Igfbp2

Functionⁱ

Inhibits IGF-mediated growth and developmental rates (By similarity). IGF-binding proteins prolong the half-life of the IGFs and have been shown to either inhibit or stimulate the growth promoting effects of the IGFs on cell culture. They alter the interaction of IGFs with their cell surface receptors.By similarity

GO - Molecular functionⁱ

insulin-like growth factor binding
Source: MGI
Inferred from physical interactionⁱ
- 7679139
insulin-like growth factor I binding Source: UniProtKB
insulin-like growth factor II binding Source: UniProtKB

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

aging Source: Ensembl
cellular response to hormone stimulus Source: Ensembl
female pregnancy Source: Ensembl
positive regulation of activated T cell proliferation Source: UniProtKB
regulation of cell growth Source: InterPro
regulation of insulin-like growth factor receptor signaling pathway Source: UniProtKB
response to drug Source: Ensembl
response to estradiol Source: Ensembl
response to estrogen Source: Ensembl
response to glucocorticoid Source: Ensembl
response to lithium ion Source: Ensembl
response to mechanical stimulus Source: Ensembl
response to nutrient Source: Ensembl
response to retinoic acid Source: Ensembl
signal transduction Source: Ensembl

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Growth factor binding
Biological process	Growth regulation

Enzyme and pathway databases

Reactomeⁱ	R-MMU-381426 Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)

Reactomeⁱ

R-MMU-381426 Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)

Protein family/group databases

MEROPS protease database More...MEROPSⁱ	I31.953

MEROPSⁱ

I31.953

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Insulin-like growth factor-binding protein 2 Short name: IBP-2 Short name: IGF-binding protein 2 Short name: IGFBP-2 Short name: mIGFBP-2
Gene namesⁱ	Name:Igfbp2 Synonyms:Igfbp-2
Organismⁱ	Mus musculus (Mouse)
Taxonomic identifierⁱ	10090 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus
Proteomesⁱ	UP000000589 Componentⁱ: Chromosome 1

Organism-specific databases

MGIⁱ	MGI:96437 Igfbp2

Keywords - Cellular componentⁱ

Secreted

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Signal peptideⁱ	1 – 34	By similarityAdd BLAST		34
ChainⁱPRO_0000014371	35 – 305	Insulin-like growth factor-binding protein 2Add BLAST		271

Amino acid modifications

Feature key	Position(s)	DescriptionActions
Disulfide bondⁱ	207 ↔ 241	PROSITE-ProRule annotation
Disulfide bondⁱ	252 ↔ 263	PROSITE-ProRule annotation
Disulfide bondⁱ	265 ↔ 286	PROSITE-ProRule annotation

Post-translational modificationⁱ

O-glycosylated.By similarity

Keywords - PTMⁱ

Disulfide bond, Glycoprotein

Proteomic databases

MaxQB - The MaxQuant DataBase More...MaxQBⁱ	P47877
PaxDbⁱ	P47877
PeptideAtlas More...PeptideAtlasⁱ	P47877
PRIDEⁱ	P47877

PTM databases

iPTMnetⁱ	P47877
PhosphoSitePlusⁱ	P47877

Expressionⁱ

Tissue specificityⁱ

Highly expressed in adult liver, but also in kidney, lung, brain, spleen, testis and ovary.1 Publication

Developmental stageⁱ

Expressed embryos at day 11.5. Also expressed in fetal livers with expression increasing dramatically after birth. Expression decreases only slightly after postnatal day 3 and remains abundant thereafter.1 Publication

Gene expression databases

Bgeeⁱ	ENSMUSG00000039323 Expressed in 301 organ(s), highest expression level in liver
CleanExⁱ	MM_IGFBP2
ExpressionAtlasⁱ	P47877 baseline and differential
Genevisibleⁱ	P47877 MM

Interactionⁱ

Subunit structureⁱ

Binds IGF2 more than IGF1.

GO - Molecular functionⁱ

insulin-like growth factor binding
Source: MGI
Inferred from physical interactionⁱ
- 7679139
insulin-like growth factor I binding Source: UniProtKB
insulin-like growth factor II binding Source: UniProtKB

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

Database of interacting proteins More...DIPⁱ	DIP-60632N
IntActⁱ	P47877, 3 interactors
Molecular INTeraction database More...MINTⁱ	P47877
STRINGⁱ	10090.ENSMUSP00000046610

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	P47877
SMRⁱ	P47877
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Domainⁱ	36 – 118	IGFBP N-terminalPROSITE-ProRule annotationAdd BLAST		83
Domainⁱ	204 – 286	Thyroglobulin type-1PROSITE-ProRule annotationAdd BLAST		83

Motif

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Motifⁱ	281 – 283	Cell attachment site		3

Domainⁱ

The C-terminus is required for IGF-binding and growth inhibition.By similarity

Keywords - Domainⁱ

Signal

Phylogenomic databases

eggNOGⁱ	ENOG410IHUR Eukaryota ENOG4111GWQ LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00550000074457
HOGENOMⁱ	HOG000253012
HOVERGENⁱ	HBG002631
InParanoidⁱ	P47877
OMAⁱ	DGTMNML
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0EIN
PhylomeDBⁱ	P47877
TreeFamⁱ	TF331211

Family and domain databases

Conserved Domains Database More...CDDⁱ	cd00191 TY, 1 hit
Gene3Dⁱ	4.10.800.10, 1 hit
InterProⁱ	View protein in InterPro IPR009030 Growth_fac_rcpt_cys_sf IPR012210 IGFBP-2 IPR000867 IGFBP-like IPR009168 IGFBP1-6 IPR022321 IGFBP_1-6_chordata IPR017891 Insulin_GF-bd_Cys-rich_CS IPR000716 Thyroglobulin_1 IPR036857 Thyroglobulin_1_sf
PANTHERⁱ	PTHR11551 PTHR11551, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00219 IGFBP, 1 hit PF00086 Thyroglobulin_1, 1 hit
PRINTSⁱ	PR01976 IGFBPFAMILY PR01978 IGFBPFAMILY2
SMARTⁱ	View protein in SMART SM00121 IB, 1 hit SM00211 TY, 1 hit
SUPFAMⁱ	SSF57184 SSF57184, 1 hit SSF57610 SSF57610, 1 hit
PROSITEⁱ	View protein in PROSITE PS00222 IGFBP_N_1, 1 hit PS51323 IGFBP_N_2, 1 hit PS00484 THYROGLOBULIN_1_1, 1 hit PS51162 THYROGLOBULIN_1_2, 1 hit

Sequence (1+)ⁱ

Sequence statusⁱ: Complete.

Sequence processingⁱ: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show all Align All

P47877-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MLPRLGGPAL PLLLPSLLLL LLLGAGGCGP GVRAEVLFRC PPCTPERLAA 
        60         70         80         90        100
CGPPPDAPCA ELVREPGCGC CSVCARQEGE ACGVYIPRCA QTLRCYPNPG 
       110        120        130        140        150
SELPLKALVT GAGTCEKRRV GTTPQQVADS DDDHSEGGLV ENHVDGTMNM 
       160        170        180        190        200
LGGGSSAGRK PLKSGMKELA VFREKVNEQH RQMGKGAKHL SLEEPKKLRP 
       210        220        230        240        250
PPARTPCQQE LDQVLERIST MRLPDDRGPL EHLYSLHIPN CDKHGRYNLK 
       260        270        280        290        300
QCKMSLNGQR GECWCVNPNT GKPIQGAPTI RGDPECHLFY NEQQETGGAH 

AQSVQ

Length:305

Mass (Da):32,847

Last modified:February 10, 2009 - v2

Checksum:ⁱ179FE6A304E93A16

GO

Computationally mapped potential isoform sequencesⁱ

There is 1 potential isoform mapped to this entry.BLAST Align Show all Add to basket

	Entry	Entry name		Protein names	Gene names	Length	Annotation

	D3YU40	D3YU40_MOUSE		Insulin-like growth factor-binding ... Insulin-like growth factor-binding protein 2	Igfbp2	158	Annotation score:

Experimental Info

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Sequence conflictⁱ	47	R → A in CAA57270 (PubMed:7529732).Curated		1
Sequence conflictⁱ	133	D → H in AAB60709 (PubMed:7680327).Curated		1

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	L05439 , L05436, L05437, L05438 Genomic DNA Translation: AAB60709.1 X81580 mRNA Translation: CAA57270.1 CH466548 Genomic DNA Translation: EDL00293.1 BC012724 mRNA Translation: AAH12724.1 BC054473 mRNA Translation: AAH54473.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS15036.1
PIRⁱ	I48601 JN0508
NCBI Reference Sequences More...RefSeqⁱ	NP_032368.2, NM_008342.3
UniGeneⁱ	Mm.141936

Genome annotation databases

Ensemblⁱ	ENSMUST00000047328; ENSMUSP00000046610; ENSMUSG00000039323
GeneIDⁱ	16008
KEGGⁱ	mmu:16008
UCSC genome browser More...UCSCⁱ	uc007bkw.2 mouse

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
P47877	Insulin-like growth factor-binding protein 2		MOUSE		158	UniRef100_P47877

Protein	Similar proteins		Species	Score	Length	Source
P47877	Insulin-like growth factor-binding protein 2		RAT		304	UniRef90_P12843
Insulin-like growth factor-binding protein 2		MOUSE		158
UPI000A307AA8		MUSPA		305
UPI000333431B		JACJA		252
Insulin-like growth factor binding protein 2 (Fragment)		RAT		128
+3

Protein	Similar proteins		Species	Score	Length	Source
P47877	Insulin-like growth factor-binding protein 2	)	HUMAN		325	UniRef50_P18065
Insulin-like growth factor-binding protein 2		PIG		316
Insulin-like growth factor-binding protein 2		BOVIN		317
Insulin-like growth factor-binding protein 2		SHEEP		317
Insulin-like growth factor-binding protein 2		RAT		304
+129

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	L05439 , L05436, L05437, L05438 Genomic DNA Translation: AAB60709.1 X81580 mRNA Translation: CAA57270.1 CH466548 Genomic DNA Translation: EDL00293.1 BC012724 mRNA Translation: AAH12724.1 BC054473 mRNA Translation: AAH54473.1
CCDSⁱ	CCDS15036.1
PIRⁱ	I48601 JN0508
RefSeqⁱ	NP_032368.2, NM_008342.3
UniGeneⁱ	Mm.141936

3D structure databases

ProteinModelPortalⁱ	P47877
SMRⁱ	P47877
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

DIPⁱ	DIP-60632N
IntActⁱ	P47877, 3 interactors
MINTⁱ	P47877
STRINGⁱ	10090.ENSMUSP00000046610

Protein family/group databases

MEROPSⁱ	I31.953

MEROPSⁱ

I31.953

PTM databases

iPTMnetⁱ	P47877
PhosphoSitePlusⁱ	P47877

Proteomic databases

MaxQBⁱ	P47877
PaxDbⁱ	P47877
PeptideAtlasⁱ	P47877
PRIDEⁱ	P47877

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

Ensemblⁱ	ENSMUST00000047328; ENSMUSP00000046610; ENSMUSG00000039323
GeneIDⁱ	16008
KEGGⁱ	mmu:16008
UCSCⁱ	uc007bkw.2 mouse

Organism-specific databases

CTDⁱ	3485
MGIⁱ	MGI:96437 Igfbp2

Phylogenomic databases

eggNOGⁱ	ENOG410IHUR Eukaryota ENOG4111GWQ LUCA
GeneTreeⁱ	ENSGT00550000074457
HOGENOMⁱ	HOG000253012
HOVERGENⁱ	HBG002631
InParanoidⁱ	P47877
OMAⁱ	DGTMNML
OrthoDBⁱ	EOG091G0EIN
PhylomeDBⁱ	P47877
TreeFamⁱ	TF331211

Enzyme and pathway databases

Reactomeⁱ	R-MMU-381426 Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)

Reactomeⁱ

R-MMU-381426 Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)

Miscellaneous databases

ChiTaRSⁱ	Igfbp2 mouse
Protein Ontology More...PROⁱ	PR:P47877
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSMUSG00000039323 Expressed in 301 organ(s), highest expression level in liver
CleanExⁱ	MM_IGFBP2
ExpressionAtlasⁱ	P47877 baseline and differential
Genevisibleⁱ	P47877 MM

Family and domain databases

CDDⁱ	cd00191 TY, 1 hit
Gene3Dⁱ	4.10.800.10, 1 hit
InterProⁱ	View protein in InterPro IPR009030 Growth_fac_rcpt_cys_sf IPR012210 IGFBP-2 IPR000867 IGFBP-like IPR009168 IGFBP1-6 IPR022321 IGFBP_1-6_chordata IPR017891 Insulin_GF-bd_Cys-rich_CS IPR000716 Thyroglobulin_1 IPR036857 Thyroglobulin_1_sf
PANTHERⁱ	PTHR11551 PTHR11551, 1 hit
Pfamⁱ	View protein in Pfam PF00219 IGFBP, 1 hit PF00086 Thyroglobulin_1, 1 hit
PRINTSⁱ	PR01976 IGFBPFAMILY PR01978 IGFBPFAMILY2
SMARTⁱ	View protein in SMART SM00121 IB, 1 hit SM00211 TY, 1 hit
SUPFAMⁱ	SSF57184 SSF57184, 1 hit SSF57610 SSF57610, 1 hit
PROSITEⁱ	View protein in PROSITE PS00222 IGFBP_N_1, 1 hit PS51323 IGFBP_N_2, 1 hit PS00484 THYROGLOBULIN_1_1, 1 hit PS51162 THYROGLOBULIN_1_2, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	IBP2_MOUSE
Accessionⁱ	P47877Primary (citable) accession number: P47877 Secondary accession number(s): Q61722, Q91VK7
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	February 1, 1996
	Last sequence update:	February 10, 2009
	Last modified:	September 12, 2018
	This is version 148 of the entry and version 2 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

Documents

MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - P47877 (IBP2_MOUSE)

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Insulin-like growth factor-binding protein 2

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

Protein family/group databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted

Extracellular region or secreted

Plasma Membrane

Other locations

Keywords - Cellular componenti

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Motif

Keywords - Domaini

Phylogenomic databases

Family and domain databases

Experimental Info

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

Protein family/group databases

PTM databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

GO - Molecular functionⁱ

Structureⁱ

Family & Domainsⁱ

Keywords - Domainⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ