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Protein

DNA-binding protein inhibitor ID-4

Gene

ID4

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Transcriptional regulator (lacking a basic DNA binding domain) which negatively regulates the basic helix-loop-helix (bHLH) transcription factors by forming heterodimers and inhibiting their DNA binding and transcriptional activity. Implicated in regulating a variety of cellular processes, including cellular growth, senescence, differentiation, apoptosis, angiogenesis, and neoplastic transformation (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionRepressor
Biological processTranscription, Transcription regulation

Enzyme and pathway databases

SIGNORiP47928

Names & Taxonomyi

Protein namesi
Recommended name:
DNA-binding protein inhibitor ID-4
Alternative name(s):
Class B basic helix-loop-helix protein 27
Short name:
bHLHb27
Inhibitor of DNA binding 4
Inhibitor of differentiation 4
Gene namesi
Name:ID4
Synonyms:BHLHB27
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 6

Organism-specific databases

EuPathDBiHostDB:ENSG00000172201.10
HGNCiHGNC:5363 ID4
MIMi600581 gene
neXtProtiNX_P47928

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi3400
OpenTargetsiENSG00000172201
PharmGKBiPA29611

Polymorphism and mutation databases

BioMutaiID4
DMDMi1352422

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001272501 – 161DNA-binding protein inhibitor ID-4Add BLAST161

Proteomic databases

EPDiP47928
MaxQBiP47928
PaxDbiP47928
PeptideAtlasiP47928
PRIDEiP47928
ProteomicsDBi55823

PTM databases

iPTMnetiP47928
PhosphoSitePlusiP47928

Expressioni

Gene expression databases

BgeeiENSG00000172201
CleanExiHS_ID4
GenevisibleiP47928 HS

Organism-specific databases

HPAiHPA060800

Interactioni

Subunit structurei

Heterodimer with other HLH proteins.

Binary interactionsi

WithEntry#Exp.IntActNotes
NCK1P163333EBI-1754719,EBI-389883

GO - Molecular functioni

Protein-protein interaction databases

BioGridi109626, 7 interactors
IntActiP47928, 7 interactors
MINTiP47928
STRINGi9606.ENSP00000367972

Structurei

3D structure databases

ProteinModelPortaliP47928
SMRiP47928
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini52 – 104bHLHPROSITE-ProRule annotationAdd BLAST53

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi39 – 48Poly-Ala10
Compositional biasi118 – 124Poly-Pro7

Phylogenomic databases

eggNOGiENOG410IVMK Eukaryota
ENOG4111QS6 LUCA
GeneTreeiENSGT00390000000908
HOGENOMiHOG000234788
HOVERGENiHBG009009
InParanoidiP47928
KOiK17695
OMAiHHQRTSI
OrthoDBiEOG091G0VHR
PhylomeDBiP47928
TreeFamiTF326217

Family and domain databases

CDDicd00083 HLH, 1 hit
Gene3Di4.10.280.10, 1 hit
InterProiView protein in InterPro
IPR011598 bHLH_dom
IPR026052 DNA-bd_prot-inh
IPR036638 HLH_DNA-bd_sf
PANTHERiPTHR11723 PTHR11723, 1 hit
PfamiView protein in Pfam
PF00010 HLH, 1 hit
SMARTiView protein in SMART
SM00353 HLH, 1 hit
SUPFAMiSSF47459 SSF47459, 1 hit
PROSITEiView protein in PROSITE
PS50888 BHLH, 1 hit

Sequencei

Sequence statusi: Complete.

P47928-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKAVSPVRPS GRKAPSGCGG GELALRCLAE HGHSLGGSAA AAAAAAAARC
60 70 80 90 100
KAAEAAADEP ALCLQCDMND CYSRLRRLVP TIPPNKKVSK VEILQHVIDY
110 120 130 140 150
ILDLQLALET HPALLRQPPP PAPPHHPAGT CPAAPPRTPL TALNTDPAGA
160
VNKQGDSILC R
Length:161
Mass (Da):16,622
Last modified:February 1, 1996 - v1
Checksum:i5B14847AE7337339
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti10 – 14SGRKA → RPLR in AAA82882 (PubMed:7665172).Curated5
Sequence conflicti39 – 40AA → Q in AAA82882 (PubMed:7665172).Curated2
Sequence conflicti77 – 79RLV → WL in AAA82882 (PubMed:7665172).Curated3

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U28368 mRNA Translation: AAA73923.1
Y07958 mRNA Translation: CAA69255.1
U16153 mRNA Translation: AAA82882.1
AL022726 Genomic DNA No translation available.
BC014941 mRNA Translation: AAH14941.1
CCDSiCCDS4544.1
PIRiG01855
JE0306
RefSeqiNP_001537.1, NM_001546.3
UniGeneiHs.519601
Hs.663469

Genome annotation databases

EnsembliENST00000378700; ENSP00000367972; ENSG00000172201
GeneIDi3400
KEGGihsa:3400
UCSCiuc003ncw.5 human

Similar proteinsi

Entry informationi

Entry nameiID4_HUMAN
AccessioniPrimary (citable) accession number: P47928
Secondary accession number(s): Q13005
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1996
Last sequence update: February 1, 1996
Last modified: June 20, 2018
This is version 160 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 6
    Human chromosome 6: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

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