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Protein

Galectin-7

Gene

LGALS7

more
Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Could be involved in cell-cell and/or cell-matrix interactions necessary for normal growth control. Pro-apoptotic protein that functions intracellularly upstream of JNK activation and cytochrome c release.1 Publication

GO - Molecular functioni

  • carbohydrate binding Source: ProtInc

GO - Biological processi

  • apoptotic process Source: UniProtKB-KW
  • heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules Source: ProtInc

Keywordsi

Biological processApoptosis
LigandLectin

Names & Taxonomyi

Protein namesi
Recommended name:
Galectin-7
Short name:
Gal-7
Alternative name(s):
HKL-14
PI7
p53-induced gene 1 protein
Gene namesi
Name:LGALS7
Synonyms:PIG1
AND
Name:LGALS7B
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

EuPathDBiHostDB:ENSG00000178934.4
HostDB:ENSG00000205076.4
HGNCiHGNC:6568 LGALS7
HGNC:34447 LGALS7B
MIMi600615 gene
617139 gene
neXtProtiNX_P47929

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus, Secreted

Pathology & Biotechi

Organism-specific databases

DisGeNETi3963
653499
OpenTargetsiENSG00000178934
ENSG00000205076
PharmGKBiPA162393892

Chemistry databases

ChEMBLiCHEMBL5008
DrugBankiDB02678 2-Deoxy-2-Aminogalactose
DB02379 Beta-D-Glucose

Polymorphism and mutation databases

BioMutaiLGALS7
DMDMi1346431

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000769401 – 136Galectin-7Add BLAST136

Proteomic databases

EPDiP47929
MaxQBiP47929
PaxDbiP47929
PeptideAtlasiP47929
PRIDEiP47929
ProteomicsDBi55824

PTM databases

iPTMnetiP47929
PhosphoSitePlusiP47929
SwissPalmiP47929

Expressioni

Tissue specificityi

Mainly expressed in stratified squamous epithelium.

Inductioni

By p53/TP53.

Gene expression databases

BgeeiENSG00000178934
CleanExiHS_LGALS7
ExpressionAtlasiP47929 baseline and differential
GenevisibleiP47929 HS

Organism-specific databases

HPAiCAB025100
CAB032606
HPA001549

Interactioni

Subunit structurei

Monomer.

Protein-protein interaction databases

BioGridi110154, 49 interactors
575831, 11 interactors
IntActiP47929, 15 interactors
MINTiP47929
STRINGi9606.ENSP00000367891

Chemistry databases

BindingDBiP47929

Structurei

Secondary structure

1136
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi6 – 9Combined sources4
Beta strandi16 – 26Combined sources11
Beta strandi32 – 42Combined sources11
Beta strandi47 – 54Combined sources8
Turni55 – 58Combined sources4
Beta strandi59 – 66Combined sources8
Beta strandi85 – 93Combined sources9
Beta strandi95 – 102Combined sources8
Beta strandi105 – 111Combined sources7
Helixi116 – 118Combined sources3
Beta strandi121 – 127Combined sources7
Beta strandi129 – 135Combined sources7

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1BKZX-ray1.90A/B2-136[»]
2GALX-ray2.00A/B2-136[»]
3GALX-ray1.90A/B2-136[»]
3ZXEX-ray1.67A/B4-136[»]
3ZXFX-ray1.38A/B1-136[»]
4GALX-ray1.95A/B2-136[»]
4UW3X-ray1.48A/B1-136[»]
4UW4X-ray1.77A/B1-136[»]
4UW5X-ray2.04A/B/C/D/E/F1-136[»]
4UW6X-ray1.79A/B1-136[»]
4XBQX-ray2.23A/B1-136[»]
4Y26X-ray2.61A/B4-136[»]
5GALX-ray2.00A/B2-136[»]
5H9QX-ray1.93A/B1-136[»]
5H9SX-ray1.82A/B1-136[»]
ProteinModelPortaliP47929
SMRiP47929
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiP47929

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini6 – 136GalectinPROSITE-ProRule annotationAdd BLAST131

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni70 – 76Beta-galactoside bindingSequence analysis7

Phylogenomic databases

eggNOGiKOG3587 Eukaryota
ENOG4111EA0 LUCA
GeneTreeiENSGT00760000119105
HOGENOMiHOG000293279
HOVERGENiHBG006255
InParanoidiP47929
KOiK10092
OMAiHSAHVSH
OrthoDBiEOG09370HGL
PhylomeDBiP47929
TreeFamiTF315551

Family and domain databases

CDDicd00070 GLECT, 1 hit
InterProiView protein in InterPro
IPR013320 ConA-like_dom_sf
IPR030640 Galectin_7
IPR001079 Galectin_CRD
PANTHERiPTHR11346:SF107 PTHR11346:SF107, 1 hit
PfamiView protein in Pfam
PF00337 Gal-bind_lectin, 1 hit
SMARTiView protein in SMART
SM00908 Gal-bind_lectin, 1 hit
SM00276 GLECT, 1 hit
SUPFAMiSSF49899 SSF49899, 1 hit
PROSITEiView protein in PROSITE
PS51304 GALECTIN, 1 hit

Sequencei

Sequence statusi: Complete.

P47929-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSNVPHKSSL PEGIRPGTVL RIRGLVPPNA SRFHVNLLCG EEQGSDAALH
60 70 80 90 100
FNPRLDTSEV VFNSKEQGSW GREERGPGVP FQRGQPFEVL IIASDDGFKA
110 120 130
VVGDAQYHHF RHRLPLARVR LVEVGGDVQL DSVRIF
Length:136
Mass (Da):15,075
Last modified:January 23, 2007 - v2
Checksum:iF613D3540331C13F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L07769 mRNA Translation: AAA67899.1
U06643 mRNA Translation: AAA86820.1
CR456917 mRNA Translation: CAG33198.1
CH471126 Genomic DNA Translation: EAW56817.1
CH471126 Genomic DNA Translation: EAW56818.1
BC042911 mRNA Translation: AAH42911.2
BC061588 mRNA Translation: AAH61588.1
BC073743 mRNA Translation: AAH73743.1
CCDSiCCDS42565.1
PIRiI55469
RefSeqiNP_001035972.1, NM_001042507.3
NP_002298.1, NM_002307.3
UniGeneiHs.558355
Hs.702546

Genome annotation databases

EnsembliENST00000314980; ENSP00000313571; ENSG00000178934
ENST00000378626; ENSP00000367891; ENSG00000205076
ENST00000634448; ENSP00000489395; ENSG00000282902
ENST00000634800; ENSP00000489582; ENSG00000283082
GeneIDi3963
653499
KEGGihsa:3963
hsa:653499
UCSCiuc002oje.4 human

Similar proteinsi

Entry informationi

Entry nameiLEG7_HUMAN
AccessioniPrimary (citable) accession number: P47929
Secondary accession number(s): Q6IB87
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1996
Last sequence update: January 23, 2007
Last modified: June 20, 2018
This is version 178 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references

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