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Protein

Galectin-3

Gene

LGALS3

Organism
Cricetulus longicaudatus (Long-tailed dwarf hamster) (Chinese hamster)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Galactose-specific lectin which binds IgE. May mediate with the alpha-3, beta-1 integrin the stimulation by CSPG4 of endothelial cells migration. Together with DMBT1, required for terminal differentiation of columnar epithelial cells during early embryogenesis. In the nucleus: acts as a pre-mRNA splicing factor. Involved in acute inflammatory responses including neutrophil activation and adhesion, chemoattraction of monocytes macrophages, opsonization of apoptotic neutrophils, and activation of mast cells (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionIgE-binding protein
Biological processDifferentiation, Immunity, Innate immunity, mRNA processing, mRNA splicing
LigandLectin

Names & Taxonomyi

Protein namesi
Recommended name:
Galectin-3
Short name:
Gal-3
Alternative name(s):
35 kDa lectin
CBP30
Carbohydrate-binding protein 35
Short name:
CBP 35
Galactose-specific lectin 3
IgE-binding protein
Laminin-binding protein
Lectin L-29
Mac-2 antigen
Gene namesi
Name:LGALS3
OrganismiCricetulus longicaudatus (Long-tailed dwarf hamster) (Chinese hamster)
Taxonomic identifieri10030 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaCricetidaeCricetinaeCricetulus

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus, Secreted, Spliceosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00000769292 – 245Galectin-3Add BLAST244

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylalanineBy similarity1
Modified residuei6Phosphoserine; by CK1By similarity1
Disulfide bondi168InterchainBy similarity
Modified residuei183PhosphoserineBy similarity1

Keywords - PTMi

Acetylation, Disulfide bond, Phosphoprotein

Proteomic databases

PRIDEiP47953

Interactioni

Subunit structurei

Probably forms homo- or heterodimers. Interacts with DMBT1 (By similarity). Interacts with CD6 and ALCAM. Forms a complex with the ITGA3, ITGB1 and CSPG4. Interacts with LGALS3BP, LYPD3, CYHR1 and UACA (By similarity).By similarity

Structurei

3D structure databases

ProteinModelPortaliP47953
SMRiP47953
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati35 – 4319
Repeati44 – 5229
Repeati53 – 6139
Repeati62 – 7049
Repeati71 – 785; approximate8
Repeati79 – 886; approximate10
Repeati89 – 997; approximateAdd BLAST11
Domaini113 – 243GalectinPROSITE-ProRule annotationAdd BLAST131

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni35 – 997 X 9 AA tandem repeats of Y-P-G-X(3)-P-[GS]-AAdd BLAST65
Regioni176 – 182Beta-galactoside bindingBy similarity7

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi221 – 236Nuclear export signalBy similarityAdd BLAST16

Keywords - Domaini

Repeat

Phylogenomic databases

HOVERGENiHBG006255

Family and domain databases

CDDicd00070 GLECT, 1 hit
InterProiView protein in InterPro
IPR013320 ConA-like_dom_sf
IPR015534 Galectin_3
IPR001079 Galectin_CRD
PANTHERiPTHR11346:SF26 PTHR11346:SF26, 1 hit
PfamiView protein in Pfam
PF00337 Gal-bind_lectin, 1 hit
SMARTiView protein in SMART
SM00908 Gal-bind_lectin, 1 hit
SM00276 GLECT, 1 hit
SUPFAMiSSF49899 SSF49899, 1 hit
PROSITEiView protein in PROSITE
PS51304 GALECTIN, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P47953-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MADGFSLNDA LAGSGNPNPQ GWPGAWGNQP GAGGYPGASY PGAYPGQAPP
60 70 80 90 100
GAYPGQAPPG AYPGPTAPGA YPGPAPGAYP GQPGASGAYP SAPGAYPAAG
110 120 130 140 150
PYGAPTGALT VPYKLPLAGG VMPRMLITIM GTVKPNANRI ILNFLRGNDI
160 170 180 190 200
AFHFNPRFNE NNRRVIVCNT KQDNNWGREE RQSAFPFESG RPFKIQVLVE
210 220 230 240
ADHFKVAVND AHLLQYNHRM KNLREINQME ISGDITLTSA APTMI
Length:245
Mass (Da):25,739
Last modified:January 23, 2007 - v2
Checksum:i9469B9AA146EEF76
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X78879 mRNA Translation: CAA55479.1

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X78879 mRNA Translation: CAA55479.1

3D structure databases

ProteinModelPortaliP47953
SMRiP47953
ModBaseiSearch...
MobiDBiSearch...

Proteomic databases

PRIDEiP47953

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Phylogenomic databases

HOVERGENiHBG006255

Family and domain databases

CDDicd00070 GLECT, 1 hit
InterProiView protein in InterPro
IPR013320 ConA-like_dom_sf
IPR015534 Galectin_3
IPR001079 Galectin_CRD
PANTHERiPTHR11346:SF26 PTHR11346:SF26, 1 hit
PfamiView protein in Pfam
PF00337 Gal-bind_lectin, 1 hit
SMARTiView protein in SMART
SM00908 Gal-bind_lectin, 1 hit
SM00276 GLECT, 1 hit
SUPFAMiSSF49899 SSF49899, 1 hit
PROSITEiView protein in PROSITE
PS51304 GALECTIN, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiLEG3_CRILO
AccessioniPrimary (citable) accession number: P47953
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1996
Last sequence update: January 23, 2007
Last modified: November 22, 2017
This is version 95 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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