Igfbp6

Functionⁱ

IGF-binding proteins prolong the half-life of the IGFs and have been shown to either inhibit or stimulate the growth promoting effects of the IGFs on cell culture. They alter the interaction of IGFs with their cell surface receptors.

GO - Molecular functionⁱ

extracellular matrix structural constituent
Source: BHF-UCL
Inferred from high throughput direct assayⁱ
- 22159717
fibronectin binding
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
insulin-like growth factor I binding Source: MGI
insulin-like growth factor II binding Source: MGI

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

regulation of cell growth Source: InterPro

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Growth factor binding

Molecular function

Growth factor binding

Enzyme and pathway databases

Reactomeⁱ	R-MMU-381426 Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)

Reactomeⁱ

R-MMU-381426 Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)

Protein family/group databases

MEROPS protease database More...MEROPSⁱ	I31.952

MEROPSⁱ

I31.952

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Insulin-like growth factor-binding protein 6 Short name: IBP-6 Short name: IGF-binding protein 6 Short name: IGFBP-6
Gene namesⁱ	Name:Igfbp6 Synonyms:Igfbp-6
Organismⁱ	Mus musculus (Mouse)
Taxonomic identifierⁱ	10090 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus
Proteomesⁱ	UP000000589 Componentⁱ: Chromosome 15

Organism-specific databases

MGIⁱ	MGI:96441 Igfbp6

Keywords - Cellular componentⁱ

Secreted

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Signal peptideⁱ	1 – 25	By similarityAdd BLAST		25
ChainⁱPRO_0000014390	26 – 238	Insulin-like growth factor-binding protein 6Add BLAST		213

Amino acid modifications

Feature key	Position(s)	DescriptionActions
Disulfide bondⁱ	30 ↔ 33	PROSITE-ProRule annotation
Disulfide bondⁱ	41 ↔ 45	PROSITE-ProRule annotation
Disulfide bondⁱ	58 ↔ 64	PROSITE-ProRule annotation
Disulfide bondⁱ	72 ↔ 85	PROSITE-ProRule annotation
Disulfide bondⁱ	79 ↔ 105	PROSITE-ProRule annotation
Disulfide bondⁱ	160 ↔ 188	PROSITE-ProRule annotation
Disulfide bondⁱ	199 ↔ 210	PROSITE-ProRule annotation
Disulfide bondⁱ	212 ↔ 232	PROSITE-ProRule annotation

Post-translational modificationⁱ

O-glycosylated.

Keywords - PTMⁱ

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbⁱ	P47880
PeptideAtlas More...PeptideAtlasⁱ	P47880
PRIDEⁱ	P47880

PTM databases

PhosphoSitePlusⁱ	P47880

PhosphoSitePlusⁱ

P47880

Miscellaneous databases

PMAP-CutDBⁱ

P47880

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSMUSG00000023046 Expressed in 191 organ(s), highest expression level in uterus
CleanExⁱ	MM_IGFBP6
Genevisibleⁱ	P47880 MM

Interactionⁱ

GO - Molecular functionⁱ

fibronectin binding
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
insulin-like growth factor I binding Source: MGI
insulin-like growth factor II binding Source: MGI

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

Database of interacting proteins More...DIPⁱ	DIP-60634N
IntActⁱ	P47880, 2 interactors
STRINGⁱ	10090.ENSMUSP00000023807

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	P47880
SMRⁱ	P47880
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Domainⁱ	26 – 108	IGFBP N-terminalPROSITE-ProRule annotationAdd BLAST		83
Domainⁱ	157 – 232	Thyroglobulin type-1PROSITE-ProRule annotationAdd BLAST		76

Keywords - Domainⁱ

Signal

Phylogenomic databases

eggNOGⁱ	ENOG410IVZ3 Eukaryota ENOG410YQXU LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00550000074457
HOGENOMⁱ	HOG000253012
HOVERGENⁱ	HBG002631
InParanoidⁱ	P47880
OMAⁱ	RPNPGGV
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0L46
TreeFamⁱ	TF331211

Family and domain databases

Conserved Domains Database More...CDDⁱ	cd00191 TY, 1 hit
Gene3Dⁱ	4.10.800.10, 1 hit
InterProⁱ	View protein in InterPro IPR009030 Growth_fac_rcpt_cys_sf IPR022326 IGFBP-6 IPR000867 IGFBP-like IPR009168 IGFBP1-6 IPR022321 IGFBP_1-6_chordata IPR017891 Insulin_GF-bd_Cys-rich_CS IPR000716 Thyroglobulin_1 IPR036857 Thyroglobulin_1_sf
PANTHERⁱ	PTHR11551 PTHR11551, 1 hit PTHR11551:SF14 PTHR11551:SF14, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00086 Thyroglobulin_1, 1 hit
PRINTSⁱ	PR01976 IGFBPFAMILY PR01982 IGFBPFAMILY6
SMARTⁱ	View protein in SMART SM00121 IB, 1 hit SM00211 TY, 1 hit
SUPFAMⁱ	SSF57184 SSF57184, 1 hit SSF57610 SSF57610, 1 hit
PROSITEⁱ	View protein in PROSITE PS00222 IGFBP_N_1, 1 hit PS51323 IGFBP_N_2, 1 hit PS00484 THYROGLOBULIN_1_1, 1 hit PS51162 THYROGLOBULIN_1_2, 1 hit

Sequenceⁱ

Sequence statusⁱ: Complete.

Sequence processingⁱ: The displayed sequence is further processed into a mature form.

P47880-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MTWDGLPTQP LLMLLMLLFA AGSGSALAGC PGCGAGMQTG CRGGCVEEED 
        60         70         80         90        100
AGSPADGCTE AGGCLRREGQ PCGVYSPKCA PGLQCQPREN EEAPLRALLI 
       110        120        130        140        150
GQGRCQRARG PSEETTKESK PQGGASRSRD TNHRDRQKNP RTSAAPIRPN 
       160        170        180        190        200
PVQDSEMGPC RRHLDSVLQQ LQTEVFRGGA RGLYVPNCDL RGFYRKQQCR 
       210        220        230 
SSQGNRRGPC WCVDPMGQPL PVSPDGQGST QCSARSSG

Length:238

Mass (Da):25,347

Last modified:October 3, 2012 - v2

Checksum:ⁱDDBAFD5DB0413CF7

GO

Experimental Info

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Sequence conflictⁱ	35	A → P in CAA57274 (PubMed:7529732).Curated		1
Sequence conflictⁱ	93	A → T in CAA57274 (PubMed:7529732).Curated		1

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	X81584 mRNA Translation: CAA57274.1 AC110512 Genomic DNA No translation available. AC123791 Genomic DNA No translation available. BC012723 mRNA Translation: AAH12723.1 CH466550 Genomic DNA Translation: EDL04005.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS27871.1
PIRⁱ	I48605
NCBI Reference Sequences More...RefSeqⁱ	NP_032370.2, NM_008344.3
UniGeneⁱ	Mm.358609

Genome annotation databases

Ensemblⁱ	ENSMUST00000023807; ENSMUSP00000023807; ENSMUSG00000023046
GeneIDⁱ	16012
KEGGⁱ	mmu:16012
UCSC genome browser More...UCSCⁱ	uc011zzz.1 mouse

Similar proteinsⁱ

90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
P47880	Insulin-like growth factor-binding protein 6		RAT		226	UniRef90_P35572
UPI000A31B390		MUSCR		238

Protein	Similar proteins		Species	Score	Length	Source
P47880	Insulin-like growth factor-binding protein 6		RAT		226	UniRef50_P35572
insulin-like growth factor-binding protein 6		ERIEU		229
Insulin like growth factor binding protein 6		MYOLU		241
Insulin like growth factor binding protein 6		AILME		217
Uncharacterized protein		NEOLE		237
+9

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	X81584 mRNA Translation: CAA57274.1 AC110512 Genomic DNA No translation available. AC123791 Genomic DNA No translation available. BC012723 mRNA Translation: AAH12723.1 CH466550 Genomic DNA Translation: EDL04005.1
CCDSⁱ	CCDS27871.1
PIRⁱ	I48605
RefSeqⁱ	NP_032370.2, NM_008344.3
UniGeneⁱ	Mm.358609

3D structure databases

ProteinModelPortalⁱ	P47880
SMRⁱ	P47880
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

DIPⁱ	DIP-60634N
IntActⁱ	P47880, 2 interactors
STRINGⁱ	10090.ENSMUSP00000023807

Protein family/group databases

MEROPSⁱ	I31.952

MEROPSⁱ

I31.952

PTM databases

PhosphoSitePlusⁱ	P47880

PhosphoSitePlusⁱ

P47880

Proteomic databases

PaxDbⁱ	P47880
PeptideAtlasⁱ	P47880
PRIDEⁱ	P47880

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

Ensemblⁱ	ENSMUST00000023807; ENSMUSP00000023807; ENSMUSG00000023046
GeneIDⁱ	16012
KEGGⁱ	mmu:16012
UCSCⁱ	uc011zzz.1 mouse

Organism-specific databases

CTDⁱ	3489
MGIⁱ	MGI:96441 Igfbp6

Phylogenomic databases

eggNOGⁱ	ENOG410IVZ3 Eukaryota ENOG410YQXU LUCA
GeneTreeⁱ	ENSGT00550000074457
HOGENOMⁱ	HOG000253012
HOVERGENⁱ	HBG002631
InParanoidⁱ	P47880
OMAⁱ	RPNPGGV
OrthoDBⁱ	EOG091G0L46
TreeFamⁱ	TF331211

Enzyme and pathway databases

Reactomeⁱ	R-MMU-381426 Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)

Reactomeⁱ

R-MMU-381426 Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)

Miscellaneous databases

PMAP-CutDBⁱ	P47880
Protein Ontology More...PROⁱ	PR:P47880
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSMUSG00000023046 Expressed in 191 organ(s), highest expression level in uterus
CleanExⁱ	MM_IGFBP6
Genevisibleⁱ	P47880 MM

Family and domain databases

CDDⁱ	cd00191 TY, 1 hit
Gene3Dⁱ	4.10.800.10, 1 hit
InterProⁱ	View protein in InterPro IPR009030 Growth_fac_rcpt_cys_sf IPR022326 IGFBP-6 IPR000867 IGFBP-like IPR009168 IGFBP1-6 IPR022321 IGFBP_1-6_chordata IPR017891 Insulin_GF-bd_Cys-rich_CS IPR000716 Thyroglobulin_1 IPR036857 Thyroglobulin_1_sf
PANTHERⁱ	PTHR11551 PTHR11551, 1 hit PTHR11551:SF14 PTHR11551:SF14, 1 hit
Pfamⁱ	View protein in Pfam PF00086 Thyroglobulin_1, 1 hit
PRINTSⁱ	PR01976 IGFBPFAMILY PR01982 IGFBPFAMILY6
SMARTⁱ	View protein in SMART SM00121 IB, 1 hit SM00211 TY, 1 hit
SUPFAMⁱ	SSF57184 SSF57184, 1 hit SSF57610 SSF57610, 1 hit
PROSITEⁱ	View protein in PROSITE PS00222 IGFBP_N_1, 1 hit PS51323 IGFBP_N_2, 1 hit PS00484 THYROGLOBULIN_1_1, 1 hit PS51162 THYROGLOBULIN_1_2, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	IBP6_MOUSE
Accessionⁱ	P47880Primary (citable) accession number: P47880 Secondary accession number(s): Q91X24
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	February 1, 1996
	Last sequence update:	October 3, 2012
	Last modified:	November 7, 2018
	This is version 145 of the entry and version 2 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

Documents

MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - P47880 (IBP6_MOUSE)

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Insulin-like growth factor-binding protein 6

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

Protein family/group databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted

Extracellular region or secreted

Golgi apparatus

Other locations

Keywords - Cellular componenti

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

PTM databases

Miscellaneous databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Keywords - Domaini

Phylogenomic databases

Family and domain databases

Experimental Info

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

Protein family/group databases

PTM databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

GO - Molecular functionⁱ

Structureⁱ

Family & Domainsⁱ

Keywords - Domainⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ