We will be switching to the new UniProt website soon. Please explore and share your feedback.
Take me to the new website.
UniProtKB - P47929 (LEG7_HUMAN)
Functioni
Could be involved in cell-cell and/or cell-matrix interactions necessary for normal growth control. Pro-apoptotic protein that functions intracellularly upstream of JNK activation and cytochrome c release.
1 PublicationGO - Molecular functioni
- carbohydrate binding Source: GO_Central
- galactoside binding Source: GO_Central
GO - Biological processi
- apoptotic process Source: UniProtKB-KW
- heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules Source: ProtInc
- negative regulation of CD4-positive, alpha-beta T cell proliferation Source: GO_Central
- negative regulation of interferon-gamma production Source: GO_Central
- positive regulation of gene expression Source: GO_Central
Keywordsi
Biological process | Apoptosis |
Ligand | Lectin |
Enzyme and pathway databases
PathwayCommonsi | P47929 |
SignaLinki | P47929 |
Protein family/group databases
UniLectini | P47929 |
Names & Taxonomyi
Protein namesi | Recommended name: Galectin-7Short name: Gal-7 Alternative name(s): HKL-14 PI7 p53-induced gene 1 protein |
Gene namesi | Name:LGALS7 Synonyms:PIG1 AND Name:LGALS7B |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:6568, LGALS7 HGNC:34447, LGALS7B |
MIMi | 600615, gene 617139, gene |
neXtProti | NX_P47929 |
VEuPathDBi | HostDB:ENSG00000178934 HostDB:ENSG00000205076 |
Subcellular locationi
Cytosol
- cytosol Source: GO_Central
Extracellular region or secreted
- extracellular exosome Source: UniProtKB
- extracellular space Source: ProtInc
Nucleus
- nucleus Source: GO_Central
Keywords - Cellular componenti
Cytoplasm, Nucleus, SecretedPathology & Biotechi
Organism-specific databases
DisGeNETi | 3963 653499 |
OpenTargetsi | ENSG00000178934 ENSG00000205076 |
PharmGKBi | PA162393892 |
Miscellaneous databases
Pharosi | P47929, Tbio |
Chemistry databases
ChEMBLi | CHEMBL5008 |
DrugBanki | DB02678, beta-D-Galactosamine DB02379, Beta-D-Glucose |
Genetic variation databases
BioMutai | LGALS7B |
DMDMi | 1346431 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000076940 | 1 – 136 | Galectin-7Add BLAST | 136 |
Proteomic databases
EPDi | P47929 |
jPOSTi | P47929 |
MassIVEi | P47929 |
MaxQBi | P47929 |
PaxDbi | P47929 |
PeptideAtlasi | P47929 |
PRIDEi | P47929 |
ProteomicsDBi | 55824 |
PTM databases
GlyGeni | P47929, 1 site, 1 O-linked glycan (1 site) |
iPTMneti | P47929 |
PhosphoSitePlusi | P47929 |
SwissPalmi | P47929 |
Expressioni
Tissue specificityi
Mainly expressed in stratified squamous epithelium.
Inductioni
By p53/TP53.
Gene expression databases
Bgeei | ENSG00000178934, Expressed in skin of abdomen and 86 other tissues |
ExpressionAtlasi | P47929, baseline and differential |
Genevisiblei | P47929, HS |
Organism-specific databases
HPAi | ENSG00000178934, Tissue enriched (skin) ENSG00000205076, Tissue enhanced (esophagus, skin) |
Interactioni
Subunit structurei
Monomer.
Binary interactionsi
P47929
Protein-protein interaction databases
BioGRIDi | 110154, 120 interactors 575831, 89 interactors |
IntActi | P47929, 63 interactors |
MINTi | P47929 |
STRINGi | 9606.ENSP00000313571 |
Chemistry databases
BindingDBi | P47929 |
Miscellaneous databases
RNActi | P47929, protein |
Structurei
Secondary structure
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details3D structure databases
BMRBi | P47929 |
SMRi | P47929 |
ModBasei | Search... |
PDBe-KBi | Search... |
Miscellaneous databases
EvolutionaryTracei | P47929 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 6 – 136 | GalectinPROSITE-ProRule annotationAdd BLAST | 131 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 70 – 76 | Beta-galactoside bindingSequence analysis | 7 |
Phylogenomic databases
eggNOGi | KOG3587, Eukaryota |
GeneTreei | ENSGT01040000240531 |
HOGENOMi | CLU_037794_3_3_1 |
InParanoidi | P47929 |
OMAi | LPMGNVR |
OrthoDBi | 1486238at2759 |
PhylomeDBi | P47929 |
TreeFami | TF315551 |
Family and domain databases
CDDi | cd00070, GLECT, 1 hit |
InterProi | View protein in InterPro IPR013320, ConA-like_dom_sf IPR044156, Galectin-like IPR030640, Galectin_7 IPR001079, Galectin_CRD |
PANTHERi | PTHR11346, PTHR11346, 1 hit PTHR11346:SF107, PTHR11346:SF107, 1 hit |
Pfami | View protein in Pfam PF00337, Gal-bind_lectin, 1 hit |
SMARTi | View protein in SMART SM00908, Gal-bind_lectin, 1 hit SM00276, GLECT, 1 hit |
SUPFAMi | SSF49899, SSF49899, 1 hit |
PROSITEi | View protein in PROSITE PS51304, GALECTIN, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All
P47929-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MSNVPHKSSL PEGIRPGTVL RIRGLVPPNA SRFHVNLLCG EEQGSDAALH
60 70 80 90 100
FNPRLDTSEV VFNSKEQGSW GREERGPGVP FQRGQPFEVL IIASDDGFKA
110 120 130
VVGDAQYHHF RHRLPLARVR LVEVGGDVQL DSVRIF
Computationally mapped potential isoform sequencesi
There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basketM0R281 | M0R281_HUMAN | Galectin-7 | LGALS7 | 35 | Annotation score: |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | L07769 mRNA Translation: AAA67899.1 U06643 mRNA Translation: AAA86820.1 CR456917 mRNA Translation: CAG33198.1 CH471126 Genomic DNA Translation: EAW56817.1 CH471126 Genomic DNA Translation: EAW56818.1 BC042911 mRNA Translation: AAH42911.2 BC061588 mRNA Translation: AAH61588.1 BC073743 mRNA Translation: AAH73743.1 |
CCDSi | CCDS42565.1 |
PIRi | I55469 |
RefSeqi | NP_001035972.1, NM_001042507.3 NP_002298.1, NM_002307.3 |
Genome annotation databases
Ensembli | ENST00000314980; ENSP00000313571; ENSG00000178934 ENST00000378626; ENSP00000367891; ENSG00000205076 ENST00000634448; ENSP00000489395; ENSG00000282902 ENST00000634800; ENSP00000489582; ENSG00000283082 |
GeneIDi | 3963 653499 |
KEGGi | hsa:3963 hsa:653499 |
MANE-Selecti | ENST00000314980.5; ENSP00000313571.3; NM_001042507.4; NP_001035972.1 ENST00000378626.5; ENSP00000367891.3; NM_002307.4; NP_002298.1 |
UCSCi | uc002oje.4, human |
Similar proteinsi
Cross-referencesi
Web resourcesi
Functional Glycomics Gateway - Glycan Binding Galectin-7 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | L07769 mRNA Translation: AAA67899.1 U06643 mRNA Translation: AAA86820.1 CR456917 mRNA Translation: CAG33198.1 CH471126 Genomic DNA Translation: EAW56817.1 CH471126 Genomic DNA Translation: EAW56818.1 BC042911 mRNA Translation: AAH42911.2 BC061588 mRNA Translation: AAH61588.1 BC073743 mRNA Translation: AAH73743.1 |
CCDSi | CCDS42565.1 |
PIRi | I55469 |
RefSeqi | NP_001035972.1, NM_001042507.3 NP_002298.1, NM_002307.3 |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
1BKZ | X-ray | 1.90 | A/B | 2-136 | [»] | |
2GAL | X-ray | 2.00 | A/B | 2-136 | [»] | |
3GAL | X-ray | 1.90 | A/B | 2-136 | [»] | |
3ZXE | X-ray | 1.67 | A/B | 4-136 | [»] | |
3ZXF | X-ray | 1.38 | A/B | 1-136 | [»] | |
4GAL | X-ray | 1.95 | A/B | 2-136 | [»] | |
4UW3 | X-ray | 1.48 | A/B | 1-136 | [»] | |
4UW4 | X-ray | 1.77 | A/B | 1-136 | [»] | |
4UW5 | X-ray | 2.04 | A/B/C/D/E/F | 1-136 | [»] | |
4UW6 | X-ray | 1.79 | A/B | 1-136 | [»] | |
4XBQ | X-ray | 2.23 | A/B | 1-136 | [»] | |
4Y26 | X-ray | 2.61 | A/B | 4-136 | [»] | |
5GAL | X-ray | 2.00 | A/B | 2-136 | [»] | |
5H9Q | X-ray | 1.93 | A/B | 1-136 | [»] | |
5H9S | X-ray | 1.82 | A/B | 1-136 | [»] | |
6VTO | X-ray | 1.69 | A/B | 2-136 | [»] | |
6VTP | X-ray | 2.30 | A/B | 2-136 | [»] | |
6VTQ | X-ray | 1.95 | A/B | 2-136 | [»] | |
6VTR | X-ray | 2.30 | A/B | 2-136 | [»] | |
6VTS | X-ray | 1.90 | A/B | 2-136 | [»] | |
BMRBi | P47929 | |||||
SMRi | P47929 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 110154, 120 interactors 575831, 89 interactors |
IntActi | P47929, 63 interactors |
MINTi | P47929 |
STRINGi | 9606.ENSP00000313571 |
Chemistry databases
BindingDBi | P47929 |
ChEMBLi | CHEMBL5008 |
DrugBanki | DB02678, beta-D-Galactosamine DB02379, Beta-D-Glucose |
Protein family/group databases
UniLectini | P47929 |
PTM databases
GlyGeni | P47929, 1 site, 1 O-linked glycan (1 site) |
iPTMneti | P47929 |
PhosphoSitePlusi | P47929 |
SwissPalmi | P47929 |
Genetic variation databases
BioMutai | LGALS7B |
DMDMi | 1346431 |
Proteomic databases
EPDi | P47929 |
jPOSTi | P47929 |
MassIVEi | P47929 |
MaxQBi | P47929 |
PaxDbi | P47929 |
PeptideAtlasi | P47929 |
PRIDEi | P47929 |
ProteomicsDBi | 55824 |
Protocols and materials databases
Antibodypediai | 16627, 310 antibodies from 20 providers 652, 168 antibodies from 26 providers |
DNASUi | 653499 |
Genome annotation databases
Ensembli | ENST00000314980; ENSP00000313571; ENSG00000178934 ENST00000378626; ENSP00000367891; ENSG00000205076 ENST00000634448; ENSP00000489395; ENSG00000282902 ENST00000634800; ENSP00000489582; ENSG00000283082 |
GeneIDi | 3963 653499 |
KEGGi | hsa:3963 hsa:653499 |
MANE-Selecti | ENST00000314980.5; ENSP00000313571.3; NM_001042507.4; NP_001035972.1 ENST00000378626.5; ENSP00000367891.3; NM_002307.4; NP_002298.1 |
UCSCi | uc002oje.4, human |
Organism-specific databases
CTDi | 3963 653499 |
DisGeNETi | 3963 653499 |
GeneCardsi | LGALS7 LGALS7B |
HGNCi | HGNC:6568, LGALS7 HGNC:34447, LGALS7B |
HPAi | ENSG00000178934, Tissue enriched (skin) ENSG00000205076, Tissue enhanced (esophagus, skin) |
MIMi | 600615, gene 617139, gene |
neXtProti | NX_P47929 |
OpenTargetsi | ENSG00000178934 ENSG00000205076 |
PharmGKBi | PA162393892 |
VEuPathDBi | HostDB:ENSG00000178934 HostDB:ENSG00000205076 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG3587, Eukaryota |
GeneTreei | ENSGT01040000240531 |
HOGENOMi | CLU_037794_3_3_1 |
InParanoidi | P47929 |
OMAi | LPMGNVR |
OrthoDBi | 1486238at2759 |
PhylomeDBi | P47929 |
TreeFami | TF315551 |
Enzyme and pathway databases
PathwayCommonsi | P47929 |
SignaLinki | P47929 |
Miscellaneous databases
BioGRID-ORCSi | 3963, 6 hits in 956 CRISPR screens 653499, 21 hits in 946 CRISPR screens |
EvolutionaryTracei | P47929 |
GeneWikii | LGALS7 |
Pharosi | P47929, Tbio |
PROi | PR:P47929 |
RNActi | P47929, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000178934, Expressed in skin of abdomen and 86 other tissues |
ExpressionAtlasi | P47929, baseline and differential |
Genevisiblei | P47929, HS |
Family and domain databases
CDDi | cd00070, GLECT, 1 hit |
InterProi | View protein in InterPro IPR013320, ConA-like_dom_sf IPR044156, Galectin-like IPR030640, Galectin_7 IPR001079, Galectin_CRD |
PANTHERi | PTHR11346, PTHR11346, 1 hit PTHR11346:SF107, PTHR11346:SF107, 1 hit |
Pfami | View protein in Pfam PF00337, Gal-bind_lectin, 1 hit |
SMARTi | View protein in SMART SM00908, Gal-bind_lectin, 1 hit SM00276, GLECT, 1 hit |
SUPFAMi | SSF49899, SSF49899, 1 hit |
PROSITEi | View protein in PROSITE PS51304, GALECTIN, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | LEG7_HUMAN | |
Accessioni | P47929Primary (citable) accession number: P47929 Secondary accession number(s): Q6IB87 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | February 1, 1996 |
Last sequence update: | January 23, 2007 | |
Last modified: | February 23, 2022 | |
This is version 199 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
3D-structure, Direct protein sequencing, Reference proteomeDocuments
- Human chromosome 19
Human chromosome 19: entries, gene names and cross-references to MIM - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - PDB cross-references
Index of Protein Data Bank (PDB) cross-references