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Protein

Interleukin-11

Gene

Il11

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Cytokine that stimulates the proliferation of hematopoietic stem cells and megakaryocyte progenitor cells and induces megakaryocyte maturation resulting in increased platelet production (PubMed:8913282). Also promotes the proliferation of hepatocytes in response to liver damage (PubMed:22253262). Binding to its receptor formed by IL6ST and either IL11RA1 or IL11RA2 activates a signaling cascade that promotes cell proliferation, also in the context of various cancers (PubMed:10026196, PubMed:23948300). Signaling leads to the activation of intracellular protein kinases and the phosphorylation of STAT3 (PubMed:23948300, PubMed:22253262).4 Publications

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei168Important for interaction with IL6ST and for the stimulation of cell proliferation1 Publication1

GO - Molecular functioni

  • cytokine activity Source: MGI
  • growth factor activity Source: UniProtKB
  • interleukin-11 receptor binding Source: MGI

GO - Biological processi

Keywordsi

Molecular functionCytokine, Growth factor

Enzyme and pathway databases

ReactomeiR-MMU-6788467 IL-6-type cytokine receptor ligand interactions

Names & Taxonomyi

Protein namesi
Recommended name:
Interleukin-11
Short name:
IL-11
Gene namesi
Name:Il11
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 7

Organism-specific databases

MGIiMGI:107613 Il11

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi168W → A: Slightly increases IL11RA binding. Abolishes interaction with IL6ST. Abolishes stimulation of cell proliferation. 1 Publication1
Mutagenesisi172R → A: No effect on IL11RA binding. Decreases stimulation of cell proliferation. 1 Publication1
Mutagenesisi190R → A: Srongly reduces IL11RA binding and stimulation of cell proliferation. 1 Publication1
Mutagenesisi193L → A: Impairs IL11RA binding and mildly reduces stimulation of cell proliferation. 1 Publication1

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 21Sequence analysisAdd BLAST21
ChainiPRO_000001562022 – 199Interleukin-11Add BLAST178

Proteomic databases

PaxDbiP47873
PRIDEiP47873

PTM databases

PhosphoSitePlusiP47873

Expressioni

Inductioni

Up-regulated in hepatocytes by oxidative stress caused by liver damage.1 Publication

Gene expression databases

BgeeiENSMUSG00000004371 Expressed in 59 organ(s), highest expression level in testis
CleanExiMM_IL11
ExpressionAtlasiP47873 baseline and differential
GenevisibleiP47873 MM

Interactioni

Subunit structurei

Interacts with IL6ST and either IL11RA1 or IL11RA2, giving rise to a multimeric signaling complex.1 Publication

GO - Molecular functioni

Protein-protein interaction databases

DIPiDIP-5780N
IntActiP47873, 1 interactor
STRINGi10090.ENSMUSP00000092492

Structurei

3D structure databases

ProteinModelPortaliP47873
SMRiP47873
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni182 – 190Important for interaction with IL11RA and for the stimulation of cell proliferationBy similarityCurated9

Sequence similaritiesi

Belongs to the IL-6 superfamily.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410IWMH Eukaryota
ENOG411181Z LUCA
GeneTreeiENSGT00390000007165
HOVERGENiHBG003999
InParanoidiP47873
KOiK05417
OMAiMNSVCCL
OrthoDBiEOG091G0V1V
PhylomeDBiP47873
TreeFamiTF337294

Family and domain databases

InterProiView protein in InterPro
IPR009079 4_helix_cytokine-like_core
IPR020438 IL-11
IPR020412 IL-11_mml
PfamiView protein in Pfam
PF07400 IL11, 1 hit
PRINTSiPR01943 INTLKN11MAML
PR01927 INTRLEUKIN11
SUPFAMiSSF47266 SSF47266, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

P47873-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MNCVCRLVLV VLSLWPDRVV APGPPAGSPR VSSDPRADLD SAVLLTRSLL
60 70 80 90 100
ADTRQLAAQM RDKFPADGDH SLDSLPTLAM SAGTLGSLQL PGVLTRLRVD
110 120 130 140 150
LMSYLRHVQW LRRAGGPSLK TLEPELGALQ ARLERLLRRL QLLMSRLALP
160 170 180 190
QAAPDQPVIP LGPPASAWGS IRAAHAILGG LHLTLDWAVR GLLLLKTRL
Length:199
Mass (Da):21,522
Last modified:February 1, 1996 - v1
Checksum:i904FF7DBA896625A
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
F7A7F2F7A7F2_MOUSE
Interleukin-11
Il11
140Annotation score:

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U03421 mRNA Translation: AAC52941.1
CCDSiCCDS39740.1
RefSeqiNP_032376.1, NM_008350.4
UniGeneiMm.35814

Genome annotation databases

EnsembliENSMUST00000094892; ENSMUSP00000092492; ENSMUSG00000004371
GeneIDi16156
KEGGimmu:16156
UCSCiuc009eyo.2 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U03421 mRNA Translation: AAC52941.1
CCDSiCCDS39740.1
RefSeqiNP_032376.1, NM_008350.4
UniGeneiMm.35814

3D structure databases

ProteinModelPortaliP47873
SMRiP47873
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

DIPiDIP-5780N
IntActiP47873, 1 interactor
STRINGi10090.ENSMUSP00000092492

PTM databases

PhosphoSitePlusiP47873

Proteomic databases

PaxDbiP47873
PRIDEiP47873

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000094892; ENSMUSP00000092492; ENSMUSG00000004371
GeneIDi16156
KEGGimmu:16156
UCSCiuc009eyo.2 mouse

Organism-specific databases

CTDi3589
MGIiMGI:107613 Il11

Phylogenomic databases

eggNOGiENOG410IWMH Eukaryota
ENOG411181Z LUCA
GeneTreeiENSGT00390000007165
HOVERGENiHBG003999
InParanoidiP47873
KOiK05417
OMAiMNSVCCL
OrthoDBiEOG091G0V1V
PhylomeDBiP47873
TreeFamiTF337294

Enzyme and pathway databases

ReactomeiR-MMU-6788467 IL-6-type cytokine receptor ligand interactions

Miscellaneous databases

PROiPR:P47873
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000004371 Expressed in 59 organ(s), highest expression level in testis
CleanExiMM_IL11
ExpressionAtlasiP47873 baseline and differential
GenevisibleiP47873 MM

Family and domain databases

InterProiView protein in InterPro
IPR009079 4_helix_cytokine-like_core
IPR020438 IL-11
IPR020412 IL-11_mml
PfamiView protein in Pfam
PF07400 IL11, 1 hit
PRINTSiPR01943 INTLKN11MAML
PR01927 INTRLEUKIN11
SUPFAMiSSF47266 SSF47266, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiIL11_MOUSE
AccessioniPrimary (citable) accession number: P47873
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 1, 1996
Last sequence update: February 1, 1996
Last modified: September 12, 2018
This is version 119 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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