HTR5A

Functionⁱ

This is one of the several different receptors for 5-hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. The activity of this receptor is mediated by G proteins.

GO - Molecular functionⁱ

G-protein coupled serotonin receptor activity
Source: MGI
Inferred from direct assayⁱ
- 7988681
neurotransmitter receptor activity Source: GO_Central
serotonin binding Source: GO_Central

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

adenylate cyclase-inhibiting serotonin receptor signaling pathway Source: GO_Central
cAMP-mediated signaling Source: Ensembl
G-protein coupled receptor signaling pathway Source: Reactome
hippocampus development Source: Ensembl
response to estradiol Source: Ensembl

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	G-protein coupled receptor, Receptor, Transducer

Molecular function

G-protein coupled receptor, Receptor, Transducer

Enzyme and pathway databases

Reactomeⁱ	R-HSA-390666 Serotonin receptors R-HSA-418594 G alpha (i) signalling events

Reactomeⁱ

R-HSA-390666 Serotonin receptors
R-HSA-418594 G alpha (i) signalling events

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: 5-hydroxytryptamine receptor 5A Short name: 5-HT-5 Short name: 5-HT-5A Short name: 5-HT5A Alternative name(s): Serotonin receptor 5A
Gene namesⁱ	Name:HTR5A
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 7

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000157219.3
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:5300 HTR5A
MIMⁱ	601305 gene
neXtProtⁱ	NX_P47898

Topology

Feature key	Position(s)	DescriptionActions	Length
Topological domainⁱ	1 – 40	ExtracellularBy similarityAdd BLAST	40
Transmembraneⁱ	41 – 63	Helical; Name=1By similarityAdd BLAST	23
Topological domainⁱ	64 – 78	CytoplasmicBy similarityAdd BLAST	15
Transmembraneⁱ	79 – 99	Helical; Name=2By similarityAdd BLAST	21
Topological domainⁱ	100 – 115	ExtracellularBy similarityAdd BLAST	16
Transmembraneⁱ	116 – 137	Helical; Name=3By similarityAdd BLAST	22
Topological domainⁱ	138 – 158	CytoplasmicBy similarityAdd BLAST	21
Transmembraneⁱ	159 – 181	Helical; Name=4By similarityAdd BLAST	23
Topological domainⁱ	182 – 198	ExtracellularBy similarityAdd BLAST	17
Transmembraneⁱ	199 – 219	Helical; Name=5By similarityAdd BLAST	21
Topological domainⁱ	220 – 282	CytoplasmicBy similarityAdd BLAST	63
Transmembraneⁱ	283 – 303	Helical; Name=6By similarityAdd BLAST	21
Topological domainⁱ	304 – 320	ExtracellularBy similarityAdd BLAST	17
Transmembraneⁱ	321 – 341	Helical; Name=7By similarityAdd BLAST	21
Topological domainⁱ	342 – 357	CytoplasmicBy similarityAdd BLAST	16

Keywords - Cellular componentⁱ

Cell membrane, Membrane

Pathology & Biotechⁱ

Organism-specific databases

DisGeNET More...DisGeNETⁱ	3361
Open Targets More...OpenTargetsⁱ	ENSG00000157219
PharmGKBⁱ	PA29558

Chemistry databases

ChEMBLⁱ	CHEMBL3426
Drug and drug target database More...DrugBankⁱ	DB06216 Asenapine DB00408 Loxapine DB00334 Olanzapine
IUPHAR/BPS Guide to PHARMACOLOGY More...GuidetoPHARMACOLOGYⁱ	10

Polymorphism and mutation databases

BioMutaⁱ	HTR5A
DMDMⁱ	1345607

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000068969	1 – 357	5-hydroxytryptamine receptor 5AAdd BLAST		357

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Glycosylationⁱ	6	N-linked (GlcNAc...) asparagineSequence analysis	1
Glycosylationⁱ	21	N-linked (GlcNAc...) asparagineSequence analysis	1
Disulfide bondⁱ	120 ↔ 192	PROSITE-ProRule annotation

Keywords - PTMⁱ

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbⁱ	P47898
PeptideAtlas More...PeptideAtlasⁱ	P47898
PRIDEⁱ	P47898
ProteomicsDBⁱ	55817

PTM databases

iPTMnetⁱ	P47898
PhosphoSitePlusⁱ	P47898

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSG00000157219
CleanExⁱ	HS_HTR5A
ExpressionAtlasⁱ	P47898 baseline and differential
Genevisibleⁱ	P47898 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	CAB017467

HPAⁱ

CAB017467

Interactionⁱ

Protein-protein interaction databases

STRINGⁱ	9606.ENSP00000287907

STRINGⁱ

9606.ENSP00000287907

Chemistry databases

BindingDBⁱ

P47898

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	P47898
SMRⁱ	P47898
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Sequence similaritiesⁱ

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domainⁱ

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGⁱ	KOG3656 Eukaryota ENOG410XRW9 LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00760000118795
HOGENOMⁱ	HOG000239242
HOVERGENⁱ	HBG106962
InParanoidⁱ	P47898
KEGG Orthology (KO) More...KOⁱ	K04161
OMAⁱ	QKAALMV
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G06VI
PhylomeDBⁱ	P47898
TreeFamⁱ	TF316350

Family and domain databases

InterProⁱ	View protein in InterPro IPR001397 5HT5A_rcpt IPR002231 5HT_rcpt IPR000276 GPCR_Rhodpsn IPR017452 GPCR_Rhodpsn_7TM
PANTHERⁱ	PTHR24247:SF108 PTHR24247:SF108, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00001 7tm_1, 1 hit
PRINTSⁱ	PR00518 5HT5ARECEPTR PR01101 5HTRECEPTOR PR00237 GPCRRHODOPSN
PROSITEⁱ	View protein in PROSITE PS00237 G_PROTEIN_RECEP_F1_1, 1 hit PS50262 G_PROTEIN_RECEP_F1_2, 1 hit

Sequenceⁱ

Sequence statusⁱ: Complete.

P47898-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MDLPVNLTSF SLSTPSPLET NHSLGKDDLR PSSPLLSVFG VLILTLLGFL 
        60         70         80         90        100
VAATFAWNLL VLATILRVRT FHRVPHNLVA SMAVSDVLVA ALVMPLSLVH 
       110        120        130        140        150
ELSGRRWQLG RRLCQLWIAC DVLCCTASIW NVTAIALDRY WSITRHMEYT 
       160        170        180        190        200
LRTRKCVSNV MIALTWALSA VISLAPLLFG WGETYSEGSE ECQVSREPSY 
       210        220        230        240        250
AVFSTVGAFY LPLCVVLFVY WKIYKAAKFR VGSRKTNSVS PISEAVEVKD 
       260        270        280        290        300
SAKQPQMVFT VRHATVTFQP EGDTWREQKE QRAALMVGIL IGVFVLCWIP 
       310        320        330        340        350
FFLTELISPL CSCDIPAIWK SIFLWLGYSN SFFNPLIYTA FNKNYNSAFK 

NFFSRQH

Length:357

Mass (Da):40,255

Last modified:February 1, 1996 - v1

Checksum:ⁱ92F8A78C69169790

GO

Natural variant

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Natural variantⁱVAR_035753	262	R → C in a colorectal cancer sample; somatic mutation. 1 PublicationCorresponds to variant dbSNP:rs746290830Ensembl.		1

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	X81411, X81412 Genomic DNA Translation: CAA57168.1 AF498985 mRNA Translation: AAM21132.1 BC112021 mRNA Translation: AAI12022.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS5936.1
PIRⁱ	I37107
NCBI Reference Sequences More...RefSeqⁱ	NP_076917.1, NM_024012.3
UniGeneⁱ	Hs.65791 Hs.744621

Genome annotation databases

Ensemblⁱ	ENST00000287907; ENSP00000287907; ENSG00000157219
GeneIDⁱ	3361
KEGGⁱ	hsa:3361
UCSC genome browser More...UCSCⁱ	uc003wlu.3 human

Keywords - Coding sequence diversityⁱ

Polymorphism

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length
P47898	5-hydroxytryptamine (Serotonin) receptor 5A		HUMAN		357
Uncharacterized protein HTR5A (Fragment)		HUMAN		247
Uncharacterized protein HTR5A (Fragment)		HUMAN		110

Protein	Similar proteins		Species	Score	Length
P47898	5-hydroxytryptamine (Serotonin) receptor 5A		HUMAN		357
UPI0007195FDC		southern white rhinoceros		412
5-hydroxytryptamine receptor 5A		CANLF		360
5-hydroxytryptamine receptor 5A (Fragment)		AILME		358
5-hydroxytryptamine receptor 5A		LEPWE		358
+50

Protein	Similar proteins		Species	Score	Length
P47898	5-hydroxytryptamine receptor 5A		RAT		357
UPI000A30C4AE		MUSPA		357
5-hydroxytryptamine receptor 5A		MOUSE		357
UPI000A314BC9		MUSCR		357
5-hydroxytryptamine receptor 5A		TUPCH		405
+118

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	X81411, X81412 Genomic DNA Translation: CAA57168.1 AF498985 mRNA Translation: AAM21132.1 BC112021 mRNA Translation: AAI12022.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS5936.1
PIRⁱ	I37107
NCBI Reference Sequences More...RefSeqⁱ	NP_076917.1, NM_024012.3
UniGeneⁱ	Hs.65791 Hs.744621

3D structure databases

ProteinModelPortalⁱ	P47898
SMRⁱ	P47898
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

STRINGⁱ	9606.ENSP00000287907

STRINGⁱ

9606.ENSP00000287907

Chemistry databases

BindingDBⁱ	P47898
ChEMBLⁱ	CHEMBL3426
Drug and drug target database More...DrugBankⁱ	DB06216 Asenapine DB00408 Loxapine DB00334 Olanzapine
IUPHAR/BPS Guide to PHARMACOLOGY More...GuidetoPHARMACOLOGYⁱ	10

Protein family/group databases

GPCRDBⁱ	Search...

GPCRDBⁱ

Search...

PTM databases

iPTMnetⁱ	P47898
PhosphoSitePlusⁱ	P47898

Polymorphism and mutation databases

BioMutaⁱ	HTR5A
DMDMⁱ	1345607

Proteomic databases

PaxDbⁱ	P47898
PeptideAtlas More...PeptideAtlasⁱ	P47898
PRIDEⁱ	P47898
ProteomicsDBⁱ	55817

Protocols and materials databases

The DNASU plasmid repository More...DNASUⁱ	3361
Structural Biology Knowledgebase	Search...

Genome annotation databases

Ensemblⁱ	ENST00000287907; ENSP00000287907; ENSG00000157219
GeneIDⁱ	3361
KEGGⁱ	hsa:3361
UCSC genome browser More...UCSCⁱ	uc003wlu.3 human

Organism-specific databases

CTDⁱ	3361
DisGeNET More...DisGeNETⁱ	3361
EuPathDBⁱ	HostDB:ENSG00000157219.3
GeneCardsⁱ	HTR5A
H-InvDBⁱ	HIX0033634
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:5300 HTR5A
Human Protein Atlas More...HPAⁱ	CAB017467
MIMⁱ	601305 gene
neXtProtⁱ	NX_P47898
Open Targets More...OpenTargetsⁱ	ENSG00000157219
PharmGKBⁱ	PA29558
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	KOG3656 Eukaryota ENOG410XRW9 LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00760000118795
HOGENOMⁱ	HOG000239242
HOVERGENⁱ	HBG106962
InParanoidⁱ	P47898
KEGG Orthology (KO) More...KOⁱ	K04161
OMAⁱ	QKAALMV
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G06VI
PhylomeDBⁱ	P47898
TreeFamⁱ	TF316350

Enzyme and pathway databases

Reactomeⁱ	R-HSA-390666 Serotonin receptors R-HSA-418594 G alpha (i) signalling events

Reactomeⁱ

R-HSA-390666 Serotonin receptors
R-HSA-418594 G alpha (i) signalling events

Miscellaneous databases

GeneWikiⁱ	5-HT5A_receptor
GenomeRNAiⁱ	3361
Protein Ontology More...PROⁱ	PR:P47898
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000157219
CleanExⁱ	HS_HTR5A
ExpressionAtlasⁱ	P47898 baseline and differential
Genevisibleⁱ	P47898 HS

Family and domain databases

InterProⁱ	View protein in InterPro IPR001397 5HT5A_rcpt IPR002231 5HT_rcpt IPR000276 GPCR_Rhodpsn IPR017452 GPCR_Rhodpsn_7TM
PANTHERⁱ	PTHR24247:SF108 PTHR24247:SF108, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00001 7tm_1, 1 hit
PRINTSⁱ	PR00518 5HT5ARECEPTR PR01101 5HTRECEPTOR PR00237 GPCRRHODOPSN
PROSITEⁱ	View protein in PROSITE PS00237 G_PROTEIN_RECEP_F1_1, 1 hit PS50262 G_PROTEIN_RECEP_F1_2, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	5HT5A_HUMAN
Accessionⁱ	P47898Primary (citable) accession number: P47898 Secondary accession number(s): Q2M2D2
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	February 1, 1996
	Last sequence update:	February 1, 1996
	Last modified:	July 18, 2018
	This is version 148 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

Documents

7-transmembrane G-linked receptors
List of 7-transmembrane G-linked receptor entries
Human chromosome 7
Human chromosome 7: entries, gene names and cross-references to MIM
Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations
Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
SIMILARITY comments
Index of protein domains and families

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UniProtKB - P47898 (5HT5A_HUMAN)

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5-hydroxytryptamine receptor 5A

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Plasma membrane

Endoplasmic reticulum

Golgi apparatus

Plasma Membrane

Other locations

Topology

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Chemistry databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

Chemistry databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

Family and domain databases

Natural variant

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

Chemistry databases

Protein family/group databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Documents

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ