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UniProtKB - P47930 (FOSL2_MOUSE)
Protein
Fos-related antigen 2
Gene
Fosl2
Organism
Mus musculus (Mouse)
Status
Functioni
Controls osteoclast survival and size (PubMed:18548006).
As a dimer with JUN, activates LIF transcription (PubMed:18548006).
Activates CEBPB transcription in PGE2-activated osteoblasts (By similarity).
By similarity1 PublicationGO - Molecular functioni
- chromatin binding Source: MGI
- DNA binding Source: MGI
- DNA-binding transcription activator activity, RNA polymerase II-specific Source: MGI
- DNA-binding transcription factor activity Source: MGI
- DNA-binding transcription factor activity, RNA polymerase II-specific Source: GO_Central
- double-stranded DNA binding Source: MGI
- RNA polymerase II cis-regulatory region sequence-specific DNA binding Source: GO_Central
- RNA polymerase II transcription regulatory region sequence-specific DNA binding Source: MGI
- sequence-specific DNA binding Source: MGI
- transcription cis-regulatory region binding Source: MGI
GO - Biological processi
- keratinocyte development Source: MGI
- positive regulation of fibroblast proliferation Source: MGI
- positive regulation of transcription, DNA-templated Source: CACAO
- positive regulation of transcription by RNA polymerase II Source: MGI
- regulation of transcription by RNA polymerase II Source: GO_Central
- response to estradiol Source: MGI
- response to hypoxia Source: MGI
- transcription by RNA polymerase II Source: MGI
Keywordsi
Molecular function | DNA-binding |
Biological process | Transcription, Transcription regulation |
Names & Taxonomyi
Protein namesi | Recommended name: Fos-related antigen 2Short name: FRA-2 |
Gene namesi | Name:Fosl2 Synonyms:Fra-2, Fra2 |
Organismi | Mus musculus (Mouse) |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Proteomesi |
|
Organism-specific databases
MGIi | MGI:102858, Fosl2 |
VEuPathDBi | HostDB:ENSMUSG00000029135 |
Subcellular locationi
Nucleus
- Nucleus By similarity
Nucleus
- nucleoplasm Source: MGI
- nucleus Source: MGI
- RNA polymerase II transcription regulator complex Source: Ensembl
Keywords - Cellular componenti
NucleusPathology & Biotechi
Disruption phenotypei
Mutant pups die within a week after birth. They exhibit severe osteopenia as early as 18.5 dpc, with a 50% decrease in mineralized bone. Osteoblast numbers are not altered. The number, the relative surface covered by osteoclasts and the mean osteoclast surface are increased 3-fold, 5-fold and 2-fold, respectively. Bone resorption activity is increased. This phenotype is due to hypoxia in long bones resulting from placental defects.1 Publication
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000076484 | 1 – 326 | Fos-related antigen 2Add BLAST | 326 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 1 | N-acetylmethionineBy similarity | 1 | |
Cross-linki | 35 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity | ||
Modified residuei | 104 | N6-acetyllysine; alternateCombined sources | 1 | |
Cross-linki | 104 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2); alternateBy similarity | ||
Modified residuei | 120 | PhosphoserineBy similarity | 1 | |
Modified residuei | 200 | PhosphoserineBy similarity | 1 | |
Cross-linki | 222 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO1); alternateBy similarity | ||
Cross-linki | 222 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2); alternateBy similarity | ||
Modified residuei | 230 | PhosphoserineBy similarity | 1 | |
Cross-linki | 239 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity | ||
Modified residuei | 308 | PhosphoserineBy similarity | 1 | |
Modified residuei | 320 | PhosphoserineBy similarity | 1 |
Keywords - PTMi
Acetylation, Isopeptide bond, Phosphoprotein, Ubl conjugationProteomic databases
EPDi | P47930 |
jPOSTi | P47930 |
MaxQBi | P47930 |
PaxDbi | P47930 |
PeptideAtlasi | P47930 |
PRIDEi | P47930 |
ProteomicsDBi | 267393 [P47930-1] 267394 [P47930-2] |
PTM databases
iPTMneti | P47930 |
PhosphoSitePlusi | P47930 |
Expressioni
Gene expression databases
Bgeei | ENSMUSG00000029135, Expressed in adrenal gland and 279 other tissues |
Genevisiblei | P47930, MM |
Interactioni
Subunit structurei
Protein-protein interaction databases
BioGRIDi | 199729, 1 interactor |
ELMi | P47930 |
STRINGi | 10090.ENSMUSP00000031017 |
Miscellaneous databases
RNActi | P47930, protein |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 124 – 187 | bZIPPROSITE-ProRule annotationAdd BLAST | 64 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 1 – 39 | DisorderedSequence analysisAdd BLAST | 39 | |
Regioni | 110 – 131 | DisorderedSequence analysisAdd BLAST | 22 | |
Regioni | 126 – 128 | Basic motifPROSITE-ProRule annotation | 3 | |
Regioni | 129 – 136 | Leucine-zipperPROSITE-ProRule annotation | 8 | |
Regioni | 193 – 244 | DisorderedSequence analysisAdd BLAST | 52 | |
Regioni | 285 – 326 | DisorderedSequence analysisAdd BLAST | 42 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 1 – 32 | Polar residuesSequence analysisAdd BLAST | 32 |
Sequence similaritiesi
Phylogenomic databases
eggNOGi | KOG1414, Eukaryota |
GeneTreei | ENSGT00940000158876 |
HOGENOMi | CLU_049742_2_1_1 |
InParanoidi | P47930 |
OMAi | PNMLEPE |
OrthoDBi | 1221590at2759 |
PhylomeDBi | P47930 |
TreeFami | TF326301 |
Family and domain databases
InterProi | View protein in InterPro IPR000837, AP-1 IPR004827, bZIP IPR029814, Fra2 |
PANTHERi | PTHR23351, PTHR23351, 1 hit PTHR23351:SF25, PTHR23351:SF25, 1 hit |
Pfami | View protein in Pfam PF00170, bZIP_1, 1 hit |
PRINTSi | PR00042, LEUZIPPRFOS |
SMARTi | View protein in SMART SM00338, BRLZ, 1 hit |
PROSITEi | View protein in PROSITE PS50217, BZIP, 1 hit PS00036, BZIP_BASIC, 1 hit |
s (2)i Sequence
Sequence statusi: Complete.
This entry describes 2 produced by isoformsialternative splicing. AlignAdd to basketIsoform 1 (identifier: P47930-1) [UniParc]FASTAAdd to basket
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MYQDYPGNFD TSSRGSSGSP AHAESYSSGG GGQQKFRVDM PGSGSAFIPT
60 70 80 90 100
INAITTSQDL QWMVQPTVIT SMSNPYPRSH PYSPLPGLAS VPGHMALPRP
110 120 130 140 150
GVIKTIGTTV GRRRRDEQLS PEEEEKRRIR RERNKLAAAK CRNRRRELTE
160 170 180 190 200
KLQAETEELE EEKSGLQKEI AELQKEKEKL EFMLVAHGPV CKISPEERRS
210 220 230 240 250
PPTSGLQSLR GTGSAVGPVV VKQEPPEEDS PSSSAGMDKT QRSVIKPISI
260 270 280 290 300
AGGGFYGEEP LHTPIVVTST PAITPGTSNL VFTYPNVLEQ ESPSSPSESC
310 320
SKAHRRSSSS GDQSSDSLNS PTLLAL
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 184 | L → K in CAA58805 (PubMed:7936655).Curated | 1 | |
Sequence conflicti | 267 | V → E in BAE26674 (PubMed:16141072).Curated | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_042084 | 1 – 33 | MYQDY…GGGGQ → MSFSLF in isoform 2. 1 PublicationAdd BLAST | 33 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | X83971 mRNA Translation: CAA58805.1 X83970 Genomic DNA Translation: CAA58804.1 AK089371 mRNA Translation: BAC40860.1 AK145822 mRNA Translation: BAE26674.1 BC065131 mRNA Translation: AAH65131.1 |
CCDSi | CCDS19190.1 [P47930-1] |
PIRi | I48351 |
RefSeqi | NP_032063.2, NM_008037.4 [P47930-1] |
Genome annotation databases
Ensembli | ENSMUST00000031017; ENSMUSP00000031017; ENSMUSG00000029135 [P47930-1] |
GeneIDi | 14284 |
KEGGi | mmu:14284 |
UCSCi | uc008wzi.2, mouse [P47930-1] uc008wzj.1, mouse [P47930-2] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | X83971 mRNA Translation: CAA58805.1 X83970 Genomic DNA Translation: CAA58804.1 AK089371 mRNA Translation: BAC40860.1 AK145822 mRNA Translation: BAE26674.1 BC065131 mRNA Translation: AAH65131.1 |
CCDSi | CCDS19190.1 [P47930-1] |
PIRi | I48351 |
RefSeqi | NP_032063.2, NM_008037.4 [P47930-1] |
3D structure databases
SMRi | P47930 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 199729, 1 interactor |
ELMi | P47930 |
STRINGi | 10090.ENSMUSP00000031017 |
PTM databases
iPTMneti | P47930 |
PhosphoSitePlusi | P47930 |
Proteomic databases
EPDi | P47930 |
jPOSTi | P47930 |
MaxQBi | P47930 |
PaxDbi | P47930 |
PeptideAtlasi | P47930 |
PRIDEi | P47930 |
ProteomicsDBi | 267393 [P47930-1] 267394 [P47930-2] |
Protocols and materials databases
Antibodypediai | 1415, 577 antibodies from 36 providers |
DNASUi | 14284 |
Genome annotation databases
Ensembli | ENSMUST00000031017; ENSMUSP00000031017; ENSMUSG00000029135 [P47930-1] |
GeneIDi | 14284 |
KEGGi | mmu:14284 |
UCSCi | uc008wzi.2, mouse [P47930-1] uc008wzj.1, mouse [P47930-2] |
Organism-specific databases
CTDi | 2355 |
MGIi | MGI:102858, Fosl2 |
VEuPathDBi | HostDB:ENSMUSG00000029135 |
Phylogenomic databases
eggNOGi | KOG1414, Eukaryota |
GeneTreei | ENSGT00940000158876 |
HOGENOMi | CLU_049742_2_1_1 |
InParanoidi | P47930 |
OMAi | PNMLEPE |
OrthoDBi | 1221590at2759 |
PhylomeDBi | P47930 |
TreeFami | TF326301 |
Miscellaneous databases
BioGRID-ORCSi | 14284, 1 hit in 64 CRISPR screens |
ChiTaRSi | Fosl2, mouse |
PROi | PR:P47930 |
RNActi | P47930, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSMUSG00000029135, Expressed in adrenal gland and 279 other tissues |
Genevisiblei | P47930, MM |
Family and domain databases
InterProi | View protein in InterPro IPR000837, AP-1 IPR004827, bZIP IPR029814, Fra2 |
PANTHERi | PTHR23351, PTHR23351, 1 hit PTHR23351:SF25, PTHR23351:SF25, 1 hit |
Pfami | View protein in Pfam PF00170, bZIP_1, 1 hit |
PRINTSi | PR00042, LEUZIPPRFOS |
SMARTi | View protein in SMART SM00338, BRLZ, 1 hit |
PROSITEi | View protein in PROSITE PS50217, BZIP, 1 hit PS00036, BZIP_BASIC, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | FOSL2_MOUSE | |
Accessioni | P47930Primary (citable) accession number: P47930 Secondary accession number(s): Q3UKX7, Q8C231 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | February 1, 1996 |
Last sequence update: | July 27, 2011 | |
Last modified: | February 23, 2022 | |
This is version 149 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families