UniProtKB - P47876 (IBP1_MOUSE)
Protein
Insulin-like growth factor-binding protein 1
Gene
Igfbp1
Organism
Mus musculus (Mouse)
Status
Functioni
IGF-binding proteins prolong the half-life of the IGFs and have been shown to either inhibit or stimulate the growth promoting effects of the IGFs on cell culture. They alter the interaction of IGFs with their cell surface receptors. Promotes cell migration (By similarity).By similarity
GO - Molecular functioni
- insulin-like growth factor binding Source: MGI
- insulin-like growth factor I binding Source: MGI
- insulin-like growth factor II binding Source: MGI
GO - Biological processi
- aging Source: Ensembl
- insulin receptor signaling pathway Source: Ensembl
- positive regulation of cell growth Source: Ensembl
- regulation of insulin-like growth factor receptor signaling pathway Source: GO_Central
- tissue regeneration Source: Ensembl
Keywordsi
Molecular function | Growth factor binding |
Enzyme and pathway databases
Reactomei | R-MMU-381426, Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) R-MMU-8957275, Post-translational protein phosphorylation |
Protein family/group databases
MEROPSi | I31.951 |
Names & Taxonomyi
Protein namesi | Recommended name: Insulin-like growth factor-binding protein 1Short name: IBP-1 Short name: IGF-binding protein 1 Short name: IGFBP-1 |
Gene namesi | Name:Igfbp1 Synonyms:Igfbp-1 |
Organismi | Mus musculus (Mouse) |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Proteomesi |
|
Organism-specific databases
MGIi | MGI:96436, Igfbp1 |
Subcellular locationi
Extracellular region or secreted
Extracellular region or secreted
- extracellular space Source: MGI
Golgi apparatus
- Golgi apparatus Source: MGI
Keywords - Cellular componenti
SecretedPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 25 | By similarityAdd BLAST | 25 | |
ChainiPRO_0000014366 | 26 – 272 | Insulin-like growth factor-binding protein 1Add BLAST | 247 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Disulfide bondi | 73 ↔ 86 | PROSITE-ProRule annotation | ||
Disulfide bondi | 80 ↔ 106 | PROSITE-ProRule annotation | ||
Modified residuei | 139 | PhosphoserineBy similarity | 1 | |
Modified residuei | 157 | PhosphoserineBy similarity | 1 | |
Modified residuei | 169 | PhosphoserineBy similarity | 1 | |
Modified residuei | 170 | PhosphothreonineBy similarity | 1 | |
Modified residuei | 171 | PhosphotyrosineBy similarity | 1 | |
Disulfide bondi | 189 ↔ 219 | PROSITE-ProRule annotation | ||
Disulfide bondi | 230 ↔ 241 | PROSITE-ProRule annotation | ||
Disulfide bondi | 243 ↔ 264 | PROSITE-ProRule annotation | ||
Modified residuei | 255 | PhosphoserineBy similarity | 1 |
Keywords - PTMi
Disulfide bond, PhosphoproteinProteomic databases
PaxDbi | P47876 |
PeptideAtlasi | P47876 |
PRIDEi | P47876 |
PTM databases
iPTMneti | P47876 |
PhosphoSitePlusi | P47876 |
Expressioni
Gene expression databases
Bgeei | ENSMUSG00000020429, Expressed in liver and 77 other tissues |
Genevisiblei | P47876, MM |
Interactioni
Subunit structurei
Binds equally well IGF1 and IGF2.
GO - Molecular functioni
- insulin-like growth factor binding Source: MGI
- insulin-like growth factor I binding Source: MGI
- insulin-like growth factor II binding Source: MGI
Protein-protein interaction databases
DIPi | DIP-60631N |
IntActi | P47876, 2 interactors |
STRINGi | 10090.ENSMUSP00000020704 |
Miscellaneous databases
RNActi | P47876, protein |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 28 – 109 | IGFBP N-terminalPROSITE-ProRule annotationAdd BLAST | 82 | |
Domaini | 186 – 264 | Thyroglobulin type-1PROSITE-ProRule annotationAdd BLAST | 79 |
Motif
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Motifi | 259 – 261 | Cell attachment site | 3 |
Keywords - Domaini
SignalPhylogenomic databases
eggNOGi | ENOG502QWRP, Eukaryota |
GeneTreei | ENSGT00940000157394 |
HOGENOMi | CLU_070833_3_0_1 |
InParanoidi | P47876 |
OMAi | PWHCAPC |
OrthoDBi | 979270at2759 |
TreeFami | TF331211 |
Family and domain databases
CDDi | cd00191, TY, 1 hit |
Gene3Di | 4.10.800.10, 1 hit |
InterProi | View protein in InterPro IPR009030, Growth_fac_rcpt_cys_sf IPR000867, IGFBP-like IPR022322, IGFBP1 IPR022321, IGFBP_1-6_chordata IPR017891, Insulin_GF-bd_Cys-rich_CS IPR000716, Thyroglobulin_1 IPR036857, Thyroglobulin_1_sf |
Pfami | View protein in Pfam PF00219, IGFBP, 1 hit PF00086, Thyroglobulin_1, 1 hit |
PRINTSi | PR01976, IGFBPFAMILY PR01977, IGFBPFAMILY1 |
SMARTi | View protein in SMART SM00121, IB, 1 hit SM00211, TY, 1 hit |
SUPFAMi | SSF57184, SSF57184, 1 hit SSF57610, SSF57610, 1 hit |
PROSITEi | View protein in PROSITE PS00222, IGFBP_N_1, 1 hit PS51323, IGFBP_N_2, 1 hit PS00484, THYROGLOBULIN_1_1, 1 hit PS51162, THYROGLOBULIN_1_2, 1 hit |
i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
P47876-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MPEFLTVVSW PFLILLSFQI GVAAGAPQPW HCAPCTAERL GLCPPVPASC
60 70 80 90 100
PEISRPAGCG CCPTCALPMG AACGVATARC AQGLSCRALP GEPRPLHALT
110 120 130 140 150
RGQGACVPEP AAPATSTLFS SQHEEAKAAV VSADELSESP EMTEEQLLDS
160 170 180 190 200
FHLMAPSRED QPILWNAIST YSSMRAREIA DLKKWKEPCQ RELYKVLERL
210 220 230 240 250
AAAQQKAGDE IYKFYLPNCN KNGFYHSKQC ETSLDGEAGL CWCVYPWSGK
260 270
KIPGSLETRG DPNCHQYFNV HN
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 23 | A → V in CAA57269 (PubMed:7529732).Curated | 1 | |
Sequence conflicti | 106 – 107 | CV → SL in CAA47832 (PubMed:7509771).Curated | 2 | |
Sequence conflicti | 229 | Q → E in CAA57269 (PubMed:7529732).Curated | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | X81579 mRNA Translation: CAA57269.1 AL607124 Genomic DNA No translation available. CH466574 Genomic DNA Translation: EDL40608.1 X67493 Genomic DNA Translation: CAA47832.1 |
CCDSi | CCDS24427.1 |
PIRi | I48600 S25113 |
RefSeqi | NP_032367.3, NM_008341.4 |
Genome annotation databases
Ensembli | ENSMUST00000020704; ENSMUSP00000020704; ENSMUSG00000020429 |
GeneIDi | 16006 |
KEGGi | mmu:16006 |
UCSCi | uc007hzh.2, mouse |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | X81579 mRNA Translation: CAA57269.1 AL607124 Genomic DNA No translation available. CH466574 Genomic DNA Translation: EDL40608.1 X67493 Genomic DNA Translation: CAA47832.1 |
CCDSi | CCDS24427.1 |
PIRi | I48600 S25113 |
RefSeqi | NP_032367.3, NM_008341.4 |
3D structure databases
SMRi | P47876 |
ModBasei | Search... |
Protein-protein interaction databases
DIPi | DIP-60631N |
IntActi | P47876, 2 interactors |
STRINGi | 10090.ENSMUSP00000020704 |
Protein family/group databases
MEROPSi | I31.951 |
PTM databases
iPTMneti | P47876 |
PhosphoSitePlusi | P47876 |
Proteomic databases
PaxDbi | P47876 |
PeptideAtlasi | P47876 |
PRIDEi | P47876 |
Protocols and materials databases
Antibodypediai | 3841, 644 antibodies |
Genome annotation databases
Ensembli | ENSMUST00000020704; ENSMUSP00000020704; ENSMUSG00000020429 |
GeneIDi | 16006 |
KEGGi | mmu:16006 |
UCSCi | uc007hzh.2, mouse |
Organism-specific databases
CTDi | 3484 |
MGIi | MGI:96436, Igfbp1 |
Phylogenomic databases
eggNOGi | ENOG502QWRP, Eukaryota |
GeneTreei | ENSGT00940000157394 |
HOGENOMi | CLU_070833_3_0_1 |
InParanoidi | P47876 |
OMAi | PWHCAPC |
OrthoDBi | 979270at2759 |
TreeFami | TF331211 |
Enzyme and pathway databases
Reactomei | R-MMU-381426, Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) R-MMU-8957275, Post-translational protein phosphorylation |
Miscellaneous databases
BioGRID-ORCSi | 16006, 2 hits in 17 CRISPR screens |
ChiTaRSi | Igfbp1, mouse |
PROi | PR:P47876 |
RNActi | P47876, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSMUSG00000020429, Expressed in liver and 77 other tissues |
Genevisiblei | P47876, MM |
Family and domain databases
CDDi | cd00191, TY, 1 hit |
Gene3Di | 4.10.800.10, 1 hit |
InterProi | View protein in InterPro IPR009030, Growth_fac_rcpt_cys_sf IPR000867, IGFBP-like IPR022322, IGFBP1 IPR022321, IGFBP_1-6_chordata IPR017891, Insulin_GF-bd_Cys-rich_CS IPR000716, Thyroglobulin_1 IPR036857, Thyroglobulin_1_sf |
Pfami | View protein in Pfam PF00219, IGFBP, 1 hit PF00086, Thyroglobulin_1, 1 hit |
PRINTSi | PR01976, IGFBPFAMILY PR01977, IGFBPFAMILY1 |
SMARTi | View protein in SMART SM00121, IB, 1 hit SM00211, TY, 1 hit |
SUPFAMi | SSF57184, SSF57184, 1 hit SSF57610, SSF57610, 1 hit |
PROSITEi | View protein in PROSITE PS00222, IGFBP_N_1, 1 hit PS51323, IGFBP_N_2, 1 hit PS00484, THYROGLOBULIN_1_1, 1 hit PS51162, THYROGLOBULIN_1_2, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | IBP1_MOUSE | |
Accessioni | P47876Primary (citable) accession number: P47876 Secondary accession number(s): Q5SVY8, Q61732 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | February 1, 1996 |
Last sequence update: | October 3, 2012 | |
Last modified: | December 2, 2020 | |
This is version 158 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot