Insulin-like growth factor-binding protein 3

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functionⁱ

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functionⁱ

• fibronectin binding Source: MGI <p>Inferred from Direct Assay</p> <p>Used to indicate a direct assay for the function, process or component indicated by the GO term.</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#ida">GO evidence code guide</a></p> Inferred from direct assayⁱ
  • "IGFBP-3 and IGFBP-5 associate with the cell binding domain (CBD) of fibronectin."
    Beattie J., Kreiner M., Allan G.J., Flint D.J., Domingues D., van der Walle C.F.
    Biochem. Biophys. Res. Commun. 381:572-576(2009) [PubMed] [Europe PMC] [Abstract]
• insulin-like growth factor binding Source: MGI <p>Inferred from Physical Interaction</p> <p>Covers physical interactions between the gene product of interest and another molecule (or ion, or complex).</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#ipi">GO evidence code guide</a></p> Inferred from physical interactionⁱ
  • "Growth hormone deficiency in 'little' mice results in aberrant body composition, reduced insulin-like growth factor-I and insulin-like growth factor-binding protein-3 (IGFBP-3), but does not affect IGFBP-2, -1 or -4."
    Donahue L.R., Beamer W.G.
    J. Endocrinol. 136:91-104(1993) [PubMed] [Europe PMC] [Abstract]
• insulin-like growth factor I binding Source: MGI
• insulin-like growth factor II binding Source: MGI
• protein tyrosine phosphatase activator activity Source: UniProtKB

GO - Biological processⁱ

• negative regulation of cell population proliferation Source: MGI
• negative regulation of protein phosphorylation Source: MGIInferred from sequence orthologyⁱ
  • "The requirement of pax6 for postnatal eye development: evidence from experimental mouse chimeras."
    Li S., Goldowitz D., Swanson D.J.
    Invest. Ophthalmol. Vis. Sci. 48:3292-3300(2007) [PubMed] [Europe PMC] [Abstract]
• negative regulation of smooth muscle cell migration Source: MGI
• negative regulation of smooth muscle cell proliferation Source: MGI
• negative regulation of testosterone secretion Source: MGI
• osteoblast differentiation Source: BHF-UCL <p>Inferred from Expression Pattern</p> <p>Covers cases where the annotation is inferred from the timing or location of expression of a gene.</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#iep">GO evidence code guide</a></p> Inferred from expression patternⁱ
  • "Regulation of insulin-like growth factor binding protein-5, four and a half lim-2, and a disintegrin and metalloprotease-9 expression in osteoblasts."
    Govoni K.E., Amaar Y.G., Kramer A., Winter E., Baylink D.J., Mohan S.
    Growth Horm. IGF Res. 16:49-56(2006) [PubMed] [Europe PMC] [Abstract]
• positive regulation of apoptotic DNA fragmentation Source: MGI
• positive regulation of apoptotic process Source: UniProtKB
• positive regulation of cardiac muscle cell apoptotic process Source: MGI
• positive regulation of insulin-like growth factor receptor signaling pathway Source: MGI <p>Inferred from Genetic Interaction</p> <p>Used to describe “traditional” genetic interactions such as suppressors and synthetic lethals as well as other techniques such as functional complementation, rescue experiments, or inferences about a gene drawn from the phenotype of a mutation in a different gene.</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#igi">GO evidence code guide</a></p> Inferred from genetic interactionⁱ
  • "Diminished growth and enhanced glucose metabolism in triple knockout mice containing mutations of insulin-like growth factor binding protein-3, -4, and -5."
    Ning Y., Schuller A.G., Bradshaw S., Rotwein P., Ludwig T., Frystyk J., Pintar J.E.
    Mol. Endocrinol. 20:2173-2186(2006) [PubMed] [Europe PMC] [Abstract]
• positive regulation of MAPK cascade Source: MGIInferred from genetic interactionⁱ
  • "Diminished growth and enhanced glucose metabolism in triple knockout mice containing mutations of insulin-like growth factor binding protein-3, -4, and -5."
    Ning Y., Schuller A.G., Bradshaw S., Rotwein P., Ludwig T., Frystyk J., Pintar J.E.
    Mol. Endocrinol. 20:2173-2186(2006) [PubMed] [Europe PMC] [Abstract]
• positive regulation of myoblast differentiation Source: UniProtKB
• protein phosphorylation Source: MGIInferred from sequence orthologyⁱ
  • "Contribution of the orphan nuclear receptor Nur77 to the apoptotic action of IGFBP-3."
    Lee K.W., Cobb L.J., Paharkova-Vatchkova V., Liu B., Milbrandt J., Cohen P.
    Carcinogenesis 28:1653-1658(2007) [PubMed] [Europe PMC] [Abstract]
• regulation of cell growth Source: MGIInferred from genetic interactionⁱ
  • "Diminished growth and enhanced glucose metabolism in triple knockout mice containing mutations of insulin-like growth factor binding protein-3, -4, and -5."
    Ning Y., Schuller A.G., Bradshaw S., Rotwein P., Ludwig T., Frystyk J., Pintar J.E.
    Mol. Endocrinol. 20:2173-2186(2006) [PubMed] [Europe PMC] [Abstract]
• regulation of glucose metabolic process Source: MGIInferred from genetic interactionⁱ
  • "Diminished growth and enhanced glucose metabolism in triple knockout mice containing mutations of insulin-like growth factor binding protein-3, -4, and -5."
    Ning Y., Schuller A.G., Bradshaw S., Rotwein P., Ludwig T., Frystyk J., Pintar J.E.
    Mol. Endocrinol. 20:2173-2186(2006) [PubMed] [Europe PMC] [Abstract]
• regulation of growth Source: MGIInferred from genetic interactionⁱ
  • "Diminished growth and enhanced glucose metabolism in triple knockout mice containing mutations of insulin-like growth factor binding protein-3, -4, and -5."
    Ning Y., Schuller A.G., Bradshaw S., Rotwein P., Ludwig T., Frystyk J., Pintar J.E.
    Mol. Endocrinol. 20:2173-2186(2006) [PubMed] [Europe PMC] [Abstract]
• regulation of insulin-like growth factor receptor signaling pathway Source: GO_Central <p>Inferred from Biological aspect of Ancestor</p> <p>A type of phylogenetic evidence whereby an aspect of a descendent is inferred through the characterization of an aspect of a ancestral gene.</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#iba">GO evidence code guide</a></p> Inferred from biological aspect of ancestorⁱ
  • "Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium."
    Gaudet P., Livstone M.S., Lewis S.E., Thomas P.D.
    Brief. Bioinformatics 12:449-462(2011) [PubMed] [Europe PMC] [Abstract]
• type B pancreatic cell proliferation Source: MGIInferred from genetic interactionⁱ
  • "Diminished growth and enhanced glucose metabolism in triple knockout mice containing mutations of insulin-like growth factor binding protein-3, -4, and -5."
    Ning Y., Schuller A.G., Bradshaw S., Rotwein P., Ludwig T., Frystyk J., Pintar J.E.
    Mol. Endocrinol. 20:2173-2186(2006) [PubMed] [Europe PMC] [Abstract]

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsⁱ

Enzyme and pathway databases

Protein family/group databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyⁱ

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationⁱ

Keywords - Cellular componentⁱ

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingⁱ

Molecule processing

Amino acid modifications

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationⁱ

Keywords - PTMⁱ

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressionⁱ

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactionⁱ

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structureⁱ

GO - Molecular functionⁱ

• fibronectin binding Source: MGIInferred from direct assayⁱ
  • "IGFBP-3 and IGFBP-5 associate with the cell binding domain (CBD) of fibronectin."
    Beattie J., Kreiner M., Allan G.J., Flint D.J., Domingues D., van der Walle C.F.
    Biochem. Biophys. Res. Commun. 381:572-576(2009) [PubMed] [Europe PMC] [Abstract]
• insulin-like growth factor binding Source: MGIInferred from physical interactionⁱ
  • "Growth hormone deficiency in 'little' mice results in aberrant body composition, reduced insulin-like growth factor-I and insulin-like growth factor-binding protein-3 (IGFBP-3), but does not affect IGFBP-2, -1 or -4."
    Donahue L.R., Beamer W.G.
    J. Endocrinol. 136:91-104(1993) [PubMed] [Europe PMC] [Abstract]
• insulin-like growth factor I binding Source: MGI
• insulin-like growth factor II binding Source: MGI

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structureⁱ

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsⁱ

Domains and Repeats

Keywords - Domainⁱ

Phylogenomic databases

Family and domain databases

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequenceⁱ

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusⁱ: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingⁱ: The displayed sequence is further processed into a mature form.

        10         20         30         40         50
MHPARPALWA AALTALTLLR GPPVARAGAG AVGAGPVVRC EPCDARALSQ 
        60         70         80         90        100
CAPPPTAPAC TELVREPGCG CCLTCALREG DACGVYTERC GTGLRCQPRP 
       110        120        130        140        150
AEQYPLRALL NGRGFCANAS AAGSLSTYLP SQPAPGNISE SEEEHNAGSV 
       160        170        180        190        200
ESQVVPSTHR VTDSKFHPLH AKMDVIKKGH ARDSQRYKVD YESQSTDTQN 
       210        220        230        240        250
FSSESKRETE YGPCRREMED TLNHLKFLNV LSPRGVHIPN CDKKGFYKKK 
       260        270        280        290 
QCRPSKGRKR GFCWCVDKYG QPLPGYDTKG KDDVHCLSVQ SQ         

Experimental Info

Sequence databases

Genome annotation databases

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsⁱ

• 100% Identity
• 90% Identity
• 50% Identity

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesⁱ

Sequence databases

3D structure databases

Protein-protein interaction databases

Protein family/group databases

PTM databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationⁱ

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousⁱ

Keywords - Technical termⁱ

Documents

1. MGD cross-references
   Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot