UniProtKB - P48016 (ATH1_YEAST)
Protein
Vacuolar acid trehalase
Gene
ATH1
Organism
Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Status
Functioni
Catalytic activityi
- EC:3.2.1.28
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Active sitei | 644 | Proton donorBy similarity | 1 |
GO - Molecular functioni
- alpha,alpha-trehalase activity Source: SGD
- carbohydrate binding Source: InterPro
- hydrolase activity, hydrolyzing O-glycosyl compounds Source: GO_Central
GO - Biological processi
- carbohydrate metabolic process Source: GO_Central
- cellular response to desiccation Source: SGD
- cellular response to ethanol Source: SGD
- cellular response to freezing Source: SGD
- trehalose catabolic process Source: SGD
Keywordsi
Molecular function | Glycosidase, Hydrolase |
Enzyme and pathway databases
BioCyci | MetaCyc:YPR026W-MONOMER |
Protein family/group databases
CAZyi | GH65, Glycoside Hydrolase Family 65 |
Names & Taxonomyi
Protein namesi | Recommended name: Vacuolar acid trehalase (EC:3.2.1.28)Alternative name(s): Alpha,alpha-trehalase Alpha,alpha-trehalose glucohydrolase |
Gene namesi | Name:ATH1 Ordered Locus Names:YPR026W ORF Names:YP9367.06 |
Organismi | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast) |
Taxonomic identifieri | 559292 [NCBI] |
Taxonomic lineagei | Eukaryota › Fungi › Dikarya › Ascomycota › Saccharomycotina › Saccharomycetes › Saccharomycetales › Saccharomycetaceae › Saccharomyces › |
Proteomesi |
|
Organism-specific databases
SGDi | S000006230, ATH1 |
VEuPathDBi | FungiDB:YPR026W |
Subcellular locationi
Vacuole
Note: Lysosome-like vacuoles.Curated
Cell Wall
- fungal-type cell wall Source: SGD
Vacuole
- fungal-type vacuole Source: SGD
Other locations
- cell wall-bounded periplasmic space Source: SGD
Keywords - Cellular componenti
VacuolePTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – ? | Sequence analysis | ||
ChainiPRO_0000012110 | ? – 1211 | Vacuolar acid trehalase |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Glycosylationi | 28 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 32 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 98 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 207 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 238 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 247 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 255 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 259 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 325 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 370 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 376 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 488 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 539 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 568 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 628 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 638 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 696 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 705 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 879 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 897 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 910 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 972 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 990 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 1031 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 1049 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 1064 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 1147 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 1157 | N-linked (GlcNAc...) asparagineSequence analysis | 1 |
Post-translational modificationi
Glycosylated.1 Publication
Keywords - PTMi
GlycoproteinProteomic databases
MaxQBi | P48016 |
PaxDbi | P48016 |
PRIDEi | P48016 |
PTM databases
iPTMneti | P48016 |
Interactioni
Protein-protein interaction databases
BioGRIDi | 36203, 38 interactors |
IntActi | P48016, 1 interactor |
STRINGi | 4932.YPR026W |
Miscellaneous databases
RNActi | P48016, protein |
Family & Domainsi
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 513 – 514 | Substrate bindingBy similarity | 2 | |
Regioni | 711 – 712 | Substrate bindingBy similarity | 2 |
Sequence similaritiesi
Belongs to the glycosyl hydrolase 65 family.Curated
Keywords - Domaini
SignalPhylogenomic databases
eggNOGi | KOG4125, Eukaryota |
GeneTreei | ENSGT00390000006297 |
HOGENOMi | CLU_006285_4_0_1 |
InParanoidi | P48016 |
OMAi | QPYVANG |
Family and domain databases
Gene3Di | 1.50.10.10, 1 hit 2.70.98.40, 1 hit |
InterProi | View protein in InterPro IPR008928, 6-hairpin_glycosidase_sf IPR012341, 6hp_glycosidase-like_sf IPR011013, Gal_mutarotase_sf_dom IPR005195, Glyco_hydro_65_M IPR005196, Glyco_hydro_65_N IPR037018, Glyco_hydro_65_N_sf |
Pfami | View protein in Pfam PF03632, Glyco_hydro_65m, 1 hit PF03636, Glyco_hydro_65N, 1 hit |
SUPFAMi | SSF48208, SSF48208, 1 hit SSF74650, SSF74650, 1 hit |
i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
P48016-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MKRIRSLWFN AEASYSNLNN SPSLRNKNST GNNSRSKNYR SFSRFDLINS
60 70 80 90 100
ILLLMMLFLL AIFVTALYLT KSSRLTYSHA SRAALFNPLG VISPSLGNHT
110 120 130 140 150
LNYDPEARES SKKLYELLSD FNTAYYDDEN MILGSNLFSK NTYSRQPYVA
160 170 180 190 200
NGYIGSRIPN IGFGYALDTL NFYTDAPGAL NNGWPLRNHR FAGAFVSDFY
210 220 230 240 250
CLQPKLNSTN FPELDDVGYS TVISSIPQWT NLQFSLVNDS KWFNPQNVTL
260 270 280 290 300
DDVTNYSQNL SMKDGIVTTE LDWLNSQIHV KSEIWAHRHI HPLGVVSLEI
310 320 330 340 350
SLNTDHLPSD FDSLDVNIWD ILDFNTSHRT VLHSTGTDEK NNAVFMIVQP
360 370 380 390 400
DNVPSSNCAI YSTCTVKYEN STNPINSSES FEEKDVSSNI YNVILTEDQP
410 420 430 440 450
KIIVHKYVGI MSTEFNKNKE QQDNTNIGLA KMIALNSKGN YEKLLSSHKR
460 470 480 490 500
AWYDLYNDAF IEIPSDSLLE MTARSSLFHL LANTRDYNVS SDRGLPVGVS
510 520 530 540 550
GLSSDSYGGM VFWDADIWME PALLPFFPNV AQNMNNYRNA THSQAKLNAE
560 570 580 590 600
KYGYPGAIYP WTSGKYANCT STGPCVDYEY HINVDVAMAS FSIYLNGHEG
610 620 630 640 650
IDDEYLRYTT WPIIKNAAQF FTAYVKYNSS LGLYETYNLT DPDEFANHIN
660 670 680 690 700
NGAFTNAGIK TLLKWATDIG NHLGEVVDPK WSEISKDIYI PRSSSNITLE
710 720 730 740 750
YSGMNSSVEI KQADVTLMVY PLGYINDESI LNNAIKDLYY YSERQSASGP
760 770 780 790 800
AMTYPVFVAA AAGLLNHGSS SQSYLYKSVL PYLRAPFAQF SEQSDDNFLT
810 820 830 840 850
NGLTQPAFPF LTANGGFLQS ILFGLTGIRY SYEVDPDTKK INRLLRFNPI
860 870 880 890 900
ELPLLPGGIA IRNFKYMNQV LDIIIDDHNG TIVHKSGDVP IHIKIPNRSL
910 920 930 940 950
IHDQDINFYN GSENERKPNL ERRDVDRVGD PMRMDRYGTY YLLKPKQELT
960 970 980 990 1000
VQLFKPGLNA RNNIAENKQI TNLTAGVPGD VAFSALDGNN YTHWQPLDKI
1010 1020 1030 1040 1050
HRAKLLIDLG EYNEKEITKG MILWGQRPAK NISISILPHS EKVENLFANV
1060 1070 1080 1090 1100
TEIMQNSGND QLLNETIGQL LDNAGIPVEN VIDFDGIEQE DDESLDDVQA
1110 1120 1130 1140 1150
LLHWKKEDLA KLIEQIPRLN FLKRKFVKIL DNVPVSPSEP YYEASRNQSL
1160 1170 1180 1190 1200
IEILPSNRTT FTIDYDKLQV GDKGNTDWRK TRYIVVAVQG VYDDYDDDNK
1210
GATIKEIVLN D
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 1168 – 1211 | LQVGD…IVLND → FAGG in CAA58961 (PubMed:7502577).CuratedAdd BLAST | 44 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | X84156 Genomic DNA Translation: CAA58961.1 Z49274 Genomic DNA Translation: CAA89280.1 Z71255 Genomic DNA Translation: CAA95022.1 BK006949 Genomic DNA Translation: DAA11452.1 |
PIRi | S54500 |
RefSeqi | NP_015351.1, NM_001184123.1 |
Genome annotation databases
EnsemblFungii | YPR026W_mRNA; YPR026W; YPR026W |
GeneIDi | 856137 |
KEGGi | sce:YPR026W |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | X84156 Genomic DNA Translation: CAA58961.1 Z49274 Genomic DNA Translation: CAA89280.1 Z71255 Genomic DNA Translation: CAA95022.1 BK006949 Genomic DNA Translation: DAA11452.1 |
PIRi | S54500 |
RefSeqi | NP_015351.1, NM_001184123.1 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
BioGRIDi | 36203, 38 interactors |
IntActi | P48016, 1 interactor |
STRINGi | 4932.YPR026W |
Chemistry databases
ChEMBLi | CHEMBL2366477 |
Protein family/group databases
CAZyi | GH65, Glycoside Hydrolase Family 65 |
PTM databases
iPTMneti | P48016 |
Proteomic databases
MaxQBi | P48016 |
PaxDbi | P48016 |
PRIDEi | P48016 |
Genome annotation databases
EnsemblFungii | YPR026W_mRNA; YPR026W; YPR026W |
GeneIDi | 856137 |
KEGGi | sce:YPR026W |
Organism-specific databases
SGDi | S000006230, ATH1 |
VEuPathDBi | FungiDB:YPR026W |
Phylogenomic databases
eggNOGi | KOG4125, Eukaryota |
GeneTreei | ENSGT00390000006297 |
HOGENOMi | CLU_006285_4_0_1 |
InParanoidi | P48016 |
OMAi | QPYVANG |
Enzyme and pathway databases
BioCyci | MetaCyc:YPR026W-MONOMER |
Miscellaneous databases
PROi | PR:P48016 |
RNActi | P48016, protein |
Family and domain databases
Gene3Di | 1.50.10.10, 1 hit 2.70.98.40, 1 hit |
InterProi | View protein in InterPro IPR008928, 6-hairpin_glycosidase_sf IPR012341, 6hp_glycosidase-like_sf IPR011013, Gal_mutarotase_sf_dom IPR005195, Glyco_hydro_65_M IPR005196, Glyco_hydro_65_N IPR037018, Glyco_hydro_65_N_sf |
Pfami | View protein in Pfam PF03632, Glyco_hydro_65m, 1 hit PF03636, Glyco_hydro_65N, 1 hit |
SUPFAMi | SSF48208, SSF48208, 1 hit SSF74650, SSF74650, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | ATH1_YEAST | |
Accessioni | P48016Primary (citable) accession number: P48016 Secondary accession number(s): D6W436 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | February 1, 1996 |
Last sequence update: | February 1, 1996 | |
Last modified: | February 10, 2021 | |
This is version 160 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Fungal Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Direct protein sequencing, Reference proteomeDocuments
- Yeast
Yeast (Saccharomyces cerevisiae): entries, gene names and cross-references to SGD - SIMILARITY comments
Index of protein domains and families - Yeast chromosome XVI
Yeast (Saccharomyces cerevisiae) chromosome XVI: entries and gene names - Glycosyl hydrolases
Classification of glycosyl hydrolase families and list of entries