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UniProtKB - P47898 (5HT5A_HUMAN)
Protein
5-hydroxytryptamine receptor 5A
Gene
HTR5A
Organism
Homo sapiens (Human)
Status
Functioni
This is one of the several different receptors for 5-hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. The activity of this receptor is mediated by G proteins.
GO - Molecular functioni
- G protein-coupled serotonin receptor activity Source: MGI
- neurotransmitter receptor activity Source: GO_Central
- serotonin binding Source: GO_Central
GO - Biological processi
- adenylate cyclase-activating G protein-coupled receptor signaling pathway Source: Ensembl
- adenylate cyclase-inhibiting serotonin receptor signaling pathway Source: GO_Central
- chemical synaptic transmission Source: GO_Central
- G protein-coupled receptor signaling pathway Source: ProtInc
- G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger Source: GO_Central
- hippocampus development Source: Ensembl
- response to estradiol Source: Ensembl
Keywordsi
Molecular function | G-protein coupled receptor, Receptor, Transducer |
Enzyme and pathway databases
PathwayCommonsi | P47898 |
Reactomei | R-HSA-390666, Serotonin receptors R-HSA-418594, G alpha (i) signalling events |
SignaLinki | P47898 |
SIGNORi | P47898 |
Names & Taxonomyi
Protein namesi | Recommended name: 5-hydroxytryptamine receptor 5AShort name: 5-HT-5 Short name: 5-HT-5A Short name: 5-HT5A Alternative name(s): Serotonin receptor 5A |
Gene namesi | Name:HTR5A |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
HGNCi | HGNC:5300, HTR5A |
MIMi | 601305, gene |
neXtProti | NX_P47898 |
VEuPathDBi | HostDB:ENSG00000157219 |
Subcellular locationi
Plasma membrane
Endoplasmic reticulum
- rough endoplasmic reticulum Source: Ensembl
Golgi apparatus
- Golgi apparatus Source: Ensembl
Plasma Membrane
- integral component of plasma membrane Source: GO_Central
- integral component of postsynaptic specialization membrane Source: Ensembl
- plasma membrane Source: Reactome
Other locations
- dendrite Source: GO_Central
- perikaryon Source: Ensembl
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 1 – 40 | ExtracellularBy similarityAdd BLAST | 40 | |
Transmembranei | 41 – 63 | Helical; Name=1By similarityAdd BLAST | 23 | |
Topological domaini | 64 – 78 | CytoplasmicBy similarityAdd BLAST | 15 | |
Transmembranei | 79 – 99 | Helical; Name=2By similarityAdd BLAST | 21 | |
Topological domaini | 100 – 115 | ExtracellularBy similarityAdd BLAST | 16 | |
Transmembranei | 116 – 137 | Helical; Name=3By similarityAdd BLAST | 22 | |
Topological domaini | 138 – 158 | CytoplasmicBy similarityAdd BLAST | 21 | |
Transmembranei | 159 – 181 | Helical; Name=4By similarityAdd BLAST | 23 | |
Topological domaini | 182 – 198 | ExtracellularBy similarityAdd BLAST | 17 | |
Transmembranei | 199 – 219 | Helical; Name=5By similarityAdd BLAST | 21 | |
Topological domaini | 220 – 282 | CytoplasmicBy similarityAdd BLAST | 63 | |
Transmembranei | 283 – 303 | Helical; Name=6By similarityAdd BLAST | 21 | |
Topological domaini | 304 – 320 | ExtracellularBy similarityAdd BLAST | 17 | |
Transmembranei | 321 – 341 | Helical; Name=7By similarityAdd BLAST | 21 | |
Topological domaini | 342 – 357 | CytoplasmicBy similarityAdd BLAST | 16 |
Keywords - Cellular componenti
Cell membrane, MembranePathology & Biotechi
Organism-specific databases
DisGeNETi | 3361 |
OpenTargetsi | ENSG00000157219 |
PharmGKBi | PA29558 |
Miscellaneous databases
Pharosi | P47898, Tchem |
Chemistry databases
ChEMBLi | CHEMBL3426 |
DrugBanki | DB01238, Aripiprazole DB06216, Asenapine DB00408, Loxapine DB00246, Ziprasidone |
DrugCentrali | P47898 |
GuidetoPHARMACOLOGYi | 10 |
Genetic variation databases
BioMutai | HTR5A |
DMDMi | 1345607 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000068969 | 1 – 357 | 5-hydroxytryptamine receptor 5AAdd BLAST | 357 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Glycosylationi | 6 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 21 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Disulfide bondi | 120 ↔ 192 | PROSITE-ProRule annotation |
Keywords - PTMi
Disulfide bond, GlycoproteinProteomic databases
MassIVEi | P47898 |
PaxDbi | P47898 |
PeptideAtlasi | P47898 |
PRIDEi | P47898 |
PTM databases
GlyGeni | P47898, 2 sites |
iPTMneti | P47898 |
PhosphoSitePlusi | P47898 |
Expressioni
Gene expression databases
Bgeei | ENSG00000157219, Expressed in cerebellum and 55 other tissues |
ExpressionAtlasi | P47898, baseline and differential |
Genevisiblei | P47898, HS |
Organism-specific databases
HPAi | ENSG00000157219, Tissue enriched (brain) |
Interactioni
Protein-protein interaction databases
BioGRIDi | 109593, 1 interactor |
IntActi | P47898, 1 interactor |
MINTi | P47898 |
STRINGi | 9606.ENSP00000287907 |
Chemistry databases
BindingDBi | P47898 |
Miscellaneous databases
RNActi | P47898, protein |
Family & Domainsi
Sequence similaritiesi
Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation
Keywords - Domaini
Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | KOG3656, Eukaryota |
GeneTreei | ENSGT01030000234619 |
HOGENOMi | CLU_009579_11_6_1 |
InParanoidi | P47898 |
OMAi | RRISNIM |
OrthoDBi | 817833at2759 |
PhylomeDBi | P47898 |
TreeFami | TF316350 |
Family and domain databases
InterProi | View protein in InterPro IPR001397, 5HT5A_rcpt IPR002231, 5HT_rcpt IPR000276, GPCR_Rhodpsn IPR017452, GPCR_Rhodpsn_7TM |
PANTHERi | PTHR24247:SF108, PTHR24247:SF108, 1 hit |
Pfami | View protein in Pfam PF00001, 7tm_1, 1 hit |
PRINTSi | PR00518, 5HT5ARECEPTR PR01101, 5HTRECEPTOR PR00237, GPCRRHODOPSN |
PROSITEi | View protein in PROSITE PS00237, G_PROTEIN_RECEP_F1_1, 1 hit PS50262, G_PROTEIN_RECEP_F1_2, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All
P47898-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MDLPVNLTSF SLSTPSPLET NHSLGKDDLR PSSPLLSVFG VLILTLLGFL
60 70 80 90 100
VAATFAWNLL VLATILRVRT FHRVPHNLVA SMAVSDVLVA ALVMPLSLVH
110 120 130 140 150
ELSGRRWQLG RRLCQLWIAC DVLCCTASIW NVTAIALDRY WSITRHMEYT
160 170 180 190 200
LRTRKCVSNV MIALTWALSA VISLAPLLFG WGETYSEGSE ECQVSREPSY
210 220 230 240 250
AVFSTVGAFY LPLCVVLFVY WKIYKAAKFR VGSRKTNSVS PISEAVEVKD
260 270 280 290 300
SAKQPQMVFT VRHATVTFQP EGDTWREQKE QRAALMVGIL IGVFVLCWIP
310 320 330 340 350
FFLTELISPL CSCDIPAIWK SIFLWLGYSN SFFNPLIYTA FNKNYNSAFK
NFFSRQH
Computationally mapped potential isoform sequencesi
There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basketA0A3B3ISH0 | A0A3B3ISH0_HUMAN | 5-hydroxytryptamine receptor 5A | HTR5A | 84 | Annotation score: |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_035753 | 262 | R → C in a colorectal cancer sample; somatic mutation. 1 PublicationCorresponds to variant dbSNP:rs746290830Ensembl. | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | X81411, X81412 Genomic DNA Translation: CAA57168.1 AF498985 mRNA Translation: AAM21132.1 BC112021 mRNA Translation: AAI12022.1 |
CCDSi | CCDS5936.1 |
PIRi | I37107 |
RefSeqi | NP_076917.1, NM_024012.3 |
Genome annotation databases
Ensembli | ENST00000287907; ENSP00000287907; ENSG00000157219 |
GeneIDi | 3361 |
KEGGi | hsa:3361 |
MANE-Selecti | ENST00000287907.3; ENSP00000287907.2; NM_024012.4; NP_076917.1 |
UCSCi | uc003wlu.3, human |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | X81411, X81412 Genomic DNA Translation: CAA57168.1 AF498985 mRNA Translation: AAM21132.1 BC112021 mRNA Translation: AAI12022.1 |
CCDSi | CCDS5936.1 |
PIRi | I37107 |
RefSeqi | NP_076917.1, NM_024012.3 |
3D structure databases
SMRi | P47898 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 109593, 1 interactor |
IntActi | P47898, 1 interactor |
MINTi | P47898 |
STRINGi | 9606.ENSP00000287907 |
Chemistry databases
BindingDBi | P47898 |
ChEMBLi | CHEMBL3426 |
DrugBanki | DB01238, Aripiprazole DB06216, Asenapine DB00408, Loxapine DB00246, Ziprasidone |
DrugCentrali | P47898 |
GuidetoPHARMACOLOGYi | 10 |
Protein family/group databases
GPCRDBi | Search... |
PTM databases
GlyGeni | P47898, 2 sites |
iPTMneti | P47898 |
PhosphoSitePlusi | P47898 |
Genetic variation databases
BioMutai | HTR5A |
DMDMi | 1345607 |
Proteomic databases
MassIVEi | P47898 |
PaxDbi | P47898 |
PeptideAtlasi | P47898 |
PRIDEi | P47898 |
Protocols and materials databases
Antibodypediai | 18848, 355 antibodies from 29 providers |
DNASUi | 3361 |
Genome annotation databases
Ensembli | ENST00000287907; ENSP00000287907; ENSG00000157219 |
GeneIDi | 3361 |
KEGGi | hsa:3361 |
MANE-Selecti | ENST00000287907.3; ENSP00000287907.2; NM_024012.4; NP_076917.1 |
UCSCi | uc003wlu.3, human |
Organism-specific databases
CTDi | 3361 |
DisGeNETi | 3361 |
GeneCardsi | HTR5A |
HGNCi | HGNC:5300, HTR5A |
HPAi | ENSG00000157219, Tissue enriched (brain) |
MIMi | 601305, gene |
neXtProti | NX_P47898 |
OpenTargetsi | ENSG00000157219 |
PharmGKBi | PA29558 |
VEuPathDBi | HostDB:ENSG00000157219 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG3656, Eukaryota |
GeneTreei | ENSGT01030000234619 |
HOGENOMi | CLU_009579_11_6_1 |
InParanoidi | P47898 |
OMAi | RRISNIM |
OrthoDBi | 817833at2759 |
PhylomeDBi | P47898 |
TreeFami | TF316350 |
Enzyme and pathway databases
PathwayCommonsi | P47898 |
Reactomei | R-HSA-390666, Serotonin receptors R-HSA-418594, G alpha (i) signalling events |
SignaLinki | P47898 |
SIGNORi | P47898 |
Miscellaneous databases
BioGRID-ORCSi | 3361, 4 hits in 1034 CRISPR screens |
GeneWikii | 5-HT5A_receptor |
GenomeRNAii | 3361 |
Pharosi | P47898, Tchem |
PROi | PR:P47898 |
RNActi | P47898, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000157219, Expressed in cerebellum and 55 other tissues |
ExpressionAtlasi | P47898, baseline and differential |
Genevisiblei | P47898, HS |
Family and domain databases
InterProi | View protein in InterPro IPR001397, 5HT5A_rcpt IPR002231, 5HT_rcpt IPR000276, GPCR_Rhodpsn IPR017452, GPCR_Rhodpsn_7TM |
PANTHERi | PTHR24247:SF108, PTHR24247:SF108, 1 hit |
Pfami | View protein in Pfam PF00001, 7tm_1, 1 hit |
PRINTSi | PR00518, 5HT5ARECEPTR PR01101, 5HTRECEPTOR PR00237, GPCRRHODOPSN |
PROSITEi | View protein in PROSITE PS00237, G_PROTEIN_RECEP_F1_1, 1 hit PS50262, G_PROTEIN_RECEP_F1_2, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | 5HT5A_HUMAN | |
Accessioni | P47898Primary (citable) accession number: P47898 Secondary accession number(s): Q2M2D2 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | February 1, 1996 |
Last sequence update: | February 1, 1996 | |
Last modified: | February 23, 2022 | |
This is version 171 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- 7-transmembrane G-linked receptors
List of 7-transmembrane G-linked receptor entries - Human chromosome 7
Human chromosome 7: entries, gene names and cross-references to MIM - Human entries with genetic variants
List of human entries with genetic variants - Human variants curated from literature reports
Index of human variants curated from literature reports - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families