UniProtKB - P47879 (IBP4_MOUSE)
Protein
Insulin-like growth factor-binding protein 4
Gene
Igfbp4
Organism
Mus musculus (Mouse)
Status
Functioni
IGF-binding proteins prolong the half-life of the IGFs and have been shown to either inhibit or stimulate the growth promoting effects of the IGFs on cell culture. They alter the interaction of IGFs with their cell surface receptors.
GO - Molecular functioni
- insulin-like growth factor binding Source: MGI
- insulin-like growth factor I binding Source: GO_Central
- insulin-like growth factor II binding Source: GO_Central
GO - Biological processi
- inflammatory response Source: Ensembl
- positive regulation of insulin-like growth factor receptor signaling pathway Source: MGI
- positive regulation of MAPK cascade Source: MGI
- regulation of cell growth Source: MGI
- regulation of glucose metabolic process Source: MGI
- regulation of growth Source: MGI
- regulation of insulin-like growth factor receptor signaling pathway Source: GO_Central
- type B pancreatic cell proliferation Source: MGI
Keywordsi
Molecular function | Growth factor binding |
Enzyme and pathway databases
Reactomei | R-MMU-381426, Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) R-MMU-8957275, Post-translational protein phosphorylation |
Protein family/group databases
MEROPSi | I31.952 |
Names & Taxonomyi
Protein namesi | Recommended name: Insulin-like growth factor-binding protein 4Short name: IBP-4 Short name: IGF-binding protein 4 Short name: IGFBP-4 |
Gene namesi | Name:Igfbp4 Synonyms:Igfbp-4 |
Organismi | Mus musculus (Mouse) |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Proteomesi |
|
Organism-specific databases
MGIi | MGI:96439, Igfbp4 |
Subcellular locationi
Extracellular region or secreted
Extracellular region or secreted
- extracellular space Source: MGI
Keywords - Cellular componenti
SecretedPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 21 | By similarityAdd BLAST | 21 | |
ChainiPRO_0000014383 | 22 – 254 | Insulin-like growth factor-binding protein 4Add BLAST | 233 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Disulfide bondi | 27 ↔ 53 | PROSITE-ProRule annotation | ||
Disulfide bondi | 30 ↔ 55 | PROSITE-ProRule annotation | ||
Disulfide bondi | 38 ↔ 59 | PROSITE-ProRule annotation | ||
Disulfide bondi | 44 ↔ 56 | PROSITE-ProRule annotation | ||
Disulfide bondi | 67 ↔ 80 | PROSITE-ProRule annotation | ||
Disulfide bondi | 74 ↔ 100 | PROSITE-ProRule annotation | ||
Glycosylationi | 125 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Disulfide bondi | 131 ↔ 138 | PROSITE-ProRule annotation | ||
Disulfide bondi | 170 ↔ 200 | PROSITE-ProRule annotation | ||
Disulfide bondi | 211 ↔ 222 | PROSITE-ProRule annotation | ||
Disulfide bondi | 224 ↔ 245 | PROSITE-ProRule annotation | ||
Modified residuei | 251 | PhosphoserineBy similarity | 1 |
Keywords - PTMi
Disulfide bond, Glycoprotein, PhosphoproteinProteomic databases
CPTACi | non-CPTAC-3986 |
EPDi | P47879 |
MaxQBi | P47879 |
PaxDbi | P47879 |
PeptideAtlasi | P47879 |
PRIDEi | P47879 |
PTM databases
GlyGeni | P47879, 1 site |
iPTMneti | P47879 |
PhosphoSitePlusi | P47879 |
SwissPalmi | P47879 |
Expressioni
Gene expression databases
Bgeei | ENSMUSG00000017493, Expressed in external carotid artery and 312 other tissues |
ExpressionAtlasi | P47879, baseline and differential |
Genevisiblei | P47879, MM |
Interactioni
Subunit structurei
Binds IGF2 more than IGF1.
Binary interactionsi
Hide detailsP47879
With | #Exp. | IntAct |
---|---|---|
Fzd8 [Q61091] | 3 | EBI-15706768,EBI-6171689 |
LRP6 [O75581] from Homo sapiens. | 4 | EBI-15706768,EBI-910915 |
GO - Molecular functioni
- insulin-like growth factor binding Source: MGI
- insulin-like growth factor I binding Source: GO_Central
- insulin-like growth factor II binding Source: GO_Central
Protein-protein interaction databases
DIPi | DIP-60633N |
IntActi | P47879, 2 interactors |
STRINGi | 10090.ENSMUSP00000017637 |
Miscellaneous databases
RNActi | P47879, protein |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 23 – 103 | IGFBP N-terminalPROSITE-ProRule annotationAdd BLAST | 81 | |
Domaini | 167 – 245 | Thyroglobulin type-1PROSITE-ProRule annotationAdd BLAST | 79 |
Keywords - Domaini
SignalPhylogenomic databases
eggNOGi | ENOG502QTC8, Eukaryota |
GeneTreei | ENSGT00940000159647 |
HOGENOMi | CLU_070833_3_0_1 |
InParanoidi | P47879 |
OMAi | GLCMELA |
OrthoDBi | 979270at2759 |
PhylomeDBi | P47879 |
TreeFami | TF331211 |
Family and domain databases
CDDi | cd00191, TY, 1 hit |
Gene3Di | 4.10.800.10, 1 hit |
InterProi | View protein in InterPro IPR009030, Growth_fac_rcpt_cys_sf IPR022327, IGFBP-4 IPR000867, IGFBP-like IPR022321, IGFBP_1-6_chordata IPR017891, Insulin_GF-bd_Cys-rich_CS IPR000716, Thyroglobulin_1 IPR036857, Thyroglobulin_1_sf |
PANTHERi | PTHR11551:SF7, PTHR11551:SF7, 1 hit |
Pfami | View protein in Pfam PF00219, IGFBP, 1 hit PF00086, Thyroglobulin_1, 1 hit |
PRINTSi | PR01976, IGFBPFAMILY PR01980, IGFBPFAMILY4 |
SMARTi | View protein in SMART SM00121, IB, 1 hit SM00211, TY, 1 hit |
SUPFAMi | SSF57184, SSF57184, 1 hit SSF57610, SSF57610, 1 hit |
PROSITEi | View protein in PROSITE PS00222, IGFBP_N_1, 1 hit PS51323, IGFBP_N_2, 1 hit PS00484, THYROGLOBULIN_1_1, 1 hit PS51162, THYROGLOBULIN_1_2, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All
P47879-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MLPFGLVAAL LLAAGPRPSL GDEAIHCPPC SEEKLARCRP PVGCEELVRE
60 70 80 90 100
PGCGCCATCA LGLGMPCGVY TPRCGSGMRC YPPRGVEKPL RTLMHGQGVC
110 120 130 140 150
TELSEIEAIQ ESLQTSDKDE SEHPNNSFNP CSAHDHRCLQ KHMAKIRDRS
160 170 180 190 200
KMKIVGTPRE EPRPVPQGSC QSELHRALER LAASQSRTHE DLFIIPIPNC
210 220 230 240 250
DRNGNFHPKQ CHPALDGQRG KCWCVDRKTG VKLPGGLEPK GELDCHQLAD
SFQE
Computationally mapped potential isoform sequencesi
There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketH3BLB7 | H3BLB7_MOUSE | Insulin-like growth factor-binding ... | Igfbp4 | 161 | Annotation score: | ||
H3BJT2 | H3BJT2_MOUSE | Insulin-like growth factor-binding ... | Igfbp4 | 122 | Annotation score: |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 4 – 5 | FG → CS in CAA57272 (PubMed:7529732).Curated | 2 | |
Sequence conflicti | 13 | A → T in CAA57272 (PubMed:7529732).Curated | 1 | |
Sequence conflicti | 56 | C → S in CAA57272 (PubMed:7529732).Curated | 1 | |
Sequence conflicti | 67 | C → G in CAA57272 (PubMed:7529732).Curated | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | X81582 mRNA Translation: CAA57272.1 X76066 Genomic DNA Translation: CAA53667.1 AK150229 mRNA Translation: BAE29395.1 AK165688 mRNA Translation: BAE38340.1 BC019836 mRNA Translation: AAH19836.1 Z95492 Genomic DNA Translation: CAB08859.1 |
CCDSi | CCDS25371.1 |
PIRi | I48599 I48603 |
RefSeqi | NP_034647.1, NM_010517.3 |
Genome annotation databases
Ensembli | ENSMUST00000017637; ENSMUSP00000017637; ENSMUSG00000017493 |
GeneIDi | 16010 |
KEGGi | mmu:16010 |
UCSCi | uc007lie.1, mouse |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | X81582 mRNA Translation: CAA57272.1 X76066 Genomic DNA Translation: CAA53667.1 AK150229 mRNA Translation: BAE29395.1 AK165688 mRNA Translation: BAE38340.1 BC019836 mRNA Translation: AAH19836.1 Z95492 Genomic DNA Translation: CAB08859.1 |
CCDSi | CCDS25371.1 |
PIRi | I48599 I48603 |
RefSeqi | NP_034647.1, NM_010517.3 |
3D structure databases
SMRi | P47879 |
ModBasei | Search... |
Protein-protein interaction databases
DIPi | DIP-60633N |
IntActi | P47879, 2 interactors |
STRINGi | 10090.ENSMUSP00000017637 |
Protein family/group databases
MEROPSi | I31.952 |
PTM databases
GlyGeni | P47879, 1 site |
iPTMneti | P47879 |
PhosphoSitePlusi | P47879 |
SwissPalmi | P47879 |
Proteomic databases
CPTACi | non-CPTAC-3986 |
EPDi | P47879 |
MaxQBi | P47879 |
PaxDbi | P47879 |
PeptideAtlasi | P47879 |
PRIDEi | P47879 |
Protocols and materials databases
Antibodypediai | 16491, 632 antibodies |
Genome annotation databases
Ensembli | ENSMUST00000017637; ENSMUSP00000017637; ENSMUSG00000017493 |
GeneIDi | 16010 |
KEGGi | mmu:16010 |
UCSCi | uc007lie.1, mouse |
Organism-specific databases
CTDi | 3487 |
MGIi | MGI:96439, Igfbp4 |
Phylogenomic databases
eggNOGi | ENOG502QTC8, Eukaryota |
GeneTreei | ENSGT00940000159647 |
HOGENOMi | CLU_070833_3_0_1 |
InParanoidi | P47879 |
OMAi | GLCMELA |
OrthoDBi | 979270at2759 |
PhylomeDBi | P47879 |
TreeFami | TF331211 |
Enzyme and pathway databases
Reactomei | R-MMU-381426, Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) R-MMU-8957275, Post-translational protein phosphorylation |
Miscellaneous databases
BioGRID-ORCSi | 16010, 2 hits in 17 CRISPR screens |
ChiTaRSi | Igfbp4, mouse |
PROi | PR:P47879 |
RNActi | P47879, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSMUSG00000017493, Expressed in external carotid artery and 312 other tissues |
ExpressionAtlasi | P47879, baseline and differential |
Genevisiblei | P47879, MM |
Family and domain databases
CDDi | cd00191, TY, 1 hit |
Gene3Di | 4.10.800.10, 1 hit |
InterProi | View protein in InterPro IPR009030, Growth_fac_rcpt_cys_sf IPR022327, IGFBP-4 IPR000867, IGFBP-like IPR022321, IGFBP_1-6_chordata IPR017891, Insulin_GF-bd_Cys-rich_CS IPR000716, Thyroglobulin_1 IPR036857, Thyroglobulin_1_sf |
PANTHERi | PTHR11551:SF7, PTHR11551:SF7, 1 hit |
Pfami | View protein in Pfam PF00219, IGFBP, 1 hit PF00086, Thyroglobulin_1, 1 hit |
PRINTSi | PR01976, IGFBPFAMILY PR01980, IGFBPFAMILY4 |
SMARTi | View protein in SMART SM00121, IB, 1 hit SM00211, TY, 1 hit |
SUPFAMi | SSF57184, SSF57184, 1 hit SSF57610, SSF57610, 1 hit |
PROSITEi | View protein in PROSITE PS00222, IGFBP_N_1, 1 hit PS51323, IGFBP_N_2, 1 hit PS00484, THYROGLOBULIN_1_1, 1 hit PS51162, THYROGLOBULIN_1_2, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | IBP4_MOUSE | |
Accessioni | P47879Primary (citable) accession number: P47879 Secondary accession number(s): O35666, Q3TMV0 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | February 1, 1996 |
Last sequence update: | July 15, 1998 | |
Last modified: | December 2, 2020 | |
This is version 159 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot