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Protein

60S ribosomal protein L29

Gene

RPL29

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Component of the large ribosomal subunit.1 Publication

GO - Molecular functioni

  • cadherin binding Source: BHF-UCL
  • heparin binding Source: ProtInc
  • RNA binding Source: UniProtKB
  • structural constituent of ribosome Source: GO_Central

GO - Biological processi

Keywordsi

Molecular functionHeparin-binding, Ribonucleoprotein, Ribosomal protein

Enzyme and pathway databases

ReactomeiR-HSA-156827 L13a-mediated translational silencing of Ceruloplasmin expression
R-HSA-156902 Peptide chain elongation
R-HSA-1799339 SRP-dependent cotranslational protein targeting to membrane
R-HSA-192823 Viral mRNA Translation
R-HSA-2408557 Selenocysteine synthesis
R-HSA-6791226 Major pathway of rRNA processing in the nucleolus and cytosol
R-HSA-72689 Formation of a pool of free 40S subunits
R-HSA-72706 GTP hydrolysis and joining of the 60S ribosomal subunit
R-HSA-72764 Eukaryotic Translation Termination
R-HSA-9010553 Regulation of expression of SLITs and ROBOs
R-HSA-975956 Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC)
R-HSA-975957 Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)
SignaLinkiP47914

Names & Taxonomyi

Protein namesi
Recommended name:
60S ribosomal protein L29
Alternative name(s):
Cell surface heparin-binding protein HIP
Large ribosomal subunit protein eL291 Publication
Gene namesi
Name:RPL29
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 3

Organism-specific databases

EuPathDBiHostDB:ENSG00000162244.10
HGNCiHGNC:10331 RPL29
MIMi601832 gene
neXtProtiNX_P47914

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Pathology & Biotechi

Organism-specific databases

DisGeNETi6159
OpenTargetsiENSG00000162244
PharmGKBiPA34711

Polymorphism and mutation databases

BioMutaiRPL29

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemoved1 Publication
ChainiPRO_00002191342 – 15960S ribosomal protein L29Add BLAST158

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei5N6-methyllysineCombined sources1 Publication1
Modified residuei31PhosphoserineCombined sources1
Modified residuei33N6-acetyllysineCombined sources1
Modified residuei142PhosphoserineCombined sources1

Keywords - PTMi

Acetylation, Methylation, Phosphoprotein

Proteomic databases

EPDiP47914
MaxQBiP47914
PaxDbiP47914
PeptideAtlasiP47914
PRIDEiP47914
ProteomicsDBi55822
TopDownProteomicsiP47914

PTM databases

iPTMnetiP47914
PhosphoSitePlusiP47914
SwissPalmiP47914

Expressioni

Gene expression databases

BgeeiENSG00000162244
CleanExiHS_RPL29
ExpressionAtlasiP47914 baseline and differential
GenevisibleiP47914 HS

Organism-specific databases

HPAiHPA069064

Interactioni

Subunit structurei

Component of the large ribosomal subunit.1 Publication

GO - Molecular functioni

Protein-protein interaction databases

BioGridi112078, 71 interactors
CORUMiP47914
IntActiP47914, 28 interactors
MINTiP47914
STRINGi9606.ENSP00000294189

Structurei

3D structure databases

ProteinModelPortaliP47914
SMRiP47914
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiKOG3504 Eukaryota
ENOG4112428 LUCA
GeneTreeiENSGT00390000007084
HOVERGENiHBG000386
InParanoidiP47914
KOiK02905
OMAiCRPKSQA
OrthoDBiEOG091G15LL
PhylomeDBiP47914
TreeFamiTF313858

Family and domain databases

InterProiView protein in InterPro
IPR002673 Ribosomal_L29e
PANTHERiPTHR12884 PTHR12884, 1 hit
PfamiView protein in Pfam
PF01779 Ribosomal_L29e, 1 hit
ProDomiView protein in ProDom or Entries sharing at least one domain
PD010314 Ribosomal_L29e, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P47914-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAKSKNHTTH NQSRKWHRNG IKKPRSQRYE SLKGVDPKFL RNMRFAKKHN
60 70 80 90 100
KKGLKKMQAN NAKAMSARAE AIKALVKPKE VKPKIPKGVS RKLDRLAYIA
110 120 130 140 150
HPKLGKRARA RIAKGLRLCR PKAKAKAKAK DQTKAQAAAP ASVPAQAPKR

TQAPTKASE
Length:159
Mass (Da):17,752
Last modified:January 23, 2007 - v2
Checksum:i2A0C31984EF4FF95
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti5K → R in BAF82227 (PubMed:14702039).Curated1
Sequence conflicti120R → A in CAA89008 (PubMed:8597591).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U10248 mRNA Translation: AAC50499.1
Z49148 mRNA Translation: CAA89008.1
U49083 mRNA Translation: AAC50647.1
AK289538 mRNA Translation: BAF82227.1
AK311884 mRNA Translation: BAG34825.1
BC008926 mRNA Translation: AAH08926.1
BC070190 mRNA Translation: AAH70190.1
BC070481 mRNA Translation: AAH70481.1
BC071663 mRNA Translation: AAH71663.1
CCDSiCCDS2845.1
PIRiS65784
RefSeqiNP_000983.1, NM_000992.2
UniGeneiHs.425125

Genome annotation databases

EnsembliENST00000294189; ENSP00000294189; ENSG00000162244
ENST00000466397; ENSP00000418868; ENSG00000162244
ENST00000475248; ENSP00000417048; ENSG00000162244
ENST00000479017; ENSP00000418153; ENSG00000162244
ENST00000492277; ENSP00000418346; ENSG00000162244
ENST00000495383; ENSP00000420673; ENSG00000162244
GeneIDi6159
KEGGihsa:6159
UCSCiuc003dcs.4 human

Similar proteinsi

Entry informationi

Entry nameiRL29_HUMAN
AccessioniPrimary (citable) accession number: P47914
Secondary accession number(s): A8K0H3, B2R4M8, Q6IPY3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1996
Last sequence update: January 23, 2007
Last modified: July 18, 2018
This is version 171 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. Ribosomal proteins
    Ribosomal proteins families and list of entries
  5. SIMILARITY comments
    Index of protein domains and families

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