Fosl2

Functionⁱ

Controls osteoclast survival and size. As a dimer with JUN, activates LIF transcription. Activates CEBPB transcription in PGE2-activated osteoblasts (By similarity).By similarity1 Publication

GO - Molecular functionⁱ

chromatin binding
Source: MGI
Inferred from direct assayⁱ
- 25547114
DNA binding Source: MGI
DNA-binding transcription activator activity, RNA polymerase II-specific Source: MGI
DNA-binding transcription factor activity Source: MGI
double-stranded DNA binding Source: MGI
RNA polymerase II proximal promoter sequence-specific DNA binding
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
RNA polymerase II regulatory region sequence-specific DNA binding
Source: MGI
Inferred from direct assayⁱ
- 19289495
sequence-specific DNA binding Source: MGI
transcription regulatory region DNA binding Source: MGI

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

keratinocyte development
Source: MGI
Inferred from mutant phenotypeⁱ
- 25547114
positive regulation of fibroblast proliferation
Source: MGI
Inferred from direct assayⁱ
- 7936655
positive regulation of transcription, DNA-templated
Source: CACAO
Inferred from direct assayⁱ
- 22585681
positive regulation of transcription by RNA polymerase II
Source: MGI
Inferred from direct assayⁱ
- 25547114
response to estradiol Source: MGI
response to hypoxia Source: MGI
transcription by RNA polymerase II Source: MGI

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	DNA-binding
Biological process	Transcription, Transcription regulation

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Fos-related antigen 2 Short name: FRA-2
Gene namesⁱ	Name:Fosl2 Synonyms:Fra-2, Fra2
Organismⁱ	Mus musculus (Mouse)
Taxonomic identifierⁱ	10090 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus
Proteomesⁱ	UP000000589 Componentⁱ: Chromosome 5

Organism-specific databases

MGIⁱ	MGI:102858 Fosl2

Keywords - Cellular componentⁱ

Nucleus

Pathology & Biotechⁱ

Disruption phenotypeⁱ

Mutant pups die within a week after birth. They exhibit severe osteopenia as early as 18.5 dpc, with a 50% decrease in mineralized bone. Osteoblast numbers are not altered. The number, the relative surface covered by osteoclasts and the mean osteoclast surface are increased 3-fold, 5-fold and 2-fold, respectively. Bone resorption activity is increased. This phenotype is due to hypoxia in long bones resulting from placental defects.1 Publication

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000076484	1 – 326	Fos-related antigen 2Add BLAST		326

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Modified residueⁱ	1	N-acetylmethionineBy similarity	1
Cross-linkⁱ	35	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Modified residueⁱ	104	N6-acetyllysine; alternateCombined sources	1
Cross-linkⁱ	104	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2); alternateBy similarity
Modified residueⁱ	120	PhosphoserineBy similarity	1
Modified residueⁱ	200	PhosphoserineBy similarity	1
Cross-linkⁱ	222	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO1); alternateBy similarity
Cross-linkⁱ	222	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2); alternateBy similarity
Modified residueⁱ	230	PhosphoserineBy similarity	1
Cross-linkⁱ	239	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Modified residueⁱ	308	PhosphoserineBy similarity	1
Modified residueⁱ	320	PhosphoserineBy similarity	1

Keywords - PTMⁱ

Acetylation, Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

EPDⁱ	P47930
MaxQB - The MaxQuant DataBase More...MaxQBⁱ	P47930
PaxDbⁱ	P47930
PeptideAtlas More...PeptideAtlasⁱ	P47930
PRIDEⁱ	P47930

PTM databases

iPTMnetⁱ	P47930
PhosphoSitePlusⁱ	P47930

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSMUSG00000029135 Expressed in 252 organ(s), highest expression level in adrenal gland
CleanExⁱ	MM_FOSL2
Genevisibleⁱ	P47930 MM

Interactionⁱ

Subunit structureⁱ

Heterodimer; with JUN.

Protein-protein interaction databases

BioGridⁱ	199729, 1 interactor
ELMⁱ	P47930
STRINGⁱ	10090.ENSMUSP00000031017

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	P47930
SMRⁱ	P47930
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Domainⁱ	124 – 187	bZIPPROSITE-ProRule annotationAdd BLAST		64

Region

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Regionⁱ	126 – 128	Basic motifPROSITE-ProRule annotation		3
Regionⁱ	129 – 136	Leucine-zipperPROSITE-ProRule annotation		8

Sequence similaritiesⁱ

Belongs to the bZIP family. Fos subfamily.Curated

Phylogenomic databases

eggNOGⁱ	KOG1414 Eukaryota ENOG4111CH5 LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00730000110541
HOGENOMⁱ	HOG000234334
HOVERGENⁱ	HBG005743
InParanoidⁱ	P47930
KEGG Orthology (KO) More...KOⁱ	K09030
OMAⁱ	FTYPNVL
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0GGW
TreeFamⁱ	TF326301

Family and domain databases

InterProⁱ	View protein in InterPro IPR000837 AP-1 IPR004827 bZIP IPR029814 Fra2
PANTHERⁱ	PTHR23351 PTHR23351, 1 hit PTHR23351:SF25 PTHR23351:SF25, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00170 bZIP_1, 1 hit
PRINTSⁱ	PR00042 LEUZIPPRFOS
SMARTⁱ	View protein in SMART SM00338 BRLZ, 1 hit
PROSITEⁱ	View protein in PROSITE PS50217 BZIP, 1 hit PS00036 BZIP_BASIC, 1 hit

Sequences (2)ⁱ

Sequence statusⁱ: Complete.

This entry describes 2 isoformsⁱ produced by alternative splicing. Align Add to basket

Isoform 1 (identifier: P47930-1) [UniParc]FASTA Add to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MYQDYPGNFD TSSRGSSGSP AHAESYSSGG GGQQKFRVDM PGSGSAFIPT 
        60         70         80         90        100
INAITTSQDL QWMVQPTVIT SMSNPYPRSH PYSPLPGLAS VPGHMALPRP 
       110        120        130        140        150
GVIKTIGTTV GRRRRDEQLS PEEEEKRRIR RERNKLAAAK CRNRRRELTE 
       160        170        180        190        200
KLQAETEELE EEKSGLQKEI AELQKEKEKL EFMLVAHGPV CKISPEERRS 
       210        220        230        240        250
PPTSGLQSLR GTGSAVGPVV VKQEPPEEDS PSSSAGMDKT QRSVIKPISI 
       260        270        280        290        300
AGGGFYGEEP LHTPIVVTST PAITPGTSNL VFTYPNVLEQ ESPSSPSESC 
       310        320 
SKAHRRSSSS GDQSSDSLNS PTLLAL

Length:326

Mass (Da):35,298

Last modified:July 27, 2011 - v2

Checksum:ⁱ05B0F20D7D0B790A

GO

Isoform 2 (identifier: P47930-2) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
1-33: MYQDYPGNFDTSSRGSSGSPAHAESYSSGGGGQ → MSFSLF

« Hide

        10         20         30         40         50
MSFSLFQKFR VDMPGSGSAF IPTINAITTS QDLQWMVQPT VITSMSNPYP 
        60         70         80         90        100
RSHPYSPLPG LASVPGHMAL PRPGVIKTIG TTVGRRRRDE QLSPEEEEKR 
       110        120        130        140        150
RIRRERNKLA AAKCRNRRRE LTEKLQAETE ELEEEKSGLQ KEIAELQKEK 
       160        170        180        190        200
EKLEFMLVAH GPVCKISPEE RRSPPTSGLQ SLRGTGSAVG PVVVKQEPPE 
       210        220        230        240        250
EDSPSSSAGM DKTQRSVIKP ISIAGGGFYG EEPLHTPIVV TSTPAITPGT 
       260        270        280        290 
SNLVFTYPNV LEQESPSSPS ESCSKAHRRS SSSGDQSSDS LNSPTLLAL

Note: No experimental confirmation available.

Show »

Length:299

Mass (Da):32,687

Checksum:ⁱ4879B6E93597B61E

GO

Experimental Info

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Sequence conflictⁱ	184	L → K in CAA58805 (PubMed:7936655).Curated		1
Sequence conflictⁱ	267	V → E in BAE26674 (PubMed:16141072).Curated		1

Alternative sequence

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Alternative sequenceⁱVSP_042084	1 – 33	MYQDY…GGGGQ → MSFSLF in isoform 2. 1 PublicationAdd BLAST		33

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	X83971 mRNA Translation: CAA58805.1 X83970 Genomic DNA Translation: CAA58804.1 AK089371 mRNA Translation: BAC40860.1 AK145822 mRNA Translation: BAE26674.1 BC065131 mRNA Translation: AAH65131.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS19190.1 [P47930-1]
PIRⁱ	I48351
NCBI Reference Sequences More...RefSeqⁱ	NP_032063.2, NM_008037.4 [P47930-1]
UniGeneⁱ	Mm.24684

Genome annotation databases

Ensemblⁱ	ENSMUST00000031017; ENSMUSP00000031017; ENSMUSG00000029135 [P47930-1]
GeneIDⁱ	14284
KEGGⁱ	mmu:14284
UCSC genome browser More...UCSCⁱ	uc008wzi.2 mouse [P47930-1] uc008wzj.1 mouse [P47930-2]

Keywords - Coding sequence diversityⁱ

Alternative splicing

Similar proteinsⁱ

90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
P47930	Fos-related antigen 2		RAT		326	UniRef90_P51145
Fos-related antigen 2		HUMAN		326
Fos-related antigen 2		TUPCH		343
FOS-like antigen 2-like protein		CAMFR		341
FOSL2		CEREH		327
+91
P47930-2	Fos-related antigen 2		wild yak		333	UniRef90_P47930-2
fos-related antigen 2		BALAS		327
fos-related antigen 2 isoform X1		DELLE		327
fos-related antigen 2 isoform X1		PHYCD		327
Fos-related antigen 2 (Fragment)		MACMU		202
+77

Protein	Similar proteins		Species	Score	Length	Source
P47930	Fos-related antigen 2		RAT		326	UniRef50_P51145
Fos-related antigen 2		HUMAN		326
Fos-related antigen 2		CHICK		323
Fos-related antigen 2		TUPCH		343
FOS-like antigen 2-like protein		CAMFR		341
+330

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	X83971 mRNA Translation: CAA58805.1 X83970 Genomic DNA Translation: CAA58804.1 AK089371 mRNA Translation: BAC40860.1 AK145822 mRNA Translation: BAE26674.1 BC065131 mRNA Translation: AAH65131.1
CCDSⁱ	CCDS19190.1 [P47930-1]
PIRⁱ	I48351
RefSeqⁱ	NP_032063.2, NM_008037.4 [P47930-1]
UniGeneⁱ	Mm.24684

3D structure databases

ProteinModelPortalⁱ	P47930
SMRⁱ	P47930
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	199729, 1 interactor
ELMⁱ	P47930
STRINGⁱ	10090.ENSMUSP00000031017

PTM databases

iPTMnetⁱ	P47930
PhosphoSitePlusⁱ	P47930

Proteomic databases

EPDⁱ	P47930
MaxQBⁱ	P47930
PaxDbⁱ	P47930
PeptideAtlasⁱ	P47930
PRIDEⁱ	P47930

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

Ensemblⁱ	ENSMUST00000031017; ENSMUSP00000031017; ENSMUSG00000029135 [P47930-1]
GeneIDⁱ	14284
KEGGⁱ	mmu:14284
UCSCⁱ	uc008wzi.2 mouse [P47930-1] uc008wzj.1 mouse [P47930-2]

Organism-specific databases

CTDⁱ	2355
MGIⁱ	MGI:102858 Fosl2

Phylogenomic databases

eggNOGⁱ	KOG1414 Eukaryota ENOG4111CH5 LUCA
GeneTreeⁱ	ENSGT00730000110541
HOGENOMⁱ	HOG000234334
HOVERGENⁱ	HBG005743
InParanoidⁱ	P47930
KOⁱ	K09030
OMAⁱ	FTYPNVL
OrthoDBⁱ	EOG091G0GGW
TreeFamⁱ	TF326301

Miscellaneous databases

Protein Ontology More...PROⁱ	PR:P47930
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSMUSG00000029135 Expressed in 252 organ(s), highest expression level in adrenal gland
CleanExⁱ	MM_FOSL2
Genevisibleⁱ	P47930 MM

Family and domain databases

InterProⁱ	View protein in InterPro IPR000837 AP-1 IPR004827 bZIP IPR029814 Fra2
PANTHERⁱ	PTHR23351 PTHR23351, 1 hit PTHR23351:SF25 PTHR23351:SF25, 1 hit
Pfamⁱ	View protein in Pfam PF00170 bZIP_1, 1 hit
PRINTSⁱ	PR00042 LEUZIPPRFOS
SMARTⁱ	View protein in SMART SM00338 BRLZ, 1 hit
PROSITEⁱ	View protein in PROSITE PS50217 BZIP, 1 hit PS00036 BZIP_BASIC, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	FOSL2_MOUSE
Accessionⁱ	P47930Primary (citable) accession number: P47930 Secondary accession number(s): Q3UKX7, Q8C231
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	February 1, 1996
	Last sequence update:	July 27, 2011
	Last modified:	November 7, 2018
	This is version 133 of the entry and version 2 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

Documents

SIMILARITY comments
Index of protein domains and families
MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - P47930 (FOSL2_MOUSE)

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Fos-related antigen 2

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Nucleus

Nucleus

Keywords - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Region

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

Family and domain databases

Experimental Info

Alternative sequence

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ