Lymphotactin

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functionⁱ

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functionⁱ

• CCR chemokine receptor binding Source: GO_Central <p>Inferred from Biological aspect of Ancestor</p> <p>A type of phylogenetic evidence whereby an aspect of a descendent is inferred through the characterization of an aspect of a ancestral gene.</p> <p>More information in the <a href="http://geneontology.org/page/guide%2Dgo%2Devidence%2Dcodes#iba">GO evidence code guide</a></p> Inferred from biological aspect of ancestorⁱ
  • "Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium."
    Gaudet P., Livstone M.S., Lewis S.E., Thomas P.D.
    Brief. Bioinformatics 12:449-462(2011) [PubMed] [Europe PMC] [Abstract]
• chemokine activity Source: BHF-UCL <p>Inferred from Direct Assay</p> <p>Used to indicate a direct assay for the function, process or component indicated by the GO term.</p> <p>More information in the <a href="http://geneontology.org/page/guide%2Dgo%2Devidence%2Dcodes#ida">GO evidence code guide</a></p> Inferred from direct assayⁱ
  • Ref.1

    "Molecular cloning and functional characterization of human lymphotactin."
    Kennedy J., Kelner G.S., Kleyensteuber S., Schall T.J., Weiss M.C., Yssel H., Schneider P.V., Cocks B.G., Bacon K.B., Zlotnik A.
    J. Immunol. 155:203-209(1995) [PubMed] [Europe PMC] [Abstract]

    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
• chemokine receptor binding Source: BHF-UCLInferred from direct assayⁱ
  • "Identification of single C motif-1/lymphotactin receptor XCR1."
    Yoshida T., Imai T., Kakizaki M., Nishimura M., Takagi S., Yoshie O.
    J. Biol. Chem. 273:16551-16554(1998) [PubMed] [Europe PMC] [Abstract]
• protein homodimerization activity Source: BHF-UCLInferred from direct assayⁱ
  • "Structural rearrangement of human lymphotactin, a C chemokine, under physiological solution conditions."
    Kuloglu E.S., McCaslin D.R., Markley J.L., Volkman B.F.
    J. Biol. Chem. 277:17863-17870(2002) [PubMed] [Europe PMC] [Abstract]

GO - Biological processⁱ

• antimicrobial humoral immune response mediated by antimicrobial peptide Source: UniProtKBInferred from direct assayⁱ
  • "Many chemokines including CCL20/MIP-3alpha display antimicrobial activity."
    Yang D., Chen Q., Hoover D.M., Staley P., Tucker K.D., Lubkowski J., Oppenheim J.J.
    J. Leukoc. Biol. 74:448-455(2003) [PubMed] [Europe PMC] [Abstract]
• cell-cell signaling Source: BHF-UCLInferred from direct assayⁱ
  • Ref.1

    "Molecular cloning and functional characterization of human lymphotactin."
    Kennedy J., Kelner G.S., Kleyensteuber S., Schall T.J., Weiss M.C., Yssel H., Schneider P.V., Cocks B.G., Bacon K.B., Zlotnik A.
    J. Immunol. 155:203-209(1995) [PubMed] [Europe PMC] [Abstract]

    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
• cellular response to interferon-gamma Source: GO_CentralInferred from biological aspect of ancestorⁱ
  • "Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium."
    Gaudet P., Livstone M.S., Lewis S.E., Thomas P.D.
    Brief. Bioinformatics 12:449-462(2011) [PubMed] [Europe PMC] [Abstract]
• cellular response to interleukin-1 Source: GO_CentralInferred from biological aspect of ancestorⁱ
  • "Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium."
    Gaudet P., Livstone M.S., Lewis S.E., Thomas P.D.
    Brief. Bioinformatics 12:449-462(2011) [PubMed] [Europe PMC] [Abstract]
• cellular response to interleukin-4 Source: BHF-UCL
• cellular response to transforming growth factor beta stimulus Source: BHF-UCL
• cellular response to tumor necrosis factor Source: GO_CentralInferred from biological aspect of ancestorⁱ
  • "Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium."
    Gaudet P., Livstone M.S., Lewis S.E., Thomas P.D.
    Brief. Bioinformatics 12:449-462(2011) [PubMed] [Europe PMC] [Abstract]
• chemokine-mediated signaling pathway Source: GO_CentralInferred from biological aspect of ancestorⁱ
  • "Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium."
    Gaudet P., Livstone M.S., Lewis S.E., Thomas P.D.
    Brief. Bioinformatics 12:449-462(2011) [PubMed] [Europe PMC] [Abstract]
• eosinophil chemotaxis Source: GO_CentralInferred from biological aspect of ancestorⁱ
  • "Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium."
    Gaudet P., Livstone M.S., Lewis S.E., Thomas P.D.
    Brief. Bioinformatics 12:449-462(2011) [PubMed] [Europe PMC] [Abstract]
• G protein-coupled receptor signaling pathway Source: GO_CentralInferred from biological aspect of ancestorⁱ
  • "Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium."
    Gaudet P., Livstone M.S., Lewis S.E., Thomas P.D.
    Brief. Bioinformatics 12:449-462(2011) [PubMed] [Europe PMC] [Abstract]
• inflammatory response Source: GO_CentralInferred from biological aspect of ancestorⁱ
  • "Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium."
    Gaudet P., Livstone M.S., Lewis S.E., Thomas P.D.
    Brief. Bioinformatics 12:449-462(2011) [PubMed] [Europe PMC] [Abstract]
• killing of cells of other organism Source: UniProtKBInferred from direct assayⁱ
  • "Many chemokines including CCL20/MIP-3alpha display antimicrobial activity."
    Yang D., Chen Q., Hoover D.M., Staley P., Tucker K.D., Lubkowski J., Oppenheim J.J.
    J. Leukoc. Biol. 74:448-455(2003) [PubMed] [Europe PMC] [Abstract]
• lymphocyte chemotaxis Source: GO_CentralInferred from biological aspect of ancestorⁱ
  • "Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium."
    Gaudet P., Livstone M.S., Lewis S.E., Thomas P.D.
    Brief. Bioinformatics 12:449-462(2011) [PubMed] [Europe PMC] [Abstract]
• mature natural killer cell chemotaxis Source: BHF-UCLInferred from direct assayⁱ
  • "Lymphotactin is produced by NK cells and attracts both NK cells and T cells in vivo."
    Hedrick J.A., Saylor V., Figueroa D., Mizoue L., Xu Y., Menon S., Abrams J., Handel T., Zlotnik A.
    J. Immunol. 158:1533-1540(1997) [PubMed] [Europe PMC] [Abstract]
• monocyte chemotaxis Source: GO_CentralInferred from biological aspect of ancestorⁱ
  • "Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium."
    Gaudet P., Livstone M.S., Lewis S.E., Thomas P.D.
    Brief. Bioinformatics 12:449-462(2011) [PubMed] [Europe PMC] [Abstract]
• negative regulation of CD4-positive, alpha-beta T cell proliferation Source: BHF-UCLInferred from direct assayⁱ
  • "The C-class chemokine, lymphotactin, impairs the induction of Th1-type lymphokines in human CD4(+) T cells."
    Cerdan C., Serfling E., Olive D.
    Blood 96:420-428(2000) [PubMed] [Europe PMC] [Abstract]
• negative regulation of DNA-binding transcription factor activity Source: BHF-UCLInferred from direct assayⁱ
  • "The C-class chemokine, lymphotactin, impairs the induction of Th1-type lymphokines in human CD4(+) T cells."
    Cerdan C., Serfling E., Olive D.
    Blood 96:420-428(2000) [PubMed] [Europe PMC] [Abstract]
• negative regulation of interferon-gamma production Source: BHF-UCLInferred from direct assayⁱ
  • "The C-class chemokine, lymphotactin, impairs the induction of Th1-type lymphokines in human CD4(+) T cells."
    Cerdan C., Serfling E., Olive D.
    Blood 96:420-428(2000) [PubMed] [Europe PMC] [Abstract]
• negative regulation of interleukin-2 production Source: BHF-UCLInferred from direct assayⁱ
  • "The C-class chemokine, lymphotactin, impairs the induction of Th1-type lymphokines in human CD4(+) T cells."
    Cerdan C., Serfling E., Olive D.
    Blood 96:420-428(2000) [PubMed] [Europe PMC] [Abstract]
• negative regulation of T cell cytokine production Source: BHF-UCLInferred from direct assayⁱ
  • "The C-class chemokine, lymphotactin, impairs the induction of Th1-type lymphokines in human CD4(+) T cells."
    Cerdan C., Serfling E., Olive D.
    Blood 96:420-428(2000) [PubMed] [Europe PMC] [Abstract]
• negative regulation of T-helper 1 cell activation Source: BHF-UCLInferred from direct assayⁱ
  • "The C-class chemokine, lymphotactin, impairs the induction of Th1-type lymphokines in human CD4(+) T cells."
    Cerdan C., Serfling E., Olive D.
    Blood 96:420-428(2000) [PubMed] [Europe PMC] [Abstract]
• negative regulation of T-helper 1 type immune response Source: BHF-UCL <p>Inferred by Curator</p> <p>Used for cases where an annotation is not supported by any evidence but can be reasonably inferred by a curator from other GO annotations for which evidence<br />is available.</p> <p>More information in the <a href="http://geneontology.org/page/guide%2Dgo%2Devidence%2Dcodes#ic">GO evidence code guide</a></p> Inferred by curatorⁱ
  • "The C-class chemokine, lymphotactin, impairs the induction of Th1-type lymphokines in human CD4(+) T cells."
    Cerdan C., Serfling E., Olive D.
    Blood 96:420-428(2000) [PubMed] [Europe PMC] [Abstract]
• negative regulation of transcription, DNA-templated Source: BHF-UCLInferred from direct assayⁱ
  • "The C-class chemokine, lymphotactin, impairs the induction of Th1-type lymphokines in human CD4(+) T cells."
    Cerdan C., Serfling E., Olive D.
    Blood 96:420-428(2000) [PubMed] [Europe PMC] [Abstract]
• neutrophil chemotaxis Source: GO_CentralInferred from biological aspect of ancestorⁱ
  • "Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium."
    Gaudet P., Livstone M.S., Lewis S.E., Thomas P.D.
    Brief. Bioinformatics 12:449-462(2011) [PubMed] [Europe PMC] [Abstract]
• positive regulation of B cell chemotaxis Source: BHF-UCL
• positive regulation of CD4-positive, alpha-beta T cell proliferation Source: BHF-UCL
• positive regulation of CD8-positive, alpha-beta T cell proliferation Source: BHF-UCLInferred from direct assayⁱ
  • "The C-class chemokine, lymphotactin, impairs the induction of Th1-type lymphokines in human CD4(+) T cells."
    Cerdan C., Serfling E., Olive D.
    Blood 96:420-428(2000) [PubMed] [Europe PMC] [Abstract]
• positive regulation of ERK1 and ERK2 cascade Source: GO_CentralInferred from biological aspect of ancestorⁱ
  • "Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium."
    Gaudet P., Livstone M.S., Lewis S.E., Thomas P.D.
    Brief. Bioinformatics 12:449-462(2011) [PubMed] [Europe PMC] [Abstract]
• positive regulation of granzyme A production Source: BHF-UCLInferred from direct assayⁱ
  • "XCL1 enhances regulatory activities of CD4+ CD25(high) CD127(low/-) T cells in human allergic asthma."
    Nguyen K.D., Fohner A., Booker J.D., Dong C., Krensky A.M., Nadeau K.C.
    J. Immunol. 181:5386-5395(2008) [PubMed] [Europe PMC] [Abstract]
• positive regulation of granzyme B production Source: BHF-UCLInferred from direct assayⁱ
  • "XCL1 enhances regulatory activities of CD4+ CD25(high) CD127(low/-) T cells in human allergic asthma."
    Nguyen K.D., Fohner A., Booker J.D., Dong C., Krensky A.M., Nadeau K.C.
    J. Immunol. 181:5386-5395(2008) [PubMed] [Europe PMC] [Abstract]
• positive regulation of GTPase activity Source: GO_CentralInferred from biological aspect of ancestorⁱ
  • "Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium."
    Gaudet P., Livstone M.S., Lewis S.E., Thomas P.D.
    Brief. Bioinformatics 12:449-462(2011) [PubMed] [Europe PMC] [Abstract]
• positive regulation of immunoglobulin production in mucosal tissue Source: BHF-UCL
• positive regulation of interleukin-10 production Source: BHF-UCLInferred from direct assayⁱ
  • "XCL1 enhances regulatory activities of CD4+ CD25(high) CD127(low/-) T cells in human allergic asthma."
    Nguyen K.D., Fohner A., Booker J.D., Dong C., Krensky A.M., Nadeau K.C.
    J. Immunol. 181:5386-5395(2008) [PubMed] [Europe PMC] [Abstract]
• positive regulation of leukocyte chemotaxis Source: BHF-UCL
• positive regulation of natural killer cell chemotaxis Source: BHF-UCLInferred from direct assayⁱ
  • "Lymphotactin is produced by NK cells and attracts both NK cells and T cells in vivo."
    Hedrick J.A., Saylor V., Figueroa D., Mizoue L., Xu Y., Menon S., Abrams J., Handel T., Zlotnik A.
    J. Immunol. 158:1533-1540(1997) [PubMed] [Europe PMC] [Abstract]
• positive regulation of neutrophil chemotaxis Source: BHF-UCL
• positive regulation of release of sequestered calcium ion into cytosol Source: BHF-UCLInferred from direct assayⁱ
  • Ref.1

    "Molecular cloning and functional characterization of human lymphotactin."
    Kennedy J., Kelner G.S., Kleyensteuber S., Schall T.J., Weiss M.C., Yssel H., Schneider P.V., Cocks B.G., Bacon K.B., Zlotnik A.
    J. Immunol. 155:203-209(1995) [PubMed] [Europe PMC] [Abstract]

    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
• positive regulation of T cell chemotaxis Source: BHF-UCLInferred from direct assayⁱ
  • Ref.1

    "Molecular cloning and functional characterization of human lymphotactin."
    Kennedy J., Kelner G.S., Kleyensteuber S., Schall T.J., Weiss M.C., Yssel H., Schneider P.V., Cocks B.G., Bacon K.B., Zlotnik A.
    J. Immunol. 155:203-209(1995) [PubMed] [Europe PMC] [Abstract]

    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
• positive regulation of T cell cytokine production Source: BHF-UCL
• positive regulation of T cell mediated cytotoxicity Source: BHF-UCLInferred from direct assayⁱ
  • "XCL1 enhances regulatory activities of CD4+ CD25(high) CD127(low/-) T cells in human allergic asthma."
    Nguyen K.D., Fohner A., Booker J.D., Dong C., Krensky A.M., Nadeau K.C.
    J. Immunol. 181:5386-5395(2008) [PubMed] [Europe PMC] [Abstract]
• positive regulation of T-helper 1 cell cytokine production Source: BHF-UCL
• positive regulation of T-helper 2 cell cytokine production Source: BHF-UCL
• positive regulation of thymocyte migration Source: BHF-UCL
• positive regulation of transforming growth factor beta production Source: BHF-UCLInferred from direct assayⁱ
  • "XCL1 enhances regulatory activities of CD4+ CD25(high) CD127(low/-) T cells in human allergic asthma."
    Nguyen K.D., Fohner A., Booker J.D., Dong C., Krensky A.M., Nadeau K.C.
    J. Immunol. 181:5386-5395(2008) [PubMed] [Europe PMC] [Abstract]
• regulation of inflammatory response Source: BHF-UCLInferred from direct assayⁱ
  • "XCL1 enhances regulatory activities of CD4+ CD25(high) CD127(low/-) T cells in human allergic asthma."
    Nguyen K.D., Fohner A., Booker J.D., Dong C., Krensky A.M., Nadeau K.C.
    J. Immunol. 181:5386-5395(2008) [PubMed] [Europe PMC] [Abstract]
• release of sequestered calcium ion into cytosol Source: BHF-UCL
• response to virus Source: BHF-UCLInferred from direct assayⁱ
  • "Induction of C chemokine XCL1 (lymphotactin/single C motif-1 alpha/activation-induced, T cell-derived and chemokine-related cytokine) expression by HIV-1 Tat protein."
    Kim B.O., Liu Y., Zhou B.Y., He J.J.
    J. Immunol. 172:1888-1895(2004) [PubMed] [Europe PMC] [Abstract]
• signal transduction Source: BHF-UCLInferred by curatorⁱ
  • "Identification of single C motif-1/lymphotactin receptor XCR1."
    Yoshida T., Imai T., Kakizaki M., Nishimura M., Takagi S., Yoshie O.
    J. Biol. Chem. 273:16551-16554(1998) [PubMed] [Europe PMC] [Abstract]

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsⁱ

Enzyme and pathway databases

Protein family/group databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyⁱ

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationⁱ

Keywords - Cellular componentⁱ

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechⁱ

Organism-specific databases

Miscellaneous databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingⁱ

Molecule processing

Amino acid modifications

Keywords - PTMⁱ

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressionⁱ

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityⁱ

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactionⁱ

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsⁱ

GO - Molecular functionⁱ

• CCR chemokine receptor binding Source: GO_CentralInferred from biological aspect of ancestorⁱ
  • "Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium."
    Gaudet P., Livstone M.S., Lewis S.E., Thomas P.D.
    Brief. Bioinformatics 12:449-462(2011) [PubMed] [Europe PMC] [Abstract]
• chemokine activity Source: BHF-UCLInferred from direct assayⁱ
  • Ref.1

    "Molecular cloning and functional characterization of human lymphotactin."
    Kennedy J., Kelner G.S., Kleyensteuber S., Schall T.J., Weiss M.C., Yssel H., Schneider P.V., Cocks B.G., Bacon K.B., Zlotnik A.
    J. Immunol. 155:203-209(1995) [PubMed] [Europe PMC] [Abstract]

    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
• chemokine receptor binding Source: BHF-UCLInferred from direct assayⁱ
  • "Identification of single C motif-1/lymphotactin receptor XCR1."
    Yoshida T., Imai T., Kakizaki M., Nishimura M., Takagi S., Yoshie O.
    J. Biol. Chem. 273:16551-16554(1998) [PubMed] [Europe PMC] [Abstract]
• protein homodimerization activity Source: BHF-UCLInferred from direct assayⁱ
  • "Structural rearrangement of human lymphotactin, a C chemokine, under physiological solution conditions."
    Kuloglu E.S., McCaslin D.R., Markley J.L., Volkman B.F.
    J. Biol. Chem. 277:17863-17870(2002) [PubMed] [Europe PMC] [Abstract]

Protein-protein interaction databases

Miscellaneous databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structureⁱ

Secondary structure

3D structure databases

Miscellaneous databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsⁱ

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesⁱ

Keywords - Domainⁱ

Phylogenomic databases

Family and domain databases

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequenceⁱ

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusⁱ: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingⁱ: The displayed sequence is further processed into a mature form.

        10         20         30         40         50
MRLLILALLG ICSLTAYIVE GVGSEVSDKR TCVSLTTQRL PVSRIKTYTI 
        60         70         80         90        100
TEGSLRAVIF ITKRGLKVCA DPQATWVRDV VRSMDRKSNT RNNMIQTKPT 
       110 
GTQQSTNTAV TLTG                                        

Sequence databases

Genome annotation databases

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsⁱ

• 90% Identity
• 50% Identity

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesⁱ

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross%5Freferences%5Fsection">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesⁱ

Sequence databases

3D structure databases

Protein-protein interaction databases

Protein family/group databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationⁱ

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousⁱ

Keywords - Technical termⁱ

Documents

1. PDB cross-references
   Index of Protein Data Bank (PDB) cross-references
2. SIMILARITY comments
   Index of protein domains and families
3. Human chromosome 1
   Human chromosome 1: entries, gene names and cross-references to MIM
4. MIM cross-references
   Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot