UniProtKB - P47897 (SYQ_HUMAN)

BLAST

>sp|P47897|SYQ_HUMAN Glutamine--tRNA ligase OS=Homo sapiens OX=9606 GN=QARS PE=1 SV=1
MAALDSLSLFTSLGLSEQKARETLKNSALSAQLREAATQAQQTLGSTIDKATGILLYGLA
SRLRDTRRLSFLVSYIASKKIHTEPQLSAALEYVRSHPLDPIDTVDFERECGVGVIVTPE
QIEEAVEAAINRHRPQLLVERYHFNMGLLMGEARAVLKWADGKMIKNEVDMQVLHLLGPK
LEADLEKKFKVAKARLEETDRRTAKDVVENGETADQTLSLMEQLRGEALKFHKPGENYKT
PGYVVTPHTMNLLKQHLEITGGQVRTRFPPEPNGILHIGHAKAINFNFGYAKANNGICFL
RFDDTNPEKEEAKFFTAICDMVAWLGYTPYKVTYASDYFDQLYAWAVELIRRGLAYVCHQ
RGEELKGHNTLPSPWRDRPMEESLLLFEAMRKGKFSEGEATLRMKLVMEDGKMDPVAYRV
KYTPHHRTGDKWCIYPTYDYTHCLCDSIEHITHSLCTKEFQARRSSYFWLCNALDVYCPV
QWEYGRLNLHYAVVSKRKILQLVATGAVRDWDDPRLFTLTALRRRGFPPEAINNFCARVG
VTVAQTTMEPHLLEACVRDVLNDTAPRAMAVLESLRVIITNFPAAKSLDIQVPNFPADET
KGFHQVPFAPIVFIERTDFKEEPEPGFKRLAWGQPVGLRHTGYVIELQHVVKGPSGCVES
LEVTCRRADAGEKPKAFIHWVSQPLMCEVRLYERLFQHKNPEDPTEVPGGFLSDLNLASL
HVVDAALVDCSVALAKPFDKFQFERLGYFSVDPDSHQGKLVFNRTVTLKEDPGKV

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History
Entry version 187 (10 Oct 2018)
Sequence version 1 (01 Feb 1996)
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Protein

Glutamine--tRNA ligase

Gene

QARS

Organism

Homo sapiens (Human)

Status

Reviewed-Annotation score: -Experimental evidence at protein levelⁱ

Functionⁱ

Glutamine--tRNA ligase (PubMed:26869582). Plays a critical role in brain development (PubMed:24656866).2 Publications

Catalytic activityⁱ

Sites

Feature key	Position(s)	DescriptionActions	Length
Binding siteⁱ	303	L-glutamineBy similarity	1
Binding siteⁱ	438	L-glutamineBy similarity	1
Binding siteⁱ	457	ATPBy similarity	1

Regions

Feature key	Position(s)	DescriptionActions	Length
Nucleotide bindingⁱ	271 – 273	ATPBy similarity	3
Nucleotide bindingⁱ	277 – 283	ATPBy similarity	7
Nucleotide bindingⁱ	486 – 487	ATPBy similarity	2
Nucleotide bindingⁱ	494 – 496	ATPBy similarity	3

GO - Molecular functionⁱ

ATP binding Source: UniProtKB-KW
glutamine-tRNA ligase activity
Source: UniProtKB
Inferred from direct assayⁱ
- 26869582
protein kinase binding
Source: CAFA
Inferred from physical interactionⁱ
- 11096076
protein kinase inhibitor activity
Source: CAFA
Inferred from mutant phenotypeⁱ
- 11096076

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

brain development
Source: UniProtKB
Inferred from mutant phenotypeⁱ
- 24656866
glutaminyl-tRNA aminoacylation
Source: UniProtKB
Inferred from direct assayⁱ
- 24656866
- 26869582
negative regulation of apoptotic signaling pathway
Source: CAFA
Inferred from direct assayⁱ
- 11096076
negative regulation of protein kinase activity
Source: CAFA
Inferred from direct assayⁱ
- 11096076
negative regulation of stress-activated MAPK cascade
Source: CAFA
Inferred from direct assayⁱ
- 11096076
negative regulation of transcription, DNA-templated
Source: CAFA
Inferred from direct assayⁱ
- 11096076
tRNA aminoacylation for protein translation Source: Reactome

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Aminoacyl-tRNA synthetase, Ligase
Biological process	Protein biosynthesis
Ligand	ATP-binding, Nucleotide-binding

Enzyme and pathway databases

Reactomeⁱ	R-HSA-2408517 SeMet incorporation into proteins R-HSA-379716 Cytosolic tRNA aminoacylation R-HSA-379726 Mitochondrial tRNA aminoacylation

Reactomeⁱ

R-HSA-2408517 SeMet incorporation into proteins
R-HSA-379716 Cytosolic tRNA aminoacylation
R-HSA-379726 Mitochondrial tRNA aminoacylation

Protein family/group databases

MoonProtⁱ	P47897

MoonProtⁱ

P47897

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Glutamine--tRNA ligase (EC:6.1.1.182 Publications) Alternative name(s): Glutaminyl-tRNA synthetase Short name: GlnRS2 Publications
Gene namesⁱ	Name:QARS
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Chromosome 3

Organism-specific databases

EuPathDBⁱ	HostDB:ENSG00000172053.15
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:9751 QARS
MIMⁱ	603727 gene
neXtProtⁱ	NX_P47897

Keywords - Cellular componentⁱ

Cytoplasm

Pathology & Biotechⁱ

Involvement in diseaseⁱ

Microcephaly, progressive, with seizures and cerebral and cerebellar atrophy (MSCCA)2 Publications

The disease is caused by mutations affecting the gene represented in this entry.

Disease descriptionA severe, autosomal recessive, neurodevelopmental and neurodegenerative disorder characterized by progressive microcephaly, severe seizures in infancy, atrophy of the cerebral cortex and cerebellar vermis, and mild atrophy of the cerebellar hemispheres, resulting in profoundly delayed development and hypotonia.

Mutagenesis

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Mutagenesisⁱ	175	H → A: Decreases catalytic efficiency about 60-fold. 1 Publication		1

Keywords - Diseaseⁱ

Disease mutation, Epilepsy, Primary microcephaly

Organism-specific databases

DisGeNET More...DisGeNETⁱ	5859
MalaCards human disease database More...MalaCardsⁱ	QARS
MIMⁱ	615760 phenotype
Open Targets More...OpenTargetsⁱ	ENSG00000172053
Orphanetⁱ	404437 Diffuse cerebral and cerebellar atrophy-intractable seizures-progressive microcephaly syndrome
PharmGKBⁱ	PA34093

Chemistry databases

ChEMBLⁱ	CHEMBL3054
Drug and drug target database More...DrugBankⁱ	DB00130 L-Glutamine

Polymorphism and mutation databases

DMDMⁱ	1351170

DMDMⁱ

1351170

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Initiator methionineⁱ		RemovedCombined sources1 Publication
ChainⁱPRO_0000195860	2 – 775	Glutamine--tRNA ligaseAdd BLAST		774

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Modified residueⁱ	2	N-acetylalanineCombined sources1 Publication	1
Modified residueⁱ	70	PhosphoserineCombined sources	1
Modified residueⁱ	309	N6-acetyllysineCombined sources	1
Modified residueⁱ	495	PhosphoserineCombined sources	1

Keywords - PTMⁱ

Acetylation, Phosphoprotein

Proteomic databases

EPDⁱ	P47897
MaxQB - The MaxQuant DataBase More...MaxQBⁱ	P47897
PaxDbⁱ	P47897
PeptideAtlas More...PeptideAtlasⁱ	P47897
PRIDEⁱ	P47897
ProteomicsDBⁱ	55816

PTM databases

iPTMnetⁱ	P47897
PhosphoSitePlusⁱ	P47897
SwissPalmⁱ	P47897

Expressionⁱ

Tissue specificityⁱ

Highly expressed in fetal cerebral cortex, particularly in the ventricular zone, inner subventricular zone, outer subventricular zone, and cortical plate.1 Publication

Gene expression databases

Bgeeⁱ	ENSG00000172053 Expressed in 233 organ(s), highest expression level in left lobe of thyroid gland
CleanExⁱ	HS_QARS
ExpressionAtlasⁱ	P47897 baseline and differential
Genevisibleⁱ	P47897 HS

Organism-specific databases

Human Protein Atlas More...HPAⁱ	HPA036986 HPA036987

HPAⁱ

HPA036986
HPA036987

Interactionⁱ

Subunit structureⁱ

Monomer (PubMed:26869582). Part of a multisubunit complex that groups tRNA ligases for Arg (RARS), Asp (DARS), Gln (QARS), Ile (IARS), Leu (LARS), Lys (KARS), Met (MARS) the bifunctional ligase for Glu and Pro (EPRS) and the auxiliary subunits AIMP1/p43, AIMP2/p38 and EEF1E1/p18 (PubMed:19131329, PubMed:19289464). Interacts with RARS (PubMed:24656866). Part of a complex composed of RARS, QARS and AIMP1 (PubMed:25288775).5 Publications

Binary interactionsⁱ

With	Entry	#Exp.	IntAct
ACTN2	P35609	3	EBI-347462,EBI-77797
AES	Q08117	3	EBI-10209725,EBI-717810
DTX2	Q86UW9	3	EBI-10209725,EBI-740376
KLC3	Q6P597	3	EBI-10209725,EBI-1643885
LZTS2	Q9BRK4	5	EBI-347462,EBI-741037
RNF11	Q9Y3C5	4	EBI-347462,EBI-396669
TCF12	Q99081	3	EBI-347462,EBI-722877
TRAF4	Q9BUZ4	5	EBI-347462,EBI-3650647
TRIP13	Q15645	5	EBI-347462,EBI-358993
VPS37B	Q9H9H4	3	EBI-10209725,EBI-4400866

GO - Molecular functionⁱ

protein kinase binding
Source: CAFA
Inferred from physical interactionⁱ
- 11096076

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

BioGridⁱ	111797, 196 interactors
CORUMⁱ	P47897
IntActⁱ	P47897, 111 interactors
Molecular INTeraction database More...MINTⁱ	P47897
STRINGⁱ	9606.ENSP00000307567

Chemistry databases

BindingDBⁱ

P47897

Structureⁱ

Secondary structure

Legend: HelixTurnBeta strandPDB Structure known for this area

Feature key	Position(s)	DescriptionActions	Length
Helixⁱ	6 – 12	Combined sources	7
Helixⁱ	17 – 25	Combined sources	9
Helixⁱ	27 – 42	Combined sources	16
Turnⁱ	43 – 45	Combined sources	3
Helixⁱ	50 – 62	Combined sources	13
Helixⁱ	66 – 68	Combined sources	3
Helixⁱ	69 – 77	Combined sources	9
Helixⁱ	84 – 94	Combined sources	11
Helixⁱ	104 – 110	Combined sources	7
Helixⁱ	119 – 140	Combined sources	22
Helixⁱ	141 – 143	Combined sources	3
Helixⁱ	147 – 154	Combined sources	8
Helixⁱ	162 – 177	Combined sources	16
Helixⁱ	220 – 223	Combined sources	4
Helixⁱ	226 – 229	Combined sources	4
Helixⁱ	237 – 239	Combined sources	3
Helixⁱ	249 – 260	Combined sources	12
Beta strandⁱ	265 – 268	Combined sources	4
Helixⁱ	278 – 293	Combined sources	16
Beta strandⁱ	297 – 302	Combined sources	6
Helixⁱ	312 – 324	Combined sources	13
Beta strandⁱ	330 – 334	Combined sources	5
Helixⁱ	335 – 338	Combined sources	4
Helixⁱ	339 – 351	Combined sources	13
Beta strandⁱ	354 – 358	Combined sources	5
Turnⁱ	374 – 377	Combined sources	4
Helixⁱ	380 – 391	Combined sources	12
Beta strandⁱ	401 – 404	Combined sources	4
Beta strandⁱ	416 – 420	Combined sources	5
Turnⁱ	426 – 428	Combined sources	3
Beta strandⁱ	433 – 436	Combined sources	4
Helixⁱ	438 – 448	Combined sources	11
Beta strandⁱ	452 – 457	Combined sources	6
Helixⁱ	464 – 473	Combined sources	10
Beta strandⁱ	480 – 484	Combined sources	5
Beta strandⁱ	487 – 489	Combined sources	3
Helixⁱ	496 – 504	Combined sources	9
Beta strandⁱ	507 – 510	Combined sources	4
Helixⁱ	519 – 524	Combined sources	6
Helixⁱ	529 – 539	Combined sources	11
Beta strandⁱ	546 – 548	Combined sources	3
Helixⁱ	551 – 564	Combined sources	14
Beta strandⁱ	570 – 576	Combined sources	7
Beta strandⁱ	578 – 581	Combined sources	4
Beta strandⁱ	592 – 594	Combined sources	3
Helixⁱ	599 – 601	Combined sources	3
Beta strandⁱ	603 – 606	Combined sources	4
Beta strandⁱ	613 – 615	Combined sources	3
Turnⁱ	616 – 618	Combined sources	3
Beta strandⁱ	647 – 650	Combined sources	4
Beta strandⁱ	654 – 656	Combined sources	3
Beta strandⁱ	661 – 663	Combined sources	3
Beta strandⁱ	681 – 683	Combined sources	3
Beta strandⁱ	685 – 692	Combined sources	8
Beta strandⁱ	695 – 700	Combined sources	6
Turnⁱ	702 – 705	Combined sources	4
Turnⁱ	711 – 714	Combined sources	4
Beta strandⁱ	720 – 722	Combined sources	3
Beta strandⁱ	725 – 728	Combined sources	4
Beta strandⁱ	732 – 734	Combined sources	3
Beta strandⁱ	740 – 743	Combined sources	4
Turnⁱ	744 – 746	Combined sources	3
Beta strandⁱ	747 – 751	Combined sources	5
Beta strandⁱ	757 – 759	Combined sources	3
Beta strandⁱ	761 – 766	Combined sources	6

Show more details

3D structure databases

ProteinModelPortalⁱ	P47897
SMRⁱ	P47897
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Motif

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Motifⁱ	270 – 280	"HIGH" region1 PublicationAdd BLAST		11
Motifⁱ	493 – 497	"KMSKS" region1 Publication		5

Sequence similaritiesⁱ

Belongs to the class-I aminoacyl-tRNA synthetase family.Curated

Phylogenomic databases

eggNOGⁱ	KOG1148 Eukaryota COG0008 LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00550000074972
HOGENOMⁱ	HOG000259233
HOVERGENⁱ	HBG000889
InParanoidⁱ	P47897
KEGG Orthology (KO) More...KOⁱ	K01886
OMAⁱ	VTHSICT
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G026F
PhylomeDBⁱ	P47897
TreeFamⁱ	TF105683

Family and domain databases

Gene3Dⁱ	2.40.240.10, 3 hits 3.40.50.620, 1 hit
InterProⁱ	View protein in InterPro IPR001412 aa-tRNA-synth_I_CS IPR004514 Gln-tRNA-synth IPR007638 Gln-tRNA-synth_Ib_RNA-bd_2 IPR007639 Gln-tRNA-synth_Ib_RNA-bd_N IPR000924 Glu/Gln-tRNA-synth IPR020058 Glu/Gln-tRNA-synth_Ib_cat-dom IPR020059 Glu/Gln-tRNA-synth_Ib_codon-bd IPR020056 Rbsml_L25/Gln-tRNA_synth_N IPR011035 Ribosomal_L25/Gln-tRNA_synth IPR014729 Rossmann-like_a/b/a_fold
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00749 tRNA-synt_1c, 1 hit PF03950 tRNA-synt_1c_C, 1 hit PF04558 tRNA_synt_1c_R1, 1 hit PF04557 tRNA_synt_1c_R2, 1 hit
PRINTSⁱ	PR00987 TRNASYNTHGLU
SUPFAMⁱ	SSF50715 SSF50715, 1 hit
TIGRFAMsⁱ	TIGR00440 glnS, 1 hit
PROSITEⁱ	View protein in PROSITE PS00178 AA_TRNA_LIGASE_I, 1 hit

Sequences (2+)ⁱ

Sequence statusⁱ: Complete.

Sequence processingⁱ: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsⁱ produced by alternative splicing. Align Add to basket

This entry has 2 described isoforms and 22 potential isoforms that are computationally mapped.Show all Align All

Isoform 1 (identifier: P47897-1) [UniParc]FASTA Add to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAALDSLSLF TSLGLSEQKA RETLKNSALS AQLREAATQA QQTLGSTIDK 
        60         70         80         90        100
ATGILLYGLA SRLRDTRRLS FLVSYIASKK IHTEPQLSAA LEYVRSHPLD 
       110        120        130        140        150
PIDTVDFERE CGVGVIVTPE QIEEAVEAAI NRHRPQLLVE RYHFNMGLLM 
       160        170        180        190        200
GEARAVLKWA DGKMIKNEVD MQVLHLLGPK LEADLEKKFK VAKARLEETD 
       210        220        230        240        250
RRTAKDVVEN GETADQTLSL MEQLRGEALK FHKPGENYKT PGYVVTPHTM 
       260        270        280        290        300
NLLKQHLEIT GGQVRTRFPP EPNGILHIGH AKAINFNFGY AKANNGICFL 
       310        320        330        340        350
RFDDTNPEKE EAKFFTAICD MVAWLGYTPY KVTYASDYFD QLYAWAVELI 
       360        370        380        390        400
RRGLAYVCHQ RGEELKGHNT LPSPWRDRPM EESLLLFEAM RKGKFSEGEA 
       410        420        430        440        450
TLRMKLVMED GKMDPVAYRV KYTPHHRTGD KWCIYPTYDY THCLCDSIEH 
       460        470        480        490        500
ITHSLCTKEF QARRSSYFWL CNALDVYCPV QWEYGRLNLH YAVVSKRKIL 
       510        520        530        540        550
QLVATGAVRD WDDPRLFTLT ALRRRGFPPE AINNFCARVG VTVAQTTMEP 
       560        570        580        590        600
HLLEACVRDV LNDTAPRAMA VLESLRVIIT NFPAAKSLDI QVPNFPADET 
       610        620        630        640        650
KGFHQVPFAP IVFIERTDFK EEPEPGFKRL AWGQPVGLRH TGYVIELQHV 
       660        670        680        690        700
VKGPSGCVES LEVTCRRADA GEKPKAFIHW VSQPLMCEVR LYERLFQHKN 
       710        720        730        740        750
PEDPTEVPGG FLSDLNLASL HVVDAALVDC SVALAKPFDK FQFERLGYFS 
       760        770 
VDPDSHQGKL VFNRTVTLKE DPGKV

Length:775

Mass (Da):87,799

Last modified:February 1, 1996 - v1

Checksum:ⁱADDE23E6C442FF73

Isoform 2 (identifier: P47897-2) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
78-89: SKKIHTEPQLSA → T

« Hide

        10         20         30         40         50
MAALDSLSLF TSLGLSEQKA RETLKNSALS AQLREAATQA QQTLGSTIDK 
        60         70         80         90        100
ATGILLYGLA SRLRDTRRLS FLVSYIATAL EYVRSHPLDP IDTVDFEREC 
       110        120        130        140        150
GVGVIVTPEQ IEEAVEAAIN RHRPQLLVER YHFNMGLLMG EARAVLKWAD 
       160        170        180        190        200
GKMIKNEVDM QVLHLLGPKL EADLEKKFKV AKARLEETDR RTAKDVVENG 
       210        220        230        240        250
ETADQTLSLM EQLRGEALKF HKPGENYKTP GYVVTPHTMN LLKQHLEITG 
       260        270        280        290        300
GQVRTRFPPE PNGILHIGHA KAINFNFGYA KANNGICFLR FDDTNPEKEE 
       310        320        330        340        350
AKFFTAICDM VAWLGYTPYK VTYASDYFDQ LYAWAVELIR RGLAYVCHQR 
       360        370        380        390        400
GEELKGHNTL PSPWRDRPME ESLLLFEAMR KGKFSEGEAT LRMKLVMEDG 
       410        420        430        440        450
KMDPVAYRVK YTPHHRTGDK WCIYPTYDYT HCLCDSIEHI THSLCTKEFQ 
       460        470        480        490        500
ARRSSYFWLC NALDVYCPVQ WEYGRLNLHY AVVSKRKILQ LVATGAVRDW 
       510        520        530        540        550
DDPRLFTLTA LRRRGFPPEA INNFCARVGV TVAQTTMEPH LLEACVRDVL 
       560        570        580        590        600
NDTAPRAMAV LESLRVIITN FPAAKSLDIQ VPNFPADETK GFHQVPFAPI 
       610        620        630        640        650
VFIERTDFKE EPEPGFKRLA WGQPVGLRHT GYVIELQHVV KGPSGCVESL 
       660        670        680        690        700
EVTCRRADAG EKPKAFIHWV SQPLMCEVRL YERLFQHKNP EDPTEVPGGF 
       710        720        730        740        750
LSDLNLASLH VVDAALVDCS VALAKPFDKF QFERLGYFSV DPDSHQGKLV 
       760 
FNRTVTLKED PGKV

Show »

Length:764

Mass (Da):86,579

Checksum:ⁱBA9B1C92EE0C2F72

Computationally mapped potential isoform sequencesⁱ

There are 22 potential isoforms mapped to this entry.BLAST Align Show all Add to basket

	Entry	Entry name	Protein names	Gene names	Length	Annotation

	A0A0U1RQL2	A0A0U1RQL2_HUMAN	Glutamine--tRNA ligase Glutamine--tRNA ligase	QARS	191	Annotation score:
	B4DDN1	B4DDN1_HUMAN	Glutamine--tRNA ligase Glutamine--tRNA ligase (Glutaminyl-tRNA synthetase, isoform CRA_a) (cDNA FLJ54487, highly similar to Glutaminyl-tRNA synthetase)	QARS hCG_96727	630	Annotation score:
	A0A0U1RQT0	A0A0U1RQT0_HUMAN	Glutamine--tRNA ligase Glutamine--tRNA ligase	QARS	342	Annotation score:
	H7C0R3	H7C0R3_HUMAN	Glutamine--tRNA ligase Glutamine--tRNA ligase	QARS	253	Annotation score:
	C9J165	C9J165_HUMAN	Glutamine--tRNA ligase Glutamine--tRNA ligase	QARS	339	Annotation score:
	A0A1B0GVU9	A0A1B0GVU9_HUMAN	Glutamine--tRNA ligase Glutamine--tRNA ligase	QARS	736	Annotation score:
	A0A0U1RR66	A0A0U1RR66_HUMAN	Glutamine--tRNA ligase Glutamine--tRNA ligase	QARS	173	Annotation score:
	A0A1B0GTT3	A0A1B0GTT3_HUMAN	Glutamine--tRNA ligase Glutamine--tRNA ligase	QARS	169	Annotation score:
	A0A0U1RQQ5	A0A0U1RQQ5_HUMAN	Glutamine--tRNA ligase Glutamine--tRNA ligase	QARS	194	Annotation score:
	A0A0U1RQJ6	A0A0U1RQJ6_HUMAN	Glutamine--tRNA ligase Glutamine--tRNA ligase	QARS	96	Annotation score:
There are more potential isoformsShow all

Natural variant

Feature key	Position(s)	DescriptionActions	Length
Natural variantⁱVAR_071189	45	G → V in MSCCA; results in reduced glutaminyl-tRNA aminoacylation activity; does not affect interaction with RARS. 2 PublicationsCorresponds to variant dbSNP:rs587777331EnsemblClinVar.	1
Natural variantⁱVAR_071190	57	Y → H in MSCCA; results in reduced glutaminyl-tRNA aminoacylation activity; does not affect interaction with RARS. 2 PublicationsCorresponds to variant dbSNP:rs587777333EnsemblClinVar.	1
Natural variantⁱVAR_071191	403	R → W in MSCCA; results in loss of glutaminyl-tRNA aminoacylation activity; impairs protein folding; does not interact with RARS; results in reduced protein solubility. 2 PublicationsCorresponds to variant dbSNP:rs587777332EnsemblClinVar.	1
Natural variantⁱVAR_071192	515	R → W in MSCCA; results in loss of glutaminyl-tRNA aminoacylation activity; impairs protein folding; results in reduced protein solubility. 2 PublicationsCorresponds to variant dbSNP:rs587777334EnsemblClinVar.	1

Alternative sequence

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Alternative sequenceⁱVSP_055107	78 – 89	SKKIH…PQLSA → T in isoform 2. 1 PublicationAdd BLAST		12

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	X76013 mRNA Translation: CAA53600.1 AK301559 mRNA Translation: BAG63054.1 AC135506 Genomic DNA No translation available. BC000394 mRNA Translation: AAH00394.1 BC001567 mRNA Translation: AAH01567.1 BC029739 mRNA Translation: AAH29739.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS2788.1 [P47897-1] CCDS63633.1 [P47897-2]
PIRⁱ	I37422
NCBI Reference Sequences More...RefSeqⁱ	NP_001259002.1, NM_001272073.1 [P47897-2] NP_005042.1, NM_005051.2 [P47897-1]
UniGeneⁱ	Hs.79322

Genome annotation databases

Ensemblⁱ	ENST00000306125; ENSP00000307567; ENSG00000172053 [P47897-1] ENST00000414533; ENSP00000390015; ENSG00000172053 [P47897-2]
GeneIDⁱ	5859
KEGGⁱ	hsa:5859
UCSC genome browser More...UCSCⁱ	uc003cvx.5 human [P47897-1]

Keywords - Coding sequence diversityⁱ

Alternative splicing

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
P47897	Glutamine--tRNA ligase-like		RAT		775	UniRef100_P47897
Glutamine--tRNA ligase (Fragment)		HUMAN		96
Glutamine--tRNA ligase		HUMAN		630
QARS protein (Fragment)		HUMAN		618
UPI0005148B78		HUMAN		799

Protein	Similar proteins		Species	Score	Length	Source
P47897	Glutamine--tRNA ligase		RAT		775	UniRef90_P47897
Glutamine--tRNA ligase		MOUSE		775
Glutamine--tRNA ligase		BOVIN		775
Glutamine--tRNA ligase (Fragment)		HUMAN		96
Uncharacterized protein		PONAB		793
+210

Protein	Similar proteins		Species	Score	Length	Source
P47897	Glutamine--tRNA ligase		BOVIN		775	UniRef50_P47897
Glutamine--tRNA ligase		RAT		775
Glutamine--tRNA ligase		MOUSE		775
Glutamine--tRNA ligase (Fragment)		HUMAN		96
LOW QUALITY PROTEIN: glutamine--tRNA ligase		LIPVE		793
+218

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	X76013 mRNA Translation: CAA53600.1 AK301559 mRNA Translation: BAG63054.1 AC135506 Genomic DNA No translation available. BC000394 mRNA Translation: AAH00394.1 BC001567 mRNA Translation: AAH01567.1 BC029739 mRNA Translation: AAH29739.1
CCDSⁱ	CCDS2788.1 [P47897-1] CCDS63633.1 [P47897-2]
PIRⁱ	I37422
RefSeqⁱ	NP_001259002.1, NM_001272073.1 [P47897-2] NP_005042.1, NM_005051.2 [P47897-1]
UniGeneⁱ	Hs.79322

3D structure databases

Select the link destinations: Protein Data Bank Europe More...PDBeⁱ Protein Data Bank RCSB More...RCSB PDBⁱ Protein Data Bank Japan More...PDBjⁱ Links Updated	PDB entry	Method	Resolution (Å)	Chain	Positions	PDBsum
	4R3Z	X-ray	4.03	C	1-775	[»]
	4YE6	X-ray	2.40	A	1-775	[»]
	4YE8	X-ray	3.30	A	1-775	[»]
	4YE9	X-ray	2.70	A	1-775	[»]
ProteinModelPortalⁱ	P47897
SMRⁱ	P47897
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	111797, 196 interactors
CORUMⁱ	P47897
IntActⁱ	P47897, 111 interactors
MINTⁱ	P47897
STRINGⁱ	9606.ENSP00000307567

Chemistry databases

BindingDBⁱ	P47897
ChEMBLⁱ	CHEMBL3054
DrugBankⁱ	DB00130 L-Glutamine

Protein family/group databases

MoonProtⁱ	P47897

MoonProtⁱ

P47897

PTM databases

iPTMnetⁱ	P47897
PhosphoSitePlusⁱ	P47897
SwissPalmⁱ	P47897

Polymorphism and mutation databases

DMDMⁱ	1351170

DMDMⁱ

1351170

Proteomic databases

EPDⁱ	P47897
MaxQBⁱ	P47897
PaxDbⁱ	P47897
PeptideAtlasⁱ	P47897
PRIDEⁱ	P47897
ProteomicsDBⁱ	55816

Protocols and materials databases

The DNASU plasmid repository More...DNASUⁱ	5859
Structural Biology Knowledgebase	Search...

Genome annotation databases

Ensemblⁱ	ENST00000306125; ENSP00000307567; ENSG00000172053 [P47897-1] ENST00000414533; ENSP00000390015; ENSG00000172053 [P47897-2]
GeneIDⁱ	5859
KEGGⁱ	hsa:5859
UCSCⁱ	uc003cvx.5 human [P47897-1]

Organism-specific databases

CTDⁱ	5859
DisGeNETⁱ	5859
EuPathDBⁱ	HostDB:ENSG00000172053.15
GeneCardsⁱ	QARS
HGNCⁱ	HGNC:9751 QARS
HPAⁱ	HPA036986 HPA036987
MalaCardsⁱ	QARS
MIMⁱ	603727 gene 615760 phenotype
neXtProtⁱ	NX_P47897
OpenTargetsⁱ	ENSG00000172053
Orphanetⁱ	404437 Diffuse cerebral and cerebellar atrophy-intractable seizures-progressive microcephaly syndrome
PharmGKBⁱ	PA34093
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

eggNOGⁱ	KOG1148 Eukaryota COG0008 LUCA
GeneTreeⁱ	ENSGT00550000074972
HOGENOMⁱ	HOG000259233
HOVERGENⁱ	HBG000889
InParanoidⁱ	P47897
KOⁱ	K01886
OMAⁱ	VTHSICT
OrthoDBⁱ	EOG091G026F
PhylomeDBⁱ	P47897
TreeFamⁱ	TF105683

Enzyme and pathway databases

Reactomeⁱ	R-HSA-2408517 SeMet incorporation into proteins R-HSA-379716 Cytosolic tRNA aminoacylation R-HSA-379726 Mitochondrial tRNA aminoacylation

Reactomeⁱ

R-HSA-2408517 SeMet incorporation into proteins
R-HSA-379716 Cytosolic tRNA aminoacylation
R-HSA-379726 Mitochondrial tRNA aminoacylation

Miscellaneous databases

ChiTaRSⁱ	QARS human
GeneWikiⁱ	QARS
GenomeRNAiⁱ	5859
Protein Ontology More...PROⁱ	PR:P47897
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSG00000172053 Expressed in 233 organ(s), highest expression level in left lobe of thyroid gland
CleanExⁱ	HS_QARS
ExpressionAtlasⁱ	P47897 baseline and differential
Genevisibleⁱ	P47897 HS

Family and domain databases

Gene3Dⁱ	2.40.240.10, 3 hits 3.40.50.620, 1 hit
InterProⁱ	View protein in InterPro IPR001412 aa-tRNA-synth_I_CS IPR004514 Gln-tRNA-synth IPR007638 Gln-tRNA-synth_Ib_RNA-bd_2 IPR007639 Gln-tRNA-synth_Ib_RNA-bd_N IPR000924 Glu/Gln-tRNA-synth IPR020058 Glu/Gln-tRNA-synth_Ib_cat-dom IPR020059 Glu/Gln-tRNA-synth_Ib_codon-bd IPR020056 Rbsml_L25/Gln-tRNA_synth_N IPR011035 Ribosomal_L25/Gln-tRNA_synth IPR014729 Rossmann-like_a/b/a_fold
Pfamⁱ	View protein in Pfam PF00749 tRNA-synt_1c, 1 hit PF03950 tRNA-synt_1c_C, 1 hit PF04558 tRNA_synt_1c_R1, 1 hit PF04557 tRNA_synt_1c_R2, 1 hit
PRINTSⁱ	PR00987 TRNASYNTHGLU
SUPFAMⁱ	SSF50715 SSF50715, 1 hit
TIGRFAMsⁱ	TIGR00440 glnS, 1 hit
PROSITEⁱ	View protein in PROSITE PS00178 AA_TRNA_LIGASE_I, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	SYQ_HUMAN
Accessionⁱ	P47897Primary (citable) accession number: P47897 Secondary accession number(s): B4DWJ2
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	February 1, 1996
	Last sequence update:	February 1, 1996
	Last modified:	October 10, 2018
	This is version 187 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Keywords - Technical termⁱ

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

Human chromosome 3
Human chromosome 3: entries, gene names and cross-references to MIM
Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations
Aminoacyl-tRNA synthetases
List of aminoacyl-tRNA synthetase entries
SIMILARITY comments
Index of protein domains and families
PDB cross-references
Index of Protein Data Bank (PDB) cross-references
Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

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UniProtKB - P47897 (SYQ_HUMAN)

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Glutamine--tRNA ligase

QARS

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<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

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<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

Protein family/group databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Cytosol

Other locations

Cytosol

Mitochondrion

Other locations

Keywords - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Keywords - Diseasei

Organism-specific databases

Chemistry databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

Chemistry databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Motif

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

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Family and domain databases

Natural variant

Alternative sequence

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

Chemistry databases

Protein family/group databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

Keywords - Diseaseⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

GO - Molecular functionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ