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Protein

Metallothionein-4

Gene

Mt4

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Seems to bind zinc and copper. Could play a special role in regulating zinc metabolism during the differentiation of stratified epithelia.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi6Divalent metal cation; cluster BBy similarity1
Metal bindingi8Divalent metal cation; cluster BBy similarity1
Metal bindingi14Divalent metal cation; cluster BBy similarity1
Metal bindingi16Divalent metal cation; cluster BBy similarity1
Metal bindingi20Divalent metal cation; cluster BBy similarity1
Metal bindingi22Divalent metal cation; cluster BBy similarity1
Metal bindingi25Divalent metal cation; cluster BBy similarity1
Metal bindingi27Divalent metal cation; cluster BBy similarity1
Metal bindingi30Divalent metal cation; cluster BBy similarity1
Metal bindingi34Divalent metal cation; cluster ABy similarity1
Metal bindingi35Divalent metal cation; cluster ABy similarity1
Metal bindingi37Divalent metal cation; cluster ABy similarity1
Metal bindingi38Divalent metal cation; cluster ABy similarity1
Metal bindingi42Divalent metal cation; cluster ABy similarity1
Metal bindingi45Divalent metal cation; cluster ABy similarity1
Metal bindingi49Divalent metal cation; cluster ABy similarity1
Metal bindingi51Divalent metal cation; cluster ABy similarity1
Metal bindingi58Divalent metal cation; cluster ABy similarity1
Metal bindingi60Divalent metal cation; cluster ABy similarity1
Metal bindingi61Divalent metal cation; cluster ABy similarity1

GO - Molecular functioni

  • metal ion binding Source: MGI

GO - Biological processi

Keywordsi

LigandCopper, Metal-binding, Metal-thiolate cluster, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Metallothionein-4
Short name:
MT-4
Alternative name(s):
Metallothionein-IV
Short name:
MT-IV
Gene namesi
Name:Mt4
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 8

Organism-specific databases

MGIiMGI:99692 Mt4

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001972561 – 62Metallothionein-4Add BLAST62

Proteomic databases

PaxDbiP47945
PRIDEiP47945

Expressioni

Tissue specificityi

Expressed exclusively in stratified squamous epithelia associated with oral epithelia, esophagus, upper stomach, tail, footpads and neonatal skin.

Gene expression databases

BgeeiENSMUSG00000031757 Expressed in 75 organ(s), highest expression level in tail skin
CleanExiMM_MT4
ExpressionAtlasiP47945 baseline and differential
GenevisibleiP47945 MM

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000034207

Structurei

3D structure databases

ProteinModelPortaliP47945
SMRiP47945
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiENOG410J3IA Eukaryota
ENOG4111C2K LUCA
GeneTreeiENSGT00730000111475
HOGENOMiHOG000236262
HOVERGENiHBG094959
InParanoidiP47945
KOiK14741
OMAiTCMSGGT
PhylomeDBiP47945
TreeFamiTF336054

Family and domain databases

Gene3Di4.10.10.10, 1 hit
InterProiView protein in InterPro
IPR003019 Metalthion
IPR017854 Metalthion_dom_sf
IPR023587 Metalthion_dom_sf_vert
IPR000006 Metalthion_vert
IPR018064 Metalthion_vert_metal_BS
PANTHERiPTHR23299 PTHR23299, 1 hit
PfamiView protein in Pfam
PF00131 Metallothio, 1 hit
PRINTSiPR00860 MTVERTEBRATE
SUPFAMiSSF57868 SSF57868, 1 hit
PROSITEiView protein in PROSITE
PS00203 METALLOTHIONEIN_VRT, 1 hit

Sequencei

Sequence statusi: Complete.

P47945-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MDPGECTCMS GGICICGDNC KCTTCSCKTC RKSCCPCCPP GCAKCARGCI
60
CKGGSDKCSC CP
Length:62
Mass (Da):6,277
Last modified:February 1, 1996 - v1
Checksum:i8F78DA6D0744333A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U07808 Genomic DNA Translation: AAA20233.1
CCDSiCCDS40435.1
PIRiB53640
RefSeqiNP_032657.1, NM_008631.2
UniGeneiMm.1536

Genome annotation databases

EnsembliENSMUST00000034207; ENSMUSP00000034207; ENSMUSG00000031757
GeneIDi17752
KEGGimmu:17752
UCSCiuc009mvt.1 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U07808 Genomic DNA Translation: AAA20233.1
CCDSiCCDS40435.1
PIRiB53640
RefSeqiNP_032657.1, NM_008631.2
UniGeneiMm.1536

3D structure databases

ProteinModelPortaliP47945
SMRiP47945
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000034207

Proteomic databases

PaxDbiP47945
PRIDEiP47945

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000034207; ENSMUSP00000034207; ENSMUSG00000031757
GeneIDi17752
KEGGimmu:17752
UCSCiuc009mvt.1 mouse

Organism-specific databases

CTDi84560
MGIiMGI:99692 Mt4

Phylogenomic databases

eggNOGiENOG410J3IA Eukaryota
ENOG4111C2K LUCA
GeneTreeiENSGT00730000111475
HOGENOMiHOG000236262
HOVERGENiHBG094959
InParanoidiP47945
KOiK14741
OMAiTCMSGGT
PhylomeDBiP47945
TreeFamiTF336054

Miscellaneous databases

PROiPR:P47945
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000031757 Expressed in 75 organ(s), highest expression level in tail skin
CleanExiMM_MT4
ExpressionAtlasiP47945 baseline and differential
GenevisibleiP47945 MM

Family and domain databases

Gene3Di4.10.10.10, 1 hit
InterProiView protein in InterPro
IPR003019 Metalthion
IPR017854 Metalthion_dom_sf
IPR023587 Metalthion_dom_sf_vert
IPR000006 Metalthion_vert
IPR018064 Metalthion_vert_metal_BS
PANTHERiPTHR23299 PTHR23299, 1 hit
PfamiView protein in Pfam
PF00131 Metallothio, 1 hit
PRINTSiPR00860 MTVERTEBRATE
SUPFAMiSSF57868 SSF57868, 1 hit
PROSITEiView protein in PROSITE
PS00203 METALLOTHIONEIN_VRT, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiMT4_MOUSE
AccessioniPrimary (citable) accession number: P47945
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1996
Last sequence update: February 1, 1996
Last modified: November 7, 2018
This is version 124 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Metallothioneins
    Classification of metallothioneins and list of entries
  3. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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