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Entry version 171 (12 Aug 2020)
Sequence version 2 (01 Dec 2000)
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Protein

Cysteine synthase 1

Gene

OASA1

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Acts as a major cysteine synthase, probably involved in maintaining organic sulfur level.3 Publications

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the 'Function' section provides information relevant to cofactors. A cofactor is any non-protein substance required for a protein to be catalytically active. Some cofactors are inorganic, such as the metal atoms zinc, iron, and copper in various oxidation states. Others, such as most vitamins, are organic.<p><a href='/help/cofactor' target='_top'>More...</a></p>Cofactori

pyridoxal 5'-phosphate2 Publications

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes regulatory mechanisms for enzymes, transporters or microbial transcription factors, and reports the components which regulate (by activation or inhibition) the reaction.<p><a href='/help/activity_regulation' target='_top'>More...</a></p>Activity regulationi

Interaction with the sulfate transporter SULTR1;2 enhances its catalytic activity.1 Publication

<p>This subsection of the 'Function' section describes biophysical and chemical properties, such as maximal absorption, kinetic parameters, pH dependence, redox potentials and temperature dependence.<p><a href='/help/biophysicochemical_properties' target='_top'>More...</a></p>Kineticsi

  1. KM=1.4 mM for O-acetylserine (at pH 7.0 and 25 degrees Celsius) for the cysteine synthase activity3 Publications
  2. KM=1.22 mM for O3-acetyl-L-serine for the cysteine synthase activity3 Publications
  3. KM=0.69 mM for O3-acetyl-L-serine for the cysteine synthase activity3 Publications
  4. KM=0.22 mM for Na2S (at pH 7.0 and 25 degrees Celsius) for the cysteine synthase activity3 Publications
  5. KM=5.6 µM for H2S for the cysteine synthase activity3 Publications
  1. Vmax=225 µmol/min/mg enzyme for L-cysteine for the cysteine synthase activity3 Publications
  2. Vmax=906 µmol/min/mg enzyme for L-cysteine for the cysteine synthase activity3 Publications
  3. Vmax=0.43 µmol/min/mg enzyme for H2S for the L-3-cyanoalanine synthase activity3 Publications

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section describes the metabolic pathway(s) associated with a protein.<p><a href='/help/pathway' target='_top'>More...</a></p>Pathwayi: L-cysteine biosynthesis

This protein is involved in step 2 of the subpathway that synthesizes L-cysteine from L-serine.
Proteins known to be involved in the 2 steps of the subpathway in this organism are:
  1. Serine acetyltransferase 3, mitochondrial (SAT3), Serine O-acetyltransferase (AXX17_At5g55970), Serine acetyltransferase 5 (SAT5), Serine O-acetyltransferase (AN1_LOCUS12645), Serine acetyltransferase 1, chloroplastic (SAT1), Serine acetyltransferase 4 (SAT4), Serine O-acetyltransferase (C24_LOCUS25785), Serine O-acetyltransferase (AXX17_At1g50570), Serine O-acetyltransferase (AXX17_At3g13260), Serine O-acetyltransferase (AXX17_At2g12920), Serine O-acetyltransferase (AXX17_At4g40690), Serine acetyltransferase 2 (SAT2), Serine O-acetyltransferase (C24_LOCUS20301), Serine O-acetyltransferase (AN1_LOCUS4729)
  2. Bifunctional L-3-cyanoalanine synthase/cysteine synthase D1 (CYSD1), Bifunctional L-3-cyanoalanine synthase/cysteine synthase D2 (CYSD2), Bifunctional cystathionine gamma-lyase/cysteine synthase (DES1), Cysteine synthase, chloroplastic/chromoplastic (OASB), Cysteine synthase 1 (OASA1), Cysteine synthase, mitochondrial (OASC)
This subpathway is part of the pathway L-cysteine biosynthesis, which is itself part of Amino-acid biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes L-cysteine from L-serine, the pathway L-cysteine biosynthesis and in Amino-acid biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the interaction between a single amino acid and another chemical entity. Priority is given to the annotation of physiological ligands.<p><a href='/help/binding' target='_top'>More...</a></p>Binding sitei77Pyridoxal phosphateCombined sources2 Publications1
Binding sitei269Pyridoxal phosphateCombined sources2 Publications1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • cysteine synthase activity Source: TAIR
  • pyridoxal phosphate binding Source: GO_Central

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionTransferase
Biological processAmino-acid biosynthesis, Cysteine biosynthesis
LigandPyridoxal phosphate

Enzyme and pathway databases

BioCyc Collection of Pathway/Genome Databases

More...
BioCyci
MetaCyc:AT4G14880-MONOMER

BRENDA Comprehensive Enzyme Information System

More...
BRENDAi
2.5.1.47, 399

SABIO-RK: Biochemical Reaction Kinetics Database

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SABIO-RKi
P47998

UniPathway: a resource for the exploration and annotation of metabolic pathways

More...
UniPathwayi
UPA00136;UER00200

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Cysteine synthase 1 (EC:2.5.1.47)
Alternative name(s):
At.OAS.5-8
Beta-substituted Ala synthase 1;1
Short name:
ARAth-Bsas1;1
CSase A
Short name:
AtCS-A
Cys-3A
O-acetylserine (thiol)-lyase 1
Short name:
OAS-TL A
O-acetylserine sulfhydrylase
Protein ONSET OF LEAF DEATH 3
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:OASA1
Synonyms:OAS1, OASS, OLD3
Ordered Locus Names:At4g14880
ORF Names:dl3480c
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiArabidopsis thaliana (Mouse-ear cress)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri3702 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliopsidaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000006548 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 4

Organism-specific databases

Arabidopsis Information Portal

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Araporti
AT4G14880

The Arabidopsis Information Resource

More...
TAIRi
locus:2130419, AT4G14880

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Chloroplast Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertion Graphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the 'Pathology and Biotech' section describes the in vivo effects caused by ablation of the gene (or one or more transcripts) coding for the protein described in the entry. This includes gene knockout and knockdown, provided experiments have been performed in the context of a whole organism or a specific tissue, and not at the single-cell level.<p><a href='/help/disruption_phenotype' target='_top'>More...</a></p>Disruption phenotypei

No visible phenotype but displays lower levels of thiols in roots and leaves, and also an affected sulfur balance. Also shows an increased sensitivity to cadmium stress.3 Publications

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology%5Fand%5Fbiotech%5Fsection">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi46K → A: No cysteine synthase activity. 1 Publication1
Mutagenesisi74T → A: Strong reduction of cysteine synthase activity. 1 Publication1
Mutagenesisi74T → S: Reduction of cysteine synthase activity. 1 Publication1
Mutagenesisi75S → A, N or T: Strong reduction of cysteine synthase activity. 1 Publication1
Mutagenesisi77N → A: Reduction of cysteine synthase activity. 1 Publication1
Mutagenesisi77N → D: Strong reduction of cysteine synthase activity. 1 Publication1
Mutagenesisi78T → A or S: Reduction of cysteine synthase activity. 1 Publication1
Mutagenesisi147Q → A or E: Strong reduction of cysteine synthase activity. 1 Publication1
Mutagenesisi157H → Q or N: Slight reduction of cysteine synthase activity. 1 Publication1
Mutagenesisi162G → E in old3-1; displays a early leaf death phenotype. Abolishes cysteine synthase activity. 1 Publication1
Mutagenesisi182T → A or S: Slight reduction of cysteine synthase activity. 1 Publication1
Mutagenesisi185T → A or S: Strong reduction of cysteine synthase activity. 1 Publication1
Mutagenesisi217K → A: Impaired interaction with SAT1. 1 Publication1
Mutagenesisi221H → A: Impaired interaction with SAT1. 1 Publication1
Mutagenesisi222K → A: Impaired interaction with SAT1. 1 Publication1
Mutagenesisi269S → A: Strong reduction of cysteine synthase activity. 1 Publication1
Mutagenesisi269S → T: Reduction of cysteine synthase activity. 1 Publication1

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section indicates that the initiator methionine is cleaved from the mature protein.<p><a href='/help/init_met' target='_top'>More...</a></p>Initiator methionineiRemoved1 Publication
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00001671162 – 322Cysteine synthase 1Add BLAST321

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei2N-acetylalanine1 Publication1
Modified residuei46N6-(pyridoxal phosphate)lysineCombined sources2 Publications1
Modified residuei178PhosphoserineCombined sources1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
P47998

PRoteomics IDEntifications database

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PRIDEi
P47998

ProteomicsDB: a multi-organism proteome resource

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ProteomicsDBi
222595

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

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iPTMneti
P47998

MetOSite database of methionine sulfoxide sites

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MetOSitei
P47998

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
P47998, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
P47998, AT

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Homodimer.

Interacts with SAT1.

Component of the cysteine synthase complex (CSC) composed of two OAS-TL dimers and one SAT hexamer.

Interacts with SULTR1;2.

3 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
12442, 8 interactors

Protein interaction database and analysis system

More...
IntActi
P47998, 5 interactors

STRING: functional protein association networks

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STRINGi
3702.AT4G14880.4

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1322
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
P47998

Database of comparative protein structure models

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ModBasei
Search...

Protein Data Bank in Europe - Knowledge Base

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PDBe-KBi
Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...
EvolutionaryTracei
P47998

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni144 – 287SUTR1;2 binding1 PublicationAdd BLAST144
Regioni181 – 185Pyridoxal phosphate bindingCombined sources2 Publications5
Regioni217 – 222SAT1 binding1 Publication6

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG1252, Eukaryota

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_021018_1_0_1

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
P47998

KEGG Orthology (KO)

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KOi
K01738

Identification of Orthologs from Complete Genome Data

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OMAi
WDSGERY

Database of Orthologous Groups

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OrthoDBi
1016546at2759

Database for complete collections of gene phylogenies

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PhylomeDBi
P47998

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

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Gene3Di
3.40.50.1100, 2 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR005856, Cys_synth
IPR005859, CysK
IPR001216, P-phosphate_BS
IPR001926, PLP-dep
IPR036052, Trypto_synt_PLP_dependent

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00291, PALP, 1 hit

Superfamily database of structural and functional annotation

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SUPFAMi
SSF53686, SSF53686, 1 hit

TIGRFAMs; a protein family database

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TIGRFAMsi
TIGR01139, cysK, 1 hit
TIGR01136, cysKM, 1 hit

PROSITE; a protein domain and family database

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PROSITEi
View protein in PROSITE
PS00901, CYS_SYNTHASE, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

P47998-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MASRIAKDVT ELIGNTPLVY LNNVAEGCVG RVAAKLEMME PCSSVKDRIG
60 70 80 90 100
FSMISDAEKK GLIKPGESVL IEPTSGNTGV GLAFTAAAKG YKLIITMPAS
110 120 130 140 150
MSTERRIILL AFGVELVLTD PAKGMKGAIA KAEEILAKTP NGYMLQQFEN
160 170 180 190 200
PANPKIHYET TGPEIWKGTG GKIDGFVSGI GTGGTITGAG KYLKEQNANV
210 220 230 240 250
KLYGVEPVES AILSGGKPGP HKIQGIGAGF IPSVLNVDLI DEVVQVSSDE
260 270 280 290 300
SIDMARQLAL KEGLLVGISS GAAAAAAIKL AQRPENAGKL FVAIFPSFGE
310 320
RYLSTVLFDA TRKEAEAMTF EA
Length:322
Mass (Da):33,805
Last modified:December 1, 2000 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i5B3E7F3D9DA5908B
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti20Missing in AAK76499 (PubMed:14593172).Curated1
Sequence conflicti273A → E in CAA58893 (PubMed:7729527).Curated1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
X80376 mRNA Translation: CAA56593.2
X84097 mRNA Translation: CAA58893.1
AJ272027 Genomic DNA Translation: CAB72932.1
Z97337 Genomic DNA Translation: CAB10267.1
AL161540 Genomic DNA Translation: CAB78530.1
CP002687 Genomic DNA Translation: AEE83512.1
CP002687 Genomic DNA Translation: AEE83513.1
CP002687 Genomic DNA Translation: AEE83514.1
CP002687 Genomic DNA Translation: AEE83515.1
CP002687 Genomic DNA Translation: ANM66097.1
AY045825 mRNA Translation: AAK76499.1
BT025878 mRNA Translation: ABF85780.1

Protein sequence database of the Protein Information Resource

More...
PIRi
A71412
S48694

NCBI Reference Sequences

More...
RefSeqi
NP_001190732.1, NM_001203803.1
NP_001190733.1, NM_001203804.1
NP_001328013.1, NM_001340975.1
NP_193224.1, NM_117574.4
NP_849386.1, NM_179055.3

Genome annotation databases

Ensembl plant genome annotation project

More...
EnsemblPlantsi
AT4G14880.1; AT4G14880.1; AT4G14880
AT4G14880.2; AT4G14880.2; AT4G14880
AT4G14880.3; AT4G14880.3; AT4G14880
AT4G14880.4; AT4G14880.4; AT4G14880
AT4G14880.5; AT4G14880.5; AT4G14880

Database of genes from NCBI RefSeq genomes

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GeneIDi
827145

Gramene; a comparative resource for plants

More...
Gramenei
AT4G14880.1; AT4G14880.1; AT4G14880
AT4G14880.2; AT4G14880.2; AT4G14880
AT4G14880.3; AT4G14880.3; AT4G14880
AT4G14880.4; AT4G14880.4; AT4G14880
AT4G14880.5; AT4G14880.5; AT4G14880

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
ath:AT4G14880

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X80376 mRNA Translation: CAA56593.2
X84097 mRNA Translation: CAA58893.1
AJ272027 Genomic DNA Translation: CAB72932.1
Z97337 Genomic DNA Translation: CAB10267.1
AL161540 Genomic DNA Translation: CAB78530.1
CP002687 Genomic DNA Translation: AEE83512.1
CP002687 Genomic DNA Translation: AEE83513.1
CP002687 Genomic DNA Translation: AEE83514.1
CP002687 Genomic DNA Translation: AEE83515.1
CP002687 Genomic DNA Translation: ANM66097.1
AY045825 mRNA Translation: AAK76499.1
BT025878 mRNA Translation: ABF85780.1
PIRiA71412
S48694
RefSeqiNP_001190732.1, NM_001203803.1
NP_001190733.1, NM_001203804.1
NP_001328013.1, NM_001340975.1
NP_193224.1, NM_117574.4
NP_849386.1, NM_179055.3

3D structure databases

Select the link destinations:

Protein Data Bank Europe

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PDBei

Protein Data Bank RCSB

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RCSB PDBi

Protein Data Bank Japan

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PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1Z7WX-ray2.20A1-322[»]
1Z7YX-ray2.70A1-322[»]
2ISQX-ray2.80A3-322[»]
SMRiP47998
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGRIDi12442, 8 interactors
IntActiP47998, 5 interactors
STRINGi3702.AT4G14880.4

PTM databases

iPTMnetiP47998
MetOSiteiP47998

Proteomic databases

PaxDbiP47998
PRIDEiP47998
ProteomicsDBi222595

Genome annotation databases

EnsemblPlantsiAT4G14880.1; AT4G14880.1; AT4G14880
AT4G14880.2; AT4G14880.2; AT4G14880
AT4G14880.3; AT4G14880.3; AT4G14880
AT4G14880.4; AT4G14880.4; AT4G14880
AT4G14880.5; AT4G14880.5; AT4G14880
GeneIDi827145
GrameneiAT4G14880.1; AT4G14880.1; AT4G14880
AT4G14880.2; AT4G14880.2; AT4G14880
AT4G14880.3; AT4G14880.3; AT4G14880
AT4G14880.4; AT4G14880.4; AT4G14880
AT4G14880.5; AT4G14880.5; AT4G14880
KEGGiath:AT4G14880

Organism-specific databases

AraportiAT4G14880
TAIRilocus:2130419, AT4G14880

Phylogenomic databases

eggNOGiKOG1252, Eukaryota
HOGENOMiCLU_021018_1_0_1
InParanoidiP47998
KOiK01738
OMAiWDSGERY
OrthoDBi1016546at2759
PhylomeDBiP47998

Enzyme and pathway databases

UniPathwayiUPA00136;UER00200
BioCyciMetaCyc:AT4G14880-MONOMER
BRENDAi2.5.1.47, 399
SABIO-RKiP47998

Miscellaneous databases

EvolutionaryTraceiP47998

Protein Ontology

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PROi
PR:P47998

Gene expression databases

ExpressionAtlasiP47998, baseline and differential
GenevisibleiP47998, AT

Family and domain databases

Gene3Di3.40.50.1100, 2 hits
InterProiView protein in InterPro
IPR005856, Cys_synth
IPR005859, CysK
IPR001216, P-phosphate_BS
IPR001926, PLP-dep
IPR036052, Trypto_synt_PLP_dependent
PfamiView protein in Pfam
PF00291, PALP, 1 hit
SUPFAMiSSF53686, SSF53686, 1 hit
TIGRFAMsiTIGR01139, cysK, 1 hit
TIGR01136, cysKM, 1 hit
PROSITEiView protein in PROSITE
PS00901, CYS_SYNTHASE, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiCYSK1_ARATH
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P47998
Secondary accession number(s): O23343
, Q1EC56, Q42570, Q94AS7
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1996
Last sequence update: December 1, 2000
Last modified: August 12, 2020
This is version 171 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Reference proteome

Documents

  1. Arabidopsis thaliana
    Arabidopsis thaliana: entries and gene names
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. SIMILARITY comments
    Index of protein domains and families
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