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Protein

Neuronal pentraxin-2

Gene

NPTX2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Likely to play role in the modification of cellular properties that underlie long-term plasticity. Binds to agar matrix in a calcium-dependent manner (By similarity).By similarity

Cofactori

Ca2+By similarityNote: Binds 2 calcium ions per subunit.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi277Calcium 1By similarity1
Metal bindingi355Calcium 1By similarity1
Metal bindingi355Calcium 2PROSITE-ProRule annotation1
Metal bindingi356Calcium 1; via carbonyl oxygenBy similarity1
Metal bindingi357Calcium 1By similarity1
Metal bindingi357Calcium 2PROSITE-ProRule annotation1
Metal bindingi367Calcium 2PROSITE-ProRule annotation1

GO - Molecular functioni

GO - Biological processi

  • associative learning Source: Ensembl
  • chemical synaptic transmission Source: UniProtKB
  • regulation of postsynaptic neurotransmitter receptor activity Source: SynGO

Keywordsi

LigandCalcium, Lectin, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Neuronal pentraxin-2
Short name:
NP2
Alternative name(s):
Neuronal pentraxin II
Short name:
NP-II
Gene namesi
Name:NPTX2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 7

Organism-specific databases

EuPathDBiHostDB:ENSG00000106236.3
HGNCiHGNC:7953 NPTX2
MIMi600750 gene
neXtProtiNX_P47972

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Organism-specific databases

DisGeNETi4885
OpenTargetsiENSG00000106236
PharmGKBiPA31739

Polymorphism and mutation databases

BioMutaiNPTX2
DMDMi20981708

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 15Sequence analysisAdd BLAST15
ChainiPRO_000002355116 – 431Neuronal pentraxin-2Add BLAST416

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi148N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi189N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi253 ↔ 313PROSITE-ProRule annotation
Glycosylationi393N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

EPDiP47972
PaxDbiP47972
PeptideAtlasiP47972
PRIDEiP47972
ProteomicsDBi55826

PTM databases

iPTMnetiP47972
PhosphoSitePlusiP47972

Expressioni

Tissue specificityi

Brain, pancreas, liver, heart and skeletal muscle. Highest levels are seen in the testis.

Gene expression databases

BgeeiENSG00000106236 Expressed in 169 organ(s), highest expression level in adenohypophysis
CleanExiHS_NPTX2
GenevisibleiP47972 HS

Organism-specific databases

HPAiCAB020801
HPA049799
HPA058320

Interactioni

Subunit structurei

Homooligomer or heterooligomer (probably pentamer) with neuronal pentraxin receptor (NPTXR).1 Publication

Protein-protein interaction databases

BioGridi110945, 6 interactors
IntActiP47972, 1 interactor
STRINGi9606.ENSP00000265634

Structurei

3D structure databases

ProteinModelPortaliP47972
SMRiP47972
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini223 – 424Pentraxin (PTX)PROSITE-ProRule annotationAdd BLAST202

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410IFFF Eukaryota
ENOG410XR4W LUCA
GeneTreeiENSGT00760000119128
HOGENOMiHOG000231267
HOVERGENiHBG003608
InParanoidiP47972
OMAiDNLAPWH
OrthoDBiEOG091G0AHP
PhylomeDBiP47972
TreeFamiTF330208

Family and domain databases

CDDicd00152 PTX, 1 hit
InterProiView protein in InterPro
IPR013320 ConA-like_dom_sf
IPR030476 Pentaxin_CS
IPR001759 Pentraxin-related
PfamiView protein in Pfam
PF00354 Pentaxin, 1 hit
PRINTSiPR00895 PENTAXIN
SMARTiView protein in SMART
SM00159 PTX, 1 hit
SUPFAMiSSF49899 SSF49899, 1 hit
PROSITEiView protein in PROSITE
PS00289 PTX_1, 1 hit
PS51828 PTX_2, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P47972-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MLALLAASVA LAVAAGAQDS PAPGSRFVCT ALPPEAVHAG CPLPAMPMQG
60 70 80 90 100
GAQSPEEELR AAVLQLRETV VQQKETLGAQ REAIRELTGK LARCEGLAGG
110 120 130 140 150
KARGAGATGK DTMGDLPRDP GHVVEQLSRS LQTLKDRLES LEHQLRANVS
160 170 180 190 200
NAGLPGDFRE VLQQRLGELE RQLLRKVAEL EDEKSLLHNE TSAHRQKTES
210 220 230 240 250
TLNALLQRVT ELERGNSAFK SPDAFKVSLP LRTNYLYGKI KKTLPELYAF
260 270 280 290 300
TICLWLRSSA SPGIGTPFSY AVPGQANEIV LIEWGNNPIE LLINDKVAQL
310 320 330 340 350
PLFVSDGKWH HICVTWTTRD GMWEAFQDGE KLGTGENLAP WHPIKPGGVL
360 370 380 390 400
ILGQEQDTVG GRFDATQAFV GELSQFNIWD RVLRAQEIVN IANCSTNMPG
410 420 430
NIIPWVDNNV DVFGGASKWP VETCEERLLD L
Length:431
Mass (Da):47,042
Last modified:May 15, 2002 - v2
Checksum:i87B7BF9BA1049AC5
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti78 – 82GAQRE → ASAR in AAA68980 (PubMed:8530029).Curated5
Sequence conflicti78 – 82GAQRE → ASAR in AAA92296 (PubMed:8530029).Curated5
Sequence conflicti280V → L in AAA68980 (PubMed:8530029).Curated1
Sequence conflicti280V → L in AAA92296 (PubMed:8530029).Curated1
Sequence conflicti427R → A in AAA68980 (PubMed:8530029).Curated1
Sequence conflicti427R → A in AAA92296 (PubMed:8530029).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U29195
, U29191, U29192, U29193, U29194 Genomic DNA Translation: AAA68980.2
U26662 mRNA Translation: AAA92296.1
AC074121 Genomic DNA Translation: AAQ93363.1
CH236956 Genomic DNA Translation: EAL23889.1
CH471091 Genomic DNA Translation: EAW76705.1
BC009924 mRNA Translation: AAH09924.1
BC034781 mRNA Translation: AAH34781.1
BC035339 mRNA Translation: AAH35339.1
BC048275 mRNA Translation: AAH48275.2
CCDSiCCDS5657.1
RefSeqiNP_002514.1, NM_002523.2
UniGeneiHs.3281

Genome annotation databases

EnsembliENST00000265634; ENSP00000265634; ENSG00000106236
GeneIDi4885
KEGGihsa:4885
UCSCiuc003upl.3 human

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U29195
, U29191, U29192, U29193, U29194 Genomic DNA Translation: AAA68980.2
U26662 mRNA Translation: AAA92296.1
AC074121 Genomic DNA Translation: AAQ93363.1
CH236956 Genomic DNA Translation: EAL23889.1
CH471091 Genomic DNA Translation: EAW76705.1
BC009924 mRNA Translation: AAH09924.1
BC034781 mRNA Translation: AAH34781.1
BC035339 mRNA Translation: AAH35339.1
BC048275 mRNA Translation: AAH48275.2
CCDSiCCDS5657.1
RefSeqiNP_002514.1, NM_002523.2
UniGeneiHs.3281

3D structure databases

ProteinModelPortaliP47972
SMRiP47972
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi110945, 6 interactors
IntActiP47972, 1 interactor
STRINGi9606.ENSP00000265634

PTM databases

iPTMnetiP47972
PhosphoSitePlusiP47972

Polymorphism and mutation databases

BioMutaiNPTX2
DMDMi20981708

Proteomic databases

EPDiP47972
PaxDbiP47972
PeptideAtlasiP47972
PRIDEiP47972
ProteomicsDBi55826

Protocols and materials databases

DNASUi4885
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000265634; ENSP00000265634; ENSG00000106236
GeneIDi4885
KEGGihsa:4885
UCSCiuc003upl.3 human

Organism-specific databases

CTDi4885
DisGeNETi4885
EuPathDBiHostDB:ENSG00000106236.3
GeneCardsiNPTX2
HGNCiHGNC:7953 NPTX2
HPAiCAB020801
HPA049799
HPA058320
MIMi600750 gene
neXtProtiNX_P47972
OpenTargetsiENSG00000106236
PharmGKBiPA31739
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IFFF Eukaryota
ENOG410XR4W LUCA
GeneTreeiENSGT00760000119128
HOGENOMiHOG000231267
HOVERGENiHBG003608
InParanoidiP47972
OMAiDNLAPWH
OrthoDBiEOG091G0AHP
PhylomeDBiP47972
TreeFamiTF330208

Miscellaneous databases

GeneWikiiNPTX2
GenomeRNAii4885
PROiPR:P47972
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000106236 Expressed in 169 organ(s), highest expression level in adenohypophysis
CleanExiHS_NPTX2
GenevisibleiP47972 HS

Family and domain databases

CDDicd00152 PTX, 1 hit
InterProiView protein in InterPro
IPR013320 ConA-like_dom_sf
IPR030476 Pentaxin_CS
IPR001759 Pentraxin-related
PfamiView protein in Pfam
PF00354 Pentaxin, 1 hit
PRINTSiPR00895 PENTAXIN
SMARTiView protein in SMART
SM00159 PTX, 1 hit
SUPFAMiSSF49899 SSF49899, 1 hit
PROSITEiView protein in PROSITE
PS00289 PTX_1, 1 hit
PS51828 PTX_2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiNPTX2_HUMAN
AccessioniPrimary (citable) accession number: P47972
Secondary accession number(s): A4D267, Q86XV7, Q96G70
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1996
Last sequence update: May 15, 2002
Last modified: October 10, 2018
This is version 156 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 7
    Human chromosome 7: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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Main funding by: National Institutes of Health

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