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Entry version 131 (02 Jun 2021)
Sequence version 1 (01 Feb 1996)
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Protein

3-hydroxy-3-methylglutaryl-coenzyme A reductase 2

Gene

HMG2

Organism
Solanum lycopersicum (Tomato) (Lycopersicon esculentum)
Status
Reviewed-Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein inferred from homologyi <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Catalyzes the synthesis of mevalonate. The specific precursor of all isoprenoid compounds present in plants.

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section describes the metabolic pathway(s) associated with a protein.<p><a href='/help/pathway' target='_top'>More...</a></p>Pathwayi: (R)-mevalonate biosynthesis

This protein is involved in step 3 of the subpathway that synthesizes (R)-mevalonate from acetyl-CoA. This subpathway is part of the pathway (R)-mevalonate biosynthesis, which is itself part of Metabolic intermediate biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes (R)-mevalonate from acetyl-CoA, the pathway (R)-mevalonate biosynthesis and in Metabolic intermediate biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei281Charge relay systemBy similarity1
Active sitei413Charge relay systemBy similarity1
Active sitei489Charge relay systemBy similarity1
Active sitei587Proton donorPROSITE-ProRule annotation1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionOxidoreductase
Biological processIsoprene biosynthesis
LigandNADP

Enzyme and pathway databases

UniPathway: a resource for the exploration and annotation of metabolic pathways

More...
UniPathwayi
UPA00058;UER00103

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
3-hydroxy-3-methylglutaryl-coenzyme A reductase 2 (EC:1.1.1.34)
Short name:
HMG-CoA reductase 2
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:HMG2
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiSolanum lycopersicum (Tomato) (Lycopersicon esculentum)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri4081 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliopsidaeudicotyledonsGunneridaePentapetalaeasteridslamiidsSolanalesSolanaceaeSolanoideaeSolaneaeSolanumSolanum subgen. Lycopersicon
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000004994 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Unplaced

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei44 – 67HelicalSequence analysisAdd BLAST24
Transmembranei95 – 115HelicalSequence analysisAdd BLAST21

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001144431 – 6023-hydroxy-3-methylglutaryl-coenzyme A reductase 2Add BLAST602

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi124N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi345N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi458N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi591N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
P48022

PRoteomics IDEntifications database

More...
PRIDEi
P48022

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
P48022, baseline and differential

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
4081.Solyc02g038740.2.1

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
P48022

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni116 – 187LinkerBy similarityAdd BLAST72
Regioni188 – 602CatalyticBy similarityAdd BLAST415

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the HMG-CoA reductase family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG2480, Eukaryota

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
P48022

Database of Orthologous Groups

More...
OrthoDBi
907394at2759

Family and domain databases

Conserved Domains Database

More...
CDDi
cd00643, HMG-CoA_reductase_classI, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.10.3270.10, 1 hit
3.30.70.420, 1 hit
3.90.770.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR002202, HMG_CoA_Rdtase
IPR023074, HMG_CoA_Rdtase_cat_sf
IPR023076, HMG_CoA_Rdtase_CS
IPR004554, HMG_CoA_Rdtase_eu_arc
IPR023282, HMG_CoA_Rdtase_N
IPR009023, HMG_CoA_Rdtase_NAD(P)-bd_sf
IPR009029, HMG_CoA_Rdtase_sub-bd_dom_sf

The PANTHER Classification System

More...
PANTHERi
PTHR10572, PTHR10572, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00368, HMG-CoA_red, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR00071, HMGCOARDTASE

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF55035, SSF55035, 1 hit
SSF56542, SSF56542, 1 hit

TIGRFAMs; a protein family database

More...
TIGRFAMsi
TIGR00533, HMG_CoA_R_NADP, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00066, HMG_COA_REDUCTASE_1, 1 hit
PS00318, HMG_COA_REDUCTASE_2, 1 hit
PS01192, HMG_COA_REDUCTASE_3, 1 hit
PS50065, HMG_COA_REDUCTASE_4, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

P48022-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MDVRRRSEEP VYPSKVFAAD EKPLKPHKKQ QQQQEDKNTL LIDASDALPL
60 70 80 90 100
PLYLTTNGLF FTMFFSVMYF LLSRWREKIR NSTPLHVVTL SELGAIVSLI
110 120 130 140 150
ASVIYLLGFF GIGFVQTFVS RGNNDSWDEN DEEFLLKEDS RCGPATTLGC
160 170 180 190 200
AVPAPPARQI APMAPPQPSM SMVEKPAPLI TSASSGEDEE IIKSVVQGKI
210 220 230 240 250
PSYSLESKLG DCKRAASIRK EVMQRITGKS LEGLPLEGFN YESILGQCCE
260 270 280 290 300
MPIGYVQIPV GIAGPLLLNG KEFSVPMATT EGCLVASTNR GCKAIYASGG
310 320 330 340 350
ATCILLRDGM TRAPCVRFGT AKRAAELKFF VEDPIKFESL ANVFNQSSRF
360 370 380 390 400
ARLQRIQCAI AGKNLYMRLC CSTGDAMGMN MVSKGVQNVL DYLQNEYPDM
410 420 430 440 450
DVIGISGNFC SDKKPAAVNW IEGRGKSVVC EAIITEEVVK KVLKTEVAAL
460 470 480 490 500
VELNMLKNLT GSAMAGALGG FNAHASNIVS AVFIATGQDP AQNIESSHCI
510 520 530 540 550
TMMEAVNDGK DLHISVTMPS IEVGTVGGGT QLASQSACLN LLGVKGANRE
560 570 580 590 600
APGSNARLLA TVVAGSVLAG ELSLMSAISS GQLVNSHMKY NRSTKDVTKA

SS
Length:602
Mass (Da):64,715
Last modified:February 1, 1996 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i0266E55E2EB953BD
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti56Missing in AAB62581 (PubMed:8883384).Curated1
Sequence conflicti186G → E in AAB62581 (PubMed:8883384).Curated1
Sequence conflicti339S → T in AAB62581 (PubMed:8883384).Curated1
Sequence conflicti369 – 370LC → FV in AAB62581 (PubMed:8883384).Curated2

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
M63642 Genomic DNA Translation: AAA34169.1
U68072 Genomic DNA Translation: AAB62581.1

Protein sequence database of the Protein Information Resource

More...
PIRi
S25316

NCBI Reference Sequences

More...
RefSeqi
NP_001296119.1, NM_001309190.1

Genome annotation databases

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
101265292

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
sly:101265292

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M63642 Genomic DNA Translation: AAA34169.1
U68072 Genomic DNA Translation: AAB62581.1
PIRiS25316
RefSeqiNP_001296119.1, NM_001309190.1

3D structure databases

SMRiP48022
ModBaseiSearch...

Protein-protein interaction databases

STRINGi4081.Solyc02g038740.2.1

Proteomic databases

PaxDbiP48022
PRIDEiP48022

Genome annotation databases

GeneIDi101265292
KEGGisly:101265292

Phylogenomic databases

eggNOGiKOG2480, Eukaryota
InParanoidiP48022
OrthoDBi907394at2759

Enzyme and pathway databases

UniPathwayiUPA00058;UER00103

Gene expression databases

ExpressionAtlasiP48022, baseline and differential

Family and domain databases

CDDicd00643, HMG-CoA_reductase_classI, 1 hit
Gene3Di1.10.3270.10, 1 hit
3.30.70.420, 1 hit
3.90.770.10, 1 hit
InterProiView protein in InterPro
IPR002202, HMG_CoA_Rdtase
IPR023074, HMG_CoA_Rdtase_cat_sf
IPR023076, HMG_CoA_Rdtase_CS
IPR004554, HMG_CoA_Rdtase_eu_arc
IPR023282, HMG_CoA_Rdtase_N
IPR009023, HMG_CoA_Rdtase_NAD(P)-bd_sf
IPR009029, HMG_CoA_Rdtase_sub-bd_dom_sf
PANTHERiPTHR10572, PTHR10572, 1 hit
PfamiView protein in Pfam
PF00368, HMG-CoA_red, 1 hit
PRINTSiPR00071, HMGCOARDTASE
SUPFAMiSSF55035, SSF55035, 1 hit
SSF56542, SSF56542, 1 hit
TIGRFAMsiTIGR00533, HMG_CoA_R_NADP, 1 hit
PROSITEiView protein in PROSITE
PS00066, HMG_COA_REDUCTASE_1, 1 hit
PS00318, HMG_COA_REDUCTASE_2, 1 hit
PS01192, HMG_COA_REDUCTASE_3, 1 hit
PS50065, HMG_COA_REDUCTASE_4, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiHMDH2_SOLLC
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P48022
Secondary accession number(s): O24028
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1996
Last sequence update: February 1, 1996
Last modified: June 2, 2021
This is version 131 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families
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