69416 Dimerization of procaspase-8
R-HSA-75157 FasL/ CD95L signaling
R-HSA-8862803 Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models

SIGNORⁱ

P48023

Miscellaneous databases

ChiTaRSⁱ	FASLG human
GeneWikiⁱ	Fas_ligand
GenomeRNAiⁱ	356
PMAP-CutDBⁱ	P48023
Protein Ontology More...PROⁱ	PR:P48023
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000117560 Expressed in 60 organ(s), highest expression level in leukocyte
CleanExⁱ	HS_FASLG
ExpressionAtlasⁱ	P48023 baseline and differential
Genevisibleⁱ	P48023 HS

Family and domain databases

CDDⁱ	cd00184 TNF, 1 hit
Gene3Dⁱ	2.60.120.40, 1 hit
InterProⁱ	View protein in InterPro IPR028326 FASL IPR006053 TNF IPR021184 TNF_CS IPR006052 TNF_dom IPR008983 Tumour_necrosis_fac-like_dom
Pfamⁱ	View protein in Pfam PF00229 TNF, 1 hit
PRINTSⁱ	PR01681 FASLIGAND PR01234 TNECROSISFCT
SMARTⁱ	View protein in SMART SM00207 TNF, 1 hit
SUPFAMⁱ	SSF49842 SSF49842, 1 hit
PROSITEⁱ	View protein in PROSITE PS00251 TNF_1, 1 hit PS50049 TNF_2, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	TNFL6_HUMAN
Accessionⁱ	P48023Primary (citable) accession number: P48023 Secondary accession number(s): Q9BZP9
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	February 1, 1996
	Last sequence update:	February 1, 1996
	Last modified:	September 12, 2018
	This is version 201 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

3D-structure, Complete proteome, Reference proteome

Documents

Human chromosome 1
Human chromosome 1: entries, gene names and cross-references to MIM
Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations
Human cell differentiation molecules
CD nomenclature of surface proteins of human leucocytes and list of entries
SIMILARITY comments
Index of protein domains and families
PDB cross-references
Index of Protein Data Bank (PDB) cross-references
Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

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UniProtKB - P48023 (TNFL6_HUMAN)

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Tumor necrosis factor ligand superfamily member 6

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<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

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Enzyme and pathway databases

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

GO - Molecular functionⁱ

Structureⁱ

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Keywords - Domainⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

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Keywords - Technical termⁱ