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Protein

Olfactory receptor 3A1

Gene

OR3A1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Odorant receptor.Curated

GO - Molecular functioni

GO - Biological processi

  • G-protein coupled receptor signaling pathway Source: GO_Central
  • signal transduction Source: ProtInc

Keywordsi

Molecular functionG-protein coupled receptor, Receptor, Transducer
Biological processOlfaction, Sensory transduction

Enzyme and pathway databases

ReactomeiR-HSA-381753 Olfactory Signaling Pathway

Names & Taxonomyi

Protein namesi
Recommended name:
Olfactory receptor 3A1
Alternative name(s):
Olfactory receptor 17-40
Short name:
OR17-40
Olfactory receptor OR17-15
Gene namesi
Name:OR3A1
Synonyms:OLFRA03
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 17

Organism-specific databases

EuPathDBiHostDB:ENSG00000180090.4
HGNCiHGNC:8282 OR3A1
neXtProtiNX_P47881

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 28ExtracellularSequence analysisAdd BLAST28
Transmembranei29 – 52Helical; Name=1Sequence analysisAdd BLAST24
Topological domaini53 – 60CytoplasmicSequence analysis8
Transmembranei61 – 82Helical; Name=2Sequence analysisAdd BLAST22
Topological domaini83 – 103ExtracellularSequence analysisAdd BLAST21
Transmembranei104 – 123Helical; Name=3Sequence analysisAdd BLAST20
Topological domaini124 – 143CytoplasmicSequence analysisAdd BLAST20
Transmembranei144 – 161Helical; Name=4Sequence analysisAdd BLAST18
Topological domaini162 – 199ExtracellularSequence analysisAdd BLAST38
Transmembranei200 – 223Helical; Name=5Sequence analysisAdd BLAST24
Topological domaini224 – 240CytoplasmicSequence analysisAdd BLAST17
Transmembranei241 – 264Helical; Name=6Sequence analysisAdd BLAST24
Topological domaini265 – 275ExtracellularSequence analysisAdd BLAST11
Transmembranei276 – 295Helical; Name=7Sequence analysisAdd BLAST20
Topological domaini296 – 315CytoplasmicSequence analysisAdd BLAST20

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000180090
PharmGKBiPA32223

Polymorphism and mutation databases

BioMutaiOR3A1
DMDMi148880124

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001505151 – 315Olfactory receptor 3A1Add BLAST315

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi8N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi100 ↔ 192PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiP47881
PeptideAtlasiP47881
PRIDEiP47881
ProteomicsDBi55808

PTM databases

iPTMnetiP47881
PhosphoSitePlusiP47881

Expressioni

Gene expression databases

BgeeiENSG00000180090
CleanExiHS_OR3A1
ExpressionAtlasiP47881 baseline and differential
GenevisibleiP47881 HS

Interactioni

Protein-protein interaction databases

BioGridi111038, 1 interactor
IntActiP47881, 1 interactor
MINTiP47881
STRINGi9606.ENSP00000313803

Structurei

3D structure databases

ProteinModelPortaliP47881
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IKVP Eukaryota
ENOG411141Z LUCA
GeneTreeiENSGT00840000129832
HOGENOMiHOG000041362
HOVERGENiHBG017625
InParanoidiP47881
KOiK04257
PhylomeDBiP47881
TreeFamiTF352732

Family and domain databases

InterProiView protein in InterPro
IPR000276 GPCR_Rhodpsn
IPR017452 GPCR_Rhodpsn_7TM
IPR000725 Olfact_rcpt
PfamiView protein in Pfam
PF13853 7tm_4, 1 hit
PRINTSiPR00237 GPCRRHODOPSN
PR00245 OLFACTORYR
PROSITEiView protein in PROSITE
PS00237 G_PROTEIN_RECEP_F1_1, 1 hit
PS50262 G_PROTEIN_RECEP_F1_2, 1 hit

Sequencei

Sequence statusi: Complete.

P47881-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MQPESGANGT VIAEFILLGL LEAPGLQPVV FVLFLFAYLV TVRGNLSILA
60 70 80 90 100
AVLVEPKLHT PMYFFLGNLS VLDVGCISVT VPSMLSRLLS RKRAVPCGAC
110 120 130 140 150
LTQLFFFHLF VGVDCFLLTA MAYDRFLAIC RPLTYSTRMS QTVQRMLVAA
160 170 180 190 200
SWACAFTNAL THTVAMSTLN FCGPNVINHF YCDLPQLFQL SCSSTQLNEL
210 220 230 240 250
LLFAVGFIMA GTPMALIVIS YIHVAAAVLR IRSVEGRKKA FSTCGSHLTV
260 270 280 290 300
VAIFYGSGIF NYMRLGSTKL SDKDKAVGIF NTVINPMLNP IIYSFRNPDV
310
QSAIWRMLTG RRSLA
Length:315
Mass (Da):34,609
Last modified:May 29, 2007 - v2
Checksum:iDF32977D5EA7D7CA
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti120A → D in AAA18347 (PubMed:8004088).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_05754278S → G. Corresponds to variant dbSNP:rs16952828Ensembl.1
Natural variantiVAR_012059125R → Q4 PublicationsCorresponds to variant dbSNP:rs703903Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X80391 Genomic DNA Translation: CAA56602.1
U58675 Genomic DNA No translation available.
AF087924 Genomic DNA Translation: AAF37314.1
AC087498 Genomic DNA No translation available.
BC069414 mRNA Translation: AAH69414.1
BC096187 mRNA Translation: AAH96187.1
BC096188 mRNA Translation: AAH96188.1
BC096189 mRNA Translation: AAH96189.1
BC096190 mRNA Translation: AAH96190.1
U04683 Genomic DNA Translation: AAA18347.1
BK004238 Genomic DNA Translation: DAA04636.1
CCDSiCCDS11023.1
PIRiI38476
JC4658
RefSeqiNP_002541.2, NM_002550.2
XP_016880184.1, XM_017024695.1
XP_016880185.1, XM_017024696.1
UniGeneiHs.647410

Genome annotation databases

EnsembliENST00000323404; ENSP00000313803; ENSG00000180090
GeneIDi4994
KEGGihsa:4994
UCSCiuc002fvh.1 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiOR3A1_HUMAN
AccessioniPrimary (citable) accession number: P47881
Secondary accession number(s): Q4VB06, Q6IFM4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1996
Last sequence update: May 29, 2007
Last modified: June 20, 2018
This is version 156 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. SIMILARITY comments
    Index of protein domains and families

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