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Protein

Insulin-like growth factor-binding protein 3

Gene

Igfbp3

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

IGF-binding proteins prolong the half-life of the IGFs and have been shown to either inhibit or stimulate the growth promoting effects of the IGFs on cell culture. They alter the interaction of IGFs with their cell surface receptors. Also exhibits IGF-independent antiproliferative and apoptotic effects mediated by its receptor TMEM219/IGFBP-3R.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionGrowth factor binding

Enzyme and pathway databases

ReactomeiR-MMU-381426 Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)
R-MMU-6803211 TP53 Regulates Transcription of Death Receptors and Ligands
R-MMU-8957275 Post-translational protein phosphorylation

Protein family/group databases

MEROPSiI31.952

Names & Taxonomyi

Protein namesi
Recommended name:
Insulin-like growth factor-binding protein 3
Short name:
IBP-3
Short name:
IGF-binding protein 3
Short name:
IGFBP-3
Gene namesi
Name:Igfbp3
Synonyms:Igfbp-3
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 11

Organism-specific databases

MGIiMGI:96438 Igfbp3

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 27By similarityAdd BLAST27
ChainiPRO_000001437928 – 292Insulin-like growth factor-binding protein 3Add BLAST265

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi118N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi137N-linked (GlcNAc...) asparagineSequence analysis1
Modified residuei149PhosphoserineBy similarity1
Glycosylationi200N-linked (GlcNAc...) asparagineSequence analysis1
Modified residuei202PhosphoserineBy similarity1
Disulfide bondi214 ↔ 241PROSITE-ProRule annotation
Disulfide bondi252 ↔ 263PROSITE-ProRule annotation
Disulfide bondi265 ↔ 286PROSITE-ProRule annotation

Post-translational modificationi

Phosphorylated by FAM20C in the extracellular medium.By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

PaxDbiP47878
PeptideAtlasiP47878
PRIDEiP47878

PTM databases

iPTMnetiP47878
PhosphoSitePlusiP47878

Expressioni

Gene expression databases

BgeeiENSMUSG00000020427 Expressed in 285 organ(s), highest expression level in decidua
CleanExiMM_IGFBP3
GenevisibleiP47878 MM

Interactioni

Subunit structurei

Interacts with XLKD1. Binds IGF2 more than IGF1. Forms a ternary complex of about 140 to 150 kDa with IGF1 or IGF2 and a 85 kDa glycoprotein (ALS). Interacts with HN. Interacts with TMEM219 (By similarity).By similarity

GO - Molecular functioni

Protein-protein interaction databases

IntActiP47878, 1 interactor
STRINGi10090.ENSMUSP00000020702

Structurei

3D structure databases

ProteinModelPortaliP47878
SMRiP47878
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini36 – 119IGFBP N-terminalPROSITE-ProRule annotationAdd BLAST84
Domaini211 – 286Thyroglobulin type-1PROSITE-ProRule annotationAdd BLAST76

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410IHZU Eukaryota
ENOG4111MF3 LUCA
GeneTreeiENSGT00550000074457
HOGENOMiHOG000253012
HOVERGENiHBG002631
InParanoidiP47878
KOiK10138
OMAiKGDVHCY
OrthoDBiEOG091G0EIN
PhylomeDBiP47878
TreeFamiTF331211

Family and domain databases

CDDicd00191 TY, 1 hit
Gene3Di4.10.800.10, 1 hit
InterProiView protein in InterPro
IPR009030 Growth_fac_rcpt_cys_sf
IPR012211 IGFBP-3
IPR000867 IGFBP-like
IPR009168 IGFBP1-6
IPR022321 IGFBP_1-6_chordata
IPR017891 Insulin_GF-bd_Cys-rich_CS
IPR000716 Thyroglobulin_1
IPR036857 Thyroglobulin_1_sf
PANTHERiPTHR11551 PTHR11551, 1 hit
PTHR11551:SF3 PTHR11551:SF3, 1 hit
PfamiView protein in Pfam
PF00219 IGFBP, 1 hit
PF00086 Thyroglobulin_1, 1 hit
PRINTSiPR01976 IGFBPFAMILY
PR01979 IGFBPFAMILY3
SMARTiView protein in SMART
SM00121 IB, 1 hit
SM00211 TY, 1 hit
SUPFAMiSSF57184 SSF57184, 1 hit
SSF57610 SSF57610, 1 hit
PROSITEiView protein in PROSITE
PS00222 IGFBP_N_1, 1 hit
PS51323 IGFBP_N_2, 1 hit
PS00484 THYROGLOBULIN_1_1, 1 hit
PS51162 THYROGLOBULIN_1_2, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P47878-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MHPARPALWA AALTALTLLR GPPVARAGAG AVGAGPVVRC EPCDARALSQ
60 70 80 90 100
CAPPPTAPAC TELVREPGCG CCLTCALREG DACGVYTERC GTGLRCQPRP
110 120 130 140 150
AEQYPLRALL NGRGFCANAS AAGSLSTYLP SQPAPGNISE SEEEHNAGSV
160 170 180 190 200
ESQVVPSTHR VTDSKFHPLH AKMDVIKKGH ARDSQRYKVD YESQSTDTQN
210 220 230 240 250
FSSESKRETE YGPCRREMED TLNHLKFLNV LSPRGVHIPN CDKKGFYKKK
260 270 280 290
QCRPSKGRKR GFCWCVDKYG QPLPGYDTKG KDDVHCLSVQ SQ
Length:292
Mass (Da):31,687
Last modified:October 16, 2013 - v2
Checksum:i317F830AA843B73D
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti26 – 28RAG → ELA in CAA57271 (PubMed:7529732).Curated3
Sequence conflicti34Missing in CAA57271 (PubMed:7529732).Curated1
Sequence conflicti48L → V in CAA57271 (PubMed:7529732).Curated1
Sequence conflicti251Q → R in CAA57271 (PubMed:7529732).Curated1
Sequence conflicti260 – 261RG → QS in CAA57271 (PubMed:7529732).Curated2
Sequence conflicti272P → R in CAA57271 (PubMed:7529732).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X81581 mRNA Translation: CAA57271.1
AL607124 Genomic DNA No translation available.
BC058261 mRNA Translation: AAH58261.1
CCDSiCCDS24428.1
PIRiI48602
RefSeqiNP_032369.2, NM_008343.2
UniGeneiMm.29254

Genome annotation databases

EnsembliENSMUST00000020702; ENSMUSP00000020702; ENSMUSG00000020427
ENSMUST00000135887; ENSMUSP00000131670; ENSMUSG00000020427
GeneIDi16009
KEGGimmu:16009
UCSCiuc007hzi.2 mouse

Similar proteinsi

Entry informationi

Entry nameiIBP3_MOUSE
AccessioniPrimary (citable) accession number: P47878
Secondary accession number(s): Q6PE62
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1996
Last sequence update: October 16, 2013
Last modified: September 12, 2018
This is version 147 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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