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Protein

Insulin-like growth factor-binding protein 6

Gene

Igfbp6

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

IGF-binding proteins prolong the half-life of the IGFs and have been shown to either inhibit or stimulate the growth promoting effects of the IGFs on cell culture. They alter the interaction of IGFs with their cell surface receptors.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionGrowth factor binding

Enzyme and pathway databases

ReactomeiR-MMU-381426 Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)

Protein family/group databases

MEROPSiI31.952

Names & Taxonomyi

Protein namesi
Recommended name:
Insulin-like growth factor-binding protein 6
Short name:
IBP-6
Short name:
IGF-binding protein 6
Short name:
IGFBP-6
Gene namesi
Name:Igfbp6
Synonyms:Igfbp-6
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 15

Organism-specific databases

MGIiMGI:96441 Igfbp6

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 25By similarityAdd BLAST25
ChainiPRO_000001439026 – 238Insulin-like growth factor-binding protein 6Add BLAST213

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi30 ↔ 33PROSITE-ProRule annotation
Disulfide bondi41 ↔ 45PROSITE-ProRule annotation
Disulfide bondi58 ↔ 64PROSITE-ProRule annotation
Disulfide bondi72 ↔ 85PROSITE-ProRule annotation
Disulfide bondi79 ↔ 105PROSITE-ProRule annotation
Disulfide bondi160 ↔ 188PROSITE-ProRule annotation
Disulfide bondi199 ↔ 210PROSITE-ProRule annotation
Disulfide bondi212 ↔ 232PROSITE-ProRule annotation

Post-translational modificationi

O-glycosylated.

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiP47880
PeptideAtlasiP47880
PRIDEiP47880

PTM databases

PhosphoSitePlusiP47880

Miscellaneous databases

PMAP-CutDBiP47880

Expressioni

Gene expression databases

BgeeiENSMUSG00000023046 Expressed in 191 organ(s), highest expression level in uterus
CleanExiMM_IGFBP6
GenevisibleiP47880 MM

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

DIPiDIP-60634N
IntActiP47880, 2 interactors
STRINGi10090.ENSMUSP00000023807

Structurei

3D structure databases

ProteinModelPortaliP47880
SMRiP47880
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini26 – 108IGFBP N-terminalPROSITE-ProRule annotationAdd BLAST83
Domaini157 – 232Thyroglobulin type-1PROSITE-ProRule annotationAdd BLAST76

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410IVZ3 Eukaryota
ENOG410YQXU LUCA
GeneTreeiENSGT00550000074457
HOGENOMiHOG000253012
HOVERGENiHBG002631
InParanoidiP47880
OMAiRDQQRNP
OrthoDBiEOG091G0L46
TreeFamiTF331211

Family and domain databases

CDDicd00191 TY, 1 hit
Gene3Di4.10.800.10, 1 hit
InterProiView protein in InterPro
IPR009030 Growth_fac_rcpt_cys_sf
IPR022326 IGFBP-6
IPR000867 IGFBP-like
IPR009168 IGFBP1-6
IPR022321 IGFBP_1-6_chordata
IPR017891 Insulin_GF-bd_Cys-rich_CS
IPR000716 Thyroglobulin_1
IPR036857 Thyroglobulin_1_sf
PANTHERiPTHR11551 PTHR11551, 1 hit
PTHR11551:SF14 PTHR11551:SF14, 1 hit
PfamiView protein in Pfam
PF00086 Thyroglobulin_1, 1 hit
PRINTSiPR01976 IGFBPFAMILY
PR01982 IGFBPFAMILY6
SMARTiView protein in SMART
SM00121 IB, 1 hit
SM00211 TY, 1 hit
SUPFAMiSSF57184 SSF57184, 1 hit
SSF57610 SSF57610, 1 hit
PROSITEiView protein in PROSITE
PS00222 IGFBP_N_1, 1 hit
PS51323 IGFBP_N_2, 1 hit
PS00484 THYROGLOBULIN_1_1, 1 hit
PS51162 THYROGLOBULIN_1_2, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P47880-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MTWDGLPTQP LLMLLMLLFA AGSGSALAGC PGCGAGMQTG CRGGCVEEED
60 70 80 90 100
AGSPADGCTE AGGCLRREGQ PCGVYSPKCA PGLQCQPREN EEAPLRALLI
110 120 130 140 150
GQGRCQRARG PSEETTKESK PQGGASRSRD TNHRDRQKNP RTSAAPIRPN
160 170 180 190 200
PVQDSEMGPC RRHLDSVLQQ LQTEVFRGGA RGLYVPNCDL RGFYRKQQCR
210 220 230
SSQGNRRGPC WCVDPMGQPL PVSPDGQGST QCSARSSG
Length:238
Mass (Da):25,347
Last modified:October 3, 2012 - v2
Checksum:iDDBAFD5DB0413CF7
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti35A → P in CAA57274 (PubMed:7529732).Curated1
Sequence conflicti93A → T in CAA57274 (PubMed:7529732).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X81584 mRNA Translation: CAA57274.1
AC110512 Genomic DNA No translation available.
AC123791 Genomic DNA No translation available.
BC012723 mRNA Translation: AAH12723.1
CH466550 Genomic DNA Translation: EDL04005.1
CCDSiCCDS27871.1
PIRiI48605
RefSeqiNP_032370.2, NM_008344.3
UniGeneiMm.358609

Genome annotation databases

EnsembliENSMUST00000023807; ENSMUSP00000023807; ENSMUSG00000023046
GeneIDi16012
KEGGimmu:16012
UCSCiuc011zzz.1 mouse

Similar proteinsi

Entry informationi

Entry nameiIBP6_MOUSE
AccessioniPrimary (citable) accession number: P47880
Secondary accession number(s): Q91X24
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1996
Last sequence update: October 3, 2012
Last modified: September 12, 2018
This is version 144 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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