LGALS7

Functionⁱ

Could be involved in cell-cell and/or cell-matrix interactions necessary for normal growth control. Pro-apoptotic protein that functions intracellularly upstream of JNK activation and cytochrome c release.1 Publication

GO - Molecular functionⁱ

carbohydrate binding
Source: ProtInc
Traceable author statementⁱ
- 7534301

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

apoptotic process Source: UniProtKB-KW
heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules
Source: ProtInc
Traceable author statementⁱ
- 7534301

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Biological process	Apoptosis
Ligand	Lectin

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Galectin-7 Short name: Gal-7 Alternative name(s): HKL-14 PI7 p53-induced gene 1 protein
Gene namesⁱ	Name:LGALS7 Synonyms:PIG1 AND Name:LGALS7B
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 19

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000178934.4 HostDB:ENSG00000205076.4
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:6568 LGALS7 HGNC:34447 LGALS7B
MIMⁱ	600615 gene 617139 gene
neXtProtⁱ	NX_P47929

Keywords - Cellular componentⁱ

Cytoplasm, Nucleus, Secreted

Pathology & Biotechⁱ

Organism-specific databases

DisGeNET More...DisGeNETⁱ	3963 653499
Open Targets More...OpenTargetsⁱ	ENSG00000178934 ENSG00000205076
PharmGKBⁱ	PA162393892

Chemistry databases

ChEMBLⁱ	CHEMBL5008
Drug and drug target database More...DrugBankⁱ	DB02678 2-Deoxy-2-Aminogalactose DB02379 Beta-D-Glucose

Polymorphism and mutation databases

BioMutaⁱ	LGALS7
DMDMⁱ	1346431

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000076940	1 – 136	Galectin-7Add BLAST		136

Proteomic databases

EPDⁱ	P47929
MaxQB - The MaxQuant DataBase More...MaxQBⁱ	P47929
PaxDbⁱ	P47929
PeptideAtlas More...PeptideAtlasⁱ	P47929
PRIDEⁱ	P47929
ProteomicsDBⁱ	55824

PTM databases

iPTMnetⁱ	P47929
PhosphoSitePlusⁱ	P47929
SwissPalmⁱ	P47929

Expressionⁱ

Tissue specificityⁱ

Mainly expressed in stratified squamous epithelium.

Inductionⁱ

By p53/TP53.

Gene expression databases

Bgeeⁱ	ENSG00000178934
CleanExⁱ	HS_LGALS7
ExpressionAtlasⁱ	P47929 baseline and differential
Genevisibleⁱ	P47929 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	CAB025100 CAB032606 HPA001549

HPAⁱ

CAB025100
CAB032606
HPA001549

Interactionⁱ

Subunit structureⁱ

Monomer.

Protein-protein interaction databases

BioGridⁱ	110154, 49 interactors 575831, 11 interactors
IntActⁱ	P47929, 15 interactors
Molecular INTeraction database More...MINTⁱ	P47929
STRINGⁱ	9606.ENSP00000367891

Chemistry databases

BindingDBⁱ

P47929

Structureⁱ

Secondary structure

Legend: HelixTurnBeta strandPDB Structure known for this area

Show more details

Feature key	Position(s)	DescriptionActions	Length
Beta strandⁱ	6 – 9	Combined sources	4
Beta strandⁱ	16 – 26	Combined sources	11
Beta strandⁱ	32 – 42	Combined sources	11
Beta strandⁱ	47 – 54	Combined sources	8
Turnⁱ	55 – 58	Combined sources	4
Beta strandⁱ	59 – 66	Combined sources	8
Beta strandⁱ	85 – 93	Combined sources	9
Beta strandⁱ	95 – 102	Combined sources	8
Beta strandⁱ	105 – 111	Combined sources	7
Helixⁱ	116 – 118	Combined sources	3
Beta strandⁱ	121 – 127	Combined sources	7
Beta strandⁱ	129 – 135	Combined sources	7

3D structure databases

Select the link destinations: Protein Data Bank Europe More...PDBeⁱ Protein Data Bank RCSB More...RCSB PDBⁱ Protein Data Bank Japan More...PDBjⁱ Links Updated	PDB entry	Method	Resolution (Å)	Chain	Positions	PDBsum
	1BKZ	X-ray	1.90	A/B	2-136	[»]
	2GAL	X-ray	2.00	A/B	2-136	[»]
	3GAL	X-ray	1.90	A/B	2-136	[»]
	3ZXE	X-ray	1.67	A/B	4-136	[»]
	3ZXF	X-ray	1.38	A/B	1-136	[»]
	4GAL	X-ray	1.95	A/B	2-136	[»]
	4UW3	X-ray	1.48	A/B	1-136	[»]
	4UW4	X-ray	1.77	A/B	1-136	[»]
	4UW5	X-ray	2.04	A/B/C/D/E/F	1-136	[»]
	4UW6	X-ray	1.79	A/B	1-136	[»]
	4XBQ	X-ray	2.23	A/B	1-136	[»]
	4Y26	X-ray	2.61	A/B	4-136	[»]
	5GAL	X-ray	2.00	A/B	2-136	[»]
	5H9Q	X-ray	1.93	A/B	1-136	[»]
	5H9S	X-ray	1.82	A/B	1-136	[»]
ProteinModelPortalⁱ	P47929
SMRⁱ	P47929
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Miscellaneous databases

EvolutionaryTraceⁱ

P47929

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Domainⁱ	6 – 136	GalectinPROSITE-ProRule annotationAdd BLAST		131

Region

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Regionⁱ	70 – 76	Beta-galactoside bindingSequence analysis		7

Phylogenomic databases

eggNOGⁱ	KOG3587 Eukaryota ENOG4111EA0 LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00760000119105
HOGENOMⁱ	HOG000293279
HOVERGENⁱ	HBG006255
InParanoidⁱ	P47929
KEGG Orthology (KO) More...KOⁱ	K10092
OMAⁱ	HSAHVSH
Database of Orthologous Groups More...OrthoDBⁱ	EOG09370HGL
PhylomeDBⁱ	P47929
TreeFamⁱ	TF315551

Family and domain databases

Conserved Domains Database More...CDDⁱ	cd00070 GLECT, 1 hit
InterProⁱ	View protein in InterPro IPR013320 ConA-like_dom_sf IPR030640 Galectin_7 IPR001079 Galectin_CRD
PANTHERⁱ	PTHR11346:SF107 PTHR11346:SF107, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00337 Gal-bind_lectin, 1 hit
SMARTⁱ	View protein in SMART SM00908 Gal-bind_lectin, 1 hit SM00276 GLECT, 1 hit
SUPFAMⁱ	SSF49899 SSF49899, 1 hit
PROSITEⁱ	View protein in PROSITE PS51304 GALECTIN, 1 hit

Sequenceⁱ

Sequence statusⁱ: Complete.

P47929-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MSNVPHKSSL PEGIRPGTVL RIRGLVPPNA SRFHVNLLCG EEQGSDAALH 
        60         70         80         90        100
FNPRLDTSEV VFNSKEQGSW GREERGPGVP FQRGQPFEVL IIASDDGFKA 
       110        120        130 
VVGDAQYHHF RHRLPLARVR LVEVGGDVQL DSVRIF

Length:136

Mass (Da):15,075

Last modified:January 23, 2007 - v2

Checksum:ⁱF613D3540331C13F

GO

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	L07769 mRNA Translation: AAA67899.1 U06643 mRNA Translation: AAA86820.1 CR456917 mRNA Translation: CAG33198.1 CH471126 Genomic DNA Translation: EAW56817.1 CH471126 Genomic DNA Translation: EAW56818.1 BC042911 mRNA Translation: AAH42911.2 BC061588 mRNA Translation: AAH61588.1 BC073743 mRNA Translation: AAH73743.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS42565.1
PIRⁱ	I55469
NCBI Reference Sequences More...RefSeqⁱ	NP_001035972.1, NM_001042507.3 NP_002298.1, NM_002307.3
UniGeneⁱ	Hs.558355 Hs.702546

Genome annotation databases

Ensemblⁱ	ENST00000314980; ENSP00000313571; ENSG00000178934 ENST00000378626; ENSP00000367891; ENSG00000205076 ENST00000634448; ENSP00000489395; ENSG00000282902 ENST00000634800; ENSP00000489582; ENSG00000283082
GeneIDⁱ	3963 653499
KEGGⁱ	hsa:3963 hsa:653499
UCSC genome browser More...UCSCⁱ	uc002oje.4 human

Similar proteinsⁱ

90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length
P47929	Galectin		GORGO		136
Galectin		PANTR		136
UPI00062CAFFC		HUMAN		155
Galectin		SAIBB		136
Galectin		Cebus capucinus imitator		136
+7

Protein	Similar proteins		Species	Score	Length
P47929	Galectin		GORGO		136
Galectin		PANTR		136
UPI00062CAFFC		HUMAN		155
Galectin		SAIBB		136
Galectin		AOTNA		136
+31

Cross-referencesⁱ

Web resourcesⁱ

Functional Glycomics Gateway - Glycan Binding

Galectin-7

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	L07769 mRNA Translation: AAA67899.1 U06643 mRNA Translation: AAA86820.1 CR456917 mRNA Translation: CAG33198.1 CH471126 Genomic DNA Translation: EAW56817.1 CH471126 Genomic DNA Translation: EAW56818.1 BC042911 mRNA Translation: AAH42911.2 BC061588 mRNA Translation: AAH61588.1 BC073743 mRNA Translation: AAH73743.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS42565.1
PIRⁱ	I55469
NCBI Reference Sequences More...RefSeqⁱ	NP_001035972.1, NM_001042507.3 NP_002298.1, NM_002307.3
UniGeneⁱ	Hs.558355 Hs.702546

3D structure databases

Select the link destinations: Protein Data Bank Europe More...PDBeⁱ Protein Data Bank RCSB More...RCSB PDBⁱ Protein Data Bank Japan More...PDBjⁱ Links Updated	PDB entry	Method	Resolution (Å)	Chain	Positions	PDBsum
	1BKZ	X-ray	1.90	A/B	2-136	[»]
	2GAL	X-ray	2.00	A/B	2-136	[»]
	3GAL	X-ray	1.90	A/B	2-136	[»]
	3ZXE	X-ray	1.67	A/B	4-136	[»]
	3ZXF	X-ray	1.38	A/B	1-136	[»]
	4GAL	X-ray	1.95	A/B	2-136	[»]
	4UW3	X-ray	1.48	A/B	1-136	[»]
	4UW4	X-ray	1.77	A/B	1-136	[»]
	4UW5	X-ray	2.04	A/B/C/D/E/F	1-136	[»]
	4UW6	X-ray	1.79	A/B	1-136	[»]
	4XBQ	X-ray	2.23	A/B	1-136	[»]
	4Y26	X-ray	2.61	A/B	4-136	[»]
	5GAL	X-ray	2.00	A/B	2-136	[»]
	5H9Q	X-ray	1.93	A/B	1-136	[»]
	5H9S	X-ray	1.82	A/B	1-136	[»]
ProteinModelPortalⁱ	P47929
SMRⁱ	P47929
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	110154, 49 interactors 575831, 11 interactors
IntActⁱ	P47929, 15 interactors
Molecular INTeraction database More...MINTⁱ	P47929
STRINGⁱ	9606.ENSP00000367891

Chemistry databases

BindingDBⁱ	P47929
ChEMBLⁱ	CHEMBL5008
Drug and drug target database More...DrugBankⁱ	DB02678 2-Deoxy-2-Aminogalactose DB02379 Beta-D-Glucose

PTM databases

iPTMnetⁱ	P47929
PhosphoSitePlusⁱ	P47929
SwissPalmⁱ	P47929

Polymorphism and mutation databases

BioMutaⁱ	LGALS7
DMDMⁱ	1346431

Proteomic databases

EPDⁱ	P47929
MaxQB - The MaxQuant DataBase More...MaxQBⁱ	P47929
PaxDbⁱ	P47929
PeptideAtlas More...PeptideAtlasⁱ	P47929
PRIDEⁱ	P47929
ProteomicsDBⁱ	55824

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

Ensemblⁱ	ENST00000314980; ENSP00000313571; ENSG00000178934 ENST00000378626; ENSP00000367891; ENSG00000205076 ENST00000634448; ENSP00000489395; ENSG00000282902 ENST00000634800; ENSP00000489582; ENSG00000283082
GeneIDⁱ	3963 653499
KEGGⁱ	hsa:3963 hsa:653499
UCSC genome browser More...UCSCⁱ	uc002oje.4 human

Organism-specific databases

CTDⁱ	3963 653499
DisGeNET More...DisGeNETⁱ	3963 653499
EuPathDBⁱ	HostDB:ENSG00000178934.4 HostDB:ENSG00000205076.4
GeneCardsⁱ	LGALS7 LGALS7B
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:6568 LGALS7 HGNC:34447 LGALS7B
Human Protein Atlas More...HPAⁱ	CAB025100 CAB032606 HPA001549
MIMⁱ	600615 gene 617139 gene
neXtProtⁱ	NX_P47929
Open Targets More...OpenTargetsⁱ	ENSG00000178934 ENSG00000205076
PharmGKBⁱ	PA162393892
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	KOG3587 Eukaryota ENOG4111EA0 LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00760000119105
HOGENOMⁱ	HOG000293279
HOVERGENⁱ	HBG006255
InParanoidⁱ	P47929
KEGG Orthology (KO) More...KOⁱ	K10092
OMAⁱ	HSAHVSH
Database of Orthologous Groups More...OrthoDBⁱ	EOG09370HGL
PhylomeDBⁱ	P47929
TreeFamⁱ	TF315551

Miscellaneous databases

EvolutionaryTraceⁱ	P47929
GeneWikiⁱ	LGALS7
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000178934
CleanExⁱ	HS_LGALS7
ExpressionAtlasⁱ	P47929 baseline and differential
Genevisibleⁱ	P47929 HS

Family and domain databases

Conserved Domains Database More...CDDⁱ	cd00070 GLECT, 1 hit
InterProⁱ	View protein in InterPro IPR013320 ConA-like_dom_sf IPR030640 Galectin_7 IPR001079 Galectin_CRD
PANTHERⁱ	PTHR11346:SF107 PTHR11346:SF107, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00337 Gal-bind_lectin, 1 hit
SMARTⁱ	View protein in SMART SM00908 Gal-bind_lectin, 1 hit SM00276 GLECT, 1 hit
SUPFAMⁱ	SSF49899 SSF49899, 1 hit
PROSITEⁱ	View protein in PROSITE PS51304 GALECTIN, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	LEG7_HUMAN
Accessionⁱ	P47929Primary (citable) accession number: P47929 Secondary accession number(s): Q6IB87
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	February 1, 1996
	Last sequence update:	January 23, 2007
	Last modified:	June 20, 2018
	This is version 178 of the entry and version 2 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

Human chromosome 19
Human chromosome 19: entries, gene names and cross-references to MIM
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
PDB cross-references
Index of Protein Data Bank (PDB) cross-references

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Supporting data

UniProtKB - P47929 (LEG7_HUMAN)

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Galectin-7

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Nucleus

Extracellular region or secreted

Other locations

Extracellular region or secreted

Nucleus

Other locations

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Chemistry databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

Chemistry databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

3D structure databases

Miscellaneous databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Region

Phylogenomic databases

Family and domain databases

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross_references_section">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

Sequence databases

3D structure databases

Protein-protein interaction databases

Chemistry databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Documents

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Cross-referencesⁱ

Web resourcesⁱ

Entry informationⁱ

Miscellaneousⁱ