UniProtKB - P47897 (SYQ_HUMAN)
Glutamine--tRNA ligase
QARS1
Functioni
Catalytic activityi
- EC:6.1.1.181 Publication
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Binding sitei | 303 | L-glutamineBy similarity | 1 | |
Binding sitei | 438 | L-glutamineBy similarity | 1 | |
Binding sitei | 457 | ATPBy similarity | 1 |
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Nucleotide bindingi | 271 – 273 | ATPBy similarity | 3 | |
Nucleotide bindingi | 277 – 283 | ATPBy similarity | 7 | |
Nucleotide bindingi | 486 – 487 | ATPBy similarity | 2 | |
Nucleotide bindingi | 494 – 496 | ATPBy similarity | 3 |
GO - Molecular functioni
- ATP binding Source: UniProtKB-KW
- glutamine-tRNA ligase activity Source: UniProtKB
- protein kinase binding Source: CAFA
- protein kinase inhibitor activity Source: CAFA
GO - Biological processi
- brain development Source: UniProtKB
- glutaminyl-tRNA aminoacylation Source: UniProtKB
- negative regulation of apoptotic signaling pathway Source: CAFA
- negative regulation of protein kinase activity Source: CAFA
- negative regulation of stress-activated MAPK cascade Source: CAFA
- negative regulation of transcription, DNA-templated Source: CAFA
- tRNA aminoacylation for protein translation Source: Reactome
Keywordsi
Molecular function | Aminoacyl-tRNA synthetase, Ligase |
Biological process | Protein biosynthesis |
Ligand | ATP-binding, Nucleotide-binding |
Enzyme and pathway databases
PathwayCommonsi | P47897 |
Reactomei | R-HSA-2408522, Selenoamino acid metabolism R-HSA-379716, Cytosolic tRNA aminoacylation R-HSA-379726, Mitochondrial tRNA aminoacylation |
Protein family/group databases
MoonProti | P47897 |
Names & Taxonomyi
Protein namesi | Recommended name: Glutamine--tRNA ligase (EC:6.1.1.182 Publications)Alternative name(s): Glutaminyl-tRNA synthetase Short name: GlnRS2 Publications |
Gene namesi | |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
EuPathDBi | HostDB:ENSG00000172053.15 |
HGNCi | HGNC:9751, QARS1 |
MIMi | 603727, gene |
neXtProti | NX_P47897 |
Subcellular locationi
Cytosol
- cytosol Source: UniProtKB
Mitochondrion
- mitochondrial matrix Source: Reactome
Other locations
- aminoacyl-tRNA synthetase multienzyme complex Source: UniProtKB
- cytoplasm Source: UniProtKB
- protein-containing complex Source: CAFA
Keywords - Cellular componenti
CytoplasmPathology & Biotechi
Involvement in diseasei
Microcephaly, progressive, with seizures and cerebral and cerebellar atrophy (MSCCA)2 Publications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_071189 | 45 | G → V in MSCCA; results in reduced glutaminyl-tRNA aminoacylation activity; does not affect interaction with RARS1. 2 PublicationsCorresponds to variant dbSNP:rs587777331EnsemblClinVar. | 1 | |
Natural variantiVAR_071190 | 57 | Y → H in MSCCA; results in reduced glutaminyl-tRNA aminoacylation activity; does not affect interaction with RARS1. 2 PublicationsCorresponds to variant dbSNP:rs587777333EnsemblClinVar. | 1 | |
Natural variantiVAR_071191 | 403 | R → W in MSCCA; results in loss of glutaminyl-tRNA aminoacylation activity; impairs protein folding; does not interact with RARS1; results in reduced protein solubility. 2 PublicationsCorresponds to variant dbSNP:rs587777332EnsemblClinVar. | 1 | |
Natural variantiVAR_071192 | 515 | R → W in MSCCA; results in loss of glutaminyl-tRNA aminoacylation activity; impairs protein folding; results in reduced protein solubility. 2 PublicationsCorresponds to variant dbSNP:rs587777334EnsemblClinVar. | 1 |
Mutagenesis
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Mutagenesisi | 175 | H → A: Decreases catalytic efficiency about 60-fold. 1 Publication | 1 |
Keywords - Diseasei
Disease mutation, Epilepsy, Primary microcephalyOrganism-specific databases
DisGeNETi | 5859 |
MalaCardsi | QARS1 |
MIMi | 615760, phenotype |
OpenTargetsi | ENSG00000172053 |
Orphaneti | 404437, Diffuse cerebral and cerebellar atrophy-intractable seizures-progressive microcephaly syndrome 423306, Microcephaly-short stature-intellectual disability-facial dysmorphism syndrome |
PharmGKBi | PA34093 |
Miscellaneous databases
Pharosi | P47897, Tchem |
Chemistry databases
ChEMBLi | CHEMBL3054 |
DrugBanki | DB00130, L-Glutamine |
Polymorphism and mutation databases
BioMutai | QARS |
DMDMi | 1351170 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Initiator methioninei | RemovedCombined sources1 Publication | |||
ChainiPRO_0000195860 | 2 – 775 | Glutamine--tRNA ligaseAdd BLAST | 774 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 2 | N-acetylalanineCombined sources1 Publication | 1 | |
Modified residuei | 70 | PhosphoserineCombined sources | 1 | |
Modified residuei | 309 | N6-acetyllysineCombined sources | 1 | |
Modified residuei | 495 | PhosphoserineCombined sources | 1 |
Keywords - PTMi
Acetylation, PhosphoproteinProteomic databases
CPTACi | CPTAC-123 CPTAC-124 |
EPDi | P47897 |
jPOSTi | P47897 |
MassIVEi | P47897 |
MaxQBi | P47897 |
PaxDbi | P47897 |
PeptideAtlasi | P47897 |
PRIDEi | P47897 |
ProteomicsDBi | 5345 55816 [P47897-1] |
PTM databases
iPTMneti | P47897 |
MetOSitei | P47897 |
PhosphoSitePlusi | P47897 |
SwissPalmi | P47897 |
Expressioni
Tissue specificityi
Gene expression databases
Bgeei | ENSG00000172053, Expressed in left lobe of thyroid gland and 246 other tissues |
ExpressionAtlasi | P47897, baseline and differential |
Genevisiblei | P47897, HS |
Organism-specific databases
HPAi | ENSG00000172053, Low tissue specificity |
Interactioni
Subunit structurei
Monomer (PubMed:26869582).
Part of a multisubunit complex that groups tRNA ligases for Arg (RARS1), Asp (DARS1), Gln (QARS1), Ile (IARS1), Leu (LARS1), Lys (KARS1), Met (MARS1) the bifunctional ligase for Glu and Pro (EPRS1) and the auxiliary subunits AIMP1/p43, AIMP2/p38 and EEF1E1/p18 (PubMed:19131329, PubMed:19289464).
Interacts with RARS1 (PubMed:24656866).
Part of a complex composed of RARS1, QARS1 and AIMP1 (PubMed:25288775).
5 PublicationsBinary interactionsi
P47897
Isoform 2 [P47897-2]
GO - Molecular functioni
- protein kinase binding Source: CAFA
Protein-protein interaction databases
BioGRIDi | 111797, 287 interactors |
CORUMi | P47897 |
IntActi | P47897, 132 interactors |
MINTi | P47897 |
STRINGi | 9606.ENSP00000307567 |
Chemistry databases
BindingDBi | P47897 |
Miscellaneous databases
RNActi | P47897, protein |
Structurei
Secondary structure
3D structure databases
SMRi | P47897 |
ModBasei | Search... |
PDBe-KBi | Search... |
Family & Domainsi
Motif
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Motifi | 270 – 280 | 'HIGH' region1 PublicationAdd BLAST | 11 | |
Motifi | 493 – 497 | 'KMSKS' region1 Publication | 5 |
Sequence similaritiesi
Phylogenomic databases
eggNOGi | KOG1148, Eukaryota |
GeneTreei | ENSGT00550000074972 |
HOGENOMi | CLU_001882_2_3_1 |
InParanoidi | P47897 |
OMAi | AHPIEDA |
PhylomeDBi | P47897 |
TreeFami | TF105683 |
Family and domain databases
Gene3Di | 1.10.10.2420, 1 hit 1.10.8.1290, 1 hit 2.40.240.10, 2 hits 3.40.50.620, 1 hit |
InterProi | View protein in InterPro IPR001412, aa-tRNA-synth_I_CS IPR004514, Gln-tRNA-synth IPR007638, Gln-tRNA-synth_Ib_RNA-bd_2 IPR007639, Gln-tRNA-synth_Ib_RNA-bd_N IPR042558, Gln-tRNA-synth_Ib_RNA-bd_N_1 IPR042559, Gln-tRNA-synth_Ib_RNA-bd_N_2 IPR000924, Glu/Gln-tRNA-synth IPR020058, Glu/Gln-tRNA-synth_Ib_cat-dom IPR020059, Glu/Gln-tRNA-synth_Ib_codon-bd IPR020056, Rbsml_L25/Gln-tRNA_synth_N IPR011035, Ribosomal_L25/Gln-tRNA_synth IPR014729, Rossmann-like_a/b/a_fold |
Pfami | View protein in Pfam PF00749, tRNA-synt_1c, 1 hit PF03950, tRNA-synt_1c_C, 1 hit PF04558, tRNA_synt_1c_R1, 1 hit PF04557, tRNA_synt_1c_R2, 1 hit |
PRINTSi | PR00987, TRNASYNTHGLU |
SUPFAMi | SSF50715, SSF50715, 1 hit |
TIGRFAMsi | TIGR00440, glnS, 1 hit |
PROSITEi | View protein in PROSITE PS00178, AA_TRNA_LIGASE_I, 1 hit |
s (2+)i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
This entry describes 2 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 2 described isoforms and 22 potential isoforms that are computationally mapped.Show allAlign All
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MAALDSLSLF TSLGLSEQKA RETLKNSALS AQLREAATQA QQTLGSTIDK
60 70 80 90 100
ATGILLYGLA SRLRDTRRLS FLVSYIASKK IHTEPQLSAA LEYVRSHPLD
110 120 130 140 150
PIDTVDFERE CGVGVIVTPE QIEEAVEAAI NRHRPQLLVE RYHFNMGLLM
160 170 180 190 200
GEARAVLKWA DGKMIKNEVD MQVLHLLGPK LEADLEKKFK VAKARLEETD
210 220 230 240 250
RRTAKDVVEN GETADQTLSL MEQLRGEALK FHKPGENYKT PGYVVTPHTM
260 270 280 290 300
NLLKQHLEIT GGQVRTRFPP EPNGILHIGH AKAINFNFGY AKANNGICFL
310 320 330 340 350
RFDDTNPEKE EAKFFTAICD MVAWLGYTPY KVTYASDYFD QLYAWAVELI
360 370 380 390 400
RRGLAYVCHQ RGEELKGHNT LPSPWRDRPM EESLLLFEAM RKGKFSEGEA
410 420 430 440 450
TLRMKLVMED GKMDPVAYRV KYTPHHRTGD KWCIYPTYDY THCLCDSIEH
460 470 480 490 500
ITHSLCTKEF QARRSSYFWL CNALDVYCPV QWEYGRLNLH YAVVSKRKIL
510 520 530 540 550
QLVATGAVRD WDDPRLFTLT ALRRRGFPPE AINNFCARVG VTVAQTTMEP
560 570 580 590 600
HLLEACVRDV LNDTAPRAMA VLESLRVIIT NFPAAKSLDI QVPNFPADET
610 620 630 640 650
KGFHQVPFAP IVFIERTDFK EEPEPGFKRL AWGQPVGLRH TGYVIELQHV
660 670 680 690 700
VKGPSGCVES LEVTCRRADA GEKPKAFIHW VSQPLMCEVR LYERLFQHKN
710 720 730 740 750
PEDPTEVPGG FLSDLNLASL HVVDAALVDC SVALAKPFDK FQFERLGYFS
760 770
VDPDSHQGKL VFNRTVTLKE DPGKV
Computationally mapped potential isoform sequencesi
There are 22 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketB4DDN1 | B4DDN1_HUMAN | Glutaminyl-tRNA synthetase | QARS1 QARS, hCG_96727 | 630 | Annotation score: | ||
A0A1B0GVU9 | A0A1B0GVU9_HUMAN | Glutaminyl-tRNA synthetase | QARS1 | 736 | Annotation score: | ||
A0A0U1RR66 | A0A0U1RR66_HUMAN | Glutaminyl-tRNA synthetase | QARS1 | 173 | Annotation score: | ||
A0A0U1RQL2 | A0A0U1RQL2_HUMAN | Glutamine--tRNA ligase | QARS1 | 191 | Annotation score: | ||
A0A0U1RQT0 | A0A0U1RQT0_HUMAN | Glutamine--tRNA ligase | QARS1 | 342 | Annotation score: | ||
H7C0R3 | H7C0R3_HUMAN | Glutamine--tRNA ligase | QARS1 | 253 | Annotation score: | ||
C9J165 | C9J165_HUMAN | Glutamine--tRNA ligase | QARS1 | 339 | Annotation score: | ||
A0A0U1RQM8 | A0A0U1RQM8_HUMAN | Glutamine--tRNA ligase | QARS1 | 173 | Annotation score: | ||
A0A0U1RQE9 | A0A0U1RQE9_HUMAN | Glutamine--tRNA ligase | QARS1 | 187 | Annotation score: | ||
A0A0U1RQJ6 | A0A0U1RQJ6_HUMAN | Glutamine--tRNA ligase | QARS1 | 96 | Annotation score: | ||
There are more potential isoformsShow all |
Natural variant
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Natural variantiVAR_071189 | 45 | G → V in MSCCA; results in reduced glutaminyl-tRNA aminoacylation activity; does not affect interaction with RARS1. 2 PublicationsCorresponds to variant dbSNP:rs587777331EnsemblClinVar. | 1 | |
Natural variantiVAR_071190 | 57 | Y → H in MSCCA; results in reduced glutaminyl-tRNA aminoacylation activity; does not affect interaction with RARS1. 2 PublicationsCorresponds to variant dbSNP:rs587777333EnsemblClinVar. | 1 | |
Natural variantiVAR_071191 | 403 | R → W in MSCCA; results in loss of glutaminyl-tRNA aminoacylation activity; impairs protein folding; does not interact with RARS1; results in reduced protein solubility. 2 PublicationsCorresponds to variant dbSNP:rs587777332EnsemblClinVar. | 1 | |
Natural variantiVAR_071192 | 515 | R → W in MSCCA; results in loss of glutaminyl-tRNA aminoacylation activity; impairs protein folding; results in reduced protein solubility. 2 PublicationsCorresponds to variant dbSNP:rs587777334EnsemblClinVar. | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_055107 | 78 – 89 | SKKIH…PQLSA → T in isoform 2. 1 PublicationAdd BLAST | 12 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | X76013 mRNA Translation: CAA53600.1 AK301559 mRNA Translation: BAG63054.1 AC135506 Genomic DNA No translation available. BC000394 mRNA Translation: AAH00394.1 BC001567 mRNA Translation: AAH01567.1 BC029739 mRNA Translation: AAH29739.1 |
CCDSi | CCDS2788.1 [P47897-1] CCDS63633.1 [P47897-2] |
PIRi | I37422 |
RefSeqi | NP_001259002.1, NM_001272073.1 [P47897-2] NP_005042.1, NM_005051.2 [P47897-1] |
Genome annotation databases
Ensembli | ENST00000306125; ENSP00000307567; ENSG00000172053 [P47897-1] ENST00000414533; ENSP00000390015; ENSG00000172053 [P47897-2] |
GeneIDi | 5859 |
KEGGi | hsa:5859 |
UCSCi | uc003cvx.5, human [P47897-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | X76013 mRNA Translation: CAA53600.1 AK301559 mRNA Translation: BAG63054.1 AC135506 Genomic DNA No translation available. BC000394 mRNA Translation: AAH00394.1 BC001567 mRNA Translation: AAH01567.1 BC029739 mRNA Translation: AAH29739.1 |
CCDSi | CCDS2788.1 [P47897-1] CCDS63633.1 [P47897-2] |
PIRi | I37422 |
RefSeqi | NP_001259002.1, NM_001272073.1 [P47897-2] NP_005042.1, NM_005051.2 [P47897-1] |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
4R3Z | X-ray | 4.03 | C | 1-775 | [»] | |
4YE6 | X-ray | 2.40 | A | 1-775 | [»] | |
4YE8 | X-ray | 3.30 | A | 1-775 | [»] | |
4YE9 | X-ray | 2.70 | A | 1-775 | [»] | |
SMRi | P47897 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein-protein interaction databases
BioGRIDi | 111797, 287 interactors |
CORUMi | P47897 |
IntActi | P47897, 132 interactors |
MINTi | P47897 |
STRINGi | 9606.ENSP00000307567 |
Chemistry databases
BindingDBi | P47897 |
ChEMBLi | CHEMBL3054 |
DrugBanki | DB00130, L-Glutamine |
Protein family/group databases
MoonProti | P47897 |
PTM databases
iPTMneti | P47897 |
MetOSitei | P47897 |
PhosphoSitePlusi | P47897 |
SwissPalmi | P47897 |
Polymorphism and mutation databases
BioMutai | QARS |
DMDMi | 1351170 |
Proteomic databases
CPTACi | CPTAC-123 CPTAC-124 |
EPDi | P47897 |
jPOSTi | P47897 |
MassIVEi | P47897 |
MaxQBi | P47897 |
PaxDbi | P47897 |
PeptideAtlasi | P47897 |
PRIDEi | P47897 |
ProteomicsDBi | 5345 55816 [P47897-1] |
Protocols and materials databases
Antibodypediai | 30393, 137 antibodies |
DNASUi | 5859 |
Genome annotation databases
Ensembli | ENST00000306125; ENSP00000307567; ENSG00000172053 [P47897-1] ENST00000414533; ENSP00000390015; ENSG00000172053 [P47897-2] |
GeneIDi | 5859 |
KEGGi | hsa:5859 |
UCSCi | uc003cvx.5, human [P47897-1] |
Organism-specific databases
CTDi | 5859 |
DisGeNETi | 5859 |
EuPathDBi | HostDB:ENSG00000172053.15 |
GeneCardsi | QARS1 |
HGNCi | HGNC:9751, QARS1 |
HPAi | ENSG00000172053, Low tissue specificity |
MalaCardsi | QARS1 |
MIMi | 603727, gene 615760, phenotype |
neXtProti | NX_P47897 |
OpenTargetsi | ENSG00000172053 |
Orphaneti | 404437, Diffuse cerebral and cerebellar atrophy-intractable seizures-progressive microcephaly syndrome 423306, Microcephaly-short stature-intellectual disability-facial dysmorphism syndrome |
PharmGKBi | PA34093 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG1148, Eukaryota |
GeneTreei | ENSGT00550000074972 |
HOGENOMi | CLU_001882_2_3_1 |
InParanoidi | P47897 |
OMAi | AHPIEDA |
PhylomeDBi | P47897 |
TreeFami | TF105683 |
Enzyme and pathway databases
PathwayCommonsi | P47897 |
Reactomei | R-HSA-2408522, Selenoamino acid metabolism R-HSA-379716, Cytosolic tRNA aminoacylation R-HSA-379726, Mitochondrial tRNA aminoacylation |
Miscellaneous databases
BioGRID-ORCSi | 5859, 751 hits in 846 CRISPR screens |
ChiTaRSi | QARS, human |
GeneWikii | QARS |
GenomeRNAii | 5859 |
Pharosi | P47897, Tchem |
PROi | PR:P47897 |
RNActi | P47897, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000172053, Expressed in left lobe of thyroid gland and 246 other tissues |
ExpressionAtlasi | P47897, baseline and differential |
Genevisiblei | P47897, HS |
Family and domain databases
Gene3Di | 1.10.10.2420, 1 hit 1.10.8.1290, 1 hit 2.40.240.10, 2 hits 3.40.50.620, 1 hit |
InterProi | View protein in InterPro IPR001412, aa-tRNA-synth_I_CS IPR004514, Gln-tRNA-synth IPR007638, Gln-tRNA-synth_Ib_RNA-bd_2 IPR007639, Gln-tRNA-synth_Ib_RNA-bd_N IPR042558, Gln-tRNA-synth_Ib_RNA-bd_N_1 IPR042559, Gln-tRNA-synth_Ib_RNA-bd_N_2 IPR000924, Glu/Gln-tRNA-synth IPR020058, Glu/Gln-tRNA-synth_Ib_cat-dom IPR020059, Glu/Gln-tRNA-synth_Ib_codon-bd IPR020056, Rbsml_L25/Gln-tRNA_synth_N IPR011035, Ribosomal_L25/Gln-tRNA_synth IPR014729, Rossmann-like_a/b/a_fold |
Pfami | View protein in Pfam PF00749, tRNA-synt_1c, 1 hit PF03950, tRNA-synt_1c_C, 1 hit PF04558, tRNA_synt_1c_R1, 1 hit PF04557, tRNA_synt_1c_R2, 1 hit |
PRINTSi | PR00987, TRNASYNTHGLU |
SUPFAMi | SSF50715, SSF50715, 1 hit |
TIGRFAMsi | TIGR00440, glnS, 1 hit |
PROSITEi | View protein in PROSITE PS00178, AA_TRNA_LIGASE_I, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | SYQ_HUMAN | |
Accessioni | P47897Primary (citable) accession number: P47897 Secondary accession number(s): B4DWJ2 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | February 1, 1996 |
Last sequence update: | February 1, 1996 | |
Last modified: | December 2, 2020 | |
This is version 204 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
3D-structure, Direct protein sequencing, Reference proteomeDocuments
- Human chromosome 3
Human chromosome 3: entries, gene names and cross-references to MIM - Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations - MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - PDB cross-references
Index of Protein Data Bank (PDB) cross-references - SIMILARITY comments
Index of protein domains and families - Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations - Aminoacyl-tRNA synthetases
List of aminoacyl-tRNA synthetase entries