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Entry version 152 (16 Oct 2019)
Sequence version 2 (03 Oct 2012)
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Protein

Insulin-like growth factor-binding protein 6

Gene

Igfbp6

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

IGF-binding proteins prolong the half-life of the IGFs and have been shown to either inhibit or stimulate the growth promoting effects of the IGFs on cell culture. They alter the interaction of IGFs with their cell surface receptors.

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionGrowth factor binding

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-MMU-381426 Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)

Protein family/group databases

MEROPS protease database

More...
MEROPSi
I31.952

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Insulin-like growth factor-binding protein 6
Short name:
IBP-6
Short name:
IGF-binding protein 6
Short name:
IGFBP-6
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Igfbp6
Synonyms:Igfbp-6
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 15

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...
MGIi
MGI:96441 Igfbp6

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 25By similarityAdd BLAST25
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000001439026 – 238Insulin-like growth factor-binding protein 6Add BLAST213

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi30 ↔ 33PROSITE-ProRule annotation
Disulfide bondi41 ↔ 45PROSITE-ProRule annotation
Disulfide bondi58 ↔ 64PROSITE-ProRule annotation
Disulfide bondi72 ↔ 85PROSITE-ProRule annotation
Disulfide bondi79 ↔ 105PROSITE-ProRule annotation
Disulfide bondi160 ↔ 188PROSITE-ProRule annotation
Disulfide bondi199 ↔ 210PROSITE-ProRule annotation
Disulfide bondi212 ↔ 232PROSITE-ProRule annotation

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

O-glycosylated.

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

The CPTAC Assay portal

More...
CPTACi
non-CPTAC-3582

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
P47880

PeptideAtlas

More...
PeptideAtlasi
P47880

PRoteomics IDEntifications database

More...
PRIDEi
P47880

PTM databases

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
P47880

Miscellaneous databases

CutDB - Proteolytic event database

More...
PMAP-CutDBi
P47880

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSMUSG00000023046 Expressed in 191 organ(s), highest expression level in uterus

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
P47880 MM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

Database of interacting proteins

More...
DIPi
DIP-60634N

Protein interaction database and analysis system

More...
IntActi
P47880, 2 interactors

STRING: functional protein association networks

More...
STRINGi
10090.ENSMUSP00000023807

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
P47880

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini26 – 108IGFBP N-terminalPROSITE-ProRule annotationAdd BLAST83
Domaini157 – 232Thyroglobulin type-1PROSITE-ProRule annotationAdd BLAST76

Keywords - Domaini

Signal

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG410IVZ3 Eukaryota
ENOG410YQXU LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000160528

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000253012

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
P47880

KEGG Orthology (KO)

More...
KOi
K23579

Identification of Orthologs from Complete Genome Data

More...
OMAi
GQQCGVY

Database of Orthologous Groups

More...
OrthoDBi
979270at2759

TreeFam database of animal gene trees

More...
TreeFami
TF331211

Family and domain databases

Conserved Domains Database

More...
CDDi
cd00191 TY, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
4.10.800.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR009030 Growth_fac_rcpt_cys_sf
IPR022326 IGFBP-6
IPR000867 IGFBP-like
IPR009168 IGFBP1-6
IPR022321 IGFBP_1-6_chordata
IPR017891 Insulin_GF-bd_Cys-rich_CS
IPR000716 Thyroglobulin_1
IPR036857 Thyroglobulin_1_sf

The PANTHER Classification System

More...
PANTHERi
PTHR11551 PTHR11551, 1 hit
PTHR11551:SF14 PTHR11551:SF14, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00086 Thyroglobulin_1, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR01976 IGFBPFAMILY
PR01982 IGFBPFAMILY6

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00121 IB, 1 hit
SM00211 TY, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF57184 SSF57184, 1 hit
SSF57610 SSF57610, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00222 IGFBP_N_1, 1 hit
PS51323 IGFBP_N_2, 1 hit
PS00484 THYROGLOBULIN_1_1, 1 hit
PS51162 THYROGLOBULIN_1_2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

P47880-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MTWDGLPTQP LLMLLMLLFA AGSGSALAGC PGCGAGMQTG CRGGCVEEED
60 70 80 90 100
AGSPADGCTE AGGCLRREGQ PCGVYSPKCA PGLQCQPREN EEAPLRALLI
110 120 130 140 150
GQGRCQRARG PSEETTKESK PQGGASRSRD TNHRDRQKNP RTSAAPIRPN
160 170 180 190 200
PVQDSEMGPC RRHLDSVLQQ LQTEVFRGGA RGLYVPNCDL RGFYRKQQCR
210 220 230
SSQGNRRGPC WCVDPMGQPL PVSPDGQGST QCSARSSG
Length:238
Mass (Da):25,347
Last modified:October 3, 2012 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iDDBAFD5DB0413CF7
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti35A → P in CAA57274 (PubMed:7529732).Curated1
Sequence conflicti93A → T in CAA57274 (PubMed:7529732).Curated1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
X81584 mRNA Translation: CAA57274.1
AC110512 Genomic DNA No translation available.
AC123791 Genomic DNA No translation available.
BC012723 mRNA Translation: AAH12723.1
CH466550 Genomic DNA Translation: EDL04005.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS27871.1

Protein sequence database of the Protein Information Resource

More...
PIRi
I48605

NCBI Reference Sequences

More...
RefSeqi
NP_032370.2, NM_008344.3

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSMUST00000023807; ENSMUSP00000023807; ENSMUSG00000023046

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
16012

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
mmu:16012

UCSC genome browser

More...
UCSCi
uc011zzz.1 mouse

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X81584 mRNA Translation: CAA57274.1
AC110512 Genomic DNA No translation available.
AC123791 Genomic DNA No translation available.
BC012723 mRNA Translation: AAH12723.1
CH466550 Genomic DNA Translation: EDL04005.1
CCDSiCCDS27871.1
PIRiI48605
RefSeqiNP_032370.2, NM_008344.3

3D structure databases

SMRiP47880
ModBaseiSearch...

Protein-protein interaction databases

DIPiDIP-60634N
IntActiP47880, 2 interactors
STRINGi10090.ENSMUSP00000023807

Protein family/group databases

MEROPSiI31.952

PTM databases

PhosphoSitePlusiP47880

Proteomic databases

CPTACinon-CPTAC-3582
PaxDbiP47880
PeptideAtlasiP47880
PRIDEiP47880

Genome annotation databases

EnsembliENSMUST00000023807; ENSMUSP00000023807; ENSMUSG00000023046
GeneIDi16012
KEGGimmu:16012
UCSCiuc011zzz.1 mouse

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
3489
MGIiMGI:96441 Igfbp6

Phylogenomic databases

eggNOGiENOG410IVZ3 Eukaryota
ENOG410YQXU LUCA
GeneTreeiENSGT00940000160528
HOGENOMiHOG000253012
InParanoidiP47880
KOiK23579
OMAiGQQCGVY
OrthoDBi979270at2759
TreeFamiTF331211

Enzyme and pathway databases

ReactomeiR-MMU-381426 Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)

Miscellaneous databases

PMAP-CutDBiP47880

Protein Ontology

More...
PROi
PR:P47880

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSMUSG00000023046 Expressed in 191 organ(s), highest expression level in uterus
GenevisibleiP47880 MM

Family and domain databases

CDDicd00191 TY, 1 hit
Gene3Di4.10.800.10, 1 hit
InterProiView protein in InterPro
IPR009030 Growth_fac_rcpt_cys_sf
IPR022326 IGFBP-6
IPR000867 IGFBP-like
IPR009168 IGFBP1-6
IPR022321 IGFBP_1-6_chordata
IPR017891 Insulin_GF-bd_Cys-rich_CS
IPR000716 Thyroglobulin_1
IPR036857 Thyroglobulin_1_sf
PANTHERiPTHR11551 PTHR11551, 1 hit
PTHR11551:SF14 PTHR11551:SF14, 1 hit
PfamiView protein in Pfam
PF00086 Thyroglobulin_1, 1 hit
PRINTSiPR01976 IGFBPFAMILY
PR01982 IGFBPFAMILY6
SMARTiView protein in SMART
SM00121 IB, 1 hit
SM00211 TY, 1 hit
SUPFAMiSSF57184 SSF57184, 1 hit
SSF57610 SSF57610, 1 hit
PROSITEiView protein in PROSITE
PS00222 IGFBP_N_1, 1 hit
PS51323 IGFBP_N_2, 1 hit
PS00484 THYROGLOBULIN_1_1, 1 hit
PS51162 THYROGLOBULIN_1_2, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiIBP6_MOUSE
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: P47880
Secondary accession number(s): Q91X24
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1996
Last sequence update: October 3, 2012
Last modified: October 16, 2019
This is version 152 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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