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Protein

5-hydroxytryptamine receptor 5A

Gene

HTR5A

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

This is one of the several different receptors for 5-hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. The activity of this receptor is mediated by G proteins.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionG-protein coupled receptor, Receptor, Transducer

Enzyme and pathway databases

ReactomeiR-HSA-390666 Serotonin receptors
R-HSA-418594 G alpha (i) signalling events

Names & Taxonomyi

Protein namesi
Recommended name:
5-hydroxytryptamine receptor 5A
Short name:
5-HT-5
Short name:
5-HT-5A
Short name:
5-HT5A
Alternative name(s):
Serotonin receptor 5A
Gene namesi
Name:HTR5A
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 7

Organism-specific databases

EuPathDBiHostDB:ENSG00000157219.3
HGNCiHGNC:5300 HTR5A
MIMi601305 gene
neXtProtiNX_P47898

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 40ExtracellularBy similarityAdd BLAST40
Transmembranei41 – 63Helical; Name=1By similarityAdd BLAST23
Topological domaini64 – 78CytoplasmicBy similarityAdd BLAST15
Transmembranei79 – 99Helical; Name=2By similarityAdd BLAST21
Topological domaini100 – 115ExtracellularBy similarityAdd BLAST16
Transmembranei116 – 137Helical; Name=3By similarityAdd BLAST22
Topological domaini138 – 158CytoplasmicBy similarityAdd BLAST21
Transmembranei159 – 181Helical; Name=4By similarityAdd BLAST23
Topological domaini182 – 198ExtracellularBy similarityAdd BLAST17
Transmembranei199 – 219Helical; Name=5By similarityAdd BLAST21
Topological domaini220 – 282CytoplasmicBy similarityAdd BLAST63
Transmembranei283 – 303Helical; Name=6By similarityAdd BLAST21
Topological domaini304 – 320ExtracellularBy similarityAdd BLAST17
Transmembranei321 – 341Helical; Name=7By similarityAdd BLAST21
Topological domaini342 – 357CytoplasmicBy similarityAdd BLAST16

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi3361
OpenTargetsiENSG00000157219
PharmGKBiPA29558

Chemistry databases

ChEMBLiCHEMBL3426
DrugBankiDB06216 Asenapine
DB00408 Loxapine
DB00334 Olanzapine
GuidetoPHARMACOLOGYi10

Polymorphism and mutation databases

BioMutaiHTR5A
DMDMi1345607

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000689691 – 3575-hydroxytryptamine receptor 5AAdd BLAST357

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi6N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi21N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi120 ↔ 192PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiP47898
PeptideAtlasiP47898
PRIDEiP47898
ProteomicsDBi55817

PTM databases

iPTMnetiP47898
PhosphoSitePlusiP47898

Expressioni

Gene expression databases

BgeeiENSG00000157219
CleanExiHS_HTR5A
ExpressionAtlasiP47898 baseline and differential
GenevisibleiP47898 HS

Organism-specific databases

HPAiCAB017467

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000287907

Chemistry databases

BindingDBiP47898

Structurei

3D structure databases

ProteinModelPortaliP47898
SMRiP47898
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3656 Eukaryota
ENOG410XRW9 LUCA
GeneTreeiENSGT00760000118795
HOGENOMiHOG000239242
HOVERGENiHBG106962
InParanoidiP47898
KOiK04161
OMAiQKAALMV
OrthoDBiEOG091G06VI
PhylomeDBiP47898
TreeFamiTF316350

Family and domain databases

InterProiView protein in InterPro
IPR001397 5HT5A_rcpt
IPR002231 5HT_rcpt
IPR000276 GPCR_Rhodpsn
IPR017452 GPCR_Rhodpsn_7TM
PANTHERiPTHR24247:SF108 PTHR24247:SF108, 1 hit
PfamiView protein in Pfam
PF00001 7tm_1, 1 hit
PRINTSiPR00518 5HT5ARECEPTR
PR01101 5HTRECEPTOR
PR00237 GPCRRHODOPSN
PROSITEiView protein in PROSITE
PS00237 G_PROTEIN_RECEP_F1_1, 1 hit
PS50262 G_PROTEIN_RECEP_F1_2, 1 hit

Sequencei

Sequence statusi: Complete.

P47898-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDLPVNLTSF SLSTPSPLET NHSLGKDDLR PSSPLLSVFG VLILTLLGFL
60 70 80 90 100
VAATFAWNLL VLATILRVRT FHRVPHNLVA SMAVSDVLVA ALVMPLSLVH
110 120 130 140 150
ELSGRRWQLG RRLCQLWIAC DVLCCTASIW NVTAIALDRY WSITRHMEYT
160 170 180 190 200
LRTRKCVSNV MIALTWALSA VISLAPLLFG WGETYSEGSE ECQVSREPSY
210 220 230 240 250
AVFSTVGAFY LPLCVVLFVY WKIYKAAKFR VGSRKTNSVS PISEAVEVKD
260 270 280 290 300
SAKQPQMVFT VRHATVTFQP EGDTWREQKE QRAALMVGIL IGVFVLCWIP
310 320 330 340 350
FFLTELISPL CSCDIPAIWK SIFLWLGYSN SFFNPLIYTA FNKNYNSAFK

NFFSRQH
Length:357
Mass (Da):40,255
Last modified:February 1, 1996 - v1
Checksum:i92F8A78C69169790
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_035753262R → C in a colorectal cancer sample; somatic mutation. 1 PublicationCorresponds to variant dbSNP:rs746290830Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X81411, X81412 Genomic DNA Translation: CAA57168.1
AF498985 mRNA Translation: AAM21132.1
BC112021 mRNA Translation: AAI12022.1
CCDSiCCDS5936.1
PIRiI37107
RefSeqiNP_076917.1, NM_024012.3
UniGeneiHs.65791
Hs.744621

Genome annotation databases

EnsembliENST00000287907; ENSP00000287907; ENSG00000157219
GeneIDi3361
KEGGihsa:3361
UCSCiuc003wlu.3 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry namei5HT5A_HUMAN
AccessioniPrimary (citable) accession number: P47898
Secondary accession number(s): Q2M2D2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1996
Last sequence update: February 1, 1996
Last modified: July 18, 2018
This is version 148 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human chromosome 7
    Human chromosome 7: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. SIMILARITY comments
    Index of protein domains and families

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