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Protein

Lymphotactin

Gene

XCL1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Chemotactic activity for lymphocytes but not for monocytes or neutrophils. In thymus, mediates medullary accumulation of thymic dendritic cells and contributes to regulatoy T cell development, playing a role in self-tolerance establishment.By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionCytokine
Biological processChemotaxis

Enzyme and pathway databases

ReactomeiR-HSA-380108 Chemokine receptors bind chemokines
R-HSA-416476 G alpha (q) signalling events
SIGNORiP47992

Protein family/group databases

MoonDBiP47992 Curated
MoonProtiP47992

Names & Taxonomyi

Protein namesi
Recommended name:
Lymphotactin
Alternative name(s):
ATAC
C motif chemokine 1
Cytokine SCM-1
Lymphotaxin
SCM-1-alpha
Small-inducible cytokine C1
XC chemokine ligand 1
Gene namesi
Name:XCL1
Synonyms:LTN, SCYC1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

EuPathDBiHostDB:ENSG00000143184.4
HGNCiHGNC:10645 XCL1
MIMi600250 gene
neXtProtiNX_P47992

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Organism-specific databases

DisGeNETi6375
OpenTargetsiENSG00000143184
PharmGKBiPA35575

Polymorphism and mutation databases

BioMutaiXCL1
DMDMi1346471

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 21Sequence analysisAdd BLAST21
ChainiPRO_000000524822 – 114LymphotactinAdd BLAST93

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi32 ↔ 691 Publication

Keywords - PTMi

Disulfide bond

Proteomic databases

PaxDbiP47992
PeptideAtlasiP47992
PRIDEiP47992
ProteomicsDBi55830

PTM databases

PhosphoSitePlusiP47992

Miscellaneous databases

PMAP-CutDBiP47992

Expressioni

Tissue specificityi

Highest level in spleen, lower in peripheral leukocytes and very low levels in lung, colon and small intestine.

Gene expression databases

BgeeiENSG00000143184 Expressed in 65 organ(s), highest expression level in leukocyte
CleanExiHS_XCL1
GenevisibleiP47992 HS

Organism-specific databases

HPAiHPA057725

Interactioni

Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

BioGridi112277, 9 interactors
DIPiDIP-29876N
IntActiP47992, 18 interactors
STRINGi9606.ENSP00000356792

Structurei

Secondary structure

1114
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliP47992
SMRiP47992
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP47992

Family & Domainsi

Sequence similaritiesi

Belongs to the intercrine gamma family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410IZ5E Eukaryota
ENOG4111C3M LUCA
GeneTreeiENSGT00390000005120
HOGENOMiHOG000036685
HOVERGENiHBG102118
InParanoidiP47992
KOiK05507
OMAiWVKKAVE
OrthoDBiEOG091G15G5
PhylomeDBiP47992
TreeFamiTF334888

Family and domain databases

CDDicd00271 Chemokine_C, 1 hit
InterProiView protein in InterPro
IPR001811 Chemokine_IL8-like_dom
IPR008105 Chemokine_XCL1/XCL2
IPR036048 Interleukin_8-like_sf
PANTHERiPTHR12015:SF101 PTHR12015:SF101, 1 hit
PfamiView protein in Pfam
PF00048 IL8, 1 hit
PRINTSiPR01731 LYMPHOTACTIN
SMARTiView protein in SMART
SM00199 SCY, 1 hit
SUPFAMiSSF54117 SSF54117, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P47992-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MRLLILALLG ICSLTAYIVE GVGSEVSDKR TCVSLTTQRL PVSRIKTYTI
60 70 80 90 100
TEGSLRAVIF ITKRGLKVCA DPQATWVRDV VRSMDRKSNT RNNMIQTKPT
110
GTQQSTNTAV TLTG
Length:114
Mass (Da):12,517
Last modified:February 1, 1996 - v1
Checksum:iFABA16063C3FC165
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U23772 mRNA Translation: AAC50164.1
D43768 mRNA Translation: BAA07825.1
X86474 mRNA Translation: CAA60198.1
D63790 Genomic DNA Translation: BAA09859.1
AL031736 Genomic DNA No translation available.
BC069817 mRNA Translation: AAH69817.1
BC070309 mRNA Translation: AAH70309.1
CCDSiCCDS1274.1
PIRiS60650 ETHUL
RefSeqiNP_002986.1, NM_002995.2
XP_011508167.1, XM_011509865.2
UniGeneiHs.458346
Hs.546295

Genome annotation databases

EnsembliENST00000367818; ENSP00000356792; ENSG00000143184
GeneIDi6375
KEGGihsa:6375
UCSCiuc001gfo.2 human

Similar proteinsi

Cross-referencesi

Web resourcesi

Wikipedia

XCL1 entry

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U23772 mRNA Translation: AAC50164.1
D43768 mRNA Translation: BAA07825.1
X86474 mRNA Translation: CAA60198.1
D63790 Genomic DNA Translation: BAA09859.1
AL031736 Genomic DNA No translation available.
BC069817 mRNA Translation: AAH69817.1
BC070309 mRNA Translation: AAH70309.1
CCDSiCCDS1274.1
PIRiS60650 ETHUL
RefSeqiNP_002986.1, NM_002995.2
XP_011508167.1, XM_011509865.2
UniGeneiHs.458346
Hs.546295

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1J8INMR-A22-114[»]
1J9ONMR-A22-114[»]
2HDMNMR-A23-114[»]
2JP1NMR-A/B22-114[»]
2N54NMR-A/B22-114[»]
2NYZX-ray2.60D/E22-114[»]
ProteinModelPortaliP47992
SMRiP47992
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi112277, 9 interactors
DIPiDIP-29876N
IntActiP47992, 18 interactors
STRINGi9606.ENSP00000356792

Protein family/group databases

MoonDBiP47992 Curated
MoonProtiP47992

PTM databases

PhosphoSitePlusiP47992

Polymorphism and mutation databases

BioMutaiXCL1
DMDMi1346471

Proteomic databases

PaxDbiP47992
PeptideAtlasiP47992
PRIDEiP47992
ProteomicsDBi55830

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000367818; ENSP00000356792; ENSG00000143184
GeneIDi6375
KEGGihsa:6375
UCSCiuc001gfo.2 human

Organism-specific databases

CTDi6375
DisGeNETi6375
EuPathDBiHostDB:ENSG00000143184.4
GeneCardsiXCL1
HGNCiHGNC:10645 XCL1
HPAiHPA057725
MIMi600250 gene
neXtProtiNX_P47992
OpenTargetsiENSG00000143184
PharmGKBiPA35575
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IZ5E Eukaryota
ENOG4111C3M LUCA
GeneTreeiENSGT00390000005120
HOGENOMiHOG000036685
HOVERGENiHBG102118
InParanoidiP47992
KOiK05507
OMAiWVKKAVE
OrthoDBiEOG091G15G5
PhylomeDBiP47992
TreeFamiTF334888

Enzyme and pathway databases

ReactomeiR-HSA-380108 Chemokine receptors bind chemokines
R-HSA-416476 G alpha (q) signalling events
SIGNORiP47992

Miscellaneous databases

ChiTaRSiXCL1 human
EvolutionaryTraceiP47992
GenomeRNAii6375
PMAP-CutDBiP47992
PROiPR:P47992
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000143184 Expressed in 65 organ(s), highest expression level in leukocyte
CleanExiHS_XCL1
GenevisibleiP47992 HS

Family and domain databases

CDDicd00271 Chemokine_C, 1 hit
InterProiView protein in InterPro
IPR001811 Chemokine_IL8-like_dom
IPR008105 Chemokine_XCL1/XCL2
IPR036048 Interleukin_8-like_sf
PANTHERiPTHR12015:SF101 PTHR12015:SF101, 1 hit
PfamiView protein in Pfam
PF00048 IL8, 1 hit
PRINTSiPR01731 LYMPHOTACTIN
SMARTiView protein in SMART
SM00199 SCY, 1 hit
SUPFAMiSSF54117 SSF54117, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiXCL1_HUMAN
AccessioniPrimary (citable) accession number: P47992
Secondary accession number(s): Q52MA8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1996
Last sequence update: February 1, 1996
Last modified: September 12, 2018
This is version 162 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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