UniProtKB - P47992 (XCL1_HUMAN)
Protein
Lymphotactin
Gene
XCL1
Organism
Homo sapiens (Human)
Status
Functioni
Chemotactic activity for lymphocytes but not for monocytes or neutrophils. In thymus, mediates medullary accumulation of thymic dendritic cells and contributes to regulatoy T cell development, playing a role in self-tolerance establishment.By similarity
GO - Molecular functioni
- CCR chemokine receptor binding Source: GO_Central
- chemokine activity Source: BHF-UCL
- chemokine receptor binding Source: BHF-UCL
- protein homodimerization activity Source: BHF-UCL
GO - Biological processi
- antimicrobial humoral immune response mediated by antimicrobial peptide Source: UniProtKB
- cell-cell signaling Source: BHF-UCL
- cellular response to interferon-gamma Source: GO_Central
- cellular response to interleukin-1 Source: GO_Central
- cellular response to interleukin-4 Source: BHF-UCL
- cellular response to transforming growth factor beta stimulus Source: BHF-UCL
- cellular response to tumor necrosis factor Source: GO_Central
- chemokine-mediated signaling pathway Source: GO_Central
- G protein-coupled receptor signaling pathway Source: GO_Central
- inflammatory response Source: GO_Central
- killing of cells of other organism Source: UniProtKB
- lymphocyte chemotaxis Source: GO_Central
- mature natural killer cell chemotaxis Source: BHF-UCL
- monocyte chemotaxis Source: GO_Central
- negative regulation of CD4-positive, alpha-beta T cell proliferation Source: BHF-UCL
- negative regulation of DNA-binding transcription factor activity Source: BHF-UCL
- negative regulation of interferon-gamma production Source: BHF-UCL
- negative regulation of interleukin-2 production Source: BHF-UCL
- negative regulation of T cell cytokine production Source: BHF-UCL
- negative regulation of T-helper 1 cell activation Source: BHF-UCL
- negative regulation of T-helper 1 type immune response Source: BHF-UCL
- negative regulation of transcription, DNA-templated Source: BHF-UCL
- neutrophil chemotaxis Source: GO_Central
- positive regulation of B cell chemotaxis Source: BHF-UCL
- positive regulation of CD4-positive, alpha-beta T cell proliferation Source: BHF-UCL
- positive regulation of CD8-positive, alpha-beta T cell proliferation Source: BHF-UCL
- positive regulation of ERK1 and ERK2 cascade Source: GO_Central
- positive regulation of granzyme A production Source: BHF-UCL
- positive regulation of granzyme B production Source: BHF-UCL
- positive regulation of GTPase activity Source: GO_Central
- positive regulation of immunoglobulin production in mucosal tissue Source: BHF-UCL
- positive regulation of interleukin-10 production Source: BHF-UCL
- positive regulation of leukocyte chemotaxis Source: BHF-UCL
- positive regulation of natural killer cell chemotaxis Source: BHF-UCL
- positive regulation of neutrophil chemotaxis Source: BHF-UCL
- positive regulation of release of sequestered calcium ion into cytosol Source: BHF-UCL
- positive regulation of T cell chemotaxis Source: BHF-UCL
- positive regulation of T cell cytokine production Source: BHF-UCL
- positive regulation of T cell mediated cytotoxicity Source: BHF-UCL
- positive regulation of T-helper 1 cell cytokine production Source: BHF-UCL
- positive regulation of T-helper 2 cell cytokine production Source: BHF-UCL
- positive regulation of thymocyte migration Source: BHF-UCL
- positive regulation of transforming growth factor beta production Source: BHF-UCL
- regulation of inflammatory response Source: BHF-UCL
- release of sequestered calcium ion into cytosol Source: BHF-UCL
- response to virus Source: BHF-UCL
- signal transduction Source: BHF-UCL
Keywordsi
Molecular function | Cytokine |
Biological process | Chemotaxis |
Enzyme and pathway databases
PathwayCommonsi | P47992 |
Reactomei | R-HSA-380108, Chemokine receptors bind chemokines R-HSA-416476, G alpha (q) signalling events |
SIGNORi | P47992 |
Protein family/group databases
MoonDBi | P47992, Curated |
MoonProti | P47992 |
Names & Taxonomyi
Protein namesi | Recommended name: LymphotactinAlternative name(s): ATAC C motif chemokine 1 Cytokine SCM-1 Lymphotaxin SCM-1-alpha Small-inducible cytokine C1 XC chemokine ligand 1 |
Gene namesi | Name:XCL1 Synonyms:LTN, SCYC1 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
EuPathDBi | HostDB:ENSG00000143184.4 |
HGNCi | HGNC:10645, XCL1 |
MIMi | 600250, gene |
neXtProti | NX_P47992 |
Subcellular locationi
Extracellular region or secreted
Extracellular region or secreted
- extracellular region Source: Reactome
- extracellular space Source: BHF-UCL
Keywords - Cellular componenti
SecretedPathology & Biotechi
Organism-specific databases
DisGeNETi | 6375 |
OpenTargetsi | ENSG00000143184 |
PharmGKBi | PA35575 |
Miscellaneous databases
Pharosi | P47992, Tbio |
Polymorphism and mutation databases
BioMutai | XCL1 |
DMDMi | 1346471 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 21 | Sequence analysisAdd BLAST | 21 | |
ChainiPRO_0000005248 | 22 – 114 | LymphotactinAdd BLAST | 93 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Disulfide bondi | 32 ↔ 69 | 1 Publication |
Keywords - PTMi
Disulfide bondProteomic databases
MassIVEi | P47992 |
PaxDbi | P47992 |
PeptideAtlasi | P47992 |
PRIDEi | P47992 |
ProteomicsDBi | 55830 |
PTM databases
PhosphoSitePlusi | P47992 |
Expressioni
Tissue specificityi
Highest level in spleen, lower in peripheral leukocytes and very low levels in lung, colon and small intestine.
Gene expression databases
Bgeei | ENSG00000143184, Expressed in leukocyte and 86 other tissues |
Genevisiblei | P47992, HS |
Organism-specific databases
HPAi | ENSG00000143184, Group enriched (blood, lymphoid tissue) |
Interactioni
Binary interactionsi
Hide detailsP47992
GO - Molecular functioni
- CCR chemokine receptor binding Source: GO_Central
- chemokine activity Source: BHF-UCL
- chemokine receptor binding Source: BHF-UCL
- protein homodimerization activity Source: BHF-UCL
Protein-protein interaction databases
BioGRIDi | 112277, 9 interactors |
DIPi | DIP-29876N |
IntActi | P47992, 25 interactors |
STRINGi | 9606.ENSP00000356792 |
Miscellaneous databases
RNActi | P47992, protein |
Structurei
Secondary structure
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details3D structure databases
BMRBi | P47992 |
SMRi | P47992 |
ModBasei | Search... |
PDBe-KBi | Search... |
Miscellaneous databases
EvolutionaryTracei | P47992 |
Family & Domainsi
Sequence similaritiesi
Belongs to the intercrine gamma family.Curated
Keywords - Domaini
SignalPhylogenomic databases
eggNOGi | ENOG502S6ZP, Eukaryota |
GeneTreei | ENSGT00970000193327 |
HOGENOMi | CLU_141716_2_0_1 |
InParanoidi | P47992 |
OMAi | VPDKSIC |
OrthoDBi | 1553663at2759 |
PhylomeDBi | P47992 |
TreeFami | TF334888 |
Family and domain databases
CDDi | cd00271, Chemokine_C, 1 hit |
InterProi | View protein in InterPro IPR039809, Chemokine_b/g/d IPR001811, Chemokine_IL8-like_dom IPR008105, Chemokine_XCL1/XCL2 IPR036048, Interleukin_8-like_sf |
PANTHERi | PTHR12015, PTHR12015, 1 hit PTHR12015:SF101, PTHR12015:SF101, 1 hit |
Pfami | View protein in Pfam PF00048, IL8, 1 hit |
PRINTSi | PR01731, LYMPHOTACTIN |
SMARTi | View protein in SMART SM00199, SCY, 1 hit |
SUPFAMi | SSF54117, SSF54117, 1 hit |
i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
P47992-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MRLLILALLG ICSLTAYIVE GVGSEVSDKR TCVSLTTQRL PVSRIKTYTI
60 70 80 90 100
TEGSLRAVIF ITKRGLKVCA DPQATWVRDV VRSMDRKSNT RNNMIQTKPT
110
GTQQSTNTAV TLTG
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U23772 mRNA Translation: AAC50164.1 D43768 mRNA Translation: BAA07825.1 X86474 mRNA Translation: CAA60198.1 D63790 Genomic DNA Translation: BAA09859.1 AL031736 Genomic DNA No translation available. BC069817 mRNA Translation: AAH69817.1 BC070309 mRNA Translation: AAH70309.1 |
CCDSi | CCDS1274.1 |
PIRi | S60650, ETHUL |
RefSeqi | NP_002986.1, NM_002995.2 XP_011508167.1, XM_011509865.2 |
Genome annotation databases
Ensembli | ENST00000367818; ENSP00000356792; ENSG00000143184 |
GeneIDi | 6375 |
KEGGi | hsa:6375 |
UCSCi | uc001gfo.2, human |
Similar proteinsi
Cross-referencesi
Web resourcesi
Wikipedia XCL1 entry |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U23772 mRNA Translation: AAC50164.1 D43768 mRNA Translation: BAA07825.1 X86474 mRNA Translation: CAA60198.1 D63790 Genomic DNA Translation: BAA09859.1 AL031736 Genomic DNA No translation available. BC069817 mRNA Translation: AAH69817.1 BC070309 mRNA Translation: AAH70309.1 |
CCDSi | CCDS1274.1 |
PIRi | S60650, ETHUL |
RefSeqi | NP_002986.1, NM_002995.2 XP_011508167.1, XM_011509865.2 |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
1J8I | NMR | - | A | 22-114 | [»] | |
1J9O | NMR | - | A | 22-114 | [»] | |
2HDM | NMR | - | A | 23-114 | [»] | |
2JP1 | NMR | - | A/B | 22-114 | [»] | |
2N54 | NMR | - | A/B | 22-114 | [»] | |
2NYZ | X-ray | 2.60 | D/E | 22-114 | [»] | |
BMRBi | P47992 | |||||
SMRi | P47992 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 112277, 9 interactors |
DIPi | DIP-29876N |
IntActi | P47992, 25 interactors |
STRINGi | 9606.ENSP00000356792 |
Protein family/group databases
MoonDBi | P47992, Curated |
MoonProti | P47992 |
PTM databases
PhosphoSitePlusi | P47992 |
Polymorphism and mutation databases
BioMutai | XCL1 |
DMDMi | 1346471 |
Proteomic databases
MassIVEi | P47992 |
PaxDbi | P47992 |
PeptideAtlasi | P47992 |
PRIDEi | P47992 |
ProteomicsDBi | 55830 |
Protocols and materials databases
Antibodypediai | 20539, 391 antibodies |
Genome annotation databases
Ensembli | ENST00000367818; ENSP00000356792; ENSG00000143184 |
GeneIDi | 6375 |
KEGGi | hsa:6375 |
UCSCi | uc001gfo.2, human |
Organism-specific databases
CTDi | 6375 |
DisGeNETi | 6375 |
EuPathDBi | HostDB:ENSG00000143184.4 |
GeneCardsi | XCL1 |
HGNCi | HGNC:10645, XCL1 |
HPAi | ENSG00000143184, Group enriched (blood, lymphoid tissue) |
MIMi | 600250, gene |
neXtProti | NX_P47992 |
OpenTargetsi | ENSG00000143184 |
PharmGKBi | PA35575 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | ENOG502S6ZP, Eukaryota |
GeneTreei | ENSGT00970000193327 |
HOGENOMi | CLU_141716_2_0_1 |
InParanoidi | P47992 |
OMAi | VPDKSIC |
OrthoDBi | 1553663at2759 |
PhylomeDBi | P47992 |
TreeFami | TF334888 |
Enzyme and pathway databases
PathwayCommonsi | P47992 |
Reactomei | R-HSA-380108, Chemokine receptors bind chemokines R-HSA-416476, G alpha (q) signalling events |
SIGNORi | P47992 |
Miscellaneous databases
BioGRID-ORCSi | 6375, 68 hits in 803 CRISPR screens |
EvolutionaryTracei | P47992 |
GenomeRNAii | 6375 |
Pharosi | P47992, Tbio |
PROi | PR:P47992 |
RNActi | P47992, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000143184, Expressed in leukocyte and 86 other tissues |
Genevisiblei | P47992, HS |
Family and domain databases
CDDi | cd00271, Chemokine_C, 1 hit |
InterProi | View protein in InterPro IPR039809, Chemokine_b/g/d IPR001811, Chemokine_IL8-like_dom IPR008105, Chemokine_XCL1/XCL2 IPR036048, Interleukin_8-like_sf |
PANTHERi | PTHR12015, PTHR12015, 1 hit PTHR12015:SF101, PTHR12015:SF101, 1 hit |
Pfami | View protein in Pfam PF00048, IL8, 1 hit |
PRINTSi | PR01731, LYMPHOTACTIN |
SMARTi | View protein in SMART SM00199, SCY, 1 hit |
SUPFAMi | SSF54117, SSF54117, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | XCL1_HUMAN | |
Accessioni | P47992Primary (citable) accession number: P47992 Secondary accession number(s): Q52MA8 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | February 1, 1996 |
Last sequence update: | February 1, 1996 | |
Last modified: | December 2, 2020 | |
This is version 178 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
3D-structure, Reference proteomeDocuments
- MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families - Human chromosome 1
Human chromosome 1: entries, gene names and cross-references to MIM