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Protein

P2Y purinoceptor 1

Gene

P2RY1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Receptor for extracellular adenine nucleotides such as ADP (PubMed:9442040, PubMed:9038354, PubMed:25822790). In platelets, binding to ADP leads to mobilization of intracellular calcium ions via activation of phospholipase C, a change in platelet shape, and ultimately platelet aggregation (PubMed:9442040).3 Publications

<p>This subsection of the ‘Function’ section describes regulatory mechanisms for enzymes, transporters or microbial transcription factors, and reports the components which regulate (by activation or inhibition) the reaction.<p><a href='/help/activity_regulation' target='_top'>More...</a></p>Activity regulationi

ATP functions as antagonist and inhibits ADP-induced mobilization of Ca2+ (PubMed:9038354). The P2Y1 receptor-specific antagonists A3P5PS, A3P5P and A2P5P inhibit downstream signaling mediated by mobilization of Ca2+ from intracellular stores, and platelet shape changes in response to extracellular ADP (PubMed:9442040).2 Publications

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Function’ section describes the interaction between a single amino acid and another chemical entity. Priority is given to the annotation of physiological ligands.<p><a href='/help/binding' target='_top'>More...</a></p>Binding sitei46ADPCombined sources1 Publication1
Binding sitei310ADPCombined sources1 Publication1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Function’ section describes a region in the protein which binds nucleotide phosphates. It always involves more than one amino acid and includes all residues involved in nucleotide-binding.<p><a href='/help/np_bind' target='_top'>More...</a></p>Nucleotide bindingi203 – 205ADPCombined sources1 Publication3
Nucleotide bindingi283 – 287ADPCombined sources1 Publication5
Nucleotide bindingi303 – 306ADPCombined sources1 Publication4

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionG-protein coupled receptor, Receptor, Transducer
Biological processBlood coagulation, Hemostasis
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-416476 G alpha (q) signalling events
R-HSA-417957 P2Y receptors
R-HSA-418592 ADP signalling through P2Y purinoceptor 1

Protein family/group databases

Transport Classification Database

More...
TCDBi
9.A.14.13.22 the g-protein-coupled receptor (gpcr) family

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
P2Y purinoceptor 1
Short name:
P2Y1
Alternative name(s):
ADP receptor1 Publication
Purinergic receptor
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:P2RY1
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 3

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000169860.6

Human Gene Nomenclature Database

More...
HGNCi
HGNC:8539 P2RY1

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
601167 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_P47900

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini1 – 51Extracellular1 PublicationAdd BLAST51
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei52 – 74Helical; Name=11 PublicationAdd BLAST23
Topological domaini75 – 87Cytoplasmic1 PublicationAdd BLAST13
Transmembranei88 – 109Helical; Name=21 PublicationAdd BLAST22
Topological domaini110 – 125Extracellular1 PublicationAdd BLAST16
Transmembranei126 – 147Helical; Name=31 PublicationAdd BLAST22
Topological domaini148 – 166Cytoplasmic1 PublicationAdd BLAST19
Transmembranei167 – 188Helical; Name=41 PublicationAdd BLAST22
Topological domaini189 – 214Extracellular1 PublicationAdd BLAST26
Transmembranei215 – 237Helical; Name=51 PublicationAdd BLAST23
Topological domaini238 – 260Cytoplasmic1 PublicationAdd BLAST23
Transmembranei261 – 284Helical; Name=61 PublicationAdd BLAST24
Topological domaini285 – 303Extracellular1 PublicationAdd BLAST19
Transmembranei304 – 325Helical; Name=71 PublicationAdd BLAST22
Topological domaini326 – 373Cytoplasmic1 PublicationAdd BLAST48

Keywords - Cellular componenti

Cell membrane, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology_and_biotech_section">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi44L → A: Loss of ADP analog binding. 1 Publication1
Mutagenesisi110Y → F: Loss of ADP analog binding. 1 Publication1
Mutagenesisi203Y → A: Loss of ADP analog binding. 1 Publication1
Mutagenesisi205T → A: Loss of ADP analog binding. 1 Publication1
Mutagenesisi283N → A: Loss of ADP analog binding. 1 Publication1
Mutagenesisi306Y → F: Strongly decreased affinity for ADP analog. 1 Publication1

Organism-specific databases

DisGeNET

More...
DisGeNETi
5028

Open Targets

More...
OpenTargetsi
ENSG00000169860

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA32868

Chemistry databases

ChEMBL database of bioactive drug-like small molecules

More...
ChEMBLi
CHEMBL4315

IUPHAR/BPS Guide to PHARMACOLOGY

More...
GuidetoPHARMACOLOGYi
323

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
P2RY1

Domain mapping of disease mutations (DMDM)

More...
DMDMi
1352692

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000700061 – 373P2Y purinoceptor 1Add BLAST373

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi11N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi27N-linked (GlcNAc...) asparagineSequence analysis1
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi42 ↔ 296Combined sources1 Publication
Glycosylationi113N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi124 ↔ 202PROSITE-ProRule annotationCombined sources1 Publication
Glycosylationi197N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
P47900

PeptideAtlas

More...
PeptideAtlasi
P47900

PRoteomics IDEntifications database

More...
PRIDEi
P47900

ProteomicsDB human proteome resource

More...
ProteomicsDBi
55818

Consortium for Top Down Proteomics

More...
TopDownProteomicsi
P47900

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
P47900

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
P47900

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000169860 Expressed in 182 organ(s), highest expression level in gingival epithelium

CleanEx database of gene expression profiles

More...
CleanExi
HS_P2RY1

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
P47900 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA015577

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

WithEntry#Exp.IntActNotes
SLC9A3R1O147452EBI-8677223,EBI-349787

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
111067, 12 interactors

Protein interaction database and analysis system

More...
IntActi
P47900, 1 interactor

Molecular INTeraction database

More...
MINTi
P47900

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000304767

Chemistry databases

BindingDB database of measured binding affinities

More...
BindingDBi
P47900

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1373
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

More...
ProteinModelPortali
P47900

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
P47900

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG410IEMX Eukaryota
ENOG410Z2ZK LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000153332

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000231307

The HOVERGEN Database of Homologous Vertebrate Genes

More...
HOVERGENi
HBG101120

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
P47900

KEGG Orthology (KO)

More...
KOi
K04270

Identification of Orthologs from Complete Genome Data

More...
OMAi
HRYTGVV

Database of Orthologous Groups

More...
OrthoDBi
EOG091G093Y

Database for complete collections of gene phylogenies

More...
PhylomeDBi
P47900

TreeFam database of animal gene trees

More...
TreeFami
TF350009

Family and domain databases

Conserved Domains Database

More...
CDDi
cd15377 7tmA_P2Y1, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR000276 GPCR_Rhodpsn
IPR017452 GPCR_Rhodpsn_7TM
IPR000142 P2Y1_rcpt

The PANTHER Classification System

More...
PANTHERi
PTHR24231:SF2 PTHR24231:SF2, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00001 7tm_1, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR00237 GPCRRHODOPSN
PR00595 P2Y1PRNOCPTR

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00237 G_PROTEIN_RECEP_F1_1, 1 hit
PS50262 G_PROTEIN_RECEP_F1_2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

P47900-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MTEVLWPAVP NGTDAAFLAG PGSSWGNSTV ASTAAVSSSF KCALTKTGFQ
60 70 80 90 100
FYYLPAVYIL VFIIGFLGNS VAIWMFVFHM KPWSGISVYM FNLALADFLY
110 120 130 140 150
VLTLPALIFY YFNKTDWIFG DAMCKLQRFI FHVNLYGSIL FLTCISAHRY
160 170 180 190 200
SGVVYPLKSL GRLKKKNAIC ISVLVWLIVV VAISPILFYS GTGVRKNKTI
210 220 230 240 250
TCYDTTSDEY LRSYFIYSMC TTVAMFCVPL VLILGCYGLI VRALIYKDLD
260 270 280 290 300
NSPLRRKSIY LVIIVLTVFA VSYIPFHVMK TMNLRARLDF QTPAMCAFND
310 320 330 340 350
RVYATYQVTR GLASLNSCVD PILYFLAGDT FRRRLSRATR KASRRSEANL
360 370
QSKSEDMTLN ILPEFKQNGD TSL
Length:373
Mass (Da):42,072
Last modified:February 1, 1996 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i4DC7C668B4145392
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti138Missing in CAA89066 (PubMed:8666290).Curated1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
Z49205 mRNA Translation: CAA89066.1
U42030 mRNA Translation: AAA97873.1
U42029 mRNA Translation: AAA97872.1
S81950 Genomic DNA Translation: AAB47091.1
AJ006945 Genomic DNA Translation: CAA07339.1
AY136752 mRNA Translation: AAN01278.1
BC074784 mRNA Translation: AAH74784.1
BC074785 mRNA Translation: AAH74785.1
AF018284 mRNA Translation: AAB94556.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS3169.1

Protein sequence database of the Protein Information Resource

More...
PIRi
JC4737

NCBI Reference Sequences

More...
RefSeqi
NP_002554.1, NM_002563.4

UniGene gene-oriented nucleotide sequence clusters

More...
UniGenei
Hs.654526
Hs.79881

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000305097; ENSP00000304767; ENSG00000169860

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
5028

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:5028

UCSC genome browser

More...
UCSCi
uc003ezq.4 human

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z49205 mRNA Translation: CAA89066.1
U42030 mRNA Translation: AAA97873.1
U42029 mRNA Translation: AAA97872.1
S81950 Genomic DNA Translation: AAB47091.1
AJ006945 Genomic DNA Translation: CAA07339.1
AY136752 mRNA Translation: AAN01278.1
BC074784 mRNA Translation: AAH74784.1
BC074785 mRNA Translation: AAH74785.1
AF018284 mRNA Translation: AAB94556.1
CCDSiCCDS3169.1
PIRiJC4737
RefSeqiNP_002554.1, NM_002563.4
UniGeneiHs.654526
Hs.79881

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...
PDBei

Protein Data Bank RCSB

More...
RCSB PDBi

Protein Data Bank Japan

More...
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1Y36model-A1-373[»]
4XNVX-ray2.20A2-247[»]
A253-373[»]
4XNWX-ray2.70A/C2-247[»]
A/C253-373[»]
ProteinModelPortaliP47900
SMRiP47900
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi111067, 12 interactors
IntActiP47900, 1 interactor
MINTiP47900
STRINGi9606.ENSP00000304767

Chemistry databases

BindingDBiP47900
ChEMBLiCHEMBL4315
GuidetoPHARMACOLOGYi323

Protein family/group databases

TCDBi9.A.14.13.22 the g-protein-coupled receptor (gpcr) family

Information system for G protein-coupled receptors (GPCRs)

More...
GPCRDBi
Search...

PTM databases

iPTMnetiP47900
PhosphoSitePlusiP47900

Polymorphism and mutation databases

BioMutaiP2RY1
DMDMi1352692

Proteomic databases

PaxDbiP47900
PeptideAtlasiP47900
PRIDEiP47900
ProteomicsDBi55818
TopDownProteomicsiP47900

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000305097; ENSP00000304767; ENSG00000169860
GeneIDi5028
KEGGihsa:5028
UCSCiuc003ezq.4 human

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
5028
DisGeNETi5028
EuPathDBiHostDB:ENSG00000169860.6

GeneCards: human genes, protein and diseases

More...
GeneCardsi
P2RY1
HGNCiHGNC:8539 P2RY1
HPAiHPA015577
MIMi601167 gene
neXtProtiNX_P47900
OpenTargetsiENSG00000169860
PharmGKBiPA32868

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiENOG410IEMX Eukaryota
ENOG410Z2ZK LUCA
GeneTreeiENSGT00940000153332
HOGENOMiHOG000231307
HOVERGENiHBG101120
InParanoidiP47900
KOiK04270
OMAiHRYTGVV
OrthoDBiEOG091G093Y
PhylomeDBiP47900
TreeFamiTF350009

Enzyme and pathway databases

ReactomeiR-HSA-416476 G alpha (q) signalling events
R-HSA-417957 P2Y receptors
R-HSA-418592 ADP signalling through P2Y purinoceptor 1

Miscellaneous databases

The Gene Wiki collection of pages on human genes and proteins

More...
GeneWikii
P2RY1

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
5028

Protein Ontology

More...
PROi
PR:P47900

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
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Gene expression databases

BgeeiENSG00000169860 Expressed in 182 organ(s), highest expression level in gingival epithelium
CleanExiHS_P2RY1
GenevisibleiP47900 HS

Family and domain databases

CDDicd15377 7tmA_P2Y1, 1 hit
InterProiView protein in InterPro
IPR000276 GPCR_Rhodpsn
IPR017452 GPCR_Rhodpsn_7TM
IPR000142 P2Y1_rcpt
PANTHERiPTHR24231:SF2 PTHR24231:SF2, 1 hit
PfamiView protein in Pfam
PF00001 7tm_1, 1 hit
PRINTSiPR00237 GPCRRHODOPSN
PR00595 P2Y1PRNOCPTR
PROSITEiView protein in PROSITE
PS00237 G_PROTEIN_RECEP_F1_1, 1 hit
PS50262 G_PROTEIN_RECEP_F1_2, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiP2RY1_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P47900
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1996
Last sequence update: February 1, 1996
Last modified: December 5, 2018
This is version 170 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families
  3. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
  4. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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