ID4

Functionⁱ

Transcriptional regulator (lacking a basic DNA binding domain) which negatively regulates the basic helix-loop-helix (bHLH) transcription factors by forming heterodimers and inhibiting their DNA binding and transcriptional activity. Implicated in regulating a variety of cellular processes, including cellular growth, senescence, differentiation, apoptosis, angiogenesis, and neoplastic transformation (By similarity).By similarity

GO - Molecular functionⁱ

DNA-binding transcription factor activity
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
DNA-binding transcription factor activity, RNA polymerase II-specific
Source: NTNU_SB
Inferred from sequence modelⁱ
- 19274049
protein dimerization activity Source: InterPro
RNA polymerase II transcription factor binding
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
transcription corepressor activity
Source: ProtInc
Traceable author statementⁱ
- 7665172
transcription factor binding
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

cellular protein localization Source: Ensembl
central nervous system myelination Source: Ensembl
cerebral cortex neuron differentiation Source: Ensembl
circadian rhythm
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
fat cell differentiation Source: Ensembl
G1/S transition of mitotic cell cycle Source: Ensembl
hippocampus development Source: Ensembl
negative regulation of astrocyte differentiation Source: Ensembl
negative regulation of DNA binding
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
negative regulation of fat cell differentiation Source: Ensembl
negative regulation of neuron differentiation
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
negative regulation of oligodendrocyte differentiation Source: Ensembl
negative regulation of transcription, DNA-templated
Source: GDB
Inferred from direct assayⁱ
- 11136250
negative regulation of transcription by RNA polymerase II Source: Ensembl
neuroblast proliferation Source: Ensembl
neuron differentiation
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
positive regulation of cell proliferation Source: Ensembl
positive regulation of osteoblast differentiation Source: Ensembl
positive regulation of transcription by RNA polymerase II Source: Ensembl
prostate gland epithelium morphogenesis Source: Ensembl
prostate gland stromal morphogenesis Source: Ensembl
regulation of cell cycle
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
regulation of transcription by RNA polymerase II
Source: ProtInc
Traceable author statementⁱ
- 7665172
seminal vesicle morphogenesis Source: Ensembl

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Repressor
Biological process	Transcription, Transcription regulation

Enzyme and pathway databases

SIGNORⁱ	P47928

SIGNORⁱ

P47928

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: DNA-binding protein inhibitor ID-4 Alternative name(s): Class B basic helix-loop-helix protein 27 Short name: bHLHb27 Inhibitor of DNA binding 4 Inhibitor of differentiation 4
Gene namesⁱ	Name:ID4 Synonyms:BHLHB27
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 6

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000172201.10
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:5363 ID4
MIMⁱ	600581 gene
neXtProtⁱ	NX_P47928

Keywords - Cellular componentⁱ

Nucleus

Pathology & Biotechⁱ

Organism-specific databases

DisGeNET More...DisGeNETⁱ	3400
Open Targets More...OpenTargetsⁱ	ENSG00000172201
PharmGKBⁱ	PA29611

Polymorphism and mutation databases

BioMutaⁱ	ID4
DMDMⁱ	1352422

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000127250	1 – 161	DNA-binding protein inhibitor ID-4Add BLAST		161

Proteomic databases

EPDⁱ	P47928
MaxQB - The MaxQuant DataBase More...MaxQBⁱ	P47928
PaxDbⁱ	P47928
PeptideAtlas More...PeptideAtlasⁱ	P47928
PRIDEⁱ	P47928
ProteomicsDBⁱ	55823

PTM databases

iPTMnetⁱ	P47928
PhosphoSitePlusⁱ	P47928

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSG00000172201 Expressed in 226 organ(s), highest expression level in oviduct epithelium
CleanExⁱ	HS_ID4
Genevisibleⁱ	P47928 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	HPA060800

HPAⁱ

HPA060800

Interactionⁱ

Subunit structureⁱ

Heterodimer with other HLH proteins.

Binary interactionsⁱ

With	Entry	#Exp.	IntAct	Notes
NCK1	P16333	3	EBI-1754719,EBI-389883

With

Entry

#Exp.

IntAct

Notes

NCK1

P16333

3

EBI-1754719,EBI-389883

GO - Molecular functionⁱ

protein dimerization activity Source: InterPro
RNA polymerase II transcription factor binding
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
transcription factor binding
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

BioGridⁱ	109626, 7 interactors
IntActⁱ	P47928, 7 interactors
Molecular INTeraction database More...MINTⁱ	P47928
STRINGⁱ	9606.ENSP00000367972

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	P47928
SMRⁱ	P47928
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Domainⁱ	52 – 104	bHLHPROSITE-ProRule annotationAdd BLAST		53

Compositional bias

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Compositional biasⁱ	39 – 48	Poly-Ala		10
Compositional biasⁱ	118 – 124	Poly-Pro		7

Phylogenomic databases

eggNOGⁱ	ENOG410IVMK Eukaryota ENOG4111QS6 LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00390000000908
HOGENOMⁱ	HOG000234788
HOVERGENⁱ	HBG009009
InParanoidⁱ	P47928
KEGG Orthology (KO) More...KOⁱ	K17695
OMAⁱ	HHQRTSI
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0VHR
PhylomeDBⁱ	P47928
TreeFamⁱ	TF326217

Family and domain databases

Conserved Domains Database More...CDDⁱ	cd00083 HLH, 1 hit
Gene3Dⁱ	4.10.280.10, 1 hit
InterProⁱ	View protein in InterPro IPR011598 bHLH_dom IPR026052 DNA-bd_prot-inh IPR036638 HLH_DNA-bd_sf
PANTHERⁱ	PTHR11723 PTHR11723, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00010 HLH, 1 hit
SMARTⁱ	View protein in SMART SM00353 HLH, 1 hit
SUPFAMⁱ	SSF47459 SSF47459, 1 hit
PROSITEⁱ	View protein in PROSITE PS50888 BHLH, 1 hit

Sequenceⁱ

Sequence statusⁱ: Complete.

P47928-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MKAVSPVRPS GRKAPSGCGG GELALRCLAE HGHSLGGSAA AAAAAAAARC 
        60         70         80         90        100
KAAEAAADEP ALCLQCDMND CYSRLRRLVP TIPPNKKVSK VEILQHVIDY 
       110        120        130        140        150
ILDLQLALET HPALLRQPPP PAPPHHPAGT CPAAPPRTPL TALNTDPAGA 
       160 
VNKQGDSILC R

Length:161

Mass (Da):16,622

Last modified:February 1, 1996 - v1

Checksum:ⁱ5B14847AE7337339

GO

Experimental Info

Feature key	Position(s)	DescriptionActions	Length
Sequence conflictⁱ	10 – 14	SGRKA → RPLR in AAA82882 (PubMed:7665172).Curated	5
Sequence conflictⁱ	39 – 40	AA → Q in AAA82882 (PubMed:7665172).Curated	2
Sequence conflictⁱ	77 – 79	RLV → WL in AAA82882 (PubMed:7665172).Curated	3

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	U28368 mRNA Translation: AAA73923.1 Y07958 mRNA Translation: CAA69255.1 U16153 mRNA Translation: AAA82882.1 AL022726 Genomic DNA No translation available. BC014941 mRNA Translation: AAH14941.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS4544.1
PIRⁱ	G01855 JE0306
NCBI Reference Sequences More...RefSeqⁱ	NP_001537.1, NM_001546.3
UniGeneⁱ	Hs.519601 Hs.663469

Genome annotation databases

Ensemblⁱ	ENST00000378700; ENSP00000367972; ENSG00000172201
GeneIDⁱ	3400
KEGGⁱ	hsa:3400
UCSC genome browser More...UCSCⁱ	uc003ncw.5 human

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
P47928	ID4 isoform 1		PANTR		161	UniRef100_P47928
DNA-binding protein inhibitor ID-4		CALJA		161
DNA-binding protein inhibitor ID-4		MACMU		161
DNA-binding protein inhibitor ID-4		PIG		161
DNA-binding protein inhibitor ID-4		NEOSC		161
+16

Protein	Similar proteins		Species	Score	Length	Source
P47928	DNA-binding protein inhibitor ID-4		MOUSE		161	UniRef90_P41139
DNA-binding protein inhibitor ID-4		PIG		161
Uncharacterized protein		MONDO		162
Inhibitor of DNA-binding 4, HLH protein		RAT		161
DNA-binding protein inhibitor ID-4		MESAU		161
+49

Protein	Similar proteins		Species	Score	Length	Source
P47928	DNA-binding protein inhibitor ID-4		MOUSE		161	UniRef50_P41139
DNA-binding protein inhibitor ID-4		PIG		161
DNA-binding protein inhibitor ID-4		XENLA		131
Uncharacterized protein		MONDO		162
Uncharacterized protein		LOXAF		161
+141

Cross-referencesⁱ

Web resourcesⁱ

Atlas of Genetics and Cytogenetics in Oncology and Haematology

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	U28368 mRNA Translation: AAA73923.1 Y07958 mRNA Translation: CAA69255.1 U16153 mRNA Translation: AAA82882.1 AL022726 Genomic DNA No translation available. BC014941 mRNA Translation: AAH14941.1
CCDSⁱ	CCDS4544.1
PIRⁱ	G01855 JE0306
RefSeqⁱ	NP_001537.1, NM_001546.3
UniGeneⁱ	Hs.519601 Hs.663469

3D structure databases

ProteinModelPortalⁱ	P47928
SMRⁱ	P47928
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	109626, 7 interactors
IntActⁱ	P47928, 7 interactors
MINTⁱ	P47928
STRINGⁱ	9606.ENSP00000367972

PTM databases

iPTMnetⁱ	P47928
PhosphoSitePlusⁱ	P47928

Polymorphism and mutation databases

BioMutaⁱ	ID4
DMDMⁱ	1352422

Proteomic databases

EPDⁱ	P47928
MaxQBⁱ	P47928
PaxDbⁱ	P47928
PeptideAtlasⁱ	P47928
PRIDEⁱ	P47928
ProteomicsDBⁱ	55823

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

Ensemblⁱ	ENST00000378700; ENSP00000367972; ENSG00000172201
GeneIDⁱ	3400
KEGGⁱ	hsa:3400
UCSCⁱ	uc003ncw.5 human

Organism-specific databases

CTDⁱ	3400
DisGeNETⁱ	3400
EuPathDBⁱ	HostDB:ENSG00000172201.10
GeneCardsⁱ	ID4
HGNCⁱ	HGNC:5363 ID4
HPAⁱ	HPA060800
MIMⁱ	600581 gene
neXtProtⁱ	NX_P47928
OpenTargetsⁱ	ENSG00000172201
PharmGKBⁱ	PA29611
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	ENOG410IVMK Eukaryota ENOG4111QS6 LUCA
GeneTreeⁱ	ENSGT00390000000908
HOGENOMⁱ	HOG000234788
HOVERGENⁱ	HBG009009
InParanoidⁱ	P47928
KOⁱ	K17695
OMAⁱ	HHQRTSI
OrthoDBⁱ	EOG091G0VHR
PhylomeDBⁱ	P47928
TreeFamⁱ	TF326217

Enzyme and pathway databases

SIGNORⁱ	P47928

SIGNORⁱ

P47928

Miscellaneous databases

GeneWikiⁱ	ID4
GenomeRNAiⁱ	3400
Protein Ontology More...PROⁱ	PR:P47928
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000172201 Expressed in 226 organ(s), highest expression level in oviduct epithelium
CleanExⁱ	HS_ID4
Genevisibleⁱ	P47928 HS

Family and domain databases

CDDⁱ	cd00083 HLH, 1 hit
Gene3Dⁱ	4.10.280.10, 1 hit
InterProⁱ	View protein in InterPro IPR011598 bHLH_dom IPR026052 DNA-bd_prot-inh IPR036638 HLH_DNA-bd_sf
PANTHERⁱ	PTHR11723 PTHR11723, 1 hit
Pfamⁱ	View protein in Pfam PF00010 HLH, 1 hit
SMARTⁱ	View protein in SMART SM00353 HLH, 1 hit
SUPFAMⁱ	SSF47459 SSF47459, 1 hit
PROSITEⁱ	View protein in PROSITE PS50888 BHLH, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	ID4_HUMAN
Accessionⁱ	P47928Primary (citable) accession number: P47928 Secondary accession number(s): Q13005
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	February 1, 1996
	Last sequence update:	February 1, 1996
	Last modified:	November 7, 2018
	This is version 162 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

Documents

MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
Human chromosome 6
Human chromosome 6: entries, gene names and cross-references to MIM

UniProtKB

UniParc

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UniRef

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Supporting data

UniProtKB - P47928 (ID4_HUMAN)

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DNA-binding protein inhibitor ID-4

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Nucleus

Nucleus

Other locations

Keywords - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Compositional bias

Phylogenomic databases

Family and domain databases

Experimental Info

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross_references_section">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Expressionⁱ

Interactionⁱ

GO - Molecular functionⁱ

Structureⁱ

Family & Domainsⁱ

Cross-referencesⁱ

Web resourcesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ