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Protein

Insulin-like growth factor-binding protein 4

Gene

Igfbp4

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

IGF-binding proteins prolong the half-life of the IGFs and have been shown to either inhibit or stimulate the growth promoting effects of the IGFs on cell culture. They alter the interaction of IGFs with their cell surface receptors.

GO - Molecular functioni

  • insulin-like growth factor binding Source: MGI
  • insulin-like growth factor I binding Source: GO_Central
  • insulin-like growth factor II binding Source: GO_Central

GO - Biological processi

Keywordsi

Molecular functionGrowth factor binding

Enzyme and pathway databases

ReactomeiR-MMU-381426 Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)
R-MMU-8957275 Post-translational protein phosphorylation

Protein family/group databases

MEROPSiI31.952

Names & Taxonomyi

Protein namesi
Recommended name:
Insulin-like growth factor-binding protein 4
Short name:
IBP-4
Short name:
IGF-binding protein 4
Short name:
IGFBP-4
Gene namesi
Name:Igfbp4
Synonyms:Igfbp-4
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 11

Organism-specific databases

MGIiMGI:96439 Igfbp4

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 21By similarityAdd BLAST21
ChainiPRO_000001438322 – 254Insulin-like growth factor-binding protein 4Add BLAST233

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi27 ↔ 53PROSITE-ProRule annotation
Disulfide bondi30 ↔ 55PROSITE-ProRule annotation
Disulfide bondi38 ↔ 59PROSITE-ProRule annotation
Disulfide bondi44 ↔ 56PROSITE-ProRule annotation
Disulfide bondi67 ↔ 80PROSITE-ProRule annotation
Disulfide bondi74 ↔ 100PROSITE-ProRule annotation
Glycosylationi125N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi131 ↔ 138PROSITE-ProRule annotation
Disulfide bondi170 ↔ 200PROSITE-ProRule annotation
Disulfide bondi211 ↔ 222PROSITE-ProRule annotation
Disulfide bondi224 ↔ 245PROSITE-ProRule annotation
Modified residuei251PhosphoserineBy similarity1

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

EPDiP47879
MaxQBiP47879
PaxDbiP47879
PeptideAtlasiP47879
PRIDEiP47879

PTM databases

iPTMnetiP47879
PhosphoSitePlusiP47879
SwissPalmiP47879

Miscellaneous databases

PMAP-CutDBiP47879

Expressioni

Gene expression databases

BgeeiENSMUSG00000017493 Expressed in 294 organ(s), highest expression level in external carotid artery
CleanExiMM_IGFBP4
ExpressionAtlasiP47879 baseline and differential
GenevisibleiP47879 MM

Interactioni

Subunit structurei

Binds IGF2 more than IGF1.

Binary interactionsi

GO - Molecular functioni

Protein-protein interaction databases

DIPiDIP-60633N
IntActiP47879, 2 interactors
STRINGi10090.ENSMUSP00000017637

Structurei

3D structure databases

ProteinModelPortaliP47879
SMRiP47879
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini23 – 103IGFBP N-terminalPROSITE-ProRule annotationAdd BLAST81
Domaini167 – 245Thyroglobulin type-1PROSITE-ProRule annotationAdd BLAST79

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410IKZ1 Eukaryota
ENOG4111HXV LUCA
GeneTreeiENSGT00550000074457
HOGENOMiHOG000253012
HOVERGENiHBG002631
InParanoidiP47879
OMAiKGMPCGV
OrthoDBiEOG091G0EIN
PhylomeDBiP47879
TreeFamiTF331211

Family and domain databases

CDDicd00191 TY, 1 hit
Gene3Di4.10.800.10, 1 hit
InterProiView protein in InterPro
IPR009030 Growth_fac_rcpt_cys_sf
IPR022327 IGFBP-4
IPR000867 IGFBP-like
IPR009168 IGFBP1-6
IPR022321 IGFBP_1-6_chordata
IPR017891 Insulin_GF-bd_Cys-rich_CS
IPR000716 Thyroglobulin_1
IPR036857 Thyroglobulin_1_sf
PANTHERiPTHR11551 PTHR11551, 1 hit
PTHR11551:SF7 PTHR11551:SF7, 1 hit
PfamiView protein in Pfam
PF00219 IGFBP, 1 hit
PF00086 Thyroglobulin_1, 1 hit
PRINTSiPR01976 IGFBPFAMILY
PR01980 IGFBPFAMILY4
SMARTiView protein in SMART
SM00121 IB, 1 hit
SM00211 TY, 1 hit
SUPFAMiSSF57184 SSF57184, 1 hit
SSF57610 SSF57610, 1 hit
PROSITEiView protein in PROSITE
PS00222 IGFBP_N_1, 1 hit
PS51323 IGFBP_N_2, 1 hit
PS00484 THYROGLOBULIN_1_1, 1 hit
PS51162 THYROGLOBULIN_1_2, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All

P47879-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MLPFGLVAAL LLAAGPRPSL GDEAIHCPPC SEEKLARCRP PVGCEELVRE
60 70 80 90 100
PGCGCCATCA LGLGMPCGVY TPRCGSGMRC YPPRGVEKPL RTLMHGQGVC
110 120 130 140 150
TELSEIEAIQ ESLQTSDKDE SEHPNNSFNP CSAHDHRCLQ KHMAKIRDRS
160 170 180 190 200
KMKIVGTPRE EPRPVPQGSC QSELHRALER LAASQSRTHE DLFIIPIPNC
210 220 230 240 250
DRNGNFHPKQ CHPALDGQRG KCWCVDRKTG VKLPGGLEPK GELDCHQLAD

SFQE
Length:254
Mass (Da):27,807
Last modified:July 15, 1998 - v2
Checksum:i58EF89CB514AEE17
GO

Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
H3BLB7H3BLB7_MOUSE
Insulin-like growth factor-binding ...
Igfbp4
161Annotation score:
H3BJT2H3BJT2_MOUSE
Insulin-like growth factor-binding ...
Igfbp4
122Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti4 – 5FG → CS in CAA57272 (PubMed:7529732).Curated2
Sequence conflicti13A → T in CAA57272 (PubMed:7529732).Curated1
Sequence conflicti56C → S in CAA57272 (PubMed:7529732).Curated1
Sequence conflicti67C → G in CAA57272 (PubMed:7529732).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X81582 mRNA Translation: CAA57272.1
X76066 Genomic DNA Translation: CAA53667.1
AK150229 mRNA Translation: BAE29395.1
AK165688 mRNA Translation: BAE38340.1
BC019836 mRNA Translation: AAH19836.1
Z95492 Genomic DNA Translation: CAB08859.1
CCDSiCCDS25371.1
PIRiI48599
I48603
RefSeqiNP_034647.1, NM_010517.3
UniGeneiMm.233799

Genome annotation databases

EnsembliENSMUST00000017637; ENSMUSP00000017637; ENSMUSG00000017493
GeneIDi16010
KEGGimmu:16010
UCSCiuc007lie.1 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X81582 mRNA Translation: CAA57272.1
X76066 Genomic DNA Translation: CAA53667.1
AK150229 mRNA Translation: BAE29395.1
AK165688 mRNA Translation: BAE38340.1
BC019836 mRNA Translation: AAH19836.1
Z95492 Genomic DNA Translation: CAB08859.1
CCDSiCCDS25371.1
PIRiI48599
I48603
RefSeqiNP_034647.1, NM_010517.3
UniGeneiMm.233799

3D structure databases

ProteinModelPortaliP47879
SMRiP47879
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

DIPiDIP-60633N
IntActiP47879, 2 interactors
STRINGi10090.ENSMUSP00000017637

Protein family/group databases

MEROPSiI31.952

PTM databases

iPTMnetiP47879
PhosphoSitePlusiP47879
SwissPalmiP47879

Proteomic databases

EPDiP47879
MaxQBiP47879
PaxDbiP47879
PeptideAtlasiP47879
PRIDEiP47879

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000017637; ENSMUSP00000017637; ENSMUSG00000017493
GeneIDi16010
KEGGimmu:16010
UCSCiuc007lie.1 mouse

Organism-specific databases

CTDi3487
MGIiMGI:96439 Igfbp4

Phylogenomic databases

eggNOGiENOG410IKZ1 Eukaryota
ENOG4111HXV LUCA
GeneTreeiENSGT00550000074457
HOGENOMiHOG000253012
HOVERGENiHBG002631
InParanoidiP47879
OMAiKGMPCGV
OrthoDBiEOG091G0EIN
PhylomeDBiP47879
TreeFamiTF331211

Enzyme and pathway databases

ReactomeiR-MMU-381426 Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)
R-MMU-8957275 Post-translational protein phosphorylation

Miscellaneous databases

ChiTaRSiIgfbp4 mouse
PMAP-CutDBiP47879
PROiPR:P47879
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000017493 Expressed in 294 organ(s), highest expression level in external carotid artery
CleanExiMM_IGFBP4
ExpressionAtlasiP47879 baseline and differential
GenevisibleiP47879 MM

Family and domain databases

CDDicd00191 TY, 1 hit
Gene3Di4.10.800.10, 1 hit
InterProiView protein in InterPro
IPR009030 Growth_fac_rcpt_cys_sf
IPR022327 IGFBP-4
IPR000867 IGFBP-like
IPR009168 IGFBP1-6
IPR022321 IGFBP_1-6_chordata
IPR017891 Insulin_GF-bd_Cys-rich_CS
IPR000716 Thyroglobulin_1
IPR036857 Thyroglobulin_1_sf
PANTHERiPTHR11551 PTHR11551, 1 hit
PTHR11551:SF7 PTHR11551:SF7, 1 hit
PfamiView protein in Pfam
PF00219 IGFBP, 1 hit
PF00086 Thyroglobulin_1, 1 hit
PRINTSiPR01976 IGFBPFAMILY
PR01980 IGFBPFAMILY4
SMARTiView protein in SMART
SM00121 IB, 1 hit
SM00211 TY, 1 hit
SUPFAMiSSF57184 SSF57184, 1 hit
SSF57610 SSF57610, 1 hit
PROSITEiView protein in PROSITE
PS00222 IGFBP_N_1, 1 hit
PS51323 IGFBP_N_2, 1 hit
PS00484 THYROGLOBULIN_1_1, 1 hit
PS51162 THYROGLOBULIN_1_2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiIBP4_MOUSE
AccessioniPrimary (citable) accession number: P47879
Secondary accession number(s): O35666, Q3TMV0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1996
Last sequence update: July 15, 1998
Last modified: September 12, 2018
This is version 146 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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