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Entry version 144 (29 Sep 2021)
Sequence version 2 (01 Oct 1996)
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Protein

Potassium transport protein 1

Gene

trk1

Organism
Schizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
Status
Reviewed-Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein inferred from homologyi <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Together with TRK2, defines the major, high-affinity potassium influx transport system. Involved in maintenance of the proper sodium/potassium ratio in the cell and in regulating the plasma membrane potential.

1 Publication

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processIon transport, Potassium transport, Transport
LigandPotassium

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Potassium transport protein 1
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:trk1
Synonyms:trk
ORF Names:SPAC3F10.02c
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiSchizosaccharomyces pombe (strain 972 / ATCC 24843) (Fission yeast)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri284812 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaTaphrinomycotinaSchizosaccharomycetesSchizosaccharomycetalesSchizosaccharomycetaceaeSchizosaccharomyces
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000002485 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome I

Organism-specific databases

Schizosaccharomyces pombe database

More...
PomBasei
SPAC3F10.02c, trk1

Eukaryotic Pathogen, Vector and Host Database Resources

More...
VEuPathDBi
FungiDB:SPAC3F10.02c

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei24 – 44HelicalSequence analysisAdd BLAST21
Transmembranei80 – 100HelicalSequence analysisAdd BLAST21
Transmembranei469 – 489HelicalSequence analysisAdd BLAST21
Transmembranei507 – 527HelicalSequence analysisAdd BLAST21
Transmembranei537 – 557HelicalSequence analysisAdd BLAST21
Transmembranei600 – 620HelicalSequence analysisAdd BLAST21
Transmembranei662 – 682HelicalSequence analysisAdd BLAST21
Transmembranei715 – 735HelicalSequence analysisAdd BLAST21
Transmembranei747 – 767HelicalSequence analysisAdd BLAST21

Keywords - Cellular componenti

Cell membrane, Membrane

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000704611 – 841Potassium transport protein 1Add BLAST841

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi116N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi164N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi215N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi401N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi771N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
P47946

PRoteomics IDEntifications database

More...
PRIDEi
P47946

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
P47946

SwissPalm database of S-palmitoylation events

More...
SwissPalmi
P47946

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
279483, 34 interactors

STRING: functional protein association networks

More...
STRINGi
4896.SPAC3F10.02c.1

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
P47946

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni173 – 192DisorderedSequence analysisAdd BLAST20

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the TrkH potassium transport family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG1341, Eukaryota

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_005947_0_1_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
P47946

Database for complete collections of gene phylogenies

More...
PhylomeDBi
P47946

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR003445, Cat_transpt
IPR004773, K/Na_transp_Trk/HKT
IPR015958, Trk_fungi

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF02386, TrkH, 1 hit

PIRSF; a whole-protein classification database

More...
PIRSFi
PIRSF002450, K+_transpter_TRK, 1 hit

TIGRFAMs; a protein family database

More...
TIGRFAMsi
TIGR00934, 2a38euk, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

P47946-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MVLNYIQRWF KWVIPTFGFL AIHYIYIISL TIIASILLFT GGTTTKIKYI
60 70 80 90 100
DALFLASSAT TQTGLNSVDL NSLSIWQQFI LYGFTAITVP IWMHGSISFI
110 120 130 140 150
RLYWFRRKFK DVVRQNRTRK FQRKLRKSLM KKSEDDEEQG VRGRKIRVML
160 170 180 190 200
PYLHSLRSPT SLKNFSRFDT HDSTNNPYFP DNPPSPKADI SKDEYFGKYL
210 220 230 240 250
PKKSDTLDMD LESHNMTFHD YEPSIENKNY DFGSSHSASM QMYEMDDLHP
260 270 280 290 300
RLRRQSSFIS SVNPLEADDT RETLSEGALV QESLPMAYSY SDTNLVVSRD
310 320 330 340 350
SFTLTGDDNL FPEGGLRPAN TIDGIVRSSL SSSSLSKDTE PSTVDMHIAF
360 370 380 390 400
TGLNKPTIER ERNLKLRKKS RFYKKSLRSR FSRGLHRPIR WTKSFTSNRR
410 420 430 440 450
NLTLERVLSS AFAKKREPSI SSRHTTMSLP YLSYNPTVDR NSAFVALSKE
460 470 480 490 500
QRDELGGIEY RALKCVCSMV TLYFIIFNIA AFVTFIVFAY TAVGSREVID
510 520 530 540 550
SYDLRRGWWA LFSSASSFND LGFSLIPSSF VPMNRNIFLL LISSLFIIAG
560 570 580 590 600
NTGFPCFFRT FIWTTYKLYP FSFEKKEAMA FLLDHPRRCF TLLFPSGATW
610 620 630 640 650
VLFFVLLLLN VIDLVLFMVL DTGSKAVASL PKGIRVVNAI FQSVCTRTAG
660 670 680 690 700
FTSVSISELH PAVLVSYMVM MYISVYPVAI NMRNTNVYEE RSLGVYRTED
710 720 730 740 750
DEGKSFLKDH LTEQLSYDLW YIFLGLFIIC ICEGGKISNP LDTDFSIFTV
760 770 780 790 800
LFEVVSAYGT VGLSTGLSSS NCSLSARFTT ISKLVIIALE LRGRHRGLPR
810 820 830 840
AVDRAILLPS EKNNLKEEED YQRRHGFSID NARGSIAVSR D
Length:841
Mass (Da):96,045
Last modified:October 1, 1996 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i42D08CFE21C6A5D5
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti3 – 27LNYIQ…HYIYI → QVGDTNFWIQGNSLYLH in AAC41667 (PubMed:7642145).CuratedAdd BLAST25
Sequence conflicti36I → V in AAC41667 (PubMed:7642145).Curated1
Sequence conflicti269D → Y in AAC41667 (PubMed:7642145).Curated1
Sequence conflicti416R → H in AAC41667 (PubMed:7642145).Curated1
Sequence conflicti471T → I in AAC41667 (PubMed:7642145).Curated1
Sequence conflicti803D → V in AAC41667 (PubMed:7642145).Curated1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
L36563 Genomic DNA Translation: AAC41667.1
CU329670 Genomic DNA Translation: CAA93300.1

Protein sequence database of the Protein Information Resource

More...
PIRi
S50225
T38703

NCBI Reference Sequences

More...
RefSeqi
NP_593934.1, NM_001019362.2

Genome annotation databases

Ensembl fungal genome annotation project

More...
EnsemblFungii
SPAC3F10.02c.1; SPAC3F10.02c.1:pep; SPAC3F10.02c

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
2543048

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
spo:SPAC3F10.02c

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L36563 Genomic DNA Translation: AAC41667.1
CU329670 Genomic DNA Translation: CAA93300.1
PIRiS50225
T38703
RefSeqiNP_593934.1, NM_001019362.2

3D structure databases

SMRiP47946
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi279483, 34 interactors
STRINGi4896.SPAC3F10.02c.1

PTM databases

iPTMnetiP47946
SwissPalmiP47946

Proteomic databases

PaxDbiP47946
PRIDEiP47946

Genome annotation databases

EnsemblFungiiSPAC3F10.02c.1; SPAC3F10.02c.1:pep; SPAC3F10.02c
GeneIDi2543048
KEGGispo:SPAC3F10.02c

Organism-specific databases

PomBaseiSPAC3F10.02c, trk1
VEuPathDBiFungiDB:SPAC3F10.02c

Phylogenomic databases

eggNOGiKOG1341, Eukaryota
HOGENOMiCLU_005947_0_1_1
InParanoidiP47946
PhylomeDBiP47946

Miscellaneous databases

Protein Ontology

More...
PROi
PR:P47946

Family and domain databases

InterProiView protein in InterPro
IPR003445, Cat_transpt
IPR004773, K/Na_transp_Trk/HKT
IPR015958, Trk_fungi
PfamiView protein in Pfam
PF02386, TrkH, 1 hit
PIRSFiPIRSF002450, K+_transpter_TRK, 1 hit
TIGRFAMsiTIGR00934, 2a38euk, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiTRK1_SCHPO
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P47946
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1996
Last sequence update: October 1, 1996
Last modified: September 29, 2021
This is version 144 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Schizosaccharomyces pombe
    Schizosaccharomyces pombe: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families
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