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Protein

Olfactory receptor 3A2

Gene

OR3A2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Odorant receptor.Curated

Caution

It is uncertain whether Met-1 or Met-7 is the initiator.Curated

GO - Molecular functioni

  • G-protein coupled receptor activity Source: UniProtKB-KW
  • olfactory receptor activity Source: GO_Central
  • signaling receptor activity Source: ProtInc

GO - Biological processi

  • G-protein coupled receptor signaling pathway Source: GO_Central
  • sensory perception of chemical stimulus Source: ProtInc
  • signal transduction Source: ProtInc

Keywordsi

Molecular functionG-protein coupled receptor, Receptor, Transducer
Biological processOlfaction, Sensory transduction

Enzyme and pathway databases

ReactomeiR-HSA-381753 Olfactory Signaling Pathway

Names & Taxonomyi

Protein namesi
Recommended name:
Olfactory receptor 3A2
Alternative name(s):
Olfactory receptor 17-228
Short name:
OR17-228
Olfactory receptor OR17-14
Gene namesi
Name:OR3A2
Synonyms:OLFRA04
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 17

Organism-specific databases

EuPathDBiHostDB:ENSG00000221882.2
HGNCiHGNC:8283 OR3A2
neXtProtiNX_P47893

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 35ExtracellularSequence analysisAdd BLAST35
Transmembranei36 – 58Helical; Name=1Sequence analysisAdd BLAST23
Topological domaini59 – 66CytoplasmicSequence analysis8
Transmembranei67 – 88Helical; Name=2Sequence analysisAdd BLAST22
Topological domaini89 – 109ExtracellularSequence analysisAdd BLAST21
Transmembranei110 – 129Helical; Name=3Sequence analysisAdd BLAST20
Topological domaini130 – 149CytoplasmicSequence analysisAdd BLAST20
Transmembranei150 – 167Helical; Name=4Sequence analysisAdd BLAST18
Topological domaini168 – 205ExtracellularSequence analysisAdd BLAST38
Transmembranei206 – 229Helical; Name=5Sequence analysisAdd BLAST24
Topological domaini230 – 246CytoplasmicSequence analysisAdd BLAST17
Transmembranei247 – 270Helical; Name=6Sequence analysisAdd BLAST24
Topological domaini271 – 281ExtracellularSequence analysisAdd BLAST11
Transmembranei282 – 301Helical; Name=7Sequence analysisAdd BLAST20
Topological domaini302 – 321CytoplasmicSequence analysisAdd BLAST20

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000221882
PharmGKBiPA32224

Polymorphism and mutation databases

BioMutaiOR3A2
DMDMi226694173

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001505181 – 321Olfactory receptor 3A2Add BLAST321

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi14N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi106 ↔ 198PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiP47893
PeptideAtlasiP47893
PRIDEiP47893
ProteomicsDBi55814

PTM databases

iPTMnetiP47893
PhosphoSitePlusiP47893

Expressioni

Gene expression databases

BgeeiENSG00000221882
CleanExiHS_OR3A2
ExpressionAtlasiP47893 baseline and differential
GenevisibleiP47893 HS

Interactioni

Protein-protein interaction databases

BioGridi111039, 1 interactor
IntActiP47893, 1 interactor
STRINGi9606.ENSP00000386180

Structurei

3D structure databases

ProteinModelPortaliP47893
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IKVP Eukaryota
ENOG411141Z LUCA
GeneTreeiENSGT00840000129832
HOGENOMiHOG000041362
HOVERGENiHBG017625
InParanoidiP47893
KOiK04257
OMAiSYEACLS
OrthoDBiEOG091G0AZH
PhylomeDBiP47893
TreeFamiTF352732

Family and domain databases

InterProiView protein in InterPro
IPR000276 GPCR_Rhodpsn
IPR017452 GPCR_Rhodpsn_7TM
IPR000725 Olfact_rcpt
PfamiView protein in Pfam
PF13853 7tm_4, 1 hit
PRINTSiPR00237 GPCRRHODOPSN
PR00245 OLFACTORYR
PROSITEiView protein in PROSITE
PS50262 G_PROTEIN_RECEP_F1_2, 1 hit

Sequencei

Sequence statusi: Complete.

P47893-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSLQKLMEPE AGTNRTAVAE FILLGLVQTE EMQPVVFVLL LFAYLVTTGG
60 70 80 90 100
NLSILAAVLV EPKLHAPMYF FLGNLSVLDV GCITVTVPAM LGRLLSHKST
110 120 130 140 150
ISYDACLSQL FFFHLLAGMD CFLLTAMAYD RLLAICQPLT YSTRMSQTVQ
160 170 180 190 200
RMLVAASLAC AFTNALTHTV AMSTLNFCGP NEVNHFYCDL PQLFQLSCSS
210 220 230 240 250
TQLNELLLFA VGFIMAGTPL VLIITAYSHV AAAVLRIRSV EGRKKAFSTC
260 270 280 290 300
GSHLTVVCLF FGRGIFNYMR LGSEEASDKD KGVGVFNTVI NPMLNPLIYS
310 320
LRNPDVQGAL WQIFLGRRSL T
Length:321
Mass (Da):35,207
Last modified:April 14, 2009 - v3
Checksum:i642FCD0CC1660F8A
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti128A → G in AAA17448 (PubMed:8004088).Curated1
Sequence conflicti134A → G in AAA17448 (PubMed:8004088).Curated1
Sequence conflicti142S → R in AAA17448 (PubMed:8004088).Curated1
Sequence conflicti171A → G in AAA17448 (PubMed:8004088).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_062032190L → V. Corresponds to variant dbSNP:rs9901356Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC087498 Genomic DNA No translation available.
BC095517 mRNA Translation: AAH95517.1
AF087930 Genomic DNA Translation: AAF37318.1
U04713 Genomic DNA Translation: AAA17448.1
BK004239 Genomic DNA Translation: DAA04637.1
CCDSiCCDS42233.1
PIRiI38484
RefSeqiNP_002542.3, NM_002551.3
UniGeneiHs.647414

Genome annotation databases

EnsembliENST00000408891; ENSP00000386180; ENSG00000221882
GeneIDi4995
KEGGihsa:4995
UCSCiuc002fvg.4 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiOR3A2_HUMAN
AccessioniPrimary (citable) accession number: P47893
Secondary accession number(s): Q6IFM3, Q9P1Q3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1996
Last sequence update: April 14, 2009
Last modified: June 20, 2018
This is version 152 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. SIMILARITY comments
    Index of protein domains and families

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