Igfbp1

Functionⁱ

IGF-binding proteins prolong the half-life of the IGFs and have been shown to either inhibit or stimulate the growth promoting effects of the IGFs on cell culture. They alter the interaction of IGFs with their cell surface receptors. Promotes cell migration (By similarity).By similarity

GO - Molecular functionⁱ

insulin-like growth factor binding
Source: MGI
Inferred from physical interactionⁱ
- 7679139
insulin-like growth factor I binding Source: MGI
insulin-like growth factor II binding Source: MGI

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

aging Source: Ensembl
insulin receptor signaling pathway Source: Ensembl
positive regulation of cell growth Source: Ensembl
tissue regeneration Source: Ensembl

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Growth factor binding

Molecular function

Growth factor binding

Enzyme and pathway databases

Reactomeⁱ	R-MMU-381426 Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) R-MMU-8957275 Post-translational protein phosphorylation

Reactomeⁱ

R-MMU-381426 Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)
R-MMU-8957275 Post-translational protein phosphorylation

Protein family/group databases

MEROPS protease database More...MEROPSⁱ	I31.951

MEROPSⁱ

I31.951

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Insulin-like growth factor-binding protein 1 Short name: IBP-1 Short name: IGF-binding protein 1 Short name: IGFBP-1
Gene namesⁱ	Name:Igfbp1 Synonyms:Igfbp-1
Organismⁱ	Mus musculus (Mouse)
Taxonomic identifierⁱ	10090 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus
Proteomesⁱ	UP000000589 Componentⁱ: Chromosome 11

Organism-specific databases

MGIⁱ	MGI:96436 Igfbp1

Keywords - Cellular componentⁱ

Secreted

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Signal peptideⁱ	1 – 25	By similarityAdd BLAST		25
ChainⁱPRO_0000014366	26 – 272	Insulin-like growth factor-binding protein 1Add BLAST		247

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Disulfide bondⁱ	73 ↔ 86	PROSITE-ProRule annotation
Disulfide bondⁱ	80 ↔ 106	PROSITE-ProRule annotation
Modified residueⁱ	139	PhosphoserineBy similarity	1
Modified residueⁱ	157	PhosphoserineBy similarity	1
Modified residueⁱ	169	PhosphoserineBy similarity	1
Modified residueⁱ	170	PhosphothreonineBy similarity	1
Modified residueⁱ	171	PhosphotyrosineBy similarity	1
Disulfide bondⁱ	189 ↔ 219	PROSITE-ProRule annotation
Disulfide bondⁱ	230 ↔ 241	PROSITE-ProRule annotation
Disulfide bondⁱ	243 ↔ 264	PROSITE-ProRule annotation
Modified residueⁱ	255	PhosphoserineBy similarity	1

Keywords - PTMⁱ

Disulfide bond, Phosphoprotein

Proteomic databases

PaxDbⁱ	P47876
PeptideAtlas More...PeptideAtlasⁱ	P47876
PRIDEⁱ	P47876

PTM databases

iPTMnetⁱ	P47876
PhosphoSitePlusⁱ	P47876

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSMUSG00000020429 Expressed in 59 organ(s), highest expression level in liver
CleanExⁱ	MM_IGFBP1
Genevisibleⁱ	P47876 MM

Interactionⁱ

Subunit structureⁱ

Binds equally well IGF1 and IGF2.

GO - Molecular functionⁱ

insulin-like growth factor binding
Source: MGI
Inferred from physical interactionⁱ
- 7679139
insulin-like growth factor I binding Source: MGI
insulin-like growth factor II binding Source: MGI

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

Database of interacting proteins More...DIPⁱ	DIP-60631N
IntActⁱ	P47876, 2 interactors
STRINGⁱ	10090.ENSMUSP00000020704

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	P47876
SMRⁱ	P47876
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Domainⁱ	28 – 109	IGFBP N-terminalPROSITE-ProRule annotationAdd BLAST		82
Domainⁱ	186 – 264	Thyroglobulin type-1PROSITE-ProRule annotationAdd BLAST		79

Motif

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Motifⁱ	259 – 261	Cell attachment site		3

Keywords - Domainⁱ

Signal

Phylogenomic databases

eggNOGⁱ	ENOG410IITJ Eukaryota ENOG4111H9A LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00550000074457
HOGENOMⁱ	HOG000253012
HOVERGENⁱ	HBG002631
InParanoidⁱ	P47876
OMAⁱ	WCVYPWS
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0EIN
TreeFamⁱ	TF331211

Family and domain databases

Conserved Domains Database More...CDDⁱ	cd00191 TY, 1 hit
Gene3Dⁱ	4.10.800.10, 1 hit
InterProⁱ	View protein in InterPro IPR009030 Growth_fac_rcpt_cys_sf IPR000867 IGFBP-like IPR022322 IGFBP1 IPR009168 IGFBP1-6 IPR022321 IGFBP_1-6_chordata IPR017891 Insulin_GF-bd_Cys-rich_CS IPR000716 Thyroglobulin_1 IPR036857 Thyroglobulin_1_sf
PANTHERⁱ	PTHR11551 PTHR11551, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00219 IGFBP, 1 hit PF00086 Thyroglobulin_1, 1 hit
PRINTSⁱ	PR01976 IGFBPFAMILY PR01977 IGFBPFAMILY1
SMARTⁱ	View protein in SMART SM00121 IB, 1 hit SM00211 TY, 1 hit
SUPFAMⁱ	SSF57184 SSF57184, 1 hit SSF57610 SSF57610, 1 hit
PROSITEⁱ	View protein in PROSITE PS00222 IGFBP_N_1, 1 hit PS51323 IGFBP_N_2, 1 hit PS00484 THYROGLOBULIN_1_1, 1 hit PS51162 THYROGLOBULIN_1_2, 1 hit

Sequenceⁱ

Sequence statusⁱ: Complete.

Sequence processingⁱ: The displayed sequence is further processed into a mature form.

P47876-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MPEFLTVVSW PFLILLSFQI GVAAGAPQPW HCAPCTAERL GLCPPVPASC 
        60         70         80         90        100
PEISRPAGCG CCPTCALPMG AACGVATARC AQGLSCRALP GEPRPLHALT 
       110        120        130        140        150
RGQGACVPEP AAPATSTLFS SQHEEAKAAV VSADELSESP EMTEEQLLDS 
       160        170        180        190        200
FHLMAPSRED QPILWNAIST YSSMRAREIA DLKKWKEPCQ RELYKVLERL 
       210        220        230        240        250
AAAQQKAGDE IYKFYLPNCN KNGFYHSKQC ETSLDGEAGL CWCVYPWSGK 
       260        270 
KIPGSLETRG DPNCHQYFNV HN

Length:272

Mass (Da):29,570

Last modified:October 3, 2012 - v2

Checksum:ⁱCD4FCD3C5AB69B60

GO

Experimental Info

Feature key	Position(s)	DescriptionActions	Length
Sequence conflictⁱ	23	A → V in CAA57269 (PubMed:7529732).Curated	1
Sequence conflictⁱ	106 – 107	CV → SL in CAA47832 (PubMed:7509771).Curated	2
Sequence conflictⁱ	229	Q → E in CAA57269 (PubMed:7529732).Curated	1

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	X81579 mRNA Translation: CAA57269.1 AL607124 Genomic DNA Translation: CAI24501.1 CH466574 Genomic DNA Translation: EDL40608.1 X67493 Genomic DNA Translation: CAA47832.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS24427.1
PIRⁱ	I48600 S25113
NCBI Reference Sequences More...RefSeqⁱ	NP_032367.3, NM_008341.4
UniGeneⁱ	Mm.21300

Genome annotation databases

Ensemblⁱ	ENSMUST00000020704; ENSMUSP00000020704; ENSMUSG00000020429
GeneIDⁱ	16006
KEGGⁱ	mmu:16006
UCSC genome browser More...UCSCⁱ	uc007hzh.2 mouse

Similar proteinsⁱ

90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
P47876	Insulin-like growth factor-binding protein 1		RAT		272	UniRef90_P21743
UPI000A3124F2		MUSPA		272
UPI000A31AD0A		MUSCR		272

Protein	Similar proteins		Species	Score	Length	Source
P47876	Insulin-like growth factor-binding protein 1		RAT		272	UniRef50_P21743
Insulin-like growth factor-binding protein 1		BOVIN		263
Insulin-like growth factor-binding protein 1		PIG		262
Uncharacterized protein		CAVPO		273
insulin-like growth factor-binding protein 1		NEOSC		255
+103

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	X81579 mRNA Translation: CAA57269.1 AL607124 Genomic DNA Translation: CAI24501.1 CH466574 Genomic DNA Translation: EDL40608.1 X67493 Genomic DNA Translation: CAA47832.1
CCDSⁱ	CCDS24427.1
PIRⁱ	I48600 S25113
RefSeqⁱ	NP_032367.3, NM_008341.4
UniGeneⁱ	Mm.21300

3D structure databases

ProteinModelPortalⁱ	P47876
SMRⁱ	P47876
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

DIPⁱ	DIP-60631N
IntActⁱ	P47876, 2 interactors
STRINGⁱ	10090.ENSMUSP00000020704

Protein family/group databases

MEROPSⁱ	I31.951

MEROPSⁱ

I31.951

PTM databases

iPTMnetⁱ	P47876
PhosphoSitePlusⁱ	P47876

Proteomic databases

PaxDbⁱ	P47876
PeptideAtlasⁱ	P47876
PRIDEⁱ	P47876

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

Ensemblⁱ	ENSMUST00000020704; ENSMUSP00000020704; ENSMUSG00000020429
GeneIDⁱ	16006
KEGGⁱ	mmu:16006
UCSCⁱ	uc007hzh.2 mouse

Organism-specific databases

CTDⁱ	3484
MGIⁱ	MGI:96436 Igfbp1

Phylogenomic databases

eggNOGⁱ	ENOG410IITJ Eukaryota ENOG4111H9A LUCA
GeneTreeⁱ	ENSGT00550000074457
HOGENOMⁱ	HOG000253012
HOVERGENⁱ	HBG002631
InParanoidⁱ	P47876
OMAⁱ	WCVYPWS
OrthoDBⁱ	EOG091G0EIN
TreeFamⁱ	TF331211

Enzyme and pathway databases

Reactomeⁱ	R-MMU-381426 Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) R-MMU-8957275 Post-translational protein phosphorylation

Reactomeⁱ

R-MMU-381426 Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)
R-MMU-8957275 Post-translational protein phosphorylation

Miscellaneous databases

Protein Ontology More...PROⁱ	PR:P47876
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSMUSG00000020429 Expressed in 59 organ(s), highest expression level in liver
CleanExⁱ	MM_IGFBP1
Genevisibleⁱ	P47876 MM

Family and domain databases

CDDⁱ	cd00191 TY, 1 hit
Gene3Dⁱ	4.10.800.10, 1 hit
InterProⁱ	View protein in InterPro IPR009030 Growth_fac_rcpt_cys_sf IPR000867 IGFBP-like IPR022322 IGFBP1 IPR009168 IGFBP1-6 IPR022321 IGFBP_1-6_chordata IPR017891 Insulin_GF-bd_Cys-rich_CS IPR000716 Thyroglobulin_1 IPR036857 Thyroglobulin_1_sf
PANTHERⁱ	PTHR11551 PTHR11551, 1 hit
Pfamⁱ	View protein in Pfam PF00219 IGFBP, 1 hit PF00086 Thyroglobulin_1, 1 hit
PRINTSⁱ	PR01976 IGFBPFAMILY PR01977 IGFBPFAMILY1
SMARTⁱ	View protein in SMART SM00121 IB, 1 hit SM00211 TY, 1 hit
SUPFAMⁱ	SSF57184 SSF57184, 1 hit SSF57610 SSF57610, 1 hit
PROSITEⁱ	View protein in PROSITE PS00222 IGFBP_N_1, 1 hit PS51323 IGFBP_N_2, 1 hit PS00484 THYROGLOBULIN_1_1, 1 hit PS51162 THYROGLOBULIN_1_2, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	IBP1_MOUSE
Accessionⁱ	P47876Primary (citable) accession number: P47876 Secondary accession number(s): Q5SVY8, Q61732
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	February 1, 1996
	Last sequence update:	October 3, 2012
	Last modified:	November 7, 2018
	This is version 146 of the entry and version 2 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

Documents

MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - P47876 (IBP1_MOUSE)

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Insulin-like growth factor-binding protein 1

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

Protein family/group databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted

Extracellular region or secreted

Golgi apparatus

Keywords - Cellular componenti

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Motif

Keywords - Domaini

Phylogenomic databases

Family and domain databases

Experimental Info

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

Protein family/group databases

PTM databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

GO - Molecular functionⁱ

Structureⁱ

Family & Domainsⁱ

Keywords - Domainⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ