Igfbp3

Functionⁱ

IGF-binding proteins prolong the half-life of the IGFs and have been shown to either inhibit or stimulate the growth promoting effects of the IGFs on cell culture. They alter the interaction of IGFs with their cell surface receptors. Also exhibits IGF-independent antiproliferative and apoptotic effects mediated by its receptor TMEM219/IGFBP-3R.

GO - Molecular functionⁱ

fibronectin binding
Source: MGI
Inferred from direct assayⁱ
- 19236847
insulin-like growth factor binding
Source: MGI
Inferred from physical interactionⁱ
- 7679139
insulin-like growth factor I binding Source: MGI
insulin-like growth factor II binding Source: MGI
protein tyrosine phosphatase activator activity Source: UniProtKB

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

negative regulation of cell proliferation Source: MGI
negative regulation of protein phosphorylation
Source: MGI
Inferred from sequence orthologyⁱ
- 17591901
negative regulation of smooth muscle cell migration Source: MGI
negative regulation of smooth muscle cell proliferation Source: MGI
negative regulation of testosterone secretion Source: MGI
osteoblast differentiation
Source: BHF-UCL
Inferred from expression patternⁱ
- 16311053
positive regulation of apoptotic DNA fragmentation Source: MGI
positive regulation of apoptotic process Source: UniProtKB
positive regulation of cardiac muscle cell apoptotic process Source: MGI
positive regulation of insulin-like growth factor receptor signaling pathway
Source: MGI
Inferred from genetic interactionⁱ
- 16675541
positive regulation of MAPK cascade
Source: MGI
Inferred from genetic interactionⁱ
- 16675541
positive regulation of myoblast differentiation Source: UniProtKB
protein phosphorylation
Source: MGI
Inferred from sequence orthologyⁱ
- 17434920
regulation of cell growth
Source: MGI
Inferred from genetic interactionⁱ
- 16675541
regulation of glucose metabolic process
Source: MGI
Inferred from genetic interactionⁱ
- 16675541
regulation of growth
Source: MGI
Inferred from genetic interactionⁱ
- 16675541
type B pancreatic cell proliferation
Source: MGI
Inferred from genetic interactionⁱ
- 16675541

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Growth factor binding

Molecular function

Growth factor binding

Enzyme and pathway databases

Reactomeⁱ	R-MMU-381426 Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) R-MMU-6803211 TP53 Regulates Transcription of Death Receptors and Ligands R-MMU-8957275 Post-translational protein phosphorylation

Reactomeⁱ

R-MMU-381426 Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)
R-MMU-6803211 TP53 Regulates Transcription of Death Receptors and Ligands
R-MMU-8957275 Post-translational protein phosphorylation

Protein family/group databases

MEROPS protease database More...MEROPSⁱ	I31.952

MEROPSⁱ

I31.952

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Insulin-like growth factor-binding protein 3 Short name: IBP-3 Short name: IGF-binding protein 3 Short name: IGFBP-3
Gene namesⁱ	Name:Igfbp3 Synonyms:Igfbp-3
Organismⁱ	Mus musculus (Mouse)
Taxonomic identifierⁱ	10090 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus
Proteomesⁱ	UP000000589 Componentⁱ: Chromosome 11

Organism-specific databases

MGIⁱ	MGI:96438 Igfbp3

Keywords - Cellular componentⁱ

Secreted

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Signal peptideⁱ	1 – 27	By similarityAdd BLAST		27
ChainⁱPRO_0000014379	28 – 292	Insulin-like growth factor-binding protein 3Add BLAST		265

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Glycosylationⁱ	118	N-linked (GlcNAc...) asparagineSequence analysis	1
Glycosylationⁱ	137	N-linked (GlcNAc...) asparagineSequence analysis	1
Modified residueⁱ	149	PhosphoserineBy similarity	1
Glycosylationⁱ	200	N-linked (GlcNAc...) asparagineSequence analysis	1
Modified residueⁱ	202	PhosphoserineBy similarity	1
Disulfide bondⁱ	214 ↔ 241	PROSITE-ProRule annotation
Disulfide bondⁱ	252 ↔ 263	PROSITE-ProRule annotation
Disulfide bondⁱ	265 ↔ 286	PROSITE-ProRule annotation

Post-translational modificationⁱ

Phosphorylated by FAM20C in the extracellular medium.By similarity

Keywords - PTMⁱ

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

PaxDbⁱ	P47878
PeptideAtlas More...PeptideAtlasⁱ	P47878
PRIDEⁱ	P47878

PTM databases

iPTMnetⁱ	P47878
PhosphoSitePlusⁱ	P47878

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSMUSG00000020427 Expressed in 285 organ(s), highest expression level in decidua
CleanExⁱ	MM_IGFBP3
Genevisibleⁱ	P47878 MM

Interactionⁱ

Subunit structureⁱ

Interacts with XLKD1. Binds IGF2 more than IGF1. Forms a ternary complex of about 140 to 150 kDa with IGF1 or IGF2 and a 85 kDa glycoprotein (ALS). Interacts with HN. Interacts with TMEM219 (By similarity).By similarity

GO - Molecular functionⁱ

fibronectin binding
Source: MGI
Inferred from direct assayⁱ
- 19236847
insulin-like growth factor binding
Source: MGI
Inferred from physical interactionⁱ
- 7679139
insulin-like growth factor I binding Source: MGI
insulin-like growth factor II binding Source: MGI

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

IntActⁱ	P47878, 1 interactor
STRINGⁱ	10090.ENSMUSP00000020702

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	P47878
SMRⁱ	P47878
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Domainⁱ	36 – 119	IGFBP N-terminalPROSITE-ProRule annotationAdd BLAST		84
Domainⁱ	211 – 286	Thyroglobulin type-1PROSITE-ProRule annotationAdd BLAST		76

Keywords - Domainⁱ

Signal

Phylogenomic databases

eggNOGⁱ	ENOG410IHZU Eukaryota ENOG4111MF3 LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00550000074457
HOGENOMⁱ	HOG000253012
HOVERGENⁱ	HBG002631
InParanoidⁱ	P47878
KEGG Orthology (KO) More...KOⁱ	K10138
OMAⁱ	KGDVHCY
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0EIN
PhylomeDBⁱ	P47878
TreeFamⁱ	TF331211

Family and domain databases

Conserved Domains Database More...CDDⁱ	cd00191 TY, 1 hit
Gene3Dⁱ	4.10.800.10, 1 hit
InterProⁱ	View protein in InterPro IPR009030 Growth_fac_rcpt_cys_sf IPR012211 IGFBP-3 IPR000867 IGFBP-like IPR009168 IGFBP1-6 IPR022321 IGFBP_1-6_chordata IPR017891 Insulin_GF-bd_Cys-rich_CS IPR000716 Thyroglobulin_1 IPR036857 Thyroglobulin_1_sf
PANTHERⁱ	PTHR11551 PTHR11551, 1 hit PTHR11551:SF3 PTHR11551:SF3, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00219 IGFBP, 1 hit PF00086 Thyroglobulin_1, 1 hit
PRINTSⁱ	PR01976 IGFBPFAMILY PR01979 IGFBPFAMILY3
SMARTⁱ	View protein in SMART SM00121 IB, 1 hit SM00211 TY, 1 hit
SUPFAMⁱ	SSF57184 SSF57184, 1 hit SSF57610 SSF57610, 1 hit
PROSITEⁱ	View protein in PROSITE PS00222 IGFBP_N_1, 1 hit PS51323 IGFBP_N_2, 1 hit PS00484 THYROGLOBULIN_1_1, 1 hit PS51162 THYROGLOBULIN_1_2, 1 hit

Sequenceⁱ

Sequence statusⁱ: Complete.

Sequence processingⁱ: The displayed sequence is further processed into a mature form.

P47878-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MHPARPALWA AALTALTLLR GPPVARAGAG AVGAGPVVRC EPCDARALSQ 
        60         70         80         90        100
CAPPPTAPAC TELVREPGCG CCLTCALREG DACGVYTERC GTGLRCQPRP 
       110        120        130        140        150
AEQYPLRALL NGRGFCANAS AAGSLSTYLP SQPAPGNISE SEEEHNAGSV 
       160        170        180        190        200
ESQVVPSTHR VTDSKFHPLH AKMDVIKKGH ARDSQRYKVD YESQSTDTQN 
       210        220        230        240        250
FSSESKRETE YGPCRREMED TLNHLKFLNV LSPRGVHIPN CDKKGFYKKK 
       260        270        280        290 
QCRPSKGRKR GFCWCVDKYG QPLPGYDTKG KDDVHCLSVQ SQ

Length:292

Mass (Da):31,687

Last modified:October 16, 2013 - v2

Checksum:ⁱ317F830AA843B73D

GO

Experimental Info

Feature key	Position(s)	DescriptionActions	Length
Sequence conflictⁱ	26 – 28	RAG → ELA in CAA57271 (PubMed:7529732).Curated	3
Sequence conflictⁱ	34	Missing in CAA57271 (PubMed:7529732).Curated	1
Sequence conflictⁱ	48	L → V in CAA57271 (PubMed:7529732).Curated	1
Sequence conflictⁱ	251	Q → R in CAA57271 (PubMed:7529732).Curated	1
Sequence conflictⁱ	260 – 261	RG → QS in CAA57271 (PubMed:7529732).Curated	2
Sequence conflictⁱ	272	P → R in CAA57271 (PubMed:7529732).Curated	1

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	X81581 mRNA Translation: CAA57271.1 AL607124 Genomic DNA No translation available. BC058261 mRNA Translation: AAH58261.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS24428.1
PIRⁱ	I48602
NCBI Reference Sequences More...RefSeqⁱ	NP_032369.2, NM_008343.2
UniGeneⁱ	Mm.29254

Genome annotation databases

Ensemblⁱ	ENSMUST00000020702; ENSMUSP00000020702; ENSMUSG00000020427 ENSMUST00000135887; ENSMUSP00000131670; ENSMUSG00000020427
GeneIDⁱ	16009
KEGGⁱ	mmu:16009
UCSC genome browser More...UCSCⁱ	uc007hzi.2 mouse

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
P47878	Insulin-like growth factor-binding protein 3		CRIGR		75	UniRef100_P47878
Uncharacterized protein (Fragment)		MOUSE		210

Protein	Similar proteins		Species	Score	Length	Source
P47878	Insulin-like growth factor-binding protein 3		RAT		292	UniRef90_P15473
Insulin-like growth factor-binding protein 3		CRIGR		75
Uncharacterized protein (Fragment)		MOUSE		210
insulin-like growth factor-binding protein 3		MESAU		292
UPI000A3081DD		MUSPA		298
+9

Protein	Similar proteins		Species	Score	Length	Source
P47878	Insulin-like growth factor-binding protein 3		RAT		292	UniRef50_P15473
insulin-like growth factor-binding protein 3		MESAU		292
Insulin-like growth factor-binding protein 3		CRIGR		75
Uncharacterized protein (Fragment)		MOUSE		210
Insulin like growth factor binding protein 3		OTOGA		293
+79

Entry informationⁱ

Entry nameⁱ	IBP3_MOUSE
Accessionⁱ	P47878Primary (citable) accession number: P47878 Secondary accession number(s): Q6PE62
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	February 1, 1996
	Last sequence update:	October 16, 2013
	Last modified:	September 12, 2018
	This is version 147 of the entry and version 2 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - P47878 (IBP3_MOUSE)

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Insulin-like growth factor-binding protein 3

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

Protein family/group databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted

Extracellular region or secreted

Nucleus

Other locations

Keywords - Cellular componenti

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Keywords - Domaini

Phylogenomic databases

Family and domain databases

Experimental Info

Sequence databases

Genome annotation databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

GO - Molecular functionⁱ

Structureⁱ

Family & Domainsⁱ

Keywords - Domainⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ