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Protein

60S ribosomal protein L6

Gene

Rpl6

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Component of the large ribosomal subunit.By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionRibonucleoprotein, Ribosomal protein

Enzyme and pathway databases

ReactomeiR-MMU-975957 Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC)

Names & Taxonomyi

Protein namesi
Recommended name:
60S ribosomal protein L6
Alternative name(s):
TAX-responsive enhancer element-binding protein 107
Short name:
TAXREB107
Gene namesi
Name:Rpl6
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 5

Organism-specific databases

MGIiMGI:108057 Rpl6

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Endoplasmic reticulum

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001710101 – 29660S ribosomal protein L6Add BLAST296

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Cross-linki5Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Modified residuei102N6-succinyllysineCombined sources1
Modified residuei135PhosphoserineBy similarity1
Modified residuei215N6-succinyllysineCombined sources1
Modified residuei247N6-acetyllysineCombined sources1

Keywords - PTMi

Acetylation, Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

EPDiP47911
PaxDbiP47911
PeptideAtlasiP47911
PRIDEiP47911

PTM databases

iPTMnetiP47911
PhosphoSitePlusiP47911
SwissPalmiP47911

Expressioni

Gene expression databases

BgeeiENSMUSG00000029614
CleanExiMM_RPL6
ExpressionAtlasiP47911 baseline and differential
GenevisibleiP47911 MM

Interactioni

Subunit structurei

Component of the large ribosomal subunit (By similarity). May bind IPO9 with low affinity (PubMed:11823430).By similarity1 Publication

Protein-protein interaction databases

BioGridi202987, 4 interactors
CORUMiP47911
IntActiP47911, 8 interactors
MINTiP47911
STRINGi10090.ENSMUSP00000031617

Structurei

3D structure databases

ProteinModelPortaliP47911
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG1694 Eukaryota
COG2163 LUCA
GeneTreeiENSGT00390000003682
HOGENOMiHOG000207317
HOVERGENiHBG002565
InParanoidiP47911
KOiK02934
OMAiRKGDKPH
OrthoDBiEOG091G0L13
PhylomeDBiP47911
TreeFamiTF300115

Family and domain databases

Gene3Di2.30.30.30, 1 hit
InterProiView protein in InterPro
IPR000915 60S_ribosomal_L6E
IPR014722 Rib_L2_dom2
IPR005568 Ribosomal_L6_N
IPR008991 Translation_prot_SH3-like_sf
PANTHERiPTHR10715 PTHR10715, 1 hit
PfamiView protein in Pfam
PF01159 Ribosomal_L6e, 1 hit
PF03868 Ribosomal_L6e_N, 1 hit
SUPFAMiSSF50104 SSF50104, 1 hit
PROSITEiView protein in PROSITE
PS01170 RIBOSOMAL_L6E, 1 hit

Sequencei

Sequence statusi: Complete.

P47911-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAGEKAPDTK EKKPAAKKAG SDAAASRPRA AKVAKKVHPK GKKPKKAKPH
60 70 80 90 100
CSRNPVLVRG IGRYSRSAMY SRKALYKRKY SAAKTKVEKK KKKEKVLATV
110 120 130 140 150
TKTVGGDKNG GTRVVKLRKM PRYYPTEDVP RKLLSHGKKP FSQHVRRLRS
160 170 180 190 200
SITPGTVLII LTGRHRGKRV VFLKQLDSGL LLVTGPLVIN RVPLRRTHQK
210 220 230 240 250
FVIATSTKVD ISDVKIPKHL TDAYFKKKQL RKPRHQEGEI FDTEKEKYEI
260 270 280 290
TEQRKADQKA VDLQILPKIK AVPQLQGYLR SQFSLTNGMY PHKLVF
Length:296
Mass (Da):33,510
Last modified:January 23, 2007 - v3
Checksum:iD65D5EF517660836
GO

Sequence cautioni

The sequence CAA57513 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti5K → R (PubMed:7537974).Curated1
Sequence conflicti10K → M in CAA57513 (PubMed:7537974).Curated1
Sequence conflicti75L → F in AAH62880 (PubMed:15489334).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF374195 Genomic DNA Translation: AAK56936.1
BC062880 mRNA Translation: AAH62880.1
X81987 mRNA Translation: CAA57513.1 Different initiation.
CCDSiCCDS19632.1
PIRiS55922
RefSeqiNP_035420.2, NM_011290.5
XP_006530290.1, XM_006530227.1
UniGeneiMm.262021

Genome annotation databases

EnsembliENSMUST00000031617; ENSMUSP00000031617; ENSMUSG00000029614
GeneIDi19988
KEGGimmu:19988
UCSCiuc008ziq.3 mouse

Similar proteinsi

Entry informationi

Entry nameiRL6_MOUSE
AccessioniPrimary (citable) accession number: P47911
Secondary accession number(s): Q6P5I2, Q925C3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1996
Last sequence update: January 23, 2007
Last modified: July 18, 2018
This is version 144 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. Ribosomal proteins
    Ribosomal proteins families and list of entries
  3. SIMILARITY comments
    Index of protein domains and families

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