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Protein

Insulin-like growth factor-binding protein 2

Gene

Igfbp2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Inhibits IGF-mediated growth and developmental rates (By similarity). IGF-binding proteins prolong the half-life of the IGFs and have been shown to either inhibit or stimulate the growth promoting effects of the IGFs on cell culture. They alter the interaction of IGFs with their cell surface receptors.By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionGrowth factor binding
Biological processGrowth regulation

Enzyme and pathway databases

ReactomeiR-MMU-381426 Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)

Protein family/group databases

MEROPSiI31.953

Names & Taxonomyi

Protein namesi
Recommended name:
Insulin-like growth factor-binding protein 2
Short name:
IBP-2
Short name:
IGF-binding protein 2
Short name:
IGFBP-2
Short name:
mIGFBP-2
Gene namesi
Name:Igfbp2
Synonyms:Igfbp-2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 1

Organism-specific databases

MGIiMGI:96437 Igfbp2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 34By similarityAdd BLAST34
ChainiPRO_000001437135 – 305Insulin-like growth factor-binding protein 2Add BLAST271

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi207 ↔ 241PROSITE-ProRule annotation
Disulfide bondi252 ↔ 263PROSITE-ProRule annotation
Disulfide bondi265 ↔ 286PROSITE-ProRule annotation

Post-translational modificationi

O-glycosylated.By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

MaxQBiP47877
PaxDbiP47877
PeptideAtlasiP47877
PRIDEiP47877

PTM databases

iPTMnetiP47877
PhosphoSitePlusiP47877

Expressioni

Tissue specificityi

Highly expressed in adult liver, but also in kidney, lung, brain, spleen, testis and ovary.1 Publication

Developmental stagei

Expressed embryos at day 11.5. Also expressed in fetal livers with expression increasing dramatically after birth. Expression decreases only slightly after postnatal day 3 and remains abundant thereafter.1 Publication

Gene expression databases

BgeeiENSMUSG00000039323 Expressed in 301 organ(s), highest expression level in liver
CleanExiMM_IGFBP2
ExpressionAtlasiP47877 baseline and differential
GenevisibleiP47877 MM

Interactioni

Subunit structurei

Binds IGF2 more than IGF1.

GO - Molecular functioni

Protein-protein interaction databases

DIPiDIP-60632N
IntActiP47877, 3 interactors
MINTiP47877
STRINGi10090.ENSMUSP00000046610

Structurei

3D structure databases

ProteinModelPortaliP47877
SMRiP47877
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini36 – 118IGFBP N-terminalPROSITE-ProRule annotationAdd BLAST83
Domaini204 – 286Thyroglobulin type-1PROSITE-ProRule annotationAdd BLAST83

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi281 – 283Cell attachment site3

Domaini

The C-terminus is required for IGF-binding and growth inhibition.By similarity

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410IHUR Eukaryota
ENOG4111GWQ LUCA
GeneTreeiENSGT00550000074457
HOGENOMiHOG000253012
HOVERGENiHBG002631
InParanoidiP47877
OMAiDGTMNML
OrthoDBiEOG091G0EIN
PhylomeDBiP47877
TreeFamiTF331211

Family and domain databases

CDDicd00191 TY, 1 hit
Gene3Di4.10.800.10, 1 hit
InterProiView protein in InterPro
IPR009030 Growth_fac_rcpt_cys_sf
IPR012210 IGFBP-2
IPR000867 IGFBP-like
IPR009168 IGFBP1-6
IPR022321 IGFBP_1-6_chordata
IPR017891 Insulin_GF-bd_Cys-rich_CS
IPR000716 Thyroglobulin_1
IPR036857 Thyroglobulin_1_sf
PANTHERiPTHR11551 PTHR11551, 1 hit
PfamiView protein in Pfam
PF00219 IGFBP, 1 hit
PF00086 Thyroglobulin_1, 1 hit
PRINTSiPR01976 IGFBPFAMILY
PR01978 IGFBPFAMILY2
SMARTiView protein in SMART
SM00121 IB, 1 hit
SM00211 TY, 1 hit
SUPFAMiSSF57184 SSF57184, 1 hit
SSF57610 SSF57610, 1 hit
PROSITEiView protein in PROSITE
PS00222 IGFBP_N_1, 1 hit
PS51323 IGFBP_N_2, 1 hit
PS00484 THYROGLOBULIN_1_1, 1 hit
PS51162 THYROGLOBULIN_1_2, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

P47877-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MLPRLGGPAL PLLLPSLLLL LLLGAGGCGP GVRAEVLFRC PPCTPERLAA
60 70 80 90 100
CGPPPDAPCA ELVREPGCGC CSVCARQEGE ACGVYIPRCA QTLRCYPNPG
110 120 130 140 150
SELPLKALVT GAGTCEKRRV GTTPQQVADS DDDHSEGGLV ENHVDGTMNM
160 170 180 190 200
LGGGSSAGRK PLKSGMKELA VFREKVNEQH RQMGKGAKHL SLEEPKKLRP
210 220 230 240 250
PPARTPCQQE LDQVLERIST MRLPDDRGPL EHLYSLHIPN CDKHGRYNLK
260 270 280 290 300
QCKMSLNGQR GECWCVNPNT GKPIQGAPTI RGDPECHLFY NEQQETGGAH

AQSVQ
Length:305
Mass (Da):32,847
Last modified:February 10, 2009 - v2
Checksum:i179FE6A304E93A16
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
D3YU40D3YU40_MOUSE
Insulin-like growth factor-binding ...
Igfbp2
158Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti47R → A in CAA57270 (PubMed:7529732).Curated1
Sequence conflicti133D → H in AAB60709 (PubMed:7680327).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L05439
, L05436, L05437, L05438 Genomic DNA Translation: AAB60709.1
X81580 mRNA Translation: CAA57270.1
CH466548 Genomic DNA Translation: EDL00293.1
BC012724 mRNA Translation: AAH12724.1
BC054473 mRNA Translation: AAH54473.1
CCDSiCCDS15036.1
PIRiI48601
JN0508
RefSeqiNP_032368.2, NM_008342.3
UniGeneiMm.141936

Genome annotation databases

EnsembliENSMUST00000047328; ENSMUSP00000046610; ENSMUSG00000039323
GeneIDi16008
KEGGimmu:16008
UCSCiuc007bkw.2 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L05439
, L05436, L05437, L05438 Genomic DNA Translation: AAB60709.1
X81580 mRNA Translation: CAA57270.1
CH466548 Genomic DNA Translation: EDL00293.1
BC012724 mRNA Translation: AAH12724.1
BC054473 mRNA Translation: AAH54473.1
CCDSiCCDS15036.1
PIRiI48601
JN0508
RefSeqiNP_032368.2, NM_008342.3
UniGeneiMm.141936

3D structure databases

ProteinModelPortaliP47877
SMRiP47877
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

DIPiDIP-60632N
IntActiP47877, 3 interactors
MINTiP47877
STRINGi10090.ENSMUSP00000046610

Protein family/group databases

MEROPSiI31.953

PTM databases

iPTMnetiP47877
PhosphoSitePlusiP47877

Proteomic databases

MaxQBiP47877
PaxDbiP47877
PeptideAtlasiP47877
PRIDEiP47877

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000047328; ENSMUSP00000046610; ENSMUSG00000039323
GeneIDi16008
KEGGimmu:16008
UCSCiuc007bkw.2 mouse

Organism-specific databases

CTDi3485
MGIiMGI:96437 Igfbp2

Phylogenomic databases

eggNOGiENOG410IHUR Eukaryota
ENOG4111GWQ LUCA
GeneTreeiENSGT00550000074457
HOGENOMiHOG000253012
HOVERGENiHBG002631
InParanoidiP47877
OMAiDGTMNML
OrthoDBiEOG091G0EIN
PhylomeDBiP47877
TreeFamiTF331211

Enzyme and pathway databases

ReactomeiR-MMU-381426 Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)

Miscellaneous databases

ChiTaRSiIgfbp2 mouse
PROiPR:P47877
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000039323 Expressed in 301 organ(s), highest expression level in liver
CleanExiMM_IGFBP2
ExpressionAtlasiP47877 baseline and differential
GenevisibleiP47877 MM

Family and domain databases

CDDicd00191 TY, 1 hit
Gene3Di4.10.800.10, 1 hit
InterProiView protein in InterPro
IPR009030 Growth_fac_rcpt_cys_sf
IPR012210 IGFBP-2
IPR000867 IGFBP-like
IPR009168 IGFBP1-6
IPR022321 IGFBP_1-6_chordata
IPR017891 Insulin_GF-bd_Cys-rich_CS
IPR000716 Thyroglobulin_1
IPR036857 Thyroglobulin_1_sf
PANTHERiPTHR11551 PTHR11551, 1 hit
PfamiView protein in Pfam
PF00219 IGFBP, 1 hit
PF00086 Thyroglobulin_1, 1 hit
PRINTSiPR01976 IGFBPFAMILY
PR01978 IGFBPFAMILY2
SMARTiView protein in SMART
SM00121 IB, 1 hit
SM00211 TY, 1 hit
SUPFAMiSSF57184 SSF57184, 1 hit
SSF57610 SSF57610, 1 hit
PROSITEiView protein in PROSITE
PS00222 IGFBP_N_1, 1 hit
PS51323 IGFBP_N_2, 1 hit
PS00484 THYROGLOBULIN_1_1, 1 hit
PS51162 THYROGLOBULIN_1_2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiIBP2_MOUSE
AccessioniPrimary (citable) accession number: P47877
Secondary accession number(s): Q61722, Q91VK7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1996
Last sequence update: February 10, 2009
Last modified: September 12, 2018
This is version 148 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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