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UniProtKB - P47877 (IBP2_MOUSE)
Protein
Insulin-like growth factor-binding protein 2
Gene
Igfbp2
Organism
Mus musculus (Mouse)
Status
Functioni
Inhibits IGF-mediated growth and developmental rates (By similarity).
IGF-binding proteins prolong the half-life of the IGFs and have been shown to either inhibit or stimulate the growth promoting effects of the IGFs on cell culture. They alter the interaction of IGFs with their cell surface receptors.
By similarityGO - Molecular functioni
- insulin-like growth factor binding Source: MGI
- insulin-like growth factor I binding Source: UniProtKB
- insulin-like growth factor II binding Source: UniProtKB
GO - Biological processi
- aging Source: Ensembl
- cellular response to hormone stimulus Source: Ensembl
- female pregnancy Source: Ensembl
- positive regulation of activated T cell proliferation Source: UniProtKB
- regulation of growth Source: UniProtKB-KW
- regulation of insulin-like growth factor receptor signaling pathway Source: UniProtKB
- response to estradiol Source: Ensembl
- response to estrogen Source: Ensembl
- response to glucocorticoid Source: Ensembl
- response to lithium ion Source: Ensembl
- response to mechanical stimulus Source: Ensembl
- response to nutrient Source: Ensembl
- response to retinoic acid Source: Ensembl
- response to xenobiotic stimulus Source: Ensembl
- signal transduction Source: Ensembl
Keywordsi
Molecular function | Growth factor binding |
Biological process | Growth regulation |
Enzyme and pathway databases
Reactomei | R-MMU-381426, Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) |
Protein family/group databases
MEROPSi | I31.953 |
Names & Taxonomyi
Protein namesi | Recommended name: Insulin-like growth factor-binding protein 2Short name: IBP-2 Short name: IGF-binding protein 2 Short name: IGFBP-2 Short name: mIGFBP-2 |
Gene namesi | Name:Igfbp2 Synonyms:Igfbp-2 |
Organismi | Mus musculus (Mouse) |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Proteomesi |
|
Organism-specific databases
MGIi | MGI:96437, Igfbp2 |
VEuPathDBi | HostDB:ENSMUSG00000039323 |
Subcellular locationi
Extracellular region or secreted
Extracellular region or secreted
- extracellular region Source: UniProtKB
- extracellular space Source: MGI
Plasma Membrane
- apical plasma membrane Source: MGI
Other locations
- cytoplasmic vesicle Source: MGI
Keywords - Cellular componenti
SecretedPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 34 | By similarityAdd BLAST | 34 | |
ChainiPRO_0000014371 | 35 – 305 | Insulin-like growth factor-binding protein 2Add BLAST | 271 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Disulfide bondi | 207 ↔ 241 | PROSITE-ProRule annotation | ||
Disulfide bondi | 252 ↔ 263 | PROSITE-ProRule annotation | ||
Disulfide bondi | 265 ↔ 286 | PROSITE-ProRule annotation |
Post-translational modificationi
O-glycosylated.By similarity
Keywords - PTMi
Disulfide bond, GlycoproteinProteomic databases
CPTACi | non-CPTAC-3985 |
MaxQBi | P47877 |
PaxDbi | P47877 |
PeptideAtlasi | P47877 |
PRIDEi | P47877 |
ProteomicsDBi | 267080 |
PTM databases
iPTMneti | P47877 |
PhosphoSitePlusi | P47877 |
Expressioni
Tissue specificityi
Highly expressed in adult liver, but also in kidney, lung, brain, spleen, testis and ovary.1 Publication
Developmental stagei
Expressed embryos at day 11.5. Also expressed in fetal livers with expression increasing dramatically after birth. Expression decreases only slightly after postnatal day 3 and remains abundant thereafter.1 Publication
Gene expression databases
Bgeei | ENSMUSG00000039323, Expressed in liver and 320 other tissues |
Genevisiblei | P47877, MM |
Interactioni
Subunit structurei
Binds IGF2 more than IGF1.
GO - Molecular functioni
- insulin-like growth factor binding Source: MGI
- insulin-like growth factor I binding Source: UniProtKB
- insulin-like growth factor II binding Source: UniProtKB
Protein-protein interaction databases
BioGRIDi | 200554, 2 interactors |
DIPi | DIP-60632N |
IntActi | P47877, 2 interactors |
STRINGi | 10090.ENSMUSP00000046610 |
Miscellaneous databases
RNActi | P47877, protein |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 36 – 118 | IGFBP N-terminalPROSITE-ProRule annotationAdd BLAST | 83 | |
Domaini | 204 – 286 | Thyroglobulin type-1PROSITE-ProRule annotationAdd BLAST | 83 |
Motif
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Motifi | 281 – 283 | Cell attachment site | 3 |
Domaini
The C-terminus is required for IGF-binding and growth inhibition.By similarity
Keywords - Domaini
SignalPhylogenomic databases
eggNOGi | ENOG502QRWQ, Eukaryota |
GeneTreei | ENSGT00940000158542 |
HOGENOMi | CLU_070833_3_0_1 |
InParanoidi | P47877 |
OMAi | AEPCAEM |
OrthoDBi | 979270at2759 |
PhylomeDBi | P47877 |
TreeFami | TF331211 |
Family and domain databases
CDDi | cd00191, TY, 1 hit |
Gene3Di | 4.10.800.10, 1 hit |
InterProi | View protein in InterPro IPR009030, Growth_fac_rcpt_cys_sf IPR012210, IGFBP-2 IPR000867, IGFBP-like IPR022321, IGFBP_1-6_chordata IPR017891, Insulin_GF-bd_Cys-rich_CS IPR000716, Thyroglobulin_1 IPR036857, Thyroglobulin_1_sf |
Pfami | View protein in Pfam PF00219, IGFBP, 1 hit PF00086, Thyroglobulin_1, 1 hit |
PRINTSi | PR01976, IGFBPFAMILY PR01978, IGFBPFAMILY2 |
SMARTi | View protein in SMART SM00121, IB, 1 hit SM00211, TY, 1 hit |
SUPFAMi | SSF57184, SSF57184, 1 hit SSF57610, SSF57610, 1 hit |
PROSITEi | View protein in PROSITE PS00222, IGFBP_N_1, 1 hit PS51323, IGFBP_N_2, 1 hit PS00484, THYROGLOBULIN_1_1, 1 hit PS51162, THYROGLOBULIN_1_2, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All
P47877-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MLPRLGGPAL PLLLPSLLLL LLLGAGGCGP GVRAEVLFRC PPCTPERLAA
60 70 80 90 100
CGPPPDAPCA ELVREPGCGC CSVCARQEGE ACGVYIPRCA QTLRCYPNPG
110 120 130 140 150
SELPLKALVT GAGTCEKRRV GTTPQQVADS DDDHSEGGLV ENHVDGTMNM
160 170 180 190 200
LGGGSSAGRK PLKSGMKELA VFREKVNEQH RQMGKGAKHL SLEEPKKLRP
210 220 230 240 250
PPARTPCQQE LDQVLERIST MRLPDDRGPL EHLYSLHIPN CDKHGRYNLK
260 270 280 290 300
QCKMSLNGQR GECWCVNPNT GKPIQGAPTI RGDPECHLFY NEQQETGGAH
AQSVQ
Computationally mapped potential isoform sequencesi
There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basketD3YU40 | D3YU40_MOUSE | Insulin-like growth factor-binding ... | Igfbp2 | 158 | Annotation score: |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 47 | R → A in CAA57270 (PubMed:7529732).Curated | 1 | |
Sequence conflicti | 133 | D → H in AAB60709 (PubMed:7680327).Curated | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | L05439 , L05436, L05437, L05438 Genomic DNA Translation: AAB60709.1 X81580 mRNA Translation: CAA57270.1 CH466548 Genomic DNA Translation: EDL00293.1 BC012724 mRNA Translation: AAH12724.1 BC054473 mRNA Translation: AAH54473.1 |
CCDSi | CCDS15036.1 |
PIRi | I48601 JN0508 |
RefSeqi | NP_032368.2, NM_008342.3 |
Genome annotation databases
Ensembli | ENSMUST00000047328; ENSMUSP00000046610; ENSMUSG00000039323 |
GeneIDi | 16008 |
KEGGi | mmu:16008 |
UCSCi | uc007bkw.2, mouse |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | L05439 , L05436, L05437, L05438 Genomic DNA Translation: AAB60709.1 X81580 mRNA Translation: CAA57270.1 CH466548 Genomic DNA Translation: EDL00293.1 BC012724 mRNA Translation: AAH12724.1 BC054473 mRNA Translation: AAH54473.1 |
CCDSi | CCDS15036.1 |
PIRi | I48601 JN0508 |
RefSeqi | NP_032368.2, NM_008342.3 |
3D structure databases
AlphaFoldDBi | P47877 |
SMRi | P47877 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 200554, 2 interactors |
DIPi | DIP-60632N |
IntActi | P47877, 2 interactors |
STRINGi | 10090.ENSMUSP00000046610 |
Protein family/group databases
MEROPSi | I31.953 |
PTM databases
iPTMneti | P47877 |
PhosphoSitePlusi | P47877 |
Proteomic databases
CPTACi | non-CPTAC-3985 |
MaxQBi | P47877 |
PaxDbi | P47877 |
PeptideAtlasi | P47877 |
PRIDEi | P47877 |
ProteomicsDBi | 267080 |
Protocols and materials databases
Antibodypediai | 11351, 471 antibodies from 37 providers |
DNASUi | 16008 |
Genome annotation databases
Ensembli | ENSMUST00000047328; ENSMUSP00000046610; ENSMUSG00000039323 |
GeneIDi | 16008 |
KEGGi | mmu:16008 |
UCSCi | uc007bkw.2, mouse |
Organism-specific databases
CTDi | 3485 |
MGIi | MGI:96437, Igfbp2 |
VEuPathDBi | HostDB:ENSMUSG00000039323 |
Phylogenomic databases
eggNOGi | ENOG502QRWQ, Eukaryota |
GeneTreei | ENSGT00940000158542 |
HOGENOMi | CLU_070833_3_0_1 |
InParanoidi | P47877 |
OMAi | AEPCAEM |
OrthoDBi | 979270at2759 |
PhylomeDBi | P47877 |
TreeFami | TF331211 |
Enzyme and pathway databases
Reactomei | R-MMU-381426, Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) |
Miscellaneous databases
BioGRID-ORCSi | 16008, 2 hits in 74 CRISPR screens |
ChiTaRSi | Igfbp2, mouse |
PROi | PR:P47877 |
RNActi | P47877, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSMUSG00000039323, Expressed in liver and 320 other tissues |
Genevisiblei | P47877, MM |
Family and domain databases
CDDi | cd00191, TY, 1 hit |
Gene3Di | 4.10.800.10, 1 hit |
InterProi | View protein in InterPro IPR009030, Growth_fac_rcpt_cys_sf IPR012210, IGFBP-2 IPR000867, IGFBP-like IPR022321, IGFBP_1-6_chordata IPR017891, Insulin_GF-bd_Cys-rich_CS IPR000716, Thyroglobulin_1 IPR036857, Thyroglobulin_1_sf |
Pfami | View protein in Pfam PF00219, IGFBP, 1 hit PF00086, Thyroglobulin_1, 1 hit |
PRINTSi | PR01976, IGFBPFAMILY PR01978, IGFBPFAMILY2 |
SMARTi | View protein in SMART SM00121, IB, 1 hit SM00211, TY, 1 hit |
SUPFAMi | SSF57184, SSF57184, 1 hit SSF57610, SSF57610, 1 hit |
PROSITEi | View protein in PROSITE PS00222, IGFBP_N_1, 1 hit PS51323, IGFBP_N_2, 1 hit PS00484, THYROGLOBULIN_1_1, 1 hit PS51162, THYROGLOBULIN_1_2, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | IBP2_MOUSE | |
Accessioni | P47877Primary (citable) accession number: P47877 Secondary accession number(s): Q61722, Q91VK7 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | February 1, 1996 |
Last sequence update: | February 10, 2009 | |
Last modified: | May 25, 2022 | |
This is version 168 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot