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UniProtKB - P47928 (ID4_HUMAN)
Protein
DNA-binding protein inhibitor ID-4
Gene
ID4
Organism
Homo sapiens (Human)
Status
Functioni
Transcriptional regulator (lacking a basic DNA binding domain) which negatively regulates the basic helix-loop-helix (bHLH) transcription factors by forming heterodimers and inhibiting their DNA binding and transcriptional activity. Implicated in regulating a variety of cellular processes, including cellular growth, senescence, differentiation, apoptosis, angiogenesis, and neoplastic transformation (By similarity).
By similarityGO - Molecular functioni
- protein dimerization activity Source: InterPro
- RNA polymerase II-specific DNA-binding transcription factor binding Source: Ensembl
- transcription regulator inhibitor activity Source: ARUK-UCL
GO - Biological processi
- cell differentiation Source: GO_Central
- cellular protein localization Source: Ensembl
- central nervous system myelination Source: Ensembl
- cerebral cortex neuron differentiation Source: Ensembl
- circadian regulation of gene expression Source: GO_Central
- fat cell differentiation Source: Ensembl
- G1/S transition of mitotic cell cycle Source: Ensembl
- hippocampus development Source: Ensembl
- negative regulation of astrocyte differentiation Source: Ensembl
- negative regulation of fat cell differentiation Source: Ensembl
- negative regulation of neuron differentiation Source: Ensembl
- negative regulation of oligodendrocyte differentiation Source: Ensembl
- negative regulation of transcription, DNA-templated Source: GDB
- negative regulation of transcription by RNA polymerase II Source: ARUK-UCL
- neuroblast proliferation Source: Ensembl
- osteoblast differentiation Source: Ensembl
- positive regulation of cell population proliferation Source: Ensembl
- positive regulation of gene expression Source: Ensembl
- positive regulation of transcription by RNA polymerase II Source: Ensembl
- prostate gland epithelium morphogenesis Source: Ensembl
- prostate gland stromal morphogenesis Source: Ensembl
- seminal vesicle morphogenesis Source: Ensembl
Keywordsi
Molecular function | Repressor |
Biological process | Transcription, Transcription regulation |
Enzyme and pathway databases
PathwayCommonsi | P47928 |
Reactomei | R-HSA-9031628, NGF-stimulated transcription |
SignaLinki | P47928 |
SIGNORi | P47928 |
Names & Taxonomyi
Protein namesi | Recommended name: DNA-binding protein inhibitor ID-4Alternative name(s): Class B basic helix-loop-helix protein 27 Short name: bHLHb27 Inhibitor of DNA binding 4 Inhibitor of differentiation 4 |
Gene namesi | Name:ID4 Synonyms:BHLHB27 |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:5363, ID4 |
MIMi | 600581, gene |
neXtProti | NX_P47928 |
VEuPathDBi | HostDB:ENSG00000172201 |
Subcellular locationi
Nucleus
Nucleus
- nucleoplasm Source: HPA
- nucleus Source: GO_Central
Other locations
- cytoplasm Source: Ensembl
Keywords - Cellular componenti
NucleusPathology & Biotechi
Organism-specific databases
DisGeNETi | 3400 |
OpenTargetsi | ENSG00000172201 |
PharmGKBi | PA29611 |
Miscellaneous databases
Pharosi | P47928, Tbio |
Genetic variation databases
BioMutai | ID4 |
DMDMi | 1352422 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000127250 | 1 – 161 | DNA-binding protein inhibitor ID-4Add BLAST | 161 |
Proteomic databases
EPDi | P47928 |
MassIVEi | P47928 |
MaxQBi | P47928 |
PaxDbi | P47928 |
PeptideAtlasi | P47928 |
PRIDEi | P47928 |
ProteomicsDBi | 55823 |
PTM databases
GlyGeni | P47928, 1 site, 1 O-linked glycan (1 site) |
iPTMneti | P47928 |
PhosphoSitePlusi | P47928 |
Expressioni
Gene expression databases
Bgeei | ENSG00000172201, Expressed in oviduct epithelium and 235 other tissues |
Genevisiblei | P47928, HS |
Organism-specific databases
HPAi | ENSG00000172201, Tissue enhanced (thyroid) |
Interactioni
Subunit structurei
Heterodimer with other HLH proteins.
Binary interactionsi
GO - Molecular functioni
- protein dimerization activity Source: InterPro
- RNA polymerase II-specific DNA-binding transcription factor binding Source: Ensembl
Protein-protein interaction databases
BioGRIDi | 109626, 16 interactors |
IntActi | P47928, 14 interactors |
MINTi | P47928 |
STRINGi | 9606.ENSP00000367972 |
Miscellaneous databases
RNActi | P47928, protein |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 52 – 104 | bHLHPROSITE-ProRule annotationAdd BLAST | 53 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 117 – 161 | DisorderedSequence analysisAdd BLAST | 45 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 117 – 134 | Pro residuesSequence analysisAdd BLAST | 18 |
Phylogenomic databases
eggNOGi | ENOG502S1WX, Eukaryota |
GeneTreei | ENSGT00940000162435 |
HOGENOMi | CLU_116790_2_0_1 |
InParanoidi | P47928 |
OMAi | ARCKMEE |
OrthoDBi | 1624054at2759 |
PhylomeDBi | P47928 |
TreeFami | TF326217 |
Family and domain databases
Gene3Di | 4.10.280.10, 1 hit |
InterProi | View protein in InterPro IPR011598, bHLH_dom IPR026052, DNA-bd_prot-inh IPR036638, HLH_DNA-bd_sf |
PANTHERi | PTHR11723, PTHR11723, 1 hit |
Pfami | View protein in Pfam PF00010, HLH, 1 hit |
SMARTi | View protein in SMART SM00353, HLH, 1 hit |
SUPFAMi | SSF47459, SSF47459, 1 hit |
PROSITEi | View protein in PROSITE PS50888, BHLH, 1 hit |
i Sequence
Sequence statusi: Complete.
P47928-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MKAVSPVRPS GRKAPSGCGG GELALRCLAE HGHSLGGSAA AAAAAAAARC
60 70 80 90 100
KAAEAAADEP ALCLQCDMND CYSRLRRLVP TIPPNKKVSK VEILQHVIDY
110 120 130 140 150
ILDLQLALET HPALLRQPPP PAPPHHPAGT CPAAPPRTPL TALNTDPAGA
160
VNKQGDSILC R
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 10 – 14 | SGRKA → RPLR in AAA82882 (PubMed:7665172).Curated | 5 | |
Sequence conflicti | 39 – 40 | AA → Q in AAA82882 (PubMed:7665172).Curated | 2 | |
Sequence conflicti | 77 – 79 | RLV → WL in AAA82882 (PubMed:7665172).Curated | 3 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U28368 mRNA Translation: AAA73923.1 Y07958 mRNA Translation: CAA69255.1 U16153 mRNA Translation: AAA82882.1 AL022726 Genomic DNA No translation available. BC014941 mRNA Translation: AAH14941.1 |
CCDSi | CCDS4544.1 |
PIRi | G01855 JE0306 |
RefSeqi | NP_001537.1, NM_001546.3 |
Genome annotation databases
Ensembli | ENST00000378700.8; ENSP00000367972.3; ENSG00000172201.12 |
GeneIDi | 3400 |
KEGGi | hsa:3400 |
MANE-Selecti | ENST00000378700.8; ENSP00000367972.3; NM_001546.4; NP_001537.1 |
UCSCi | uc003ncw.5, human |
Similar proteinsi
Cross-referencesi
Web resourcesi
Atlas of Genetics and Cytogenetics in Oncology and Haematology |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U28368 mRNA Translation: AAA73923.1 Y07958 mRNA Translation: CAA69255.1 U16153 mRNA Translation: AAA82882.1 AL022726 Genomic DNA No translation available. BC014941 mRNA Translation: AAH14941.1 |
CCDSi | CCDS4544.1 |
PIRi | G01855 JE0306 |
RefSeqi | NP_001537.1, NM_001546.3 |
3D structure databases
AlphaFoldDBi | P47928 |
SMRi | P47928 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 109626, 16 interactors |
IntActi | P47928, 14 interactors |
MINTi | P47928 |
STRINGi | 9606.ENSP00000367972 |
PTM databases
GlyGeni | P47928, 1 site, 1 O-linked glycan (1 site) |
iPTMneti | P47928 |
PhosphoSitePlusi | P47928 |
Genetic variation databases
BioMutai | ID4 |
DMDMi | 1352422 |
Proteomic databases
EPDi | P47928 |
MassIVEi | P47928 |
MaxQBi | P47928 |
PaxDbi | P47928 |
PeptideAtlasi | P47928 |
PRIDEi | P47928 |
ProteomicsDBi | 55823 |
Protocols and materials databases
Antibodypediai | 10414, 377 antibodies from 31 providers |
DNASUi | 3400 |
Genome annotation databases
Ensembli | ENST00000378700.8; ENSP00000367972.3; ENSG00000172201.12 |
GeneIDi | 3400 |
KEGGi | hsa:3400 |
MANE-Selecti | ENST00000378700.8; ENSP00000367972.3; NM_001546.4; NP_001537.1 |
UCSCi | uc003ncw.5, human |
Organism-specific databases
CTDi | 3400 |
DisGeNETi | 3400 |
GeneCardsi | ID4 |
HGNCi | HGNC:5363, ID4 |
HPAi | ENSG00000172201, Tissue enhanced (thyroid) |
MIMi | 600581, gene |
neXtProti | NX_P47928 |
OpenTargetsi | ENSG00000172201 |
PharmGKBi | PA29611 |
VEuPathDBi | HostDB:ENSG00000172201 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | ENOG502S1WX, Eukaryota |
GeneTreei | ENSGT00940000162435 |
HOGENOMi | CLU_116790_2_0_1 |
InParanoidi | P47928 |
OMAi | ARCKMEE |
OrthoDBi | 1624054at2759 |
PhylomeDBi | P47928 |
TreeFami | TF326217 |
Enzyme and pathway databases
PathwayCommonsi | P47928 |
Reactomei | R-HSA-9031628, NGF-stimulated transcription |
SignaLinki | P47928 |
SIGNORi | P47928 |
Miscellaneous databases
BioGRID-ORCSi | 3400, 14 hits in 1097 CRISPR screens |
ChiTaRSi | ID4, human |
GeneWikii | ID4 |
GenomeRNAii | 3400 |
Pharosi | P47928, Tbio |
PROi | PR:P47928 |
RNActi | P47928, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000172201, Expressed in oviduct epithelium and 235 other tissues |
Genevisiblei | P47928, HS |
Family and domain databases
Gene3Di | 4.10.280.10, 1 hit |
InterProi | View protein in InterPro IPR011598, bHLH_dom IPR026052, DNA-bd_prot-inh IPR036638, HLH_DNA-bd_sf |
PANTHERi | PTHR11723, PTHR11723, 1 hit |
Pfami | View protein in Pfam PF00010, HLH, 1 hit |
SMARTi | View protein in SMART SM00353, HLH, 1 hit |
SUPFAMi | SSF47459, SSF47459, 1 hit |
PROSITEi | View protein in PROSITE PS50888, BHLH, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | ID4_HUMAN | |
Accessioni | P47928Primary (citable) accession number: P47928 Secondary accession number(s): Q13005 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | February 1, 1996 |
Last sequence update: | February 1, 1996 | |
Last modified: | May 25, 2022 | |
This is version 183 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Human chromosome 6
Human chromosome 6: entries, gene names and cross-references to MIM - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot