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Protein

Cannabinoid receptor 2

Gene

Cnr2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Heterotrimeric G protein-coupled receptor for endocannabinoid 2-arachidonoylglycerol mediating inhibition of adenylate cyclase. May function in inflammatory response, nociceptive transmission and bone homeostasis.8 Publications

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionG-protein coupled receptor, Receptor, Transducer
Biological processInflammatory response

Enzyme and pathway databases

ReactomeiR-MMU-373076 Class A/1 (Rhodopsin-like receptors)
R-MMU-418594 G alpha (i) signalling events

Names & Taxonomyi

Protein namesi
Recommended name:
Cannabinoid receptor 2
Short name:
CB-2
Short name:
CB2
Short name:
mCB2
Gene namesi
Name:Cnr2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 4

Organism-specific databases

MGIiMGI:104650 Cnr2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 33ExtracellularSequence analysisAdd BLAST33
Transmembranei34 – 59Helical; Name=1Sequence analysisAdd BLAST26
Topological domaini60 – 71CytoplasmicSequence analysisAdd BLAST12
Transmembranei72 – 92Helical; Name=2Sequence analysisAdd BLAST21
Topological domaini93 – 104ExtracellularSequence analysisAdd BLAST12
Transmembranei105 – 129Helical; Name=3Sequence analysisAdd BLAST25
Topological domaini130 – 149CytoplasmicSequence analysisAdd BLAST20
Transmembranei150 – 172Helical; Name=4Sequence analysisAdd BLAST23
Topological domaini173 – 188ExtracellularSequence analysisAdd BLAST16
Transmembranei189 – 214Helical; Name=5Sequence analysisAdd BLAST26
Topological domaini215 – 246CytoplasmicSequence analysisAdd BLAST32
Transmembranei247 – 267Helical; Name=6Sequence analysisAdd BLAST21
Topological domaini268 – 279ExtracellularSequence analysisAdd BLAST12
Transmembranei280 – 301Helical; Name=7Sequence analysisAdd BLAST22
Topological domaini302 – 347CytoplasmicSequence analysisAdd BLAST46

Keywords - Cellular componenti

Cell membrane, Cell projection, Membrane

Pathology & Biotechi

Disruption phenotypei

Mutant mice are responsive to the psychotropic effects of cannabinoid but not to the cannabinoid-induced immunomodulation. They also show accelerated age-related trabecular bone loss and cortical expansion.1 Publication

Chemistry databases

ChEMBLiCHEMBL5373
GuidetoPHARMACOLOGYi57

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000693241 – 347Cannabinoid receptor 2Add BLAST347

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi11N-linked (GlcNAc...) asparagineSequence analysis1
Modified residuei335PhosphoserineCombined sources1
Modified residuei336PhosphoserineCombined sources1
Modified residuei338PhosphothreonineCombined sources1

Keywords - PTMi

Glycoprotein, Phosphoprotein

Proteomic databases

MaxQBiP47936
PaxDbiP47936
PRIDEiP47936

PTM databases

iPTMnetiP47936
PhosphoSitePlusiP47936

Expressioni

Tissue specificityi

Expressed by cells of hematopoietic origin. Expressed in skin in suprabasal layers and hair follicles, in brain by neurons and glial cells and by osteoblasts, osteocytes, osteoclasts (at protein level).5 Publications

Gene expression databases

BgeeiENSMUSG00000062585 Expressed in 105 organ(s), highest expression level in spleen
CleanExiMM_CNR2
GenevisibleiP47936 MM

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000069957

Chemistry databases

BindingDBiP47936

Structurei

3D structure databases

ProteinModelPortaliP47936
SMRiP47936
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3656 Eukaryota
ENOG410XRW9 LUCA
GeneTreeiENSGT00760000118804
HOGENOMiHOG000049272
HOVERGENiHBG051045
InParanoidiP47936
KOiK04278
OMAiVNFHVFH
OrthoDBiEOG091G05O3
PhylomeDBiP47936
TreeFamiTF330052

Family and domain databases

CDDicd15341 7tmA_CB2, 1 hit
InterProiView protein in InterPro
IPR001551 Canbinoid_rcpt_2
IPR002230 Cnbnoid_rcpt
IPR000276 GPCR_Rhodpsn
IPR017452 GPCR_Rhodpsn_7TM
PANTHERiPTHR22750:SF10 PTHR22750:SF10, 1 hit
PfamiView protein in Pfam
PF00001 7tm_1, 1 hit
PRINTSiPR00523 CANABINOID2R
PR00362 CANNABINOIDR
PR00237 GPCRRHODOPSN
PROSITEiView protein in PROSITE
PS00237 G_PROTEIN_RECEP_F1_1, 1 hit
PS50262 G_PROTEIN_RECEP_F1_2, 1 hit

Sequencei

Sequence statusi: Complete.

P47936-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MEGCRETEVT NGSNGGLEFN PMKEYMILSS GQQIAVAVLC TLMGLLSALE
60 70 80 90 100
NMAVLYIILS SRRLRRKPSY LFISSLAGAD FLASVIFACN FVIFHVFHGV
110 120 130 140 150
DSNAIFLLKI GSVTMTFTAS VGSLLLTAVD RYLCLCYPPT YKALVTRGRA
160 170 180 190 200
LVALCVMWVL SALISYLPLM GWTCCPSPCS ELFPLIPNDY LLGWLLFIAI
210 220 230 240 250
LFSGIIYTYG YVLWKAHRHV ATLAEHQDRQ VPGIARMRLD VRLAKTLGLV
260 270 280 290 300
LAVLLICWFP ALALMGHSLV TTLSDQVKEA FAFCSMLCLV NSMVNPIIYA
310 320 330 340
LRSGEIRSAA QHCLIGWKKY LQGLGPEGKE EGPRSSVTET EADVKTT
Length:347
Mass (Da):38,213
Last modified:February 1, 1996 - v1
Checksum:i10747611D41FF442
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti64L → V in CAA63655 (PubMed:9261404).Curated1
Sequence conflicti126L → V in CAA63655 (PubMed:9261404).Curated1
Sequence conflicti272T → M in AAA63757 (Ref. 3) Curated1
Sequence conflicti332G → A in AAA63757 (Ref. 3) Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X86405 mRNA Translation: CAA60159.1
X93168 mRNA Translation: CAA63655.1
U21681 Genomic DNA Translation: AAA63757.1
AK036658 mRNA Translation: BAC29520.1
AK037898 mRNA Translation: BAC29894.1
AK134109 mRNA Translation: BAE22017.1
AL672076 Genomic DNA Translation: CAM15899.1
CH466552 Genomic DNA Translation: EDL29965.1
BC024052 mRNA Translation: AAH24052.1
CCDSiCCDS18793.1
PIRiS70364
RefSeqiNP_001292207.1, NM_001305278.1
NP_034054.3, NM_009924.4
UniGeneiMm.297251

Genome annotation databases

EnsembliENSMUST00000068830; ENSMUSP00000069957; ENSMUSG00000062585
ENSMUST00000097843; ENSMUSP00000095454; ENSMUSG00000062585
GeneIDi12802
KEGGimmu:12802
UCSCiuc008vhh.3 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X86405 mRNA Translation: CAA60159.1
X93168 mRNA Translation: CAA63655.1
U21681 Genomic DNA Translation: AAA63757.1
AK036658 mRNA Translation: BAC29520.1
AK037898 mRNA Translation: BAC29894.1
AK134109 mRNA Translation: BAE22017.1
AL672076 Genomic DNA Translation: CAM15899.1
CH466552 Genomic DNA Translation: EDL29965.1
BC024052 mRNA Translation: AAH24052.1
CCDSiCCDS18793.1
PIRiS70364
RefSeqiNP_001292207.1, NM_001305278.1
NP_034054.3, NM_009924.4
UniGeneiMm.297251

3D structure databases

ProteinModelPortaliP47936
SMRiP47936
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000069957

Chemistry databases

BindingDBiP47936
ChEMBLiCHEMBL5373
GuidetoPHARMACOLOGYi57

Protein family/group databases

GPCRDBiSearch...

PTM databases

iPTMnetiP47936
PhosphoSitePlusiP47936

Proteomic databases

MaxQBiP47936
PaxDbiP47936
PRIDEiP47936

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000068830; ENSMUSP00000069957; ENSMUSG00000062585
ENSMUST00000097843; ENSMUSP00000095454; ENSMUSG00000062585
GeneIDi12802
KEGGimmu:12802
UCSCiuc008vhh.3 mouse

Organism-specific databases

CTDi1269
MGIiMGI:104650 Cnr2

Phylogenomic databases

eggNOGiKOG3656 Eukaryota
ENOG410XRW9 LUCA
GeneTreeiENSGT00760000118804
HOGENOMiHOG000049272
HOVERGENiHBG051045
InParanoidiP47936
KOiK04278
OMAiVNFHVFH
OrthoDBiEOG091G05O3
PhylomeDBiP47936
TreeFamiTF330052

Enzyme and pathway databases

ReactomeiR-MMU-373076 Class A/1 (Rhodopsin-like receptors)
R-MMU-418594 G alpha (i) signalling events

Miscellaneous databases

PROiPR:P47936
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000062585 Expressed in 105 organ(s), highest expression level in spleen
CleanExiMM_CNR2
GenevisibleiP47936 MM

Family and domain databases

CDDicd15341 7tmA_CB2, 1 hit
InterProiView protein in InterPro
IPR001551 Canbinoid_rcpt_2
IPR002230 Cnbnoid_rcpt
IPR000276 GPCR_Rhodpsn
IPR017452 GPCR_Rhodpsn_7TM
PANTHERiPTHR22750:SF10 PTHR22750:SF10, 1 hit
PfamiView protein in Pfam
PF00001 7tm_1, 1 hit
PRINTSiPR00523 CANABINOID2R
PR00362 CANNABINOIDR
PR00237 GPCRRHODOPSN
PROSITEiView protein in PROSITE
PS00237 G_PROTEIN_RECEP_F1_1, 1 hit
PS50262 G_PROTEIN_RECEP_F1_2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiCNR2_MOUSE
AccessioniPrimary (citable) accession number: P47936
Secondary accession number(s): Q544H5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1996
Last sequence update: February 1, 1996
Last modified: September 12, 2018
This is version 142 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  3. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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