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Protein

Metallothionein-4

Gene

MT4

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Seems to bind zinc and copper. Could play a special role in regulating zinc metabolism during the differentiation of stratified epithelia.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi6Divalent metal cation; cluster BBy similarity1
Metal bindingi8Divalent metal cation; cluster BBy similarity1
Metal bindingi14Divalent metal cation; cluster BBy similarity1
Metal bindingi16Divalent metal cation; cluster BBy similarity1
Metal bindingi20Divalent metal cation; cluster BBy similarity1
Metal bindingi22Divalent metal cation; cluster BBy similarity1
Metal bindingi25Divalent metal cation; cluster BBy similarity1
Metal bindingi27Divalent metal cation; cluster BBy similarity1
Metal bindingi30Divalent metal cation; cluster BBy similarity1
Metal bindingi34Divalent metal cation; cluster ABy similarity1
Metal bindingi35Divalent metal cation; cluster ABy similarity1
Metal bindingi37Divalent metal cation; cluster ABy similarity1
Metal bindingi38Divalent metal cation; cluster ABy similarity1
Metal bindingi42Divalent metal cation; cluster ABy similarity1
Metal bindingi45Divalent metal cation; cluster ABy similarity1
Metal bindingi49Divalent metal cation; cluster ABy similarity1
Metal bindingi51Divalent metal cation; cluster ABy similarity1
Metal bindingi58Divalent metal cation; cluster ABy similarity1
Metal bindingi60Divalent metal cation; cluster ABy similarity1
Metal bindingi61Divalent metal cation; cluster ABy similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

LigandCopper, Metal-binding, Metal-thiolate cluster, Zinc

Enzyme and pathway databases

ReactomeiR-HSA-5661231 Metallothioneins bind metals

Names & Taxonomyi

Protein namesi
Recommended name:
Metallothionein-4
Short name:
MT-4
Alternative name(s):
Metallothionein-IV
Short name:
MT-IV
Gene namesi
Name:MT4
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 16

Organism-specific databases

EuPathDBiHostDB:ENSG00000102891.3
HGNCiHGNC:18705 MT4
MIMi606206 gene
neXtProtiNX_P47944

Subcellular locationi

Pathology & Biotechi

Organism-specific databases

DisGeNETi84560
OpenTargetsiENSG00000102891
PharmGKBiPA38649

Polymorphism and mutation databases

BioMutaiMT4
DMDMi288558817

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001972551 – 62Metallothionein-4Add BLAST62

Proteomic databases

PaxDbiP47944
PeptideAtlasiP47944
PRIDEiP47944
ProteomicsDBi55825

Expressioni

Gene expression databases

BgeeiENSG00000102891 Expressed in 79 organ(s), highest expression level in skin of leg
CleanExiHS_MT4

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000219162

Structurei

3D structure databases

ProteinModelPortaliP47944
SMRiP47944
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiENOG410J3IA Eukaryota
ENOG4111C2K LUCA
GeneTreeiENSGT00730000111475
HOGENOMiHOG000236262
InParanoidiP47944
KOiK14741
OMAiTCMSGGT
PhylomeDBiP47944
TreeFamiTF336054

Family and domain databases

Gene3Di4.10.10.10, 1 hit
InterProiView protein in InterPro
IPR003019 Metalthion
IPR017854 Metalthion_dom_sf
IPR023587 Metalthion_dom_sf_vert
IPR000006 Metalthion_vert
PANTHERiPTHR23299 PTHR23299, 1 hit
PfamiView protein in Pfam
PF00131 Metallothio, 1 hit
PRINTSiPR00860 MTVERTEBRATE
SUPFAMiSSF57868 SSF57868, 1 hit

Sequencei

Sequence statusi: Complete.

P47944-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MDPRECVCMS GGICMCGDNC KCTTCNCKTY WKSCCPCCPP GCAKCARGCI
60
CKGGSDKCSC CP
Length:62
Mass (Da):6,509
Last modified:February 9, 2010 - v2
Checksum:i55DA475A17BF28C9
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_03411030Y → C2 PublicationsCorresponds to variant dbSNP:rs666636Ensembl.1
Natural variantiVAR_03411131W → R2 PublicationsCorresponds to variant dbSNP:rs666647Ensembl.1
Natural variantiVAR_03411248G → D. Corresponds to variant dbSNP:rs11643815Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U07807 Genomic DNA Translation: AAA20232.1
AC026461 mRNA No translation available.
BC113442 mRNA Translation: AAI13443.1
BC113444 mRNA Translation: AAI13445.1
CCDSiCCDS42165.1
PIRiA53640
RefSeqiNP_116324.1, NM_032935.2
UniGeneiHs.567624

Genome annotation databases

EnsembliENST00000219162; ENSP00000219162; ENSG00000102891
GeneIDi84560
KEGGihsa:84560
UCSCiuc002eje.1 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U07807 Genomic DNA Translation: AAA20232.1
AC026461 mRNA No translation available.
BC113442 mRNA Translation: AAI13443.1
BC113444 mRNA Translation: AAI13445.1
CCDSiCCDS42165.1
PIRiA53640
RefSeqiNP_116324.1, NM_032935.2
UniGeneiHs.567624

3D structure databases

ProteinModelPortaliP47944
SMRiP47944
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000219162

Polymorphism and mutation databases

BioMutaiMT4
DMDMi288558817

Proteomic databases

PaxDbiP47944
PeptideAtlasiP47944
PRIDEiP47944
ProteomicsDBi55825

Protocols and materials databases

DNASUi84560
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000219162; ENSP00000219162; ENSG00000102891
GeneIDi84560
KEGGihsa:84560
UCSCiuc002eje.1 human

Organism-specific databases

CTDi84560
DisGeNETi84560
EuPathDBiHostDB:ENSG00000102891.3
GeneCardsiMT4
HGNCiHGNC:18705 MT4
MIMi606206 gene
neXtProtiNX_P47944
OpenTargetsiENSG00000102891
PharmGKBiPA38649
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410J3IA Eukaryota
ENOG4111C2K LUCA
GeneTreeiENSGT00730000111475
HOGENOMiHOG000236262
InParanoidiP47944
KOiK14741
OMAiTCMSGGT
PhylomeDBiP47944
TreeFamiTF336054

Enzyme and pathway databases

ReactomeiR-HSA-5661231 Metallothioneins bind metals

Miscellaneous databases

ChiTaRSiMT4 human
GenomeRNAii84560
PROiPR:P47944
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000102891 Expressed in 79 organ(s), highest expression level in skin of leg
CleanExiHS_MT4

Family and domain databases

Gene3Di4.10.10.10, 1 hit
InterProiView protein in InterPro
IPR003019 Metalthion
IPR017854 Metalthion_dom_sf
IPR023587 Metalthion_dom_sf_vert
IPR000006 Metalthion_vert
PANTHERiPTHR23299 PTHR23299, 1 hit
PfamiView protein in Pfam
PF00131 Metallothio, 1 hit
PRINTSiPR00860 MTVERTEBRATE
SUPFAMiSSF57868 SSF57868, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiMT4_HUMAN
AccessioniPrimary (citable) accession number: P47944
Secondary accession number(s): Q14DA1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1996
Last sequence update: February 9, 2010
Last modified: September 12, 2018
This is version 126 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  2. Metallothioneins
    Classification of metallothioneins and list of entries
  3. SIMILARITY comments
    Index of protein domains and families
  4. Human chromosome 16
    Human chromosome 16: entries, gene names and cross-references to MIM
  5. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  6. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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Main funding by: National Institutes of Health

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