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Protein

Insulin-like growth factor-binding protein 1

Gene

Igfbp1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

IGF-binding proteins prolong the half-life of the IGFs and have been shown to either inhibit or stimulate the growth promoting effects of the IGFs on cell culture. They alter the interaction of IGFs with their cell surface receptors. Promotes cell migration (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionGrowth factor binding

Enzyme and pathway databases

ReactomeiR-MMU-381426 Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)
R-MMU-8957275 Post-translational protein phosphorylation

Protein family/group databases

MEROPSiI31.951

Names & Taxonomyi

Protein namesi
Recommended name:
Insulin-like growth factor-binding protein 1
Short name:
IBP-1
Short name:
IGF-binding protein 1
Short name:
IGFBP-1
Gene namesi
Name:Igfbp1
Synonyms:Igfbp-1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 11

Organism-specific databases

MGIiMGI:96436 Igfbp1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 25By similarityAdd BLAST25
ChainiPRO_000001436626 – 272Insulin-like growth factor-binding protein 1Add BLAST247

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi73 ↔ 86PROSITE-ProRule annotation
Disulfide bondi80 ↔ 106PROSITE-ProRule annotation
Modified residuei139PhosphoserineBy similarity1
Modified residuei157PhosphoserineBy similarity1
Modified residuei169PhosphoserineBy similarity1
Modified residuei170PhosphothreonineBy similarity1
Modified residuei171PhosphotyrosineBy similarity1
Disulfide bondi189 ↔ 219PROSITE-ProRule annotation
Disulfide bondi230 ↔ 241PROSITE-ProRule annotation
Disulfide bondi243 ↔ 264PROSITE-ProRule annotation
Modified residuei255PhosphoserineBy similarity1

Keywords - PTMi

Disulfide bond, Phosphoprotein

Proteomic databases

PaxDbiP47876
PeptideAtlasiP47876
PRIDEiP47876

PTM databases

iPTMnetiP47876
PhosphoSitePlusiP47876

Expressioni

Gene expression databases

BgeeiENSMUSG00000020429 Expressed in 59 organ(s), highest expression level in liver
CleanExiMM_IGFBP1
GenevisibleiP47876 MM

Interactioni

Subunit structurei

Binds equally well IGF1 and IGF2.

GO - Molecular functioni

Protein-protein interaction databases

DIPiDIP-60631N
IntActiP47876, 2 interactors
STRINGi10090.ENSMUSP00000020704

Structurei

3D structure databases

ProteinModelPortaliP47876
SMRiP47876
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini28 – 109IGFBP N-terminalPROSITE-ProRule annotationAdd BLAST82
Domaini186 – 264Thyroglobulin type-1PROSITE-ProRule annotationAdd BLAST79

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi259 – 261Cell attachment site3

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410IITJ Eukaryota
ENOG4111H9A LUCA
GeneTreeiENSGT00550000074457
HOGENOMiHOG000253012
HOVERGENiHBG002631
InParanoidiP47876
OMAiWCVYPWS
OrthoDBiEOG091G0EIN
TreeFamiTF331211

Family and domain databases

CDDicd00191 TY, 1 hit
Gene3Di4.10.800.10, 1 hit
InterProiView protein in InterPro
IPR009030 Growth_fac_rcpt_cys_sf
IPR000867 IGFBP-like
IPR022322 IGFBP1
IPR009168 IGFBP1-6
IPR022321 IGFBP_1-6_chordata
IPR017891 Insulin_GF-bd_Cys-rich_CS
IPR000716 Thyroglobulin_1
IPR036857 Thyroglobulin_1_sf
PANTHERiPTHR11551 PTHR11551, 1 hit
PfamiView protein in Pfam
PF00219 IGFBP, 1 hit
PF00086 Thyroglobulin_1, 1 hit
PRINTSiPR01976 IGFBPFAMILY
PR01977 IGFBPFAMILY1
SMARTiView protein in SMART
SM00121 IB, 1 hit
SM00211 TY, 1 hit
SUPFAMiSSF57184 SSF57184, 1 hit
SSF57610 SSF57610, 1 hit
PROSITEiView protein in PROSITE
PS00222 IGFBP_N_1, 1 hit
PS51323 IGFBP_N_2, 1 hit
PS00484 THYROGLOBULIN_1_1, 1 hit
PS51162 THYROGLOBULIN_1_2, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

P47876-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MPEFLTVVSW PFLILLSFQI GVAAGAPQPW HCAPCTAERL GLCPPVPASC
60 70 80 90 100
PEISRPAGCG CCPTCALPMG AACGVATARC AQGLSCRALP GEPRPLHALT
110 120 130 140 150
RGQGACVPEP AAPATSTLFS SQHEEAKAAV VSADELSESP EMTEEQLLDS
160 170 180 190 200
FHLMAPSRED QPILWNAIST YSSMRAREIA DLKKWKEPCQ RELYKVLERL
210 220 230 240 250
AAAQQKAGDE IYKFYLPNCN KNGFYHSKQC ETSLDGEAGL CWCVYPWSGK
260 270
KIPGSLETRG DPNCHQYFNV HN
Length:272
Mass (Da):29,570
Last modified:October 3, 2012 - v2
Checksum:iCD4FCD3C5AB69B60
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti23A → V in CAA57269 (PubMed:7529732).Curated1
Sequence conflicti106 – 107CV → SL in CAA47832 (PubMed:7509771).Curated2
Sequence conflicti229Q → E in CAA57269 (PubMed:7529732).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X81579 mRNA Translation: CAA57269.1
AL607124 Genomic DNA Translation: CAI24501.1
CH466574 Genomic DNA Translation: EDL40608.1
X67493 Genomic DNA Translation: CAA47832.1
CCDSiCCDS24427.1
PIRiI48600
S25113
RefSeqiNP_032367.3, NM_008341.4
UniGeneiMm.21300

Genome annotation databases

EnsembliENSMUST00000020704; ENSMUSP00000020704; ENSMUSG00000020429
GeneIDi16006
KEGGimmu:16006
UCSCiuc007hzh.2 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X81579 mRNA Translation: CAA57269.1
AL607124 Genomic DNA Translation: CAI24501.1
CH466574 Genomic DNA Translation: EDL40608.1
X67493 Genomic DNA Translation: CAA47832.1
CCDSiCCDS24427.1
PIRiI48600
S25113
RefSeqiNP_032367.3, NM_008341.4
UniGeneiMm.21300

3D structure databases

ProteinModelPortaliP47876
SMRiP47876
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

DIPiDIP-60631N
IntActiP47876, 2 interactors
STRINGi10090.ENSMUSP00000020704

Protein family/group databases

MEROPSiI31.951

PTM databases

iPTMnetiP47876
PhosphoSitePlusiP47876

Proteomic databases

PaxDbiP47876
PeptideAtlasiP47876
PRIDEiP47876

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000020704; ENSMUSP00000020704; ENSMUSG00000020429
GeneIDi16006
KEGGimmu:16006
UCSCiuc007hzh.2 mouse

Organism-specific databases

CTDi3484
MGIiMGI:96436 Igfbp1

Phylogenomic databases

eggNOGiENOG410IITJ Eukaryota
ENOG4111H9A LUCA
GeneTreeiENSGT00550000074457
HOGENOMiHOG000253012
HOVERGENiHBG002631
InParanoidiP47876
OMAiWCVYPWS
OrthoDBiEOG091G0EIN
TreeFamiTF331211

Enzyme and pathway databases

ReactomeiR-MMU-381426 Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)
R-MMU-8957275 Post-translational protein phosphorylation

Miscellaneous databases

PROiPR:P47876
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000020429 Expressed in 59 organ(s), highest expression level in liver
CleanExiMM_IGFBP1
GenevisibleiP47876 MM

Family and domain databases

CDDicd00191 TY, 1 hit
Gene3Di4.10.800.10, 1 hit
InterProiView protein in InterPro
IPR009030 Growth_fac_rcpt_cys_sf
IPR000867 IGFBP-like
IPR022322 IGFBP1
IPR009168 IGFBP1-6
IPR022321 IGFBP_1-6_chordata
IPR017891 Insulin_GF-bd_Cys-rich_CS
IPR000716 Thyroglobulin_1
IPR036857 Thyroglobulin_1_sf
PANTHERiPTHR11551 PTHR11551, 1 hit
PfamiView protein in Pfam
PF00219 IGFBP, 1 hit
PF00086 Thyroglobulin_1, 1 hit
PRINTSiPR01976 IGFBPFAMILY
PR01977 IGFBPFAMILY1
SMARTiView protein in SMART
SM00121 IB, 1 hit
SM00211 TY, 1 hit
SUPFAMiSSF57184 SSF57184, 1 hit
SSF57610 SSF57610, 1 hit
PROSITEiView protein in PROSITE
PS00222 IGFBP_N_1, 1 hit
PS51323 IGFBP_N_2, 1 hit
PS00484 THYROGLOBULIN_1_1, 1 hit
PS51162 THYROGLOBULIN_1_2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiIBP1_MOUSE
AccessioniPrimary (citable) accession number: P47876
Secondary accession number(s): Q5SVY8, Q61732
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1996
Last sequence update: October 3, 2012
Last modified: November 7, 2018
This is version 146 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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