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Protein

Plasmolipin

Gene

Pllp

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Appears to be involved in myelination. Could also participate in ion transport events as addition of plasmolipin to lipid bilayers induces the formation of ion channels, which are voltage-dependent and K+-selective.

GO - Molecular functioni

GO - Biological processi

  • ion transport Source: RGD
  • membrane raft polarization Source: GO_Central
  • myelination Source: RGD
  • protein localization Source: GO_Central
  • response to wounding Source: RGD

Keywordsi

Molecular functionIon channel
Biological processIon transport, Transport

Protein family/group databases

TCDBi1.A.64.1.1 the plasmolipin (plasmolipin) family

Names & Taxonomyi

Protein namesi
Recommended name:
Plasmolipin
Alternative name(s):
Plasma membrane proteolipid
Gene namesi
Name:Pllp
Synonyms:Pmlp, Tm4sf11
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 19

Organism-specific databases

RGDi621478 Pllp

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 35CytoplasmicSequence analysisAdd BLAST35
Transmembranei36 – 56HelicalSequence analysisAdd BLAST21
Topological domaini57 – 68ExtracellularSequence analysisAdd BLAST12
Transmembranei69 – 89HelicalSequence analysisAdd BLAST21
Topological domaini90 – 99CytoplasmicSequence analysis10
Transmembranei100 – 120HelicalSequence analysisAdd BLAST21
Topological domaini121 – 141ExtracellularSequence analysisAdd BLAST21
Transmembranei142 – 162HelicalSequence analysisAdd BLAST21
Topological domaini163 – 182CytoplasmicSequence analysisAdd BLAST20

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001568151 – 182PlasmolipinAdd BLAST182

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei9PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiP47987
PRIDEiP47987

PTM databases

iPTMnetiP47987
PhosphoSitePlusiP47987

Expressioni

Tissue specificityi

Expression restricted to the sciatic nerve, brain and kidney. In the sciatic nerve, found in Schwann cells; in the brain, in developing oligodendrocytes, especially of the corpus callosum, of cortical white matter, in the optic nerve and in the stratum radiatum and stratum oriens of the hippocampus. In kidney, segregated to the apical surface of renal tubular epithelia.

Developmental stagei

In the sciatic nerve, first detected at postnatal day P4, increases to a maximum at day P14 and then declines to moderate levels in adulthood. In the brain, onset of expression is at day P1, levels increase to reach a maximum at P20 and decline slightly to adulthood.

Gene expression databases

BgeeiENSRNOG00000016558 Expressed in 10 organ(s), highest expression level in adult mammalian kidney
GenevisibleiP47987 RN

Interactioni

Subunit structurei

Hexamer arranged as a trimer of two plasmolipin subunits.

Protein-protein interaction databases

BioGridi249048, 1 interactor
STRINGi10116.ENSRNOP00000022277

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini32 – 166MARVELPROSITE-ProRule annotationAdd BLAST135

Sequence similaritiesi

Belongs to the MAL family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG4788 Eukaryota
ENOG4111IAF LUCA
GeneTreeiENSGT00730000110954
HOGENOMiHOG000247057
HOVERGENiHBG108271
InParanoidiP47987
OMAiVLMIFNV
OrthoDBiEOG091G0RE7
PhylomeDBiP47987
TreeFamiTF316174

Family and domain databases

InterProiView protein in InterPro
IPR013295 MAL
IPR008253 Marvel
PfamiView protein in Pfam
PF01284 MARVEL, 1 hit
PRINTSiPR01884 MALPROTEIN
PROSITEiView protein in PROSITE
PS51225 MARVEL, 1 hit

Sequencei

Sequence statusi: Complete.

P47987-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAEFPSKVST RTSSPAQGVG ASVSAMRPDL GFVRSALGVL ALLQLVLGLL
60 70 80 90 100
VWALIADTPY HLYPAYGWVM FVAVFLWLVT IVFFIIYLFQ LHMKLYMVPW
110 120 130 140 150
PLVLLVFFVA ATVLYITAFV ACAAAVDLTS LRGSRPYNQR SAASFFACLV
160 170 180
MIAYGLSAFF SFQAWRGVGS NAATSQMAGG YS
Length:182
Mass (Da):19,834
Last modified:December 1, 2000 - v2
Checksum:i18F5844F9AA79F6E
GO

Sequence cautioni

The sequence AAA62133 differs from that shown. Reason: Erroneous initiation.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U13617 mRNA Translation: AAA62133.1 Different initiation.
Z49858 mRNA Translation: CAA90017.1
BC078823 mRNA Translation: AAH78823.1
PIRiA55046
RefSeqiNP_071978.1, NM_022533.1
UniGeneiRn.1721

Genome annotation databases

EnsembliENSRNOT00000022277; ENSRNOP00000022277; ENSRNOG00000016558
GeneIDi64364
KEGGirno:64364
UCSCiRGD:621478 rat

Similar proteinsi

Entry informationi

Entry nameiPLLP_RAT
AccessioniPrimary (citable) accession number: P47987
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1996
Last sequence update: December 1, 2000
Last modified: September 12, 2018
This is version 106 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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