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UniProtKB - P48023 (TNFL6_HUMAN)

Entry version 219 (10 Feb 2021)
Sequence version 1 (01 Feb 1996)
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Protein

Tumor necrosis factor ligand superfamily member 6

Gene

FASLG

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Cytokine that binds to TNFRSF6/FAS, a receptor that transduces the apoptotic signal into cells (PubMed:26334989, PubMed:9228058). Involved in cytotoxic T-cell-mediated apoptosis, natural killer cell-mediated apoptosis and in T-cell development (PubMed:9228058, PubMed:7528780, PubMed:9427603). Initiates fratricidal/suicidal activation-induced cell death (AICD) in antigen-activated T-cells contributing to the termination of immune responses (By similarity). TNFRSF6/FAS-mediated apoptosis has also a role in the induction of peripheral tolerance (By similarity). Binds to TNFRSF6B/DcR3, a decoy receptor that blocks apoptosis (PubMed:27806260).By similarity5 Publications
Induces FAS-mediated activation of NF-kappa-B, initiating non-apoptotic signaling pathways (By similarity). Can induce apoptosis but does not appear to be essential for this process (PubMed:27806260).By similarity1 Publication
Cytoplasmic form induces gene transcription inhibition.1 Publication

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionCytokine, Repressor
Biological processApoptosis, Transcription, Transcription regulation

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		P48023

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-HSA-140534, Caspase activation via Death Receptors in the presence of ligand
R-HSA-3371378, Regulation by c-FLIP
R-HSA-5213460, RIPK1-mediated regulated necrosis
R-HSA-5218900, CASP8 activity is inhibited
R-HSA-6785807, Interleukin-4 and Interleukin-13 signaling
R-HSA-69416, Dimerization of procaspase-8
R-HSA-75157, FasL/ CD95L signaling
R-HSA-8862803, Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models
R-HSA-9614657, FOXO-mediated transcription of cell death genes

SIGNOR Signaling Network Open Resource

More...SIGNORi		P48023

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Tumor necrosis factor ligand superfamily member 6
Alternative name(s):
Apoptosis antigen ligand
Short name:
APTL
CD95 ligand
Short name:
CD95-L
Fas antigen ligand
Short name:
Fas ligand
Short name:
FasL
CD_antigen: CD178
Cleaved into the following 4 chains:
Tumor necrosis factor ligand superfamily member 6, membrane form
Tumor necrosis factor ligand superfamily member 6, soluble form
Alternative name(s):
Receptor-binding FasL ectodomain
Soluble Fas ligand
Short name:
sFasL
ADAM10-processed FasL form
Short name:
APL
FasL intracellular domain
Short name:
FasL ICD
Alternative name(s):
SPPL2A-processed FasL form
Short name:
SPA
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:FASLG
Synonyms:APT1LG1, CD95L, FASL, TNFSF6
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 1

Organism-specific databases

Human Gene Nomenclature Database

More...HGNCi		HGNC:11936, FASLG

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		134638, gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_P48023

Eukaryotic Pathogen, Vector and Host Database Resources

More...VEuPathDBi		HostDB:ENSG00000117560.7

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini1 – 80CytoplasmicSequence analysisAdd BLAST80
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei81 – 102Helical; Signal-anchor for type II membrane proteinSequence analysisAdd BLAST22
Topological domaini103 – 281ExtracellularSequence analysisAdd BLAST179

Keywords - Cellular componenti

Cell membrane, Cytoplasmic vesicle, Lysosome, Membrane, Nucleus, Secreted

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the 'Pathology and Biotech' section provides information on the disease(s) associated with genetic variations in a given protein. The information is extracted from the scientific literature and diseases that are also described in the <a href="http://www.ncbi.nlm.nih.gov/sites/entrez?db=omim">OMIM</a> database are represented with a <a href="http://www.uniprot.org/diseases">controlled vocabulary</a> in the following way:<p><a href='/help/involvement_in_disease' target='_top'>More...</a></p>Involvement in diseasei

Autoimmune lymphoproliferative syndrome 1B (ALPS1B)2 Publications
The disease is caused by variants affecting the gene represented in this entry.
Disease descriptionA disorder of apoptosis that manifests in early childhood and results in the accumulation of autoreactive lymphocytes. It is characterized by non-malignant lymphadenopathy with hepatosplenomegaly, and autoimmune hemolytic anemia, thrombocytopenia and neutropenia.
Related information in OMIM
Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_075568202C → S in ALPS1B; significant reduction in cytotoxicity and apoptosis and inhibition of the shedding of the soluble form. 1 Publication1

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology%5Fand%5Fbiotech%5Fsection">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi206P → D, F or R: Lowers binding to TNFRSF6 and reduces cytotoxicity more than 100-fold. 1 Publication1
Mutagenesisi218Y → F or R: Lowers binding to TNFRSF6 and abolishes cytotoxicity. 1 Publication1
Mutagenesisi275F → L: Abolishes binding to TNRFSF6 and cytotoxicity. 1 Publication1

Organism-specific databases

DisGeNET

More...DisGeNETi		356

GeneReviews a resource of expert-authored, peer-reviewed disease descriptions.

More...GeneReviewsi		FASLG

MalaCards human disease database

More...MalaCardsi		FASLG
MIMi601859, phenotype

Open Targets

More...OpenTargetsi		ENSG00000117560

Orphanet; a database dedicated to information on rare diseases and orphan drugs

More...Orphaneti		3261, Autoimmune lymphoproliferative syndrome

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA56

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		P48023, Tbio

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...ChEMBLi		CHEMBL5714

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		FASLG

Domain mapping of disease mutations (DMDM)

More...DMDMi		1345957

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000345001 – 281Tumor necrosis factor ligand superfamily member 6, membrane formAdd BLAST281
ChainiPRO_00004171521 – 129ADAM10-processed FasL formAdd BLAST129
ChainiPRO_00004168421 – 81FasL intracellular domainAdd BLAST81
ChainiPRO_0000034501130 – 281Tumor necrosis factor ligand superfamily member 6, soluble formAdd BLAST152

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi184N-linked (GlcNAc...) asparagineSequence analysis1
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi202 ↔ 233Combined sources1 Publication
Glycosylationi250N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi260N-linked (GlcNAc...) asparagineSequence analysis1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

The soluble form derives from the membrane form by proteolytic processing. The membrane-bound form undergoes two successive intramembrane proteolytic cleavages. The first one is processed by ADAM10 producing an N-terminal fragment, which lacks the receptor-binding extracellular domain. This ADAM10-processed FasL (FasL APL) remnant form is still membrane anchored and further processed by SPPL2A that liberates the FasL intracellular domain (FasL ICD). FasL shedding by ADAM10 is a prerequisite for subsequent intramembrane cleavage by SPPL2A in T-cells.2 Publications
N-glycosylated (PubMed:9228058). Glycosylation enhances apoptotic activity (PubMed:27806260).2 Publications
Phosphorylated by FGR on tyrosine residues; this is required for ubiquitination and subsequent internalization.1 Publication
Monoubiquitinated.1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection describes interesting single amino acid sites on the sequence that are not defined in any other subsection. This subsection can be displayed in different sections ('Function', 'PTM / Processing', 'Pathology and Biotech') according to its content.<p><a href='/help/site' target='_top'>More...</a></p>Sitei81 – 82Cleavage; by SPPL2ACurated2
Sitei129 – 130Cleavage; by ADAM10Curated2

Keywords - PTMi

Disulfide bond, Glycoprotein, Ubl conjugation

Proteomic databases

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		P48023

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		P48023

PeptideAtlas

More...PeptideAtlasi		P48023

PRoteomics IDEntifications database

More...PRIDEi		P48023

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		55831 [P48023-1]
55832 [P48023-2]

PTM databases

GlyGen: Computational and Informatics Resources for Glycoscience

More...GlyGeni		P48023, 3 sites

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		P48023

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		P48023

SwissPalm database of S-palmitoylation events

More...SwissPalmi		P48023

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000117560, Expressed in granulocyte and 82 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		P48023, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		P48023, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000117560, Tissue enhanced (blood, lymphoid tissue)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Homotrimer (PubMed:27806260).

Interacts with ARHGAP9, BAIAP2L1, BTK, CACNB3, CACNB4, CRK, DLG2, DNMBP, DOCK4, EPS8L3, FGR, FYB1, FYN, HCK, ITK, ITSN2, KALRN, LYN, MACC1, MIA, MPP4, MYO15A, NCF1, NCK1, NCK2, NCKIPSD, OSTF1, PIK3R1, PSTPIP1, RIMBP3C, SAMSN1, SH3GL3, SH3PXD2B, SH3PXD2A, SH3RF2, SKAP2, SNX33, SNX9, SORBS3, SPTA1, SRC, SRGAP1, SRGAP2, SRGAP3, TEC, TJP3 and YES1.

Curated3 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Hide details

GO - Molecular functioni

Complete GO annotation on QuickGO ...

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		106852, 91 interactors

Database of interacting proteins

More...DIPi		DIP-2997N

The Eukaryotic Linear Motif resource for Functional Sites in Proteins

More...ELMi		P48023

Protein interaction database and analysis system

More...IntActi		P48023, 83 interactors

Molecular INTeraction database

More...MINTi		P48023

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000356694

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		P48023, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1281
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		P48023

Database of comparative protein structure models

More...ModBasei		Search...

Protein Data Bank in Europe - Knowledge Base

More...PDBe-KBi		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi4 – 70Pro-richAdd BLAST67
Compositional biasi45 – 65Poly-ProAdd BLAST21

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the tumor necrosis factor family.Curated

Keywords - Domaini

Signal-anchor, Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		ENOG502S09I, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT01010000222306

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_070352_2_0_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		P48023

Identification of Orthologs from Complete Genome Data

More...OMAi		PQIFWVD

Database for complete collections of gene phylogenies

More...PhylomeDBi		P48023

TreeFam database of animal gene trees

More...TreeFami		TF332169

Family and domain databases

Conserved Domains Database

More...CDDi		cd00184, TNF, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		2.60.120.40, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR028326, FASL
IPR006053, TNF
IPR021184, TNF_CS
IPR006052, TNF_dom
IPR008983, Tumour_necrosis_fac-like_dom

Pfam protein domain database

More...Pfami		View protein in Pfam
PF00229, TNF, 1 hit

Protein Motif fingerprint database; a protein domain database

More...PRINTSi		PR01681, FASLIGAND
PR01234, TNECROSISFCT

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00207, TNF, 1 hit

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF49842, SSF49842, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS00251, TNF_1, 1 hit
PS50049, TNF_2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket
Isoform 1 (identifier: P48023-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MQQPFNYPYP QIYWVDSSAS SPWAPPGTVL PCPTSVPRRP GQRRPPPPPP 
        60         70         80         90        100
PPPLPPPPPP PPLPPLPLPP LKKRGNHSTG LCLLVMFFMV LVALVGLGLG 
       110        120        130        140        150
MFQLFHLQKE LAELRESTSQ MHTASSLEKQ IGHPSPPPEK KELRKVAHLT 
       160        170        180        190        200
GKSNSRSMPL EWEDTYGIVL LSGVKYKKGG LVINETGLYF VYSKVYFRGQ 
       210        220        230        240        250
SCNNLPLSHK VYMRNSKYPQ DLVMMEGKMM SYCTTGQMWA RSSYLGAVFN 
       260        270        280 
LTSADHLYVN VSELSLVNFE ESQTFFGLYK L
Length:281
Mass (Da):31,485
Last modified:February 1, 1996 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iA8A6EB358246E9BB
GO
Isoform 2 (identifier: P48023-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     117-127: STSQMHTASSL → ATPVHPLKKRS
     128-281: Missing.

Show »
Length:127
Mass (Da):14,006
Checksum:iF617D96B26B8E3BA
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_052583189Y → S. Corresponds to variant dbSNP:rs12079514Ensembl.1
Natural variantiVAR_075568202C → S in ALPS1B; significant reduction in cytotoxicity and apoptosis and inhibition of the shedding of the soluble form. 1 Publication1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_006443117 – 127STSQMHTASSL → ATPVHPLKKRS in isoform 2. 1 PublicationAdd BLAST11
Alternative sequenceiVSP_006444128 – 281Missing in isoform 2. 1 PublicationAdd BLAST154

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
U08137 mRNA Translation: AAC50071.1
U11821 mRNA Translation: AAC50124.1
X89102 mRNA Translation: CAA61474.1
D38122 mRNA Translation: BAA07320.1
AF288573 mRNA Translation: AAG60017.1
Z96050 Genomic DNA No translation available.
BC017502 mRNA Translation: AAH17502.1
AB013303 Genomic DNA Translation: BAA32542.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS1304.1 [P48023-1]
CCDS76243.1 [P48023-2]

Protein sequence database of the Protein Information Resource

More...PIRi		I38707

NCBI Reference Sequences

More...RefSeqi		NP_000630.1, NM_000639.2 [P48023-1]
NP_001289675.1, NM_001302746.1 [P48023-2]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000340030; ENSP00000344739; ENSG00000117560 [P48023-2]
ENST00000367721; ENSP00000356694; ENSG00000117560 [P48023-1]

Database of genes from NCBI RefSeq genomes

More...GeneIDi		356

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:356

UCSC genome browser

More...UCSCi		uc001git.4, human [P48023-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross%5Freferences%5Fsection">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

FASLGbase

FASLG mutation db

Wikipedia

FAS-ligand entry

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U08137 mRNA Translation: AAC50071.1
U11821 mRNA Translation: AAC50124.1
X89102 mRNA Translation: CAA61474.1
D38122 mRNA Translation: BAA07320.1
AF288573 mRNA Translation: AAG60017.1
Z96050 Genomic DNA No translation available.
BC017502 mRNA Translation: AAH17502.1
AB013303 Genomic DNA Translation: BAA32542.1
CCDSiCCDS1304.1 [P48023-1]
CCDS76243.1 [P48023-2]
PIRiI38707
RefSeqiNP_000630.1, NM_000639.2 [P48023-1]
NP_001289675.1, NM_001302746.1 [P48023-2]

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...PDBei

Protein Data Bank RCSB

More...RCSB PDBi

Protein Data Bank Japan

More...PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1BZImodel-B/C1-281[»]
4MSVX-ray2.50A130-281[»]
5L19X-ray2.00A130-281[»]
5L36X-ray3.10A130-281[»]
SMRiP48023
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGRIDi106852, 91 interactors
DIPiDIP-2997N
ELMiP48023
IntActiP48023, 83 interactors
MINTiP48023
STRINGi9606.ENSP00000356694

Chemistry databases

ChEMBLiCHEMBL5714

PTM databases

GlyGeniP48023, 3 sites
iPTMnetiP48023
PhosphoSitePlusiP48023
SwissPalmiP48023

Genetic variation databases

BioMutaiFASLG
DMDMi1345957

Proteomic databases

MassIVEiP48023
PaxDbiP48023
PeptideAtlasiP48023
PRIDEiP48023
ProteomicsDBi55831 [P48023-1]
55832 [P48023-2]

Protocols and materials databases

ABCD curated depository of sequenced antibodies

More...ABCDi		P48023, 4 sequenced antibodies

Antibodypedia a portal for validated antibodies

More...Antibodypediai		4418, 1314 antibodies

The DNASU plasmid repository

More...DNASUi		356

Genome annotation databases

EnsembliENST00000340030; ENSP00000344739; ENSG00000117560 [P48023-2]
ENST00000367721; ENSP00000356694; ENSG00000117560 [P48023-1]
GeneIDi356
KEGGihsa:356
UCSCiuc001git.4, human [P48023-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		356
DisGeNETi356

GeneCards: human genes, protein and diseases

More...GeneCardsi		FASLG
GeneReviewsiFASLG
HGNCiHGNC:11936, FASLG
HPAiENSG00000117560, Tissue enhanced (blood, lymphoid tissue)
MalaCardsiFASLG
MIMi134638, gene
601859, phenotype
neXtProtiNX_P48023
OpenTargetsiENSG00000117560
Orphaneti3261, Autoimmune lymphoproliferative syndrome
PharmGKBiPA56
VEuPathDBiHostDB:ENSG00000117560.7

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiENOG502S09I, Eukaryota
GeneTreeiENSGT01010000222306
HOGENOMiCLU_070352_2_0_1
InParanoidiP48023
OMAiPQIFWVD
PhylomeDBiP48023
TreeFamiTF332169

Enzyme and pathway databases

PathwayCommonsiP48023
ReactomeiR-HSA-140534, Caspase activation via Death Receptors in the presence of ligand
R-HSA-3371378, Regulation by c-FLIP
R-HSA-5213460, RIPK1-mediated regulated necrosis
R-HSA-5218900, CASP8 activity is inhibited
R-HSA-6785807, Interleukin-4 and Interleukin-13 signaling
R-HSA-69416, Dimerization of procaspase-8
R-HSA-75157, FasL/ CD95L signaling
R-HSA-8862803, Deregulated CDK5 triggers multiple neurodegenerative pathways in Alzheimer's disease models
R-HSA-9614657, FOXO-mediated transcription of cell death genes
SIGNORiP48023

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		356, 5 hits in 879 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		FASLG, human

The Gene Wiki collection of pages on human genes and proteins

More...GeneWikii		Fas_ligand

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		356
PharosiP48023, Tbio

Protein Ontology

More...PROi		PR:P48023
RNActiP48023, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000117560, Expressed in granulocyte and 82 other tissues
ExpressionAtlasiP48023, baseline and differential
GenevisibleiP48023, HS

Family and domain databases

CDDicd00184, TNF, 1 hit
Gene3Di2.60.120.40, 1 hit
InterProiView protein in InterPro
IPR028326, FASL
IPR006053, TNF
IPR021184, TNF_CS
IPR006052, TNF_dom
IPR008983, Tumour_necrosis_fac-like_dom
PfamiView protein in Pfam
PF00229, TNF, 1 hit
PRINTSiPR01681, FASLIGAND
PR01234, TNECROSISFCT
SMARTiView protein in SMART
SM00207, TNF, 1 hit
SUPFAMiSSF49842, SSF49842, 1 hit
PROSITEiView protein in PROSITE
PS00251, TNF_1, 1 hit
PS50049, TNF_2, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiTNFL6_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P48023
Secondary accession number(s): Q9BZP9
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1996
Last sequence update: February 1, 1996
Last modified: February 10, 2021
This is version 219 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Reference proteome

Documents

  1. Human cell differentiation molecules
    CD nomenclature of surface proteins of human leucocytes and list of entries
  2. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  3. Human entries with genetic variants
    List of human entries with genetic variants
  4. Human variants curated from literature reports
    Index of human variants curated from literature reports
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  7. SIMILARITY comments
    Index of protein domains and families
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